PDBe 2qkr

X-ray diffraction
2.6Å resolution

Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with indirubin 3'-monoxime bound

Released:
Entry authors: Wernimont AK, Dong A, Lew J, Lin YH, Hassanali A, Arrowsmith CH, Edwards AM, Weigelt J, Sundstrom M, Bochkarev A, Hui R, Artz JD, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cdc2-like CDK2/CDC28 like protein kinase Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 36.09 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5CRJ8 (Residues: 1-295; Coverage: 100%)
Gene name: cgd5_2510
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: P43212
Unit cell:
a: 64.133Å b: 64.133Å c: 201.153Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.247 0.3
Expression system: Escherichia coli