› 2d4z

X-ray diffraction
3.1Å resolution

Crystal structure of the cytoplasmic domain of the chloride channel ClC-0

Released:
DOI: 10.2210/pdb2d4z/pdb
PDB entry 2d4z coloured by chain, front view.
PDB entry 2d4z coloured by chain, side view.
PDB entry 2d4z coloured by chain, top view.
Source organism: Torpedo marmorata
Primary publication:
Crystal structure of the cytoplasmic domain of the chloride channel ClC-0.
Meyer S, Dutzler R
Structure 14 299-307 (2006)
PMID: 16472749

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-149296 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride channel protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 250 amino acids
Theoretical weight: 27.79 KDa
Source organism: Torpedo marmorata
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21564 (Residues: 525-774; Coverage: 31%)
Sequence domains: CBS domain
Structure domains: CBS-domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P213
Unit cell:
a: 125.819Å b: 125.819Å c: 125.819Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.274 0.274 0.309
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

22 review citations

CLC chloride channels and transporters: from genes to protein structure, pathology and physiology.
Jentsch TJ. (2008)
21 more

6 mentions without citation

Chloride channels: often enigmatic, rarely predictable.
Duran et al. (2010)
5 more