3hs6 Summary

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X-ray crystal structure of eicosapentaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2

The structure was published by Vecchio, A.J., Simmons, D.M., and Malkowski, M.G., in 2010 in a paper entitled "Structural basis of fatty acid substrate binding to cyclooxygenase-2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 2 Q05769 (20-604) (PGH2_MOUSE)search Mus musculussearch 94% 591 93%
B Prostaglandin G/H synthase 2 Q05769 (20-604) (PGH2_MOUSE)search Mus musculussearch 94% 591 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (20 - 604) Prostaglandin G/H synthase 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q05769) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q05769) regulation of blood pressuresearch response to lipopolysaccharidesearch positive regulation of cell migration involved in sprouting angiogenesissearch bone mineralizationsearch positive regulation of cell proliferationsearch response to tumor necrosis factorsearch response to radiationsearch regulation of cell proliferationsearch response to glucocorticoidsearch positive regulation of smooth muscle contractionsearch response to fatty acidsearch prostaglandin biosynthetic processsearch hair cyclesearch brown fat cell differentiationsearch positive regulation of synaptic plasticitysearch negative regulation of smooth muscle contractionsearch maintenance of blood-brain barriersearch cellular response to hypoxiasearch negative regulation of calcium ion transportsearch positive regulation vascular endothelial growth factor productionsearch positive regulation of nitric oxide biosynthetic processsearch fatty acid biosynthetic processsearch response to drugsearch positive regulation of NF-kappaB import into nucleussearch embryo implantationsearch response to estradiolsearch response to vitamin Dsearch angiogenesissearch cellular response to UVsearch response to organic substancesearch cyclooxygenase pathwaysearch keratinocyte differentiationsearch positive regulation of fever generationsearch positive regulation of fibroblast growth factor productionsearch negative regulation of cell proliferationsearch response to cytokinesearch negative regulation of synaptic transmission, dopaminergicsearch response to fructosesearch ovulationsearch positive regulation of transforming growth factor beta productionsearch learningsearch fatty acid metabolic processsearch positive regulation of cell deathsearch response to organic cyclic compoundsearch oxidation-reduction processsearch memorysearch positive regulation of smooth muscle cell proliferationsearch response to manganese ionsearch positive regulation of apoptotic processsearch positive regulation of vasoconstrictionsearch response to organonitrogen compoundsearch negative regulation of cell cyclesearch prostaglandin metabolic processsearch positive regulation of brown fat cell differentiationsearch decidualizationsearch sensory perception of painsearch positive regulation of platelet-derived growth factor productionsearch positive regulation of synaptic transmission, glutamatergicsearch response to lithium ionsearch inflammatory responsesearch cellular response to ATPsearch lipid metabolic processsearch cellular response to mechanical stimulussearch response to oxidative stresssearch protein homodimerization activitysearch prostaglandin-endoperoxide synthase activitysearch heme bindingsearch peroxidase activitysearch dioxygenase activitysearch metal ion bindingsearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch enzyme bindingsearch lipid bindingsearch oxidoreductase activitysearch neuron projectionsearch caveolasearch membranesearch endoplasmic reticulum membranesearch intracellular membrane-bounded organellesearch endoplasmic reticulumsearch organelle membranesearch protein complexsearch cytoplasmsearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search