Electronic Annotation Methods
The majority of GO annotations in the GOA database are made using electronic annotation
methods.
One of the primary methods of generating electronic annotations is to manually map GO terms to
corresponding concepts in the controlled vocabularies used by the UniProt Knowledgebase, including
UniProtKB keywords (UniProtKB-KW2GO), Subcellular Locations (UniProtKB-SL2GO), Enzyme Commission
numbers (EC2GO) and cross-references to InterPro (InterPro2GO) and HAMAP (HAMAP2GO). Electronically
combining these mappings with a table of matching UniProtKB entries generates a table of
associations.
An additional electronic annotation method uses orthology data from Ensembl Compara to project GO
annotations from a source species onto one or more target species.
For each GOA association we provide an evidence code, which summarises how the association is made.
Associations that are made electronically are labelled as 'Inferred from Electronic Annotation'
(IEA).
The seven different electronic annotation pipelines are listed below. Please click on any of the
links for more information;
- Ensembl Compara
- InterPro2GO
- UniProtKB-Keyword2GO
- UniProtKB-Subcellular Location2GO
- UniPathway2GO
- EC2GO
- HAMAP2GO
