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PDB code
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Protein
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Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 in complex with su4984 inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Organelle: cytoplasm. Cellular_location: cytoplasmic domain. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Chains:
A, B
(278 residues)
CATH domains:
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The crystal structure of an eph receptor sam domain reveals a mechanism for modular dimerization.
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Source: Mus musculus. House mouse. Organism_taxid: 10090. Strain: bl21. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(72 residues)
CATH domain:
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Oligomeric structure of the human ephb2 receptor sam domain
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Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: vascular. Cell: renal microvascular endothelial. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chains:
A, B, C, D, E, F, G, H
(74 residues)
CATH domain:
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Crystal structure of a dimeric fgf2-fgfr1 complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chains:
C, D
(211 residues)
CATH domains:
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Ligand-binding portion of fibroblast growth factor receptor 2 in complex with fgf1
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chain:
A
(206 residues)
CATH domains:
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Crystal structure of a ternary fgf1-fgfr2-heparin complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: recombinant. Other_details: recombinant
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Chains:
B, D
(197 residues)
CATH domains:
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Crystal structure of fgf2 in complex with the extracellular ligand binding domain of fgf receptor 2 (fgfr2)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
E, F, G, H
(194 residues)
CATH domains:
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Crystal structure of fgf1 in complex with the extracellular ligand binding domain of fgf receptor 1 (fgfr1)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: bacteria. Expression_system_taxid: 2. Expression_system_taxid: 2
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Chains:
C, D
(191 residues)
CATH domains:
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Monomeric structure of the human ephb2 sam (sterile alpha motif) domain
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Source: Homo sapiens. Human. Organism_taxid: 9606
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Chain:
A
(71 residues)
CATH domain:
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Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 in complex with su5402 inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Organelle: cytoplasm. Cellular_location: cytoplasm. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Chains:
A, B
(283 residues)
CATH domains:
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Crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1
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Source: Fragment: human fgfr1 residues 456-765 that possesses ptk activity. Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
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Chains:
A, B
(278 residues)
CATH domains:
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Vegf in complex with domain 2 of the flt-1 receptor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chains:
X, Y
(95 residues)
CATH domain:
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Crystal structure of a ternary fgf2-fgfr1-heparin complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chains:
C, D
(211 residues)
CATH domains:
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Tie2 kinase domain
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
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Chains:
A, B
(299 residues)
CATH domains:
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Crystal structure of the insulin receptor kinase in complex with a bisubstrate inhibitor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes
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Chain:
A
(303 residues)
CATH domains:
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Bound ligand:
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Het Group 112
is 83.33% similar to
enzyme reactant ATP
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The fgfr2 tyrosine kinase domain
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
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Chain:
A
(280 residues)
CATH domains:
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Crystal structure of trkb-d5 bound to neurotrophin-4/5
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: extracellular. Cellular_location: plasma membrane. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Chains:
X, Y
(101 residues)
CATH domain:
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Human nerve growth factor receptor trka
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Chain:
A
(108 residues)
CATH domain:
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Crystallographic studies of an activation loop mutant of the insulin receptor tyrosine kinase
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Chain:
A
(282 residues)
CATH domains:
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Bound ligand:
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Het Group ACP
is 81.25% similar to
enzyme product ADP
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Type 1 insulin-like growth factor receptor (domains 1-3)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: placenta. Cellular_location: cytoplasmic membrane. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec8. Expression_system_collection: crl:1737.
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Chain:
A
(471 residues)
CATH domains:
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Bound ligand:
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Het Group NAG
is 41.38% similar to
enzyme product ADP
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Crystal structure of ser252trp apert mutant fgf receptor 2 (fgfr2) in complex with fgf2
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
E, F, G, H
(200 residues)
CATH domains:
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Solution structure of the neu/erbb-2 membrane spanning segment
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Source: Synthetic: yes. Other_details: this peptide was chemically synthesized. This sequence occurs naturally in rattus norvegicus (rat).
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Chain:
A
(35 residues)
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Crystal structure of pro253arg apert mutant fgf receptor 2 (fgfr2) in complex with fgf2
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chains:
E, F, G, H
(200 residues)
CATH domains:
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Phosphorylated insulin receptor tyrosine kinase in complex with peptide substrate and atp analog
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
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Chain:
A
(303 residues)
CATH domains:
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Bound ligand:
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Het Group ANP
is 81.25% similar to
enzyme product ADP
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Crystal structure of the tyrosine kinase domain of the human insulin receptor
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Source: Homo sapiens. Human. Organism_taxid: 9606
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Chain:
A
(303 residues)
CATH domains:
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Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains.
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expressed in: escherichia coli. Expression_system_taxid: 562
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Chains:
A, B
(511 residues)
CATH domains:
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Bound ligand:
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Het Group NAG
is 41.38% similar to
enzyme product ADP
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Crystal structure of unphosphorylated ephb2 receptor tyrosine kinase and juxtamembrane region
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Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chains:
A, B
(273 residues)
CATH domains:
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Igf-1 receptor kinase domain
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Chains:
A, B, C
(291 residues)
CATH domains:
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Bound ligand:
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Het Group ANP
is 81.25% similar to
enzyme product ADP
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Structure of the insulin-like growth factor 1 receptor kinase
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: chemically synthesized
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Chain:
A
(291 residues)
CATH domains:
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Bound ligand:
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Het Group ACP
is 81.25% similar to
enzyme product ADP
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Crystal structure of the ephb2-ephrinb2 complex
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Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chains:
A, B, C, D
(181 residues)
CATH domain:
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Crystal structure of the musk tyrosine kinase: insights into receptor autoregulation
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Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
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Chain:
A
(275 residues)
CATH domains:
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Tyrosine kinase domain from epidermal growth factor receptor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Chain:
A
(307 residues)
CATH domains:
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Epidermal growth factor receptor tyrosine kinase domain with 4- anilinoquinazoline inhibitor erlotinib
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Chain:
A
(312 residues)
CATH domains:
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Structure of the her3 (erbb3) extracellular domain
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec1. Expression_system_tissue: ovary cells.
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Chains:
A, B
(549 residues)
CATH domains:
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Bound ligand:
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Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
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Crystal structure of unactivated apo insulin-like growth factor-1 receptor kinase domain
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Chains:
A, B
(299 residues)
CATH domains:
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Crystal structure of human epidermal growth factor receptor (residues 1-501) in complex with tgf-alpha
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec8. Gene: tgfa. Expressed in: escherichia coli.
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Chains:
A, B
(499 residues)
CATH domains:
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Bound ligand:
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Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
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Crystal structure of ephrin a2 (epha2) receptor protein kinase
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
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Chains:
A, B
(263 residues)
CATH domains:
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Bound ligand:
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Het Group ANP
is 81.25% similar to
enzyme product ADP
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Crystal structure of the extracellular region of rat her2
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Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: neu. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
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Chain:
C
(592 residues)
CATH domains:
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Bound ligand:
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Het Group NAG
is 41.38% similar to
enzyme product ADP
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Crystal structure of extracellular domain of human her2 complexed with herceptin fab
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Source: Mus musculus, homo sapiens. Mouse/human. Organism_taxid: 10090, 9606. Homo sapiens. Human. Organism_taxid: 9606. Gene: her2(erbb2). Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
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Chain:
C
(581 residues)
CATH domains:
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Bound ligand:
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Het Group NAG
is 41.38% similar to
enzyme product ADP
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Structure of the extracellular domain of human epidermal growth factor (egf) receptor in an inactive (low ph) complex with egf.
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: egf. Expressed in: escherichia coli. Expression_system_taxid: 562
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Chain:
A
(612 residues)
CATH domains:
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Bound ligand:
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Het Group NAG
is 41.38% similar to
enzyme product ADP
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Crystal structure of the ligand-binding domain of the ephb2 receptor tyrosine kinase
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Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(169 residues)
CATH domain:
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Crystal structure analysis of the fgf10-fgfr2b complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgf10. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chain:
B
(209 residues)
CATH domains:
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Fgfr2 kinase domain
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
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Chain:
A
(281 residues)
CATH domains:
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Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Chain:
A
(287 residues)
CATH domains:
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Structure of apo unactivated igf-1r kinase domain at 1.5a resolution.
