1x9h Summary

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Crystal structure of phosphoglucose/phosphomannose isomerase from Pyrobaculum aerophilum in complex with fructose 6-phosphate

The structure was published by Swan, M.K., Hansen, T., Schoenheit, P., and Davies, C., in 2004 in a paper entitled "Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of glucose-6-phosphate isomerase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A glucose-6-phosphate isomerase Q8ZWV0 (1-302) (PGMI_PYRAE)search Pyrobaculum aerophilum str. IM2search 100% 302 99%
B glucose-6-phosphate isomerase Q8ZWV0 (1-302) (PGMI_PYRAE)search Pyrobaculum aerophilum str. IM2search 100% 302 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8ZWV0 (1 - 302) glucose-6-phosphate isomerase Pyrobaculum aerophilum

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q8ZWV0) double-SIS domainsearch Glucose-6-phosphate isomerase like protein; domain 1search PF01380: SIS domainsearch, PF10432: Bacterial phospho-glucose isomerase C-terminal regionsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q8ZWV0) mannose-6-phosphate isomerase activitysearch catalytic activitysearch isomerase activitysearch glucose-6-phosphate isomerase activitysearch carbohydrate bindingsearch metabolic processsearch carbohydrate metabolic processsearch

Chain InterPro annotation
A, B Sugar isomerase (SIS)search Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerasesearch Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase, C-terminalsearch