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Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with indirubin 3'-monoxime bound

X-ray diffraction
2.6Å resolution
PDB entry 2qkr coloured by chain, front view.
PDB entry 2qkr coloured by chain, side view.
PDB entry 2qkr coloured by chain, top view.
Source organism: Cryptosporidium parvum Iowa II
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin-dependent kinase 2 homolog
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Multimeric state: monomeric
Accessible surface area: 14014.12 Å2
Buried surface area: 638.13 Å2
Dissociation area: 319.06 Å2
Dissociation energy (ΔGdiss): -3.69 kcal/mol
Dissociation entropy (TΔSdiss): 3.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-176922

Macromolecules

Cyclin-dependent kinase 2 homolog
Chain: A
Length: 313 amino acids
Theoretical weight: 36.09 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5CRJ8 (Residues: 1-295; Coverage: 100%)
Gene name: cgd5_2510
Pfam: Protein kinase domain
InterPro:
CATH:
Protein kinase domain-containing protein in PDB entry 2qkr, assembly 1, front view.
Protein kinase domain-containing protein in PDB entry 2qkr, assembly 1, side view.
Protein kinase domain-containing protein in PDB entry 2qkr, assembly 1, top view.
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