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Chains:
A, B
(308 residues)
CATH domains:
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Structure of a c-kit kinase product complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. (Invitrogen))
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Chains:
A, B
(292 residues)
CATH domains:
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Bound ligand:
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Het Group ADP
corresponds to
enzyme product ADP
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The vegf-binding domain of flt-1, 20 nmr structures
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: modified qiagen pqe30 containing his-tag and genenase cleavage site
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Chain:
A
(101 residues)
CATH domain:
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The vegf-binding domain of flt-1 (minimized mean)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: modified qiagen pqe30 containing his-tag and genenase cleavage site
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Chain:
A
(101 residues)
CATH domain:
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Vascular endothelial growth factor in complex with domain 2 of the flt-1 receptor
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chains:
X, Y, T, U
(94 residues)
CATH domain:
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Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with the microbial alkaloid k-252a
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high-five.
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Chain:
A
(301 residues)
CATH domains:
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Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high-five.
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Chain:
A
(287 residues)
CATH domains:
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Crystal structure of human tyro3-d1d2
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyro3, rse, sky, dtk, byk. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
A, B
(176 residues)
CATH domains:
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Crystal structure of flt3
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
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Chain:
A
(298 residues)
CATH domains:
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Crystal structure of the insulin receptor kinase in complex with the sh2 domain of aps
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Rattus norvegicus. Norway rat.
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Chains:
A, B
(297 residues)
CATH domains:
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Bound ligand:
|
Het Group 112
is 83.33% similar to
enzyme reactant ATP
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Crystal structure of plgf in complex with domain 2 of vegfr1
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chains:
X, Y
(92 residues)
CATH domain:
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Crystal structure of the 3 ig form of fgfr3c in complex with fgf1
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgf1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fgfr3c. Expression_system_taxid: 562
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Chain:
B
(213 residues)
CATH domains:
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Insights into erbb signaling from the structure of the erbb2- pertuzumab complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, ngl, neu. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: ovary. Mus musculus. House mouse.
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Chains:
A, B
(555 residues)
CATH domains:
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Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
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The solution structure of sam domain from the receptor tyrosine kinase ephb2, nmr, 10 structures
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Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21. Expression_system_tissue: embryo.
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|
Chain:
A
(67 residues)
CATH domain:
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Shc ptb domain complexed with a trka receptor phosphopeptide, nmr, minimized average structure
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|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21 (de3). Cell_line: bl21. Gene: ptb domain of shc. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
B
(12 residues)
|
|
|
|
|
|
Ephb2 / ephrina5 complex structure
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: efna5, eplg7, lerk7, epl7. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: ephb2, epth3, nuk, sek3. Expressed in: escherichia coli.
|
|
|
Chain:
B
(181 residues)
CATH domain:
|
|
|
|
|
|
The crystal structure of hgf beta-chain in complex with the sema domain of the met receptor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
B
(499 residues)
CATH domains:
|
|
|
|
|
|
Solution structure of the psi domain from the met receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(48 residues)
CATH domain:
|
|
|
|
|
|
Structural basis for the autoinhibition and sti-571 inhibition of c- kit tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(331 residues)
CATH domains:
|
|
|
|
|
|
Structural basis for the autoinhibition and sti-571 inhibition of c- kit tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Sterile alpha motif (sam) domain of ephrin type-a receptor 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kazusa cdna fh16961. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(81 residues)
CATH domain:
|
|
|
|
|
|
Human vascular endothelial growth factor receptor 2 (kdr) kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: aorta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
|
|
Solution structure of the d2 domain of the fibroblast growth factor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(101 residues)
CATH domain:
|
|
|
|
|
|
Ngf binding domain of human trka receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
X, Y
(105 residues)
CATH domain:
|
|
|
|
|
|
Ligand binding domain of human trkb receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
X
(103 residues)
CATH domain:
|
|
|
|
|
|
Nt3 binding domain of human trkc receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(105 residues)
CATH domain:
|
|
|
|
|
|
Ngf in complex with domain 5 of the trka receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
|
|
|
Chains:
X, Y
(101 residues)
CATH domain:
|
|
|
|
|
|
The solution structure of the second fibronectin type iii domain of mouse ephrin type-a receptor 1
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: epha1. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(107 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the second fn3 domain of eph receptor a8 protein
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kazusa cdna fh16961. Other_details: cell free protein synthesis
|
|
|
Chain:
A
(111 residues)
CATH domain:
|
|
|
|
|
|
Egfr kinase domain complexed with a quinazoline inhibitor- gw572016
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Structural basis of snt ptb domain interactions with distinct neurotrophic receptors
|
|
|
Source: Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence is taken from homo sapiens (human).. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(22 residues)
|
|
|
|
|
|
Crystal structure of vegfr2 in complex with a 2-anilino-5-aryl-oxazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(261 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr2 in complex with a 2-anilino-5-aryl-oxazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
|
|
Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Structure of the extracellular domain of the epidermal growth factor receptor in complex with the fab fragment of cetuximab/erbitux/imc- c225
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_atcc_number: sf9. Mus musculus, homo sapiens. House mouse, human.
|
|
|
Chain:
A
(613 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
A structural model for the membrane-bound form of the juxtamembrane domain of the epidermal growth factor receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(53 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of erbb2 domains 1-3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, neu, ngl. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: hampster ovary cells.
|
|
|
Chain:
A
(506 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of erbb4/her4 extracellular domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: hampster ovary cells.
|
|
|
Chains:
A, B
(611 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of the grb14 bps region in complex with the insulin receptor tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: grb14. Expression_system_taxid: 562
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a complex between ptp1b and the insulin receptor tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn1, ptp1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
B, D
(297 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure and thermodynamic characterization of the ephb4 receptor in complex with an ephrin-b2 antagonist peptide reveals the determinants for receptor specificity.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb4, htk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: synthetic peptide
|
|
|
Chain:
A
(185 residues)
CATH domain:
|
|
|
|
|
|
Structure of a minimal gas6-axl complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293-ebna. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chains:
C, D
(192 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Nmr structure of the first ig module of mouse fgfr1
|
|
|
Source: Synthetic: yes. Mus musculus. Mouse. Organism_taxid: 10090
|
|
|
Chain:
A
(95 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the first ig-like domain of human fibroblast growth factor receptor 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1. Other_details: cell free protein synthesis
|
|
|
Chain:
A
(99 residues)
CATH domain:
|
|
|
|
|
|
Solution structures of the fn3 domain of human proto-oncogene tyrosine-protein kinase mer precursor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(124 residues)
CATH domain:
|
|
|
|
|
|
Solution structures of the fn3 domain of human ephrin type-b receptor 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb1. Expressed in: cell free synthesis. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(108 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the second fn3 domain from human ephrin type-b receptor 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb4, htk. Other_details: cell free protein synthesis
|
|
|
Chain:
A
(109 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of thE C-terminal sam-domain of ephaa2: ephrin type-a receptor 2 precursor (ec 2.7.10.1)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(88 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the extracellular domain of kit in complex with stem cell factor (scf)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: scf. Expressed in: escherichia coli.
|
|
|
Chains:
A, B
(468 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Solution structure of thE C-terminal sam-domain of mouse ephrin type-b receptor 1 precursor (ec 2.7.1.112)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb1, epht2, net. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(99 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of mutated egfr kinase domain (g719s)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(305 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of mutated egfr kinase domain (l858r) in complex with amppnp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(294 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the exctracellular domain of the receptor tyrosine kinase, kit
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(464 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fibroblast growth factor (fgf)8b in complex with fgf receptor (fgfr) 2c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fgfr2, bek, ksam. Expression_system_taxid: 562
|
|
|
Chains:
P, R
(197 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Cellular_location: cytoplasm. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(274 residues)
CATH domains:
|
|
|
|
|
|
Structural characterization of autoinhibited c-met kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(301 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the active egfr kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(305 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the active egfr kinase domain in complex with an atp analog-peptide conjugate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes
|
|
|
Chain:
A
(311 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 112
is 83.33% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Crystal structure of the inactive egfr kinase domain in complex with amp-pnp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(281 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
The human epha3 receptor tyrosine kinase and juxtamembrane region
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3, etk, etk1, hek. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Tie2 ligand-binding domain crystal structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cell free synthesis. Expression_system_cell_line: hek 293.
