3q87 Summary


Structure of eukaryotic translation termination complex methyltransferase Mtq2-Trm112

The structure was published by Liger, D., Mora, L., Lazar, N., et al., van Tilbeurgh, H., Heurgue-Hamard, V., and Graille, M., in 2011 in a paper entitled "Mechanism of activation of methyltransferases involved in translation by the Trm112 'hub' protein" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.997 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Putative uncharacterized protein ECU08_1170 and N6 adenine specific DNA methylase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Putative uncharacterized protein ECU08_1170 Q8SUP0 (1-125) (Q8SUP0_ENCCU)search Encephalitozoon cuniculi GB-M1search 100% 125 97%
B N6 adenine specific DNA methylase Q8SRR4 (1-164) (Q8SRR4_ENCCU)search Encephalitozoon cuniculi GB-M1search 100% 170 96%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8SUP0 (1 - 125) Putative uncharacterized protein ECU08_1170 Encephalitozoon cuniculi
Q8SRR4 (1 - 164) N6 adenine specific DNA methylase Encephalitozoon cuniculi

Chain Sequence family (Pfam)
A (Q8SUP0) PF03966: Trm112p-like proteinsearch
B (Q8SRR4) PF05175: Methyltransferase small domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q8SUP0) metal ion bindingsearch
B (Q8SRR4) nucleic acid bindingsearch methyltransferase activitysearch transferase activitysearch methylationsearch

Chain InterPro annotation
A Uncharacterised protein family UPF0434/Trm112search
B DNA methylase, N-6 adenine-specific, conserved sitesearch Methyltransferase small domainsearch S-adenosyl-L-methionine-dependent methyltransferase-likesearch