› 1ae6

X-ray diffraction
3Å resolution

IGG-FAB FRAGMENT OF MOUSE MONOCLONAL ANTIBODY CTM01

Released:
DOI: 10.2210/pdb1ae6/pdb
PDB entry 1ae6 coloured by chain, front view.
PDB entry 1ae6 coloured by chain, side view.
PDB entry 1ae6 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
VL:VH domain rotations in engineered antibodies: crystal structures of the Fab fragments from two murine antitumor antibodies and their engineered human constructs.
Banfield MJ, King DJ, Mountain A, Brady RL
Proteins 29 161-71 (1997)
PMID: 9329081

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-226347 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IGG CTM01 FAB (LIGHT CHAIN) Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.19 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 218 amino acids
Theoretical weight: 23.47 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q99LC4 (Residues: 20-119, 126-127, 128-237; Coverage: 48%)
Gene name: Igh
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX7.2
Spacegroup: P21
Unit cell:
a: 54.3Å b: 66.55Å c: 61.35Å
α: 90° β: 103.4° γ: 90°
R-values:
R R work R free
0.21 0.21 0.311

Quick links

Citations

5 review citations

The structural basis of antibody-antigen recognition.
Sela-Culang et al. (2013)
4 more

4 mentions without citation

Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.
Laffranchi et al. (2020)
3 more