› 2iol

X-ray diffraction
2Å resolution

Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 1

Released:
DOI: 10.2210/pdb2iol/pdb
PDB entry 2iol coloured by chain, front view.
PDB entry 2iol coloured by chain, side view.
PDB entry 2iol coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
LaRonde-LeBlanc N, Santhanam AN, Baker AR, Wlodawer A, Colburn NH
Mol Cell Biol 27 147-56 (2007)
PMID: 17060447

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178902 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 150 amino acids
Theoretical weight: 17.51 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q61823 (Residues: 320-469; Coverage: 32%)
Gene names: Ma3, Pdcd4, Tis
Sequence domains: MA3 domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3121
Unit cell:
a: 64.65Å b: 64.65Å c: 164.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.357 0.259 0.297
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Translational control in cancer.
Silvera et al. (2010)
8 more

3 mentions without citation

Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
LaRonde-LeBlanc et al. (2007)
2 more