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Mutant human thymidylate kinase complexed with TMP and APPNP

X-ray diffraction
1.6Å resolution
PDB entry 1e9c coloured by chain, front view.
PDB entry 1e9c coloured by chain, side view.
PDB entry 1e9c coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Thymidylate kinase
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Multimeric state: homo dimer
Accessible surface area: 16646.13 Å2
Buried surface area: 6560.24 Å2
Dissociation area: 877.01 Å2
Dissociation energy (ΔGdiss): 14.49 kcal/mol
Dissociation entropy (TΔSdiss): 12.35 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-150117

Macromolecules

Thymidylate kinase
Chain: A
Length: 215 amino acids
Theoretical weight: 24.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23919 (Residues: 1-212; Coverage: 100%)
Gene names: CDC8, DTYMK, TMPK, TYMK
Pfam: Thymidylate kinase
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: Nucleotide and nucleoside kinases
Thymidylate kinase in PDB entry 1e9c, assembly 1, front view.
Thymidylate kinase in PDB entry 1e9c, assembly 1, side view.
Thymidylate kinase in PDB entry 1e9c, assembly 1, top view.
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