› 2f36

X-ray diffraction
2.11Å resolution

Crystal Structure of the GluR5 Ligand Binding Core Dimer with Glutamate At 2.1 Angstroms Resolution

Released:
DOI: 10.2210/pdb2f36/pdb
PDB entry 2f36 coloured by chain, front view.
PDB entry 2f36 coloured by chain, side view.
PDB entry 2f36 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
Mayer ML, Ghosal A, Dolman NP, Jane DE
J Neurosci 26 2852-61 (2006)
PMID: 16540562

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149795 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 258 amino acids
Theoretical weight: 29.21 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22756 (Residues: 446-559, 682-821; Coverage: 28%)
Gene names: Glur5, Grik1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand GLU 4 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 62.694Å b: 73.784Å c: 115.918Å
α: 90° β: 99.74° γ: 90°
R-values:
R R work R free
0.191 0.186 0.241
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
8 more

6 mentions without citation

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
5 more