2q8b

X-ray diffraction
2.3Å resolution

Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-212502 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Apical membrane antigen 1 Chain: A
Molecule details ›
Chain: A
Length: 336 amino acids
Theoretical weight: 38.42 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q7KQK5 (Residues: 104-438; Coverage: 56%)
Gene name: PF3D7_1133400
Sequence domains: Apical membrane antigen 1
Structure domains: Hepatocyte Growth Factor
1F9 light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.7 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
1F9 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 210 amino acids
Theoretical weight: 22.37 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: C2
Unit cell:
a: 184.905Å b: 51.487Å c: 95.257Å
α: 90° β: 108.49° γ: 90°
R-values:
R R work R free
0.212 0.209 0.256
Expression system: Escherichia coli BL21