› 6u9w

Electron Microscopy
3.3Å resolution

Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the ATP-bound, open state

Released:
DOI: 10.2210/pdb6u9w/pdb
PDB entry 6u9w coloured by chain, front view.
PDB entry 6u9w coloured by chain, side view.
PDB entry 6u9w coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization.
McCarthy AE, Yoshioka C, Mansoor SE
Cell 179 659-670.e13 (2019)
PMID: 31587896
Related structures: EMD-20703

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179150 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
P2X purinoceptor 7 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 609 amino acids
Theoretical weight: 69.9 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q64663 (Residues: 1-595; Coverage: 100%)
Gene name: P2rx7
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
6 bound ligands:
Ligand ZN 6 x ZN
Ligand GDP 3 x GDP
Ligand NAG 6 x NAG
Ligand Q3G 3 x Q3G
Ligand PLM 12 x PLM
Ligand ATP 3 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-20703
Expression system: Homo sapiens

Quick links

Citations

31 review citations

Molecular Modeling Applied to the Discovery of New Lead Compounds for P2 Receptors Based on Natural Sources.
Alberto et al. (2020)
30 more

18 mentions without citation

Update of P2X receptor properties and their pharmacology: IUPHAR Review 30.
Illes et al. (2021)
17 more