Active Site

Ribulose bisphosphate carboxylase, large chain, active site (IPR020878)

Short name: RuBisCo_large_chain_AS


Ribulose bisphosphate carboxylase (RuBisCO) [PMID: 6351728, PMID: 12221984] catalyses the initial step in Calvin's reductive pentose phosphate cycle in plants as well as purple and green bacteria. It catalyzes the primary CO2 fixation step. RuBisCO consists of a large catalytic unit and a small subunit of undetermined function. In plants, the large subunit is coded by the chloroplastic genome while the small subunit is encoded in the nuclear genome. Rubisco is activated by carbamylation of an active site lysine, stabilized by a divalent cation, which then catalyzes the proton abstraction from the substrate ribulose 1,5 bisphosphate (RuBP) and leads to the formation of two molecules of 3-phosphoglycerate [PMID: 1969412, PMID: 9034362].

This entry represents the active site [PMID: 1969412] which includes both the active site residue and the metal ligand, and which is specific to RuBisCO large chains.

GO terms

Biological Process

GO:0015977 carbon fixation

Molecular Function

GO:0000287 magnesium ion binding
GO:0016984 ribulose-bisphosphate carboxylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns