Domain

CBS domain (IPR000644)

Short name: CBS_dom

Domain relationships

None.

Description

CBS domains are small intracellular modules that pair together to form a stable globular domain [PMID: 10200156]. Pairs of these domains have been termed a Bateman domain [PMID: 14722609]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [PMID: 14722619]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in cystathionine-beta synthase is involved in regulation by S-AdoMet [PMID: 11524006]. CBS domain pairs from AMPK bind AMP or ATP [PMID: 14722619]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [PMID: 14722619].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles
SMART