› 3kfv

X-ray diffraction
2.8Å resolution

Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form

Released:
DOI: 10.2210/pdb3kfv/pdb
PDB entry 3kfv coloured by chain, front view.
PDB entry 3kfv coloured by chain, side view.
PDB entry 3kfv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tong Y, Nedyalkova L, Tempel W, Zhong N, Guan X, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131812 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tight junction protein ZO-3 Chain: A
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 35.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O95049 (Residues: 474-775; Coverage: 33%)
Gene names: TJP3, ZO3
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand UNX 10 x UNX
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P422
Unit cell:
a: 88.654Å b: 88.654Å c: 92.311Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.222 0.29
Expression system: Escherichia coli BL21

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