› 4k1n

X-ray diffraction
6.5Å resolution

Crystal structure of full-length mouse alphaE-catenin

Released:
DOI: 10.2210/pdb4k1n/pdb
PDB entry 4k1n coloured by chain, front view.
PDB entry 4k1n coloured by chain, side view.
PDB entry 4k1n coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
An autoinhibited structure of α-catenin and its implications for vinculin recruitment to adherens junctions.
Ishiyama N, Tanaka N, Abe K, Yang YJ, Abbas YM, Umitsu M, Nagar B, Bueler SA, Rubinstein JL, Takeichi M, Ikura M
J Biol Chem 288 15913-25 (2013)
PMID: 23589308

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150678 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catenin alpha-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 912 amino acids
Theoretical weight: 100.81 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P26231 (Residues: 1-906; Coverage: 100%)
Gene names: Catna1, Ctnna1
Sequence domains: Vinculin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P32
Unit cell:
a: 144.684Å b: 144.684Å c: 136.757Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.224 0.248
Expression system: Escherichia coli BL21

Quick links

Citations

15 review citations

Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling.
Takeichi M. (2014)
14 more

9 mentions without citation

Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions.
Mège et al. (2017)
8 more