› 1ycj

X-ray diffraction
1.95Å resolution

Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

Released:
DOI: 10.2210/pdb1ycj/pdb
PDB entry 1ycj coloured by chain, front view.
PDB entry 1ycj coloured by chain, side view.
PDB entry 1ycj coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate.
Naur P, Vestergaard B, Skov LK, Egebjerg J, Gajhede M, Kastrup JS
FEBS Lett 579 1154-60 (2005)
PMID: 15710405

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.11 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22756 (Residues: 445-559, 682-820; Coverage: 28%)
Gene names: Glur5, Grik1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand SO4 7 x SO4
Ligand GLU 2 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 51.714Å b: 57.901Å c: 88.75Å
α: 90° β: 102.51° γ: 90°
R-values:
R R work R free
0.203 0.199 0.269
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
10 more

6 mentions without citation

Structural protein-ligand interaction fingerprints (SPLIF) for structure-based virtual screening: method and benchmark study.
Da et al. (2014)
5 more