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PHYSIOLOGICAL DIMER HPP PRECURSOR

Source organism: Homo sapiens
Biochemical function: enzyme activator activity
Biological process: negative regulation of chaperone-mediated autophagy
Cellular component: lumenal side of lysosomal membrane

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EC 3.4.16.5: Carboxypeptidase C

Reaction catalysed:
Release of a C-terminal amino acid with broad specificity.
Alternative Name(s):
  • Carboxypeptidase Y
  • Cathepsin A
  • Deamidase
  • Lysosomal carboxypeptidase A
  • Lysosomal protective protein
  • Phaseolin
  • Serine carboxypeptidase I
  • Serine-type carboxypeptidase I

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00450
Domain description: Serine carboxypeptidase
Occurring in:
  1. Lysosomal protective protein
The deposited structure of PDB entry 1ivy contains 2 copies of Pfam domain PF00450 (Serine carboxypeptidase) in Lysosomal protective protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001563
Domain description: Peptidase S10, serine carboxypeptidase
Occurring in:
  1. Lysosomal protective protein
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Lysosomal protective protein
IPR033124
Domain description: Serine carboxypeptidases, histidine active site
Occurring in:
  1. Lysosomal protective protein
IPR018202
Domain description: Serine carboxypeptidase, serine active site
Occurring in:
  1. Lysosomal protective protein

Structure domain

CATH CATH domain
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Lysosomal protective protein
The deposited structure of PDB entry 1ivy contains 2 copies of CATH domain 3.40.50.1820 (Rossmann fold) in Lysosomal protective protein. Showing 1 copy in chain A.
SCOP SCOP annotation
53499
Class: Alpha and beta proteins (a/b)
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Occurring in:
  1. Lysosomal protective protein
The deposited structure of PDB entry 1ivy contains 2 copies of SCOP domain 53499 (Serine carboxypeptidase-like) in Lysosomal protective protein. Showing 1 copy in chain A.

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