Transcription factor TCF/LEF (IPR024940)

Short name: TCF/LEF

Overlapping homologous superfamilies


Family relationships


Members of this family of HMG box containing factors play an essential role in the Wnt/Wingless signalling cascade. They are known to associate with beta-catenin in the nucleus to mediate Wnt signaling [PMID: 10209158, PMID: 9433138]. This family exist in vertebrates, Drosophila melanogaster and Caenorhabditis elegans, and includes transcription factor 7, transcription factor 7-like 1 and 2, lymphoid enhancer-binding factor 1 and proteins pangolin and pop-1 [PMID: 11934263].

GO terms

Biological Process

GO:0016055 Wnt signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.