|
|
|
Chain:
A
(423 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Angiopoietin-2/tie2 complex crystal structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expression_system_cell_line: hek 293. Gene: tek, tie2.
|
|
|
Chain:
B
(423 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of a mutant epha4 kinase domain (y742a)
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: epha4. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(256 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the ephb2 receptor kinase domain in complex with adp
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: ephb2, epth3, nuk, sek3. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(259 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Structural and biophysical characterization of the ephb4-ephrinb2 protein protein interaction and receptor specificity.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: hi5. Gene: ephb4, htk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: efnb2, eplg5, htkl, lerk5.
|
|
|
Chain:
A
(188 residues)
CATH domain:
|
|
|
|
|
|
Insulin receptor (domains 1-3)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
|
|
|
Chains:
A, B
(466 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
C-fms tyrosine kinase in complex with a quinolone inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Cfms tyrosine kinase (fgf kid) in complex with an arylamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Cfms tyrosine kinase (tie2 kid) in complex with an arylamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(311 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase musk
|
|
|
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: musk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(187 residues)
CATH domains:
|
|
|
|
|
|
Structure of the extracellular segment of human trka in complex with nerve growth factor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, trk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ngfb. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(347 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr kinase domain g719s mutation in complex with amp-pnp
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 g719s
|
|
|
Chain:
A
(304 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr kinase domain g719s mutation in complex with iressa
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 g719s
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain g719s mutation in complex with aee788
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 g719s
|
|
|
Chain:
A
(305 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain g719s mutation in complex with afn941
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 g719s
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain l858r mutation in complex with aee788
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 l858r
|
|
|
Chain:
A
(302 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain l858r mutation in complex with afn941
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 l858r
|
|
|
Chain:
A
(304 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain l858r mutation in complex with amp-pnp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with afn941
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(301 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with amp-pnp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(307 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with iressa
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain l858r mutation in complex with iressa
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 l858r
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the pi3-kinase p85 n-terminal sh2 domain in complex with pdgfr phosphotyrosyl peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3r1, grb1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chains:
C, D
(11 residues)
|
|
|
|
|
|
Crystal structure of non-phosphorylated ret tyrosine kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(284 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACK
is 75.00% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of phosphorylated ret tyrosine kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group AMP
is 85.19% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of phosphorylated ret tyrosine kinase domain complexed with the inhibitor zd6474
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of phosphorylated ret tyrosine kinase domain complexed with the inhibitor pp1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(283 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with an irreversible inhibitor 13-jab
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(310 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with an irreversible inhibitor 34-jab
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(309 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with aee788
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 wild-type
|
|
|
Chain:
A
(306 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain t790m mutation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 t790m
|
|
|
Chains:
A, B
(299 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain t790m mutation in complex with aee788
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 t790m
|
|
|
Chains:
A, B
(304 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain t790m mutation in compex with hki-272
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: egfr 696-1022 t790m
|
|
|
Chains:
A, B
(270 residues)
CATH domains:
|
|
|
|
|
|
Erbb2 transmembrane segment dimer spatial structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, neu, ngl. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(44 residues)
CATH domain:
|
|
|
|
|
|
Nmr structures of dimeric transmembrane domain of the receptor tyrosine kinase epha1 in lipid bicelles at ph 4.3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha1. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(38 residues)
|
|
|
|
|
|
Nmr structures of dimeric transmembrane domain of the receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha1, eph, epht, epht1. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(38 residues)
|
|
|
|
|
|
Epha2 dimeric structure in the lipidic bicelle at ph 5.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(41 residues)
CATH domain:
|
|
|
|
|
|
Heterodimeric association of transmembrane domains of erbb1 and erbb2 receptors enabling kinase activation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, neu, ngl. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: egfr, erbb1. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(44 residues)
CATH domain:
|
|
|
|
|
|
Epha2:ship2 sam:sam complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: inppl1, ship2.
|
|
|
Chain:
A
(65 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the complex of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cell-free synthesis. Synthetic: yes. Other_details: chemically synthesized
|
|
|
Chain:
B
(19 residues)
|
|
|
|
|
|
Solution structure of the chimera of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk
|
|
|
Source: Homo sapiens, synthetic construct. Human. Organism_taxid: 9606, 32630. Gene: frs3, alk. Expressed in: e. Coli-cell-free protein synthesis
|
|
|
Chain:
A
(153 residues)
CATH domain:
|
|
|
|
|
|
Solution nmr structure of the erbb4 dimeric membrane domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(44 residues)
CATH domain:
Unassigned
|
|
|
|
|
|
Pdgfr beta-tm
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfrb. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(39 residues)
|
|
|
|
|
|
Spatial structure of dimeric erbb3 transmembrane domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: cell-free synthesis.
|
|
|
Chains:
A, B
(40 residues)
CATH domain:
|
|
|
|
|
|
Spatial structure of the erbb4 dimeric tm domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(44 residues)
|
|
|
|
|
|
Nmr solution structure of eph receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha4. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(183 residues)
CATH domain:
|
|
|
|
|
|
Fgfr3tm
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr3, jtk4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(43 residues)
CATH domain:
Unassigned
|
|
|
|
|
|
Homodimeric transmembrane domain of the human receptor tyrosine kinase erbb1 (egfr, her1) in micelles
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(44 residues)
|
|
|
|
|
|
Egfr transmembrane - juxtamembrane (tm-jm) segment in bicelles: md guided nmr refined structure.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(60 residues)
CATH domain:
Unassigned
|
|
|
|
|
|
Spatial structure of dimeric vegfr2 membrane domain in dpc micelles
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(37 residues)
|
|
|
|
|
|
Nmr spatial structure of the trimeric mutant tm domain of vegfr2 receptor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C
(37 residues)
|
|
|
|
|
|
Nmr spatial structure of mutant dimeric tm domain of vegfr2 receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(37 residues)
|
|
|
|
|
|
Nmr solution structures of frs2a ptb domain with neurotrophin receptor trkb
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: frs2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
B
(23 residues)
|
|
|
|
|
|
Solution structure of the transmembrane domain of the insulin receptor in micelles
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
Spatial structure of her2/erbb2 dimeric transmembrane domain in the presence of cytoplasmic juxtamembrane domains
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(58 residues)
|
|
|
|
|
|
Spatial structure of egfr transmembrane and juxtamembrane domains in dpc micelles
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(54 residues)
CATH domain:
Unassigned
|
|
|
|
|
|
Trka transmembrane domain nmr structure in dpc micelles
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(39 residues)
|
|
|
|
|
|
Structure of a class iii rtk signaling assembly
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: kitlg, kitl, mgf, sl, slf. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: kit, sl. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
|
|
|
Chains:
X, Y, U, W
(275 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the autoinhibited human c-fms kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(317 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr2 with a benzimidazole-urea inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(299 residues)
CATH domains:
|
|
|
|
|
|
Structure of igf-1r kinase domain complexed with a benzimidazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
A
(295 residues)
CATH domains:
|
|
|
|
|
|
Synthesis, structural analysis, and sar studies of triazine derivatives as potent, selective tie-2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tek, tie2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
X
(259 residues)
CATH domains:
|
|
|
|
|
|
Synthesis, structural analysis, and sar studies of triazine derivatives as potent, selective tie-2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tek, tie2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(255 residues)
CATH domains:
|
|
|
|
|
|
Catalytic domain of the proto-oncogene tyrosine-protein kinase mer
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: peripheral blood leukocyte. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(249 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a pyridinyl-triazine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(292 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a nicotinamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(289 residues)
CATH domains:
|
|
|
|
|
|
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5- triazine tie-2 kinase inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tek, tie2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(252 residues)
CATH domains:
|
|
|
|
|
|
Nuclear magnetic resonance structure of an sh2 domain of phospholipasE C-gamma1 complexed with a high affinity binding peptide
|
|
|
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
|
|
|
Chain:
B
(12 residues)
|
|
|
|
|
|
Nuclear magnetic resonance structure of an sh2 domain of phospholipasE C-gamma1 complexed with a high affinity binding peptide
|
|
|
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
|
|
|
Chain:
B
(12 residues)
|
|
|
|
|
|
Crystal structure of unphosphorylated unactivated wild type fgf receptor 2 (fgfr2) kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of tyrosine phosphorylated activated fgf receptor 2 (fgfr2) kinase domain in complex with atp analog and substrate peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: custom-designed peptide based on phosphorylation site y769 of human fgfr2 kinase
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k659n mutation responsible for an unclassified craniosynostosis syndrome.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(288 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 62.96% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic n549h mutation responsible for crouzon syndrome.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(284 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 92.86% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic e565g mutation responsible for pfeiffer syndrome
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(282 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic n549t mutation responsible for pfeiffer syndrome
