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Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII

X-ray diffraction
2.8Å resolution
PDB entry 2vd5 coloured by chain, front view.
PDB entry 2vd5 coloured by chain, side view.
PDB entry 2vd5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Myotonin-protein kinase
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Multimeric state: homo dimer
Accessible surface area: 34515.57 Å2
Buried surface area: 4091.79 Å2
Dissociation area: 1,265.91 Å2
Dissociation energy (ΔGdiss): 21.21 kcal/mol
Dissociation entropy (TΔSdiss): 14.03 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-170737
Assembly 2
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Assembly Name: Myotonin-protein kinase
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Multimeric state: homo dimer
Accessible surface area: 34110.18 Å2
Buried surface area: 3808.76 Å2
Dissociation area: 1,121.77 Å2
Dissociation energy (ΔGdiss): 18.56 kcal/mol
Dissociation entropy (TΔSdiss): 13.93 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-170737

Macromolecules

Myotonin-protein kinase
Chains: A, B
Length: 412 amino acids
Theoretical weight: 46.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q09013 (Residues: 10-420; Coverage: 65%)
Gene names: DM1PK, DMPK, MDPK
Pfam: Protein kinase domain
InterPro:
CATH:
Myotonin-protein kinase in PDB entry 2vd5, assembly 1, front view.
Myotonin-protein kinase in PDB entry 2vd5, assembly 1, side view.
Myotonin-protein kinase in PDB entry 2vd5, assembly 1, top view.
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