M-CSA Mechanism and Catalytic Site Atlas

Urate oxidase (M-CSA:118)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this chain

The residue id shown is the one in the PDB sequence. This may be different from the resid given by the author of the PDB file.

PDB sequences identical to 1wrr

In these PDB chains all the catalytic residues are conserved and have the same numbering as the reference.

1r4s(A), 1r4u(A), 1r51(A), 1r56(A, B, C, D, E, F, G, H), 1ws2(A, B, C, D), 1ws3(A, B, C, D), 1xt4(A), 1xxj(A, B, C, D), 1xy3(A, B, C, D, E, F, G, H), 2fub(A), 2fxl(A), 3bjp(A), 3bk8(A), 3gko(A), 4cw0(A), 4cw2(A), 4cw3(A), 4cw6(A)

PDB sequences homologous to 1wrr

Reference PDB chains/ identical chains	Homologous PDB chains	Lys10A Thr57A His256A(AA) Arg176A(AA) Gln228A(AA)
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	Lys10 Thr57 His256 Arg176 Gln228
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	2yzd(E,F,B,G,D,C,A,H) 2yzc(E,F,B,G,D,C,A,H) 2yze(E,F,B,G,D,H,A,C) 2yzb(E,F,B,G,D,C,A,H)	Lys22 Thr67 His251 Arg180 Gln223
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	1vay(E,F,B,G,D,H,A,C) 1vax(E,F,B,G,D,C,A,H)	Lys12 Thr57 His241 Arg170 Gln213
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	2pes(A) 6ia9(aba,aaa)	Lys10 Thr57 His256 Arg176 Gln228
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	4mb8(B,D,A,C)	Lys23 Thr68 His264 Arg187 Gln236
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	5ayj(B,D,A,C)	Lys12 Thr72 Thr277 Arg200 Gln249
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	5ll1(E,F,B,G,D,C,A,H) 5m98(E,F,B,G,D,C,A,H)	Lys18 Thr63 His258 Arg182 Gln230
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	4xfp(B,D,A,C)	Lys6 Thr66 Thr271 Arg194 Gln243
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	4d12(A) 4d13(A) 4d19(A) 4d17(A) 7a0l(A)	Lys11 Thr58 His257 Arg177 Gln229
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	3wlv(B,D,A,C) 5y2p(B,A) 5yj2(B,A,D,C) 5z29(B,A) 5z2a(B,A)	Lys6 Thr66 Thr271 Arg194 Gln243
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	3l8w(A) 3ld4(A) 3l9g(A) 3lbg(A)	Lys11 Thr58 His257 Arg177 Gln229
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	4r99(C,B,A,D)	Lys9 Thr69 Thr273 Arg196 Gln245
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	4r8x(B,D,A,C)	Lys9 Thr69 Thr273 Arg196 Gln245
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	3pk3(A) 3f2m(A) 2zka(A) 2iba(A) 4op6(A) 3cks(A) 3pk8(A) 3plh(A) 4op9(A) 4n3m(A) 4n9s(A) 2ic0(A) 3pjk(A) 4puv(A) 3pk4(A) 2icq(A) 4oqc(A) 2zkb(A) 4pr8(A) 3ple(A) 3plj(A) 3pli(A) 3p9o(A) 3pkg(A) 3p9f(A) 3pk5(A) 3pk6(A) 3cku(A) 3plg(A) 5frc(A) 3pkl(A) 3plm(A) 3pkt(A) 3pks(A) 3pku(A) 3pkh(A) 4n9m(A) 4fsk(A) 4n9v(A) 3pkk(A) 3obp(A) 3pkf(A) 4poe(A) 6i9x(A) 6i9z(A) 6ia1(A) 6ia3(A) 6ia9(B,A) 6ic1(A) 6rgm(A)	Lys11 Thr58 His257 Arg177 Gln229
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	1j2g(B,D,A,C)	Lys13 Thr73 Thr278 Arg201 Gln250
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	5y52(B,A,D,C)	Lys12 Thr72 Thr277 Arg200 Gln249
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	5yja(B,A,D,C) 5z27(B,A) 5z2b(B,A)	Lys12 Thr72 Thr277 Arg200 Gln249
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	6a4m(A)	Lys5 Thr65 Thr269 Arg192 Gln241
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	6oe8(B,A,D,C)	Lys46 Thr91 His275 Arg204 Gln247
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	6rgt(A)	Lys11 Ala58 His257 Arg177 Gln229
1wrr(A) 1xy3(E,F,B,G,D,C,A,H) 4cw3(A) 4cw2(A) 1r56(E,F,B,G,D,H,A,C) 1r4u(A) 4cw0(A) 2fxl(A) 1ws3(B,A,D,C) 3bk8(A) 4cw6(A) 1ws2(B,D,A,C) 3bjp(A) 1xxj(B,A,D,C) 1r4s(A) 1r51(A) 3gko(A) 2fub(A) 1xt4(A)	7cmn(B,A) 7cmq(B,A) 7cuc(B,A) 7cuf(B,A) 7cug(B,A)	Lys7 Thr67 Thr272 Arg195 Gln244