PDBe 1g3j

X-ray diffraction
2.1Å resolution

CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX

Released:
Source organisms:
Primary publication:
Crystal structure of a beta-catenin/Tcf complex.
Cell 103 885-96 (2000)
PMID: 11136974

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Catenin beta-1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 532 amino acids
Theoretical weight: 58.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35222 (Residues: 133-664; Coverage: 68%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
Transcription factor 7-like 1-A Chains: B, D
Molecule details ›
Chains: B, D
Length: 61 amino acids
Theoretical weight: 6.4 KDa
Source organism: Xenopus laevis
Expression system: Escherichia coli
UniProt:
  • Canonical: P70062 (Residues: 1-61; Coverage: 11%)
Gene names: tcf3, tcf3a, tcf7l1-a
Structure domains: TCF3-CBD (Catenin binding domain)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 52.135Å b: 153.249Å c: 188.124Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.229 0.255
Expression system: Escherichia coli