› 4y5u

X-ray diffraction
2.71Å resolution

Transcription factor

Released:
DOI: 10.2210/pdb4y5u/pdb
PDB entry 4y5u coloured by chain, front view.
PDB entry 4y5u coloured by chain, side view.
PDB entry 4y5u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for DNA recognition by STAT6.
Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S
Proc Natl Acad Sci U S A 113 13015-13020 (2016)
PMID: 27803324

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154573 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Signal transducer and activator of transcription 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 549 amino acids
Theoretical weight: 61.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42226 (Residues: 113-658; Coverage: 65%)
  • Best match: P42226-3 (Residues: 3-548)
Gene name: STAT6
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 66.152Å b: 94.322Å c: 179.362Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.185 0.253
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Mechanisms and consequences of Jak-STAT signaling in the immune system.
Villarino et al. (2017)
9 more

2 mentions without citation

Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade.
Chapuy et al. (2019)
1 more