Domain

Guanylate kinase/L-type calcium channel beta subunit (IPR008145)

Short name: GK/Ca_channel_bsu

Domain relationships

Description

This entry represents a domain found in guanylate kinase (EC:2.7.4.8) and in L-type calcium channel.

Guanylate kinase (EC:2.7.4.8) (GK) [PMID: 1314905] catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown [PMID: 1310897, PMID: 8097461, PMID: 1329277] to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.

L-type calcium channnels are formed from different alpha-1 subunit isoforms that determine the pharmacological properties of the channel, since they form the drug binding domain. Other properties, such as gating voltage-dependence, G protein modulation and kinase susceptibility, are influenced by alpha-2, delta and beta subunits.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam