M-CSA Mechanism and Catalytic Site Atlas

Methylmalonyl-CoA mutase (M-CSA:62)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1req

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1e1c(B, D), 2req(A, B, C, D), 3req(A, B), 4req(A, B, C, D), 5req(B, D), 6req(A, B, C, D), 7req(A, B, C, D)

PDB sequences homologous to 1req

Reference PDB chains/ identical chains	Homologous PDB chains	His244(243)A His610(609)A Tyr243(242)A Asp608(607)A Tyr89(88)A Lys604(603)A
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	4r3u(B,A)	His256 not aligned Tyr255 not aligned Ile101 not aligned
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	3bic(B,A) 2xij(A) 2xiq(B,A)	His255 His617 Tyr254 Asp615 Tyr100 Lys611
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	4r3u(D,C)	not aligned His29 not aligned Asp27 not aligned Lys23
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	2yxb(A)	not aligned His31 not aligned Asp29 not aligned Lys25
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	His243 His609 Tyr242 Asp607 Tyr88 Lys603
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	6req(B,D) 2req(B,D) 1e1c(B,D) 5req(B,D) 1req(B,D) 7req(B,D) 4req(B,D) 3req(B)	Ile239 Ala606 Asn238 Asp604 Leu111 Glu600
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	4xc6(B,A) 4xc8(B,A) 5cjv(B,A) 4xc7(B,A) 5cjw(B,A) 5cju(B,A) 5cjt(B,A)	His800 not aligned Tyr799 not aligned Phe618 not aligned
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	5req(A,C)	His243 His609 Tyr242 Asp607 Phe88 Lys603
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	1e1c(A,C)	Ala243 His609 Tyr242 Asp607 Tyr88 Lys603
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	6oxc(A) 6oxd(A)	His260 His629 Tyr259 Asp627 Tyr105 Lys623
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	6oxc(B) 6oxd(B)	Ala225 His591 Pro224 Ala589 Phe97 Ala585
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	4r3u(B,A)	His256 not aligned Tyr255 not aligned Ile101 not aligned
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	3bic(B,A) 2xij(A) 2xiq(B,A)	His255 His617 Tyr254 Asp615 Tyr100 Lys611
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	4r3u(D,C)	not aligned His29 not aligned Asp27 not aligned Lys23
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	2yxb(A)	not aligned His31 not aligned Asp29 not aligned Lys25
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	His243 His609 Tyr242 Asp607 Tyr88 Lys603
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	6req(B,D) 2req(B,D) 1e1c(B,D) 5req(B,D) 1req(B,D) 7req(B,D) 4req(B,D) 3req(B)	Ile239 Ala606 Asn238 Asp604 Leu111 Glu600
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	4xc6(B,A) 4xc8(B,A) 5cjv(B,A) 4xc7(B,A) 5cjw(B,A) 5cju(B,A) 5cjt(B,A)	His800 not aligned Tyr799 not aligned Phe618 not aligned
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	5req(A,C)	His243 His609 Tyr242 Asp607 Phe88 Lys603
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	1e1c(A,C)	Ala243 His609 Tyr242 Asp607 Tyr88 Lys603
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	6oxc(A) 6oxd(A)	His260 His629 Tyr259 Asp627 Tyr105 Lys623
1req(A,C) 3req(A) 6req(A,C) 7req(A,C) 4req(A,C) 2req(A,C)	6oxc(B) 6oxd(B)	Ala225 His591 Pro224 Ala589 Phe97 Ala585