› 4dlo

X-ray diffraction
2.3Å resolution

Crystal structure of the GAIN and HormR domains of brain angiogenesis inhibitor 3 (BAI3)

Released:
DOI: 10.2210/pdb4dlo/pdb
PDB entry 4dlo coloured by chain, front view.
PDB entry 4dlo coloured by chain, side view.
PDB entry 4dlo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.
Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT
EMBO J 31 1364-78 (2012)
PMID: 22333914

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129921 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Adhesion G protein-coupled receptor B3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 382 amino acids
Theoretical weight: 43.26 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O60242 (Residues: 498-868; Coverage: 25%)
Gene names: ADGRB3, BAI3, KIAA0550
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand GOL 9 x GOL
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2221
Unit cell:
a: 123.364Å b: 128.008Å c: 160.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.228
Expression system: Trichoplusia ni

Quick links

Citations

67 review citations

Molecular signatures of G-protein-coupled receptors.
Venkatakrishnan et al. (2013)
66 more

8 mentions without citation

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.
Araç et al. (2012)
7 more