PDBe 2vd5

X-ray diffraction
2.8Å resolution

Structure of Human Myotonic Dystrophy Protein Kinase in Complex with the Bisindoylmaleide inhibitor BIM VIII

Released:
Source organism: Homo sapiens
Primary publication:
Structure of dystrophia myotonica protein kinase.
Protein Sci. 18 782-91 (2009)
PMID: 19309729

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myotonin-protein kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 412 amino acids
Theoretical weight: 46.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q09013 (Residues: 10-420; Coverage: 65%)
  • Best match: Q09013-2 (Residues: 1-331)
Gene names: DM1PK, DMPK, MDPK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 122.599Å b: 122.599Å c: 134.278Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.196 0.244
Expression system: Escherichia coli BL21(DE3)