Trm112-like (IPR005651)

Short name: Trm112-like

Overlapping homologous superfamilies


Family relationships



The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the strongest conservation. The entry contains:

  • Trm112, which is required for tRNA methylation in Saccharomyces cerevisiae (Baker's yeast) and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W [PMID: 15899842]. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast [PMID: 17008308]. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices [PMID: 17008308].
  • Mitochondrial protein preY, an uncharacterized protein from vertebrates.
  • UPF0434, which consists of prokaryotic proteins that are functionally uncharacterised.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.