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CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP BOUND TO RAC1

X-ray diffraction
2.3Å resolution
PDB entry 1g4u coloured by chain, front view.
PDB entry 1g4u coloured by chain, side view.
PDB entry 1g4u coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Secreted effector protein SptP and Ras-related C3 botulinum toxin substrate 1
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Multimeric state: hetero dimer
Accessible surface area: 24387.42 Å2
Buried surface area: 3188.58 Å2
Dissociation area: 1,070.42 Å2
Dissociation energy (ΔGdiss): 1.02 kcal/mol
Dissociation entropy (TΔSdiss): 12.64 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158897

Macromolecules

Secreted effector protein SptP
Chain: S
Length: 383 amino acids
Theoretical weight: 42.13 KDa
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P74873 (Residues: 161-543; Coverage: 71%)
Gene names: STM2878, sptP
Pfam:
InterPro:
CATH:
SCOP:
Secreted effector protein SptP in PDB entry 1g4u, assembly 1, front view.
Secreted effector protein SptP in PDB entry 1g4u, assembly 1, side view.
Secreted effector protein SptP in PDB entry 1g4u, assembly 1, top view.
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Ras-related C3 botulinum toxin substrate 1
Chain: R
Length: 184 amino acids
Theoretical weight: 20.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P63000 (Residues: 1-184; Coverage: 96%)
Gene names: MIG5, RAC1, TC25
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins
Ras-related C3 botulinum toxin substrate 1 in PDB entry 1g4u, assembly 1, front view.
Ras-related C3 botulinum toxin substrate 1 in PDB entry 1g4u, assembly 1, side view.
Ras-related C3 botulinum toxin substrate 1 in PDB entry 1g4u, assembly 1, top view.
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