PDBe 1oo4

Solution NMR

P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase complexed to a peptide derived from PDGFr

Released:

Function and Biology Details

Biological process:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
8-mer peptide from PDGFr Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 1 KDa
Source organism: Synthetic construct
Expression system: Not provided
UniProt:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 12.86 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P23727 (Residues: 321-431; Coverage: 15%)
Gene name: PIK3R1
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing
Expression systems:
  • Not provided
  • Escherichia coli