Function and Biology Details
Reaction catalysed:
Urate + O(2) + H(2)O = 5-hydroxyisourate + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
homo tetramer (preferred)
Assembly name:
Uricase (preferred)
PDBe Complex ID:
PDB-CPX-169432 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uricase
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 34.18 KDa
Source organism: Aspergillus flavus
Expression system: Saccharomyces cerevisiae
UniProt:
Sequence domains: Uricase
Structure domains: Urate Oxidase;
Length: 302 amino acids
Theoretical weight: 34.18 KDa
Source organism: Aspergillus flavus
Expression system: Saccharomyces cerevisiae
UniProt:
- Canonical:
Q00511 (Residues: 2-302; Coverage: 100%)
Sequence domains: Uricase
Structure domains: Urate Oxidase;
Ligands and Environments
Experiments and Validation Details
Experimental Method:
X-ray diffraction, Neutron Diffraction
Spacegroup:
I222
Unit cell:
a: 80.18Å
b: 96.26Å
c: 105.51Å
α: 90°
β: 90°
γ: 90°
R-values:
R
R work
R free
0.168
0.259
0.189
Expression system: Saccharomyces cerevisiae