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(280 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k526e mutation responsible for crouzon syndrome
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(280 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k641r mutation responsible for pfeiffer syndrome
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(280 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic e565a mutation responsible for pfeiffer syndrome
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(280 residues)
CATH domains:
|
|
|
|
|
|
Ephb2/snew antagonistic peptide complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb2, drt, epht3, epth3, erk, hek5, tyro5. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: antagonistic peptide
|
|
|
Chains:
A, B
(176 residues)
CATH domain:
|
|
|
|
|
|
Structure of the sam domain of human ephrin type-b receptor 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb4, htk, tyro11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(61 residues)
CATH domain:
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, dephosphorylated, apo structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(282 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, dephosphorylated, amp-pnp bound
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(279 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, phosphorylated, amp-pnp bound
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Human epha3 kinase domain, base structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase domain, phosphorylated, amp-pnp bound structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(283 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, y602f mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, y596f mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(280 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, y596f:y602f double mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, y596f:y602f:s768a triple mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, y596:y602:s768g triple mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, y596f:y602f:y742a triple mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(282 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, y596f:y602f:y742f triple mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region, base, amp-pnp bound structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a benzimidazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(292 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a benzoxazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(283 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of human ephrin type-a receptor 5 (epha5)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha5, ehk1, hek7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(283 residues)
CATH domains:
|
|
|
|
|
|
Erbb4 kinase domain complexed with a thienopyrimidine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(292 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of human ephrin type-a receptor 7 (epha7)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: brain. Gene: epha7, ehk3, hek11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the complex between the egfr kinase domain and a mig6 peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: errfi1, mig6. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(280 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the complex between the egfr kinase domain and a mig6 peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chains:
A, B
(288 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the complex between the egfr kinase domain and a mig6 peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chains:
A, B, C, D
(286 residues)
CATH domains:
|
|
|
|
|
|
X-ray structure of c-met with inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(268 residues)
CATH domains:
|
|
|
|
|
|
X-ray structure of su11274 bound to c-met
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
Structure of egfr in complex with hydrazone, a potent dual inhibitor
|
|
|
Source: Homo sapiens. Human. Strain: human strains undefined. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda.
|
|
|
Chain:
A
(284 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a 2,3- dihydro-1,4-benzoxazine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(294 residues)
CATH domains:
|
|
|
|
|
|
Structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i
|
|
|
Source: Listeria monocytogenes. Organism_taxid: 169963. Strain: egd-e. Variant: serovar 12a. Expressed in: escherichia coli. Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
B, D
(547 residues)
CATH domains:
|
|
|
|
|
|
Structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: low resolution, crystal form ii
|
|
|
Source: Listeria monocytogenes. Organism_taxid: 169963. Strain: egd-e. Variant: serovar 12a. Expressed in: escherichia coli. Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
B, D
(630 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(253 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(255 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(253 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Human c-met kinase in complex with azaindole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
X-ray structure of pf-02341066 bound to the kinase domain of c-met
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
X-ray structure of pha-00665752 bound to the kinase domain of c-met
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the epha4 ligand binding domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
|
|
|
Chains:
A, B
(180 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the epha4-ephrinb2 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
|
|
|
Chain:
A
(178 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the epha4-ephrina2 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
|
|
|
Chain:
A
(176 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the tie2 kinase domain in complex with a thiazolopyrimidine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the ddr2 discoidin domain bound to a triple- helical collagen peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293-ebna. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
A
(164 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the complete epha2 ectodomain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_variant: gnti-deficient. Expression_system_cell_line: hek293.
|
|
|
Chain:
A
(485 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the complete epha2 ectodomain in complex with ephrin a5 receptor binding domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_variant: gnti-deficient. Expression_system_cell_line: hek293.
|
|
|
Chain:
A
(488 residues)
|
|
|
|
|
|
Crystal structure of vegf-c in complex with domains 2 and 3 of vegfr2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
L, M, N, O
(196 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of vegf-c in complex with domains 2 and 3 of vegfr2 in a tetragonal crystal form
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
R
(201 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(287 residues)
CATH domains:
|
|
|
|
|
|
First two cadherin-like domains from human ret
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec8. Expression_system_organ: ovary.
|
|
|
Chain:
A
(236 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Structural insights into the binding of vegf-b by vegfr-1d2: recognition and specificity
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 469008.
|
|
|
Chains:
C, X
(98 residues)
CATH domain:
|
|
|
|
|
|
Structure of human anaplastic lymphoma kinase in complex with nvp- tae684
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(286 residues)
CATH domains:
|
|
|
|
|
|
Structure of human anaplastic lymphoma kinase in complex with pha- e429
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(284 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with pf- 00337210 (n,2-dimethyl-6-(7-(2-morpholinoethoxy)quinolin-4-yloxy) benzofuran-3-carboxamide)
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(296 residues)
CATH domains:
|
|
|
|
|
|
Structure of the human anaplastic lymphoma kinase in complex with crizotinib (pf-02341066)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(270 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of epha4 kinase domain in complex with vuf 12058
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(260 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of epha4 kinase domain
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(262 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of epha4 kinase domain in complex with dasatinib.
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Structure of l1196m mutant anaplastic lymphoma kinase in complex with crizotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Structure of l1196m mutant anaplastic lymphoma kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(292 residues)
CATH domains:
|
|
|
|
|
|
Structure of f1174l mutant anaplastic lymphoma kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Structure of c1156y mutant anaplastic lymphoma kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chains:
A, B
(253 residues)
CATH domains:
|
|
|
|
|
|
Solution structure of the complex of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: frs3. Other_details: cell-free protein synthesis. Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence is taken from homo sapiens.
|
|
|
Chain:
B
(19 residues)
|
|
|
|
|
|
Solution structure of the chimera of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(153 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the discoidin domain of ddr2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr2. Expressed in: pichia pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
A
(161 residues)
CATH domain:
|
|
|
|
|
|
Phosphorylated insulin receptor tyrosine kinase in complex with (4- {[5-carbamoyl-4-(3-methylanilino)pyrimidin-2-yl]amino}phenyl)acetic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: irs1.
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Complex structure of insulin-like growth factor receptor and isoquinolinedione inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r.
|
|
|
Chains:
A, B, C, D
(303 residues)
CATH domains:
|
|
|
|
|
|
Human c-met kinase domain complexed with 6-benzyloxyquinoline inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
|
|
X-ray crystal structure of human anaplastic lymphoma kinase in complex with ch5424802
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(298 residues)
CATH domains:
|
|
|
|
|
|
Structure of phosphotransferase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(288 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group M33
is 92.86% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of isolated domain iii of the extracellular region of the epidermal growth factor receptor in complex with the fab fragment of imc-11f8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: mus musculus. Expression_system_taxid: 10090. Gene: egfr, erbb1.
|
|
|
Chains:
A, B, E, I, M, P, S, V
(195 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the fab fragment of imc-11f8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: mus musculus. Expression_system_taxid: 10090. Gene: egfr, erbb1.
|
|
|
Chain:
A
(375 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a naphthamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(292 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a naphthamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(289 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the erbb4 kinase in complex with lapatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
B, D
(274 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the erbb4 kinase in its inactive conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
B, A
(275 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the erbb4 kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C
(285 residues)
CATH domains:
|
|
|
|
|
|
Dual specific bh1 fab in complex with the extracellular domain of her2/erbb-2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, neu, ngl. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: chinese hamster ovary. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(583 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a benzamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Cfms tyrosine kinase (tie2 kid) in complex with a pyrimidinopyridone inhibitor
|
|
|
Source: Homo sapiens. Human. Gene: csf1r, fms. Expressed in: spodoptera frugiperda
|
|
|
Chain:
A
(310 residues)
CATH domains:
|
|
|
|
|
|
X-ray structure of egfr in complex with oxime inhibitor
|
|
|
Source: Homo sapiens. Human. Strain: human strains undefined. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda.
|
|
|
Chain:
A
(280 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with inhibitor c52
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(261 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group OLP
is 41.67% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of catalytic domain of the proto-oncogene tyrosine- protein kinase mer in complex with adp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: peripheral blood leukocyte. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the insulin receptor kinase in complex with irs2 krlb peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: the sequence of this peptide natually exists in mus musculus.
