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P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase complexed to a peptide derived from PDGFr

Solution NMR
PDB entry 1oo4 coloured by chain, front view.
PDB entry 1oo4 coloured by chain, side view.
PDB entry 1oo4 coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 3-kinase regulatory subunit alpha and peptide
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Multimeric state: hetero dimer
Accessible surface area: 7739.43 Å2
Buried surface area: 1351.66 Å2
Dissociation area: 675.83 Å2
Dissociation energy (ΔGdiss): 6.63 kcal/mol
Dissociation entropy (TΔSdiss): 7.32 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150053

Macromolecules

Phosphatidylinositol 3-kinase regulatory subunit alpha
Chain: A
Length: 111 amino acids
Theoretical weight: 12.86 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P23727 (Residues: 321-431; Coverage: 15%)
Gene name: PIK3R1
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
SCOP: SH2 domain
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 1oo4, assembly 1, front view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 1oo4, assembly 1, side view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 1oo4, assembly 1, top view.
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8-mer peptide from PDGFr
Chain: B
Length: 8 amino acids
Theoretical weight: 1 KDa
Source organism: Bos taurus
Expression system: Not provided
8-mer peptide from PDGFr in PDB entry 1oo4, assembly 1, front view.
8-mer peptide from PDGFr in PDB entry 1oo4, assembly 1, side view.
8-mer peptide from PDGFr in PDB entry 1oo4, assembly 1, top view.
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