PDBsum entry 9ef5

Structural protein

PDB id: 9ef5

Contents

Protein chains

818 a.a.

556 a.a.

23 a.a.

24 a.a.

Ligands

NAG ×16

PDB id:

9ef5

Name:

Structural protein

Title:

Cryo-em structure of drosophila melanogaster insulin receptor (dmir) bound with one dilp2, asymmetric conformation

Structure:

Insulin-like receptor. Chain: a, b. Synonym: dir,dinr,insulin receptor homolog,dirh,receptor protein- tyrosine kinase inr. Engineered: yes. Dilp2 b-chain. Chain: c. Engineered: yes. Dilp2 a-chain.

Source:

Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: inr, dir-a, inr-a, ir, cg18402. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Synthetic: yes. Organism_taxid: 7227

Authors:

X.C.Bai

Key ref:

X.C.Bai Structural basis of the activation of the drosophila receptor by three drosophila insulin-Like peptides. To be published, . PubMed id: 41152236

Date:

19-Nov-24 Release date: 01-Oct-25

Protein chain

P09208  (INSR_DROME) -  Insulin-like receptor from Drosophila melanogaster

Seq: 2144 a.a.

Struc: 818 a.a.

Protein chain

P09208  (INSR_DROME) -  Insulin-like receptor from Drosophila melanogaster

Seq: 2144 a.a.

Struc: 556 a.a.

Protein chain

Q9VT51  (INSL2_DROME) -  Insulin-like peptide 2 from Drosophila melanogaster

Seq: 137 a.a.

Struc: 23 a.a.

Protein chain

Q9VT51  (INSL2_DROME) -  Insulin-like peptide 2 from Drosophila melanogaster

Seq: 137 a.a.

Struc: 24 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP (Bound ligand (Het Group name = NAG) matches with 41.38% similarity) + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site