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the insulin receptor kinase in complex with irs2 krlb peptide and atp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: the sequence of this peptide natually exists in mus musculus.
|
|
|
Chain:
A
(294 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ATP
corresponds to
enzyme reactant ATP
|
|
|
|
|
|
|
Crystal structure of the insulin receptor kinase in complex with irs2 krlb phosphopeptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: the sequence of this peptide natually exists in mus musculus.
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-cbl-tkb domain complexed with its binding motif in egf receptor'
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: cbl, cbl2, rnf55. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, C
(11 residues)
|
|
|
|
|
|
Crystal structure the fab fragment of matuzumab (fab72000) in complex with domain iii of the extracellular region of egfr
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Strain: ,. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell_line: myeloma. Other_details: humanized mouse. Homo sapiens.
|
|
|
Chains:
A, D
(191 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a pyrrolotriazine based inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: spodoptera frugiperda 9 (sf9).
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Fgfr tyrosine kinase domain in complex with 3-(3-methoxybenzyl)-7- azaindole
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, fgfbr, flg, flt2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(290 residues)
CATH domains:
|
|
|
|
|
|
Structure of vegfr2 kinase domain in complex with bibf1120
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(291 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the ligand binding domain of human ephrin a2 (epha2) receptor protein kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(160 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of hfgfr2 d2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(100 residues)
CATH domain:
|
|
|
|
|
|
X-ray structure of c-met with triazolopyridazine inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
|
|
X-ray structure of c-met with triazolopyridazine inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a pyrrolopyridinepyridone based inhibitor
|
|
|
Source: Homo sapiens. Human. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_cell_line: spodoptera frugiperda 9 (sf9).
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine
|
|
|
Source: Homo sapiens. Human. Gene: kdr, flk1. Expressed in: spodoptera frugiperda. Other_details: kid insert removed
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr2 in complex with a 3,4,5-trimethoxy aniline containing pyrimidine
|
|
|
Source: Homo sapiens. Human. Gene: kdr, flk1. Expressed in: spodoptera frugiperda. Other_details: kid insert removed
|
|
|
Chain:
A
(282 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of eph a4 receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha4, hek8, sek, tyro1. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(170 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domains trapped in trans-phosphorylation reaction
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(291 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a pyridone inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(288 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a bisamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(285 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a pyridone inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(284 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor
|
|
|
Source: Homo sapiens. Human. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(295 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor
|
|
|
Source: Homo sapiens. Human. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of 2:2:2 fgfr2d2:fgf1:sos complex
|
|
|
Source: Homo sapiens. Human. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Gene: fgf1, fgfa.
|
|
|
Chains:
A, C
(100 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the human ephrin a2- ephrin a1 complex
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: efna1, eplg1, lerk1, tnfaip4.
|
|
|
Chain:
A
(175 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with pqip
|
|
|
Source: Homo sapiens. Human. Gene: igf1r. Expressed in: spodoptera frugiperda.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of d2 domain from human fgfr2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(99 residues)
CATH domain:
|
|
|
|
|
|
Structure of met receptor tyrosine kinase in complex with atp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met, hcg_38705, tcag7.66. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(312 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ATP
corresponds to
enzyme reactant ATP
|
|
|
|
|
|
|
Structure of met receptor tyrosine kinase in complex with inhibitor sgx-523
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met, hcg_38705, tcag7.66. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(294 residues)
CATH domains:
|
|
|
|
|
|
Structure of mutant(y1248l) met receptor tyrosine kinase in complex with inhibitor sgx-523
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met, hcg_38705, tcag7.66. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor alw-ii-49-7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: brain. Gene: epha7, ehk3, hek11. Expressed in: escherichia coli.
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
|
|
Cfms tyrosine kinase in complex with a pyridopyrimidinone inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fgfbr, fgfr1, flg, flt2, fms, bfgfr, cek, hbgfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(279 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a benzisoxazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni.
|
|
|
Chains:
A, B
(288 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase domain in complex with inhibitor awl-ii-38.3
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Tissue: placenta. Gene: epha3. Expressed in: escherichia coli.
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Structure of c-met with pyrimidone inhibitor 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(276 residues)
CATH domains:
|
|
|
|
|
|
Structure of c-met with pyrimidone inhibitor 50
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda
|
|
|
Chains:
A, B
(276 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with motesanib
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Structure of m-csf bound to the first three domains of fms
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: csf1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: csf1r, csfmr, fms.
|
|
|
Chain:
X
(272 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Insulin receptor kinase complexed with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
|
|
Insulin receptor kinase complexed with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(293 residues)
CATH domains:
|
|
|
|
|
|
The crystal structure of the ligand-binding domain of the ephb2 receptor at 2.0 a resolution
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ephb2, epth3, nuk, sek3. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(187 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the fgfr2 d2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(100 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a pyridyl-pyrimidine benzimidazole inhibitor
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Complex structure of insulin-like growth factor receptor and 3- cyanoquinoline inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: cancer cell
|
|
|
Chains:
A, B, C, D, E, F, G, H, I, J, K, M, L, R, S, T
(302 residues)
CATH domains:
|
|
|
|
|
|
Human c-met kinase in complex with quinoxaline inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(288 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with n-(4-(2-amino-3- chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2- oxo-1,2-dihydropyridine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the human ephrin a2 ectodomain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eck, epha2, hcg_24712, rp11-276h7.1-001. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(482 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region bound to substrate kqwdnye[ptyr]iw
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3, etk, etk1, hek, tyro4. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: peptide synthesized with phosphorylation at the +2 tyrosine position
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Human epha3 kinase and juxtamembrane region bound to substrate kqwdnyefiw
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3, etk, etk1, hek, tyro4. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
|
|
Kit kinase domain in complex with sunitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(332 residues)
CATH domains:
|
|
|
|
|
|
Kit kinase domain mutant d816h in complex with sunitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(291 residues)
CATH domains:
|
|
|
|
|
|
Antibodies specifically targeting a locally misfolded region of tumor associated egfr
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell: hybridoma cell. Synthetic: yes. Other_details: peptide synthesis
|
|
|
Chain:
C
(16 residues)
|
|
|
|
|
|
Antibodies specifically targeting a locally misfolded region of tumor associated egfr
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell: hybridoma cell. Synthetic: yes. Other_details: peptide synthesis
|
|
|
Chain:
E
(16 residues)
|
|
|
|
|
|
Crystal structure of the egf receptor juxtamembrane and kinase domains
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of activated receptor tyrosine kinase in complex with substrates
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfbr, fgfr1, flg, flt2. Expressed in: escherichia coli. Expression_system_taxid: 562. Rattus norvegicus. Rat. Organism_taxid: 10116.
|
|
|
Chain:
A
(307 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of activated receptor tyrosine kinase in complex with substrates
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfbr, fgfr1, flg, flt2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C
(287 residues)
CATH domains:
|
|
|
|
|
|
Fgfr3 in complex with a fab
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr3. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: protein selected by phage display.
|
|
|
Chain:
A
(206 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the inactive egfr kinase domain in complex with amp-pnp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
B, A, C, D
(292 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of eph receptor and ephrin complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha4, hek8, sek, tyro1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: efnb2, eplg5, htkl, lerk5.
|
|
|
Chain:
A
(171 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the single-chain fv (scfv) fragment of an anti- erbb2 antibody cha21 in complex with residues 1-192 of erbb2 extracellular domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.
