› 1zyv

X-ray diffraction
1.5Å resolution

Crystal Structure Of Mutant K8DP9SR58KV59G Of Scorpion alpha-Like Neurotoxin Bmk M1 From Buthus Martensii Karsch

Released:
DOI: 10.2210/pdb1zyv/pdb
PDB entry 1zyv coloured by chain, front view.
PDB entry 1zyv coloured by chain, side view.
PDB entry 1zyv coloured by chain, top view.
Source organism: Mesobuthus martensii
Primary publication:
Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1.
Ye X, Bosmans F, Li C, Zhang Y, Wang DC, Tytgat J
J Mol Biol 353 788-803 (2005)
PMID: 16209876

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155330 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-like toxin BmK M1 Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.34 KDa
Source organism: Mesobuthus martensii
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P45697 (Residues: 20-83; Coverage: 99%)
Sequence domains: Scorpion toxin-like domain
Structure domains: Knottin, scorpion toxin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: P21212
Unit cell:
a: 47.361Å b: 43.874Å c: 25.516Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.17 0.198
Expression system: Saccharomyces cerevisiae

Quick links

Citations

5 review citations

Voltage-gated sodium channel modulation by scorpion alpha-toxins.
Bosmans et al. (2007)
4 more