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THE CRYSTAL STRUCTURE OF RUBISCO FROM ALCALIGENES EUTROPHUS TO 2.7 ANGSTROMS.

Source organism: Cupriavidus necator
Biochemical function: ribulose-bisphosphate carboxylase activity
Biological process: reductive pentose-phosphate cycle
Cellular component: not assigned

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EC 4.1.1.39: Ribulose-bisphosphate carboxylase

Reaction catalysed:
2 3-phospho-D-glycerate + 2 H(+) = D-ribulose 1,5-bisphosphate + CO(2) + H(2)O
Systematic name:
3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming)
Alternative Name(s):
  • 3-phospho-D-glycerate carboxy-lyase (dimerizing)
  • Carboxydismutase
  • D-ribulose 1,5-diphosphate carboxylase
  • D-ribulose-1,5-bisphosphate carboxylase
  • Diphosphoribulose carboxylase
  • Ribulose 1,5-bisphosphate carboxylase
  • Ribulose 1,5-bisphosphate carboxylase/oxygenase
  • Ribulose 1,5-diphosphate carboxylase
  • Ribulose 1,5-diphosphate carboxylase/oxygenase
  • Ribulose bisphosphate carboxylase/oxygenase
  • Ribulose diphosphate carboxylase
  • Ribulose diphosphate carboxylase/oxygenase
  • RuBP carboxylase
  • RuBisCO
  • Rubisco

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00101
Domain description: Ribulose bisphosphate carboxylase, small chain
Occurring in:
  1. Ribulose bisphosphate carboxylase small subunit, chromosomal
The deposited structure of PDB entry 1bxn contains 4 copies of Pfam domain PF00101 (Ribulose bisphosphate carboxylase, small chain) in Ribulose bisphosphate carboxylase small subunit, chromosomal. Showing 1 copy in chain B [auth I].

PF00016
Domain description: Ribulose bisphosphate carboxylase large chain, catalytic domain
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
The deposited structure of PDB entry 1bxn contains 4 copies of Pfam domain PF00016 (Ribulose bisphosphate carboxylase large chain, catalytic domain) in Ribulose bisphosphate carboxylase large chain, chromosomal. Showing 1 copy in chain A.

PF02788
Domain description: Ribulose bisphosphate carboxylase large chain, N-terminal domain
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
The deposited structure of PDB entry 1bxn contains 4 copies of Pfam domain PF02788 (Ribulose bisphosphate carboxylase large chain, N-terminal domain) in Ribulose bisphosphate carboxylase large chain, chromosomal. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000894
Domain description: Ribulose bisphosphate carboxylase small subunit, domain
Occurring in:
  1. Ribulose bisphosphate carboxylase small subunit, chromosomal
IPR036385
Domain description: Ribulose bisphosphate carboxylase, small subunit superfamily
Occurring in:
  1. Ribulose bisphosphate carboxylase small subunit, chromosomal
IPR036376
Domain description: Ribulose bisphosphate carboxylase, large subunit, C-terminal domain superfamily
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
IPR036422
Domain description: RuBisCO large subunit, N-terminal domain superfamily
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
IPR020888
Domain description: Ribulose bisphosphate carboxylase large subunit, type I
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
IPR033966
Domain description: RuBisCO
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
IPR024681
Domain description: Ribulose bisphosphate carboxylase, small subunit
Occurring in:
  1. Ribulose bisphosphate carboxylase small subunit, chromosomal
IPR020878
Domain description: Ribulose bisphosphate carboxylase, large chain, active site
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
IPR000685
Domain description: Ribulose bisphosphate carboxylase, large subunit, C-terminal
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
IPR017443
Domain description: Ribulose bisphosphate carboxylase, large subunit, ferrodoxin-like N-terminal
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal

Structure domains

CATH CATH domains
3.30.190.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Ribulose 1,5 Bisphosphate Carboxylase/Oxygenase
Homology: Ribulose bisphosphate carboxylase, small subunit
Occurring in:
  1. Ribulose bisphosphate carboxylase small subunit, chromosomal
The deposited structure of PDB entry 1bxn contains 4 copies of CATH domain 3.30.190.10 (Ribulose 1,5 Bisphosphate Carboxylase/Oxygenase) in Ribulose bisphosphate carboxylase small subunit, chromosomal. Showing 1 copy in chain B [auth I].
3.20.20.110
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Ribulose bisphosphate carboxylase, large subunit, C-terminal domain
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
The deposited structure of PDB entry 1bxn contains 4 copies of CATH domain 3.20.20.110 (TIM Barrel) in Ribulose bisphosphate carboxylase large chain, chromosomal. Showing 1 copy in chain A.
3.30.70.150
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: RuBisCO large subunit, N-terminal domain
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
The deposited structure of PDB entry 1bxn contains 4 copies of CATH domain 3.30.70.150 (Alpha-Beta Plaits) in Ribulose bisphosphate carboxylase large chain, chromosomal. Showing 1 copy in chain A.
SCOP SCOP annotations
55240
Class: Alpha and beta proteins (a+b)
Fold: RuBisCO, small subunit
Superfamily: RuBisCO, small subunit
Occurring in:
  1. Ribulose bisphosphate carboxylase small subunit, chromosomal
The deposited structure of PDB entry 1bxn contains 4 copies of SCOP domain 55240 (RuBisCO, small subunit) in Ribulose bisphosphate carboxylase small subunit, chromosomal. Showing 1 copy in chain B [auth I].
51650
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: RuBisCo, C-terminal domain
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
The deposited structure of PDB entry 1bxn contains 4 copies of SCOP domain 51650 (RuBisCo, large subunit, C-terminal domain) in Ribulose bisphosphate carboxylase large chain, chromosomal. Showing 1 copy in chain A.
54967
Class: Alpha and beta proteins (a+b)
Fold: Ferredoxin-like
Superfamily: RuBisCO, large subunit, small (N-terminal) domain
Occurring in:
  1. Ribulose bisphosphate carboxylase large chain, chromosomal
The deposited structure of PDB entry 1bxn contains 4 copies of SCOP domain 54967 (Ribulose 1,5-bisphosphate carboxylase-oxygenase) in Ribulose bisphosphate carboxylase large chain, chromosomal. Showing 1 copy in chain A.

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