|
|
|
Chains:
A, B
(193 residues)
CATH domain:
|
|
|
|
|
|
Sam domain of human ephrin type-a receptor 7 (epha7)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ehk3, epha7, hek11. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(71 residues)
CATH domain:
|
|
|
|
|
|
Ligand recognition by a-class eph receptors: crystal structures of the epha2 ligand-binding domain and the epha2/ephrin-a1 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Expression_system_organ: kidney. Expression_system_cell: human embryonic kidney (hek) cells.
|
|
|
Chains:
A, C, E, G, I, K, M, O
(174 residues)
CATH domain:
|
|
|
|
|
|
Sam domain of human ephrin type-a receptor 1 (epha1)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eph, epha1, epht, epht1, mgc163163. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(63 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the frizzled-like cysteine-rich domain of musk
|
|
|
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: musk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(141 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of vegfr1 in complex with n-(4-chlorophenyl)-2- ((pyridin-4-ylmethyl)amino)benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flt1. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Ligand recognition by a-class eph receptors: crystal structures of the epha2 ligand-binding domain and the epha2/ephrin-a1 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Expression_system_organ: kidney.
|
|
|
Chains:
A, B, C, D, E, F
(174 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the unliganded drosophila epidermal growth factor receptor ectodomain
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(542 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NDG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of c-met with triazolopyridazine inhibitor 13
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(280 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of insulin-like growth factor 1 receptor (igf-1r-wt) complex with bms-754807 [1-(4-((5-cyclopropyl-1h-pyrazol-3-yl)amino) pyrrolo[2,1-f][1,2,4]triazin-2-yl)-n-(6-fluoro-3-pyridinyl)-2-methyl- l-prolinamide]
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(296 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m mutant covalently binding to wz4002
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(310 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with 5-(2-thienyl)nicotinic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, fgfbr, flg, flt2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(295 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (her3)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, erbb3/her3, her3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(292 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Co-crystal structure of the sam domains of epha1 and epha2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eph, epha1, epht, epht1, mgc163163. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: epha2.
|
|
|
Chains:
A, B, C, D, E
(64 residues)
CATH domain:
|
|
|
|
|
|
Cfms tyrosine kinase in complex with 4-cyano-1h-imidazole-2-carboxylic acid (2-cyclohex-1-enyl-4-piperidin-4-yl-phenyl)-amide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms, fgfr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(304 residues)
CATH domains:
|
|
|
|
|
|
Cfms tyrosine kinase in complex with 5-cyano-furan-2-carboxylic acid [4-(4-methyl-piperazin-1-yl)-2-piperidin-1-yl-phenyl]-amide
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: csf1r, fgfr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of human ephrin type-a receptor 8 (epha8)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eek, epha8, hek3, kiaa1459. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(267 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr2 extracellular domain d7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flk1, kdr, vegfr2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(82 residues)
CATH domain:
|
|
|
|
|
|
Structure of the mutant fibroblast growth factor receptor 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, fgfbr, flg, flt2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(305 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fibroblast growth factor receptor 1 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, fgfbr, flg, flt2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(307 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of cytoplasmic kinase domain of tie2 complexed with inhibitor cep11207
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tek, tie2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(292 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a biarylamine based inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the anaplastic lymphoma kinase catalytic domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Inhibitor bound to a dfg-in structure of the kinase domain of csf-1r
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf-1r, csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Inhibitor bound to a dfg-out structure of the kinase domain of csf-1r
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf-1r, csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the anaplastic lymphoma kinase catalytic domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(304 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the anaplastic lymphoma kinase catalytic domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(308 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the erbb3 kinase domain in complex with amp-pnp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(268 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the kinase domain of c-met bound to xl880 (gsk1363089)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the drosophila epidermal growth factor receptor ectodomain in complex with spitz
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: egfr, dmel_cg10079, torpedo, degfr, c-erbb, der, top. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: cg10334, spi, spitz. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
|
|
|
Chains:
A, C
(522 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the drosophila epidermal growth factor receptor ectodomain complexed with a low affinity spitz mutant
|
|
|
Source: Drosophila melanogaster. Organism_taxid: 7227. Gene: torpedo. Degfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: spitz. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: schneider 2(s2) cells.
|
|
|
Chains:
A, C
(522 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bisphosphorylated igf1-r kinase domain (2p) in complex with a bis-azaindole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(289 residues)
CATH domains:
|
|
|
|
|
|
Igf-1rk in complex with ligand msc1609119a-1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(292 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(265 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the human ephrin a2 lbd and crd domains in complex with ephrin a1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eck, epha2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: efna1, eplg1, lerk1, tnfaip4.
|
|
|
Chain:
A
(286 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
The structure of a platelet derived growth factor receptor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgf2, pdgfb, sis. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: embryonic kidney-293 cells. Gene: pdgfrb. Expression_system_cell_line: embryonic kidney-293 cells
|
|
|
Chains:
X, Y
(274 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NDG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of epha2 ectodomain in complex with ephrin-a5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek-293. Gene: efna5, eplg7, lerk7.
|
|
|
Chains:
A, C
(406 residues)
CATH domains:
Unassigned
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Her2 extracelluar region with affinity matured 3-helix affibody zher2:342
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic: yes. Staphylococcus aureus. Organism_taxid: 1280.
|
|
|
Chain:
A
(569 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystallographic trimer of her2 extracellular regions in complex with tryptophan-rich antibody fragment
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: light chain (chain id l) was selected from a sequence
|
|
|
Chain:
A
(605 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
The extracellular and transmembrane domain interfaces in epidermal growth factor receptor signaling
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: ovary. Gene: egf. Expression_system_organ: ovary
|
|
|
Chains:
A, B
(614 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Ligand binding domain of epha7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D, E, F, G, H, I, J, K, L
(159 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of insulin-like growth factor 1 receptor (igf-1r-wt) complex with a carbon-linked proline isostere inhibitor (11b)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(302 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of insulin-like growth factor 1 receptor (igf-1r-wt) complex with a carbon-linked proline isostere inhibitor (11a)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(301 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of insulin-like growth factor 1 receptor (igf-1r-wt) complex with a carbon-linked proline isostere inhibitor (34)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Human unphosphorylated igf1-r kinase domain in complex with an hydantoin inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-cbl tkb domain in complex with double phosphorylated egfr peptide
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Other_details: synthetic peptide. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(11 residues)
|
|
|
|
|
|
Crystal structure of fgf1 complexed with the ectodomain of fgfr2b harboring the a172f pfeiffer syndrome mutation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgf1, fgfa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bek, fgfr2, kgfr, ksam.
|
|
|
Chains:
C, D
(209 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgf1 complexed with the ectodomain of fgfr2b harboring p253r apert mutation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgf1, fgfa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bek, fgfr2, kgfr, ksam.
|
|
|
Chain:
B
(211 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgf1 complexed with the ectodomain of fgfr1c exhibiting an ordered ligand specificity-determining betac'-betae loop
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgf1, fgfa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fgfbr, fgfr1, flg, flt2.
|
|
|
Chains:
C, D
(213 residues)
CATH domains:
|
|
|
|
|
|
Anti-egfr/her3 fab dl11 in complex with domain iii of egfr extracellular region
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(194 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Anti-egfr/her3 fab dl11 in complex with domains i-iii of the her3 extracellular region
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: erbb3, her3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(506 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Ligand binding domain of human ephrin type-b receptor 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb3, etk2, hek2, tyr06, tyro6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C
(171 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of cbl-b tkb domain in complex with egfr py1069 peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cblb, nbla00127, rnf56. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
D
(11 residues)
|
|
|
|
|
|
Ron in complex with ligand amp-pnp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mst1r, ptk8, ron. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(298 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr kinase domain complexed with tak-285
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7118.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the kinase domain of human her2 (erbb2).
