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Crystal structure the Fab fragment of matuzumab (Fab72000) in complex with domain III of the extracellular region of EGFR

X-ray diffraction
3.2Å resolution
PDB entry 3c09 coloured by chain, front view.
PDB entry 3c09 coloured by chain, side view.
PDB entry 3c09 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Epidermal growth factor receptor and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 26107.99 Å2
Buried surface area: 6122.07 Å2
Dissociation area: 840.59 Å2
Dissociation energy (ΔGdiss): -2.3 kcal/mol
Dissociation entropy (TΔSdiss): 12.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-233873
Assembly 2 (preferred)
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Assembly Name: Epidermal growth factor receptor and IG-light kappa chain and IG-heavy chain
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Multimeric state: hetero trimer
Accessible surface area: 25484.56 Å2
Buried surface area: 5662.24 Å2
Dissociation area: 785.77 Å2
Dissociation energy (ΔGdiss): -3.13 kcal/mol
Dissociation entropy (TΔSdiss): 12.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-233873

Macromolecules

Matuzumab Fab Light chain
Chains: B, L
Length: 212 amino acids
Theoretical weight: 23.24 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
CATH: Immunoglobulins
Matuzumab Fab Light chain in PDB entry 3c09, assembly 2, front view.
Matuzumab Fab Light chain in PDB entry 3c09, assembly 2, side view.
Matuzumab Fab Light chain in PDB entry 3c09, assembly 2, top view.
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Matuzumab Fab Heavy chain
Chains: C, H
Length: 223 amino acids
Theoretical weight: 24.04 KDa
Source organism: Mus musculus
Expression system: Mus musculus
InterPro:
CATH: Immunoglobulins
SCOP:
Matuzumab Fab Heavy chain in PDB entry 3c09, assembly 2, front view.
Matuzumab Fab Heavy chain in PDB entry 3c09, assembly 2, side view.
Matuzumab Fab Heavy chain in PDB entry 3c09, assembly 2, top view.
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Epidermal growth factor receptor
Chains: A, D
Length: 214 amino acids
Theoretical weight: 23.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 336-538; Coverage: 17%)
  • Best match: P00533-2 (Residues: 336-404)
Gene names: EGFR, ERBB, ERBB1, HER1
Pfam: Receptor L domain
InterPro:
CATH: Receptor L-domain
SCOP:
Epidermal growth factor receptor in PDB entry 3c09, assembly 2, front view.
Epidermal growth factor receptor in PDB entry 3c09, assembly 2, side view.
Epidermal growth factor receptor in PDB entry 3c09, assembly 2, top view.
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