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7118. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Structure of the apo met receptor kinase in the dually-phosphorylated, activated state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Structure of dually-phosphorylated met receptor kinase in complex with an mk-2461 analog with specificity for the activated receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(299 residues)
CATH domains:
|
|
|
|
|
|
Cocrystal structure of unphosphorylated igf with pyrimidine 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(285 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a human flt3 ligand-receptor ternary complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flt3lg. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: flt3, stk1. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
E, F, G, H
(328 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of a human flt3 ligand-receptor ternary complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flt3lg. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: flt3, stk1. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
E, F, G, H
(405 residues)
|
|
|
|
|
|
C-met kinase in complex with nvp-bvu972
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7118
|
|
|
Chains:
A, B
(292 residues)
CATH domains:
|
|
|
|
|
|
Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase tyro3 (sky)
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyro3, dtk, rse. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(241 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the extracellular domain of the epidermal growth factor receptor in complex with an adnectin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(613 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of dually phosphorylated c-met receptor kinase in complex with an mk-2461 analog
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
CATH domains:
|
|
|
|
|
|
Her2 kinase domain complexed with tak-285
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(281 residues)
CATH domains:
|
|
|
|
|
|
Structural insight into brassinosteroid perception by bri1
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: bri1, at4g39400, f23k16.30. Expression_system_cell_line: high-5. Other_details: invitrogentm
|
|
|
Chain:
A
(734 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structural insight into brassinosteroid perception by bri1
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: bri1, at4g39400, f23k16.30. Expression_system_cell_line: high-5. Other_details: invitrogentm
|
|
|
Chain:
A
(745 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the catalytic domain of c-met kinase in complex with arq 197
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(298 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the catalytic domain of fgfr1 kinase in complex with arq 069
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, fgfbr, flg, flt2. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chains:
B, A
(275 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the catalytic domain of fgfr2 kinase in complex with arq 069
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chains:
A, B
(285 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 3RH
is 40.74% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of the plant steroid receptor bri1 ectodomain
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: at4g39400, bri1, f23k16.30. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(740 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Plant steroid receptor bri1 ectodomain in complex with brassinolide
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: at4g39400, bri1, f23k16.30. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(741 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structural basis for the function of two anti-vegf receptor antibodies
|
|
|
Source: Mus musculus, homo sapiens. Mouse, human. Organism_taxid: 10090, 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: mammalian kidney cells hek293. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chain:
X
(112 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structural basis for the function of two anti-vegf receptor antibodies
|
|
|
Source: Mus musculus, homo sapiens. Mouse, human. Organism_taxid: 10090, 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: mammalian kidney cells hek293. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chain:
X
(112 residues)
CATH domain:
|
|
|
|
|
|
Structural basis for the function of two anti-vegf receptor antibodies
|
|
|
Source: Mus musculus, homo sapiens. Mouse, human. Organism_taxid: 10090, 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: mammalian kidney cells hek293. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chain:
X
(110 residues)
CATH domain:
|
|
|
|
|
|
Structural and functional characterization of an agonistic anti-human epha2 monoclonal antibody
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293. Gene: epha2, eck. Expression_system_cell_line: hek 293
|
|
|
Chains:
E, F
(176 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase mer in complex with inhibitor unc569
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(256 residues)
CATH domains:
|
|
|
|
|
|
The avrptob-bak1 complex reveals two structurally similar kinaseinteracting domains in a single type iii effector
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress, thale-cress. Organism_taxid: 3702. Gene: bak1, elg, serk3, at4g33430, f17m5.190. Expressed in: escherichia coli. Expression_system_taxid: 562. Pseudomonas syringae pv. Tomato. Organism_taxid: 323. Gene: hopab2, avrptob, pspto_3087.
|
|
|
Chains:
A, D, G, H
(304 residues)
CATH domains:
|
|
|
|
|
|
Co-structure of fibroblast growth factor receptor 1 kinase domain with 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1- yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (bgj398)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, fgfbr, flg, flt2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: tn5
|
|
|
Chains:
A, B
(305 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of n-terminal three extracellular domains of erbb4/her4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
|
|
|
Chain:
A
(479 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of c-met in complex with pyrazolone inhibitor 26
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(280 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met in complex with pyrazolone inhibitor 58a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a pyrazolone inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flk1, kdr. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(308 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: nrg1. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D, E, F
(550 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of extracellular domain of human erbb4/her4 in complex with the fab fragment of mab1479
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Strain: balb/c. Expressed in: mus musculus. Expression_system_taxid: 10090. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
E, F
(585 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the mutated egfr kinase domain (g719s/t790m) in the apo form
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(296 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the mutated egfr kinase domain (g719s/t790m) in complex with gefitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(299 residues)
CATH domains:
|
|
|
|
|
|
Structural basis for the impact of phosphorylation on plant receptor- like kinase bak1 activation
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: bak1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of apo bak1
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: bak1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Vegfr-2/vegf-a complex structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flk1, kdr, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: vegf, vegf-a, vegfa. Expressed in: pichia pastoris. Expression_system_taxid: 4922
|
|
|
Chain:
R
(185 residues)
CATH domains:
|
|
|
|
|
|
Discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk3, trkc. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(263 residues)
CATH domains:
|
|
|
|
|
|
Vegfr-2/vegf-e complex structure
|
|
|
Source: Orf virus. Orfv. Organism_taxid: 10258. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2.
|
|
|
Chain:
R
(187 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human vegfr2 kinase domain with a novel pyrrolopyrimidine inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flk1, kdr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with a back pocket binder
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human vegfr2 kinase domain with compound a.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(299 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the mutated egfr kinase domain (g719s/t790m) in complex with amppnp.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the wild-type egfr kinase domain in complex with amppnp.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(298 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the kinase domain of human vegfr2 with a [1, 3]thiazolo[5,4-b]pyridine derivative
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(301 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the kinase domain of human vegfr2 with imidazo[1, 2-b]pyridazine derivative
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human c-met kinase domain with its inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Insulin receptor ectodomain construct comprising domains l1-cr in complex with human insulin, alpha-ct peptide(704-719) and fab 83-7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ins. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Mus musculus. Mouse. Organism_taxid: 10090.
|
|
|
Chains:
E, F
(288 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Insulin receptor ectodomain construct comprising domains l1-cr in complex with high-affinity insulin analogue [d-pro-b26]-dti-nh2, alpha-ct peptide(704-719) and fab 83-7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec8 mutant. Expression_system_cell: cho cell. Mus musculus.
|
|
|
Chains:
E, F
(288 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Insulin receptor ectodomain construct comprising domains l1-cr in complex with high-affinity insulin analogue [d-pro-b26]-dti-nh2, alphact peptide(693-719) and fab 83-7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec8 mutant. Expression_system_cell: cho cell. Mus musculus.
|
|
|
Chains:
E, F
(288 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr kinase domain t790m/l858r mutant with tak-285
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(305 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain t790m/l858r mutant with compound 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(308 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain t790m/l858r mutant with hki-272
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(307 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain t790m/l858r mutant with compound 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain with compound4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(307 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain complexed with compound 20a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(317 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain complexed with compound 19b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Molecular architecture of the erbb2 extracellular domain homodimer
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
|
|
|
Chains:
A, B
(555 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Structure of her2 with an fab
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
|
|
|
Chain:
A
(555 residues)
CATH domains:
|
|
|
|
|
|
Kdr in complex with ligand lenvatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Kdr in complex with ligand sorafenib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(298 residues)
CATH domains:
|
|
|
|
|
|
Structure of human ros1 kinase domain in complex with crizotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(282 residues)
CATH domains:
|
|
|
|
|
|
X-ray structure of c-met kinase in complex with inhibitor 6-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl) quinoline.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(283 residues)
CATH domains:
|
|
|
|
|
|
X-ray structure of c-met kinase in complex with inhibitor (s)-6-(1-(6- (1-methyl-1h-pyrazol-4-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl) ethyl) quinoline.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
X-ray structure of c-met kinase in complex with inhibitor (s)-3-(1- (1h-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-n-isopropyl-(1,2,4)triazolo(4, 3- b)pyridazin-6-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(291 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephb4 in complex with staurosporine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chains:
A, B
(270 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephb2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(249 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephb1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chains:
A, B, C, D, E, F, G, H, I
(267 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephb3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
|
|
|
|
|
|
Structure of the ddr1 kinase domain in complex with ponatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: mammalian gene collection (mgc)
|
|
|
Chains:
A, B
(301 residues)
CATH domains:
|
|
|
|
|
|
X-ray structure of pf-04217903 bound to the kinase domain of c-met
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met kinase domain in complex with n'-((3z)-4- chloro-7-methyl-2-oxo-1,2-dihydro-3h-indol-3-ylidene)-2-(4- hydroxyphenyl)propanohydrazide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the kinase domain of ror2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Other_details: mammalian gene collection, open biosystems (mgc)
|
|
|
Chains:
A, B
(269 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a ddr1-fab complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293 c18. Mus musculus. House mouse. Organism_taxid: 10090.
|
|
|
Chain:
A
(341 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the vegfr2 kinase domain in complex with axitinib (ag-013736) (n-methyl-2-(3-((e)-2-pyridin-2-yl-vinyl)-1h- indazol-6- ylsulfanyl)-benzamide)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(296 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr2 (juxtamembrane and kinase domains) in complex with axitinib (ag-013736) (n-methyl-2-(3-((e)-2-pyridin-2-yl- vinyl)-1h-indazol-6-ylsulfanyl)-benzamide)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(305 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr2 (juxtamembrane and kinase domains) in complex with sunitinib (su11248) (n-2-diethylaminoethyl)-5-((z)-(5- fluoro-2-oxo-1h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3- carboxamide)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(304 residues)
CATH domains:
|
|
|
|
|
|
Structure of g1269a mutant anaplastic lymphoma kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Structure of g1269a mutant anaplastic lymphoma kinase in complex with crizotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(294 residues)
CATH domains:
|
|
|
|
|
|
Structure of l1196m,g1269a double mutant anaplastic lymphoma kinase in complex with crizotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(294 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met kinase domain in complex with 4-(3-((1h- pyrrolo(2,3-b)pyridin-3-yl)methyl)-(1,2,4)triazolo(4,3-b)(1,2,4) triazin-6-yl)benzonitrile
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Human trka in complex with the inhibitor az-23
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C
(260 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met kinase domain in complex with 4-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl)phenol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr2 (juxtamembrane and kinase domains) in complex with sorafenib (bay 43-9006)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(305 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr2 (juxtamembrane and kinase domains) in complex with tivozanib (av-951)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(307 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of apo trkb kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of trkb kinase domain in complex with cpd5n
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of trkb kinase domain in complex with ex429
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(292 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of trkb kinase domain in complex with gw2580
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(294 residues)
CATH domains:
|
|
|
|
|
|
Complex of the ephb4 kinase domain with an oxindole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(261 residues)
CATH domains:
|
|
|
|
|
|
Ephb4 kinase domain inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the human epha4 ectodomain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
|
|
|
Chains:
A, B
(514 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the human epha4 ectodomain in complex with human ephrin a5 (amine-methylated sample)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
|
|
|
Chains:
A, C
(507 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the human epha4 ectodomain in complex with human ephrin a5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
|
|
|
Chain:
A
(507 residues)
|
|
|
|
|
|
Crystal structure of the human epha4 ectodomain in complex with human ephrinb3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
|
|
|
Chains:
A, B
(505 residues)
|
|
|
|
|
|
Crystal structure of the human ddr1 kinase domain in complex with imatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: mammalian gene collection (mgc)
|
|
|
Chains:
A, B
(295 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr-3 extracellular domains d4-5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(213 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of vegf-c in complex with vegfr-3 domains d1-2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(172 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the human anaplastic lymphoma kinase in complex with 3- ((r)-1-(5-fluoro-2-(2h-1,2,3-triazol-2-yl)phenyl)ethoxy)-5-(5-methyl- 1h- pyrazol-4-yl)pyridin-2-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(291 residues)
CATH domains:
|
|
|
|
|
|
Structure of the human anaplastic lymphoma kinase in complex with 2- (5-(6-amino-5-((r)-1-(5-fluoro-2-(2h-1,2,3-triazol-2-yl)phenyl) ethoxy) pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Structure of l1196m mutant human anaplastic lymphoma kinase in complex with 2-(5-(6-amino-5-((r)-1-(5-fluoro-2-(2h-1,2,3-triazol-2- yl) phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propane-1,2-diol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(296 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of oncogenic ret tyrosine kinase m918t bound to adenosine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(295 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADN
is 70.37% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of ret tyrosine kinase domain bound to adenosine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADN
is 70.37% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the human ddr1 kinase domain in complex with ddr1-in-1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: mammalian gene collection (mgc)
|
|
|
Chain:
A
(295 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegfr-1 domain 2 in presence of zn
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta-gami plyss.
|
|
|
Chain:
X
(94 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of vegfr-1 domain 2 in presence of cobalt
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta-gami plyss.
|
|
|
Chains:
A, B, C, D
(93 residues)
CATH domain:
|
|
|
|
|
|
Structure of the human anaplastic lymphoma kinase in complex with pf- 06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16, 17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(295 residues)
CATH domains:
|
|
|
|
|
|
Structure of l1196m mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo- 10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(296 residues)
CATH domains:
|
|
|
|
|
|
Structure of the human anaplastic lymphoma kinase in complex with the inhibitor 2-((1r)-1-((3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl) oxy)ethyl)-4-fluoro-n-methylbenzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(296 residues)
CATH domains:
|
|
|
|
|
|
Structure of the human anaplastic lymphoma kinase in complex with the inhibitor 3-((1r)-1-(5-fluoro-2-(2h-1,2,3-triazol-2-yl)phenyl) ethoxy)- 5-(3-(methylsulfonyl)phenyl)pyridin-2-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Structure of the human anaplastic lymphoma kinase in complex with the inhibitor (10r)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17- dihydro- 1h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecin-15(10h)-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(295 residues)
CATH domains:
|
|
|
|
|
|
Structure of the human anaplastic lymphoma kinase in complex with the inhibitor 3-((1r)-1-(5-fluoro-2-methoxyphenyl)ethoxy)-5-(1-methyl-1h- 1,2,3-triazol-5-yl)pyridin-2-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Solution structure of a trkaig2 domain construct for use in drug discovery
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(107 residues)
CATH domain:
|
|
|
|
|
|
Structure of the human anaplastic lymphoma kinase in complex with the inhibitor (5r)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20- tetrahydro-7,11-(azeno)pyrido(2',1':2,3)imidazo(4,5-h)(2,5,11) benzoxadiazacyclotetradecine-14-carbonitrile
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Structure of the human anaplastic lymphoma kinase in complex with the inhibitor 7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17- dihydro-1h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecin-15(10h)-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Human igf in complex with a dyrk1b inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(288 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met in complex with triazolopyridazine inhibitor 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(286 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met in complex with triazolopyridinone inhibitor 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(286 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met in complex with triazolopyridinone inhibitor 24
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human interleukin-34 bound to human csf-1r
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: il34, c16orf77. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: tni pro. Gene: csf1r, fms. Expression_system_cell_line: tni pro
|
|
|
Chain:
C
(272 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of c-met in complex with ly2801653
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(283 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of eph receptor 5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bsk, ehk1, epha5, hek7, tyro4. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(174 residues)
CATH domain:
|
|
|
|
|
|
Structure of mouse interleukin-34 in complex with mouse fms
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: il34. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek. Gene: csf1r, csfmr, fms. Expression_system_cell_line: hek
|
|
|
Chain:
X
(283 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of apo trka
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(284 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with compound 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(278 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with compound 6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(278 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with compound 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(279 residues)
CATH domains:
|
|
|
|
|
|
Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase tyro3 (sky)
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyro3, dtk, rse. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(224 residues)
CATH domains:
|
|
|
|
|
|
Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase tyro3 (sky)
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyro3, dtk, rse. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(169 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the apo f1174l anaplastic lymphoma kinase catalytic domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(304 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the apo r1275q anaplastic lymphoma kinase catalytic domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(292 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the r1275q anaplastic lymphoma kinase catalytic domain in complex with a benzoxazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human anaplastic lymphoma kinase in complex with piperidine-carboxamide inhibitor 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(295 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(296 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human anaplastic lymphoma kinase in complex with acyliminobenzimidazole inhibitor 36
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(308 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the sema-psi extracellular domains of human ron receptor tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mst1r, ptk8, ron. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
|
|
|
Chain:
A
(513 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Human epha3 kinase domain in complex with compound 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group C07
is 41.67% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr kinase in complex with bibw2992
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(307 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase t790m in complex with bibw2992
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B
(299 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of cmet in complex with novel inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: c-met, met. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of cmet in complex with novel inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cmet, met. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase domain in complex with ligand 66
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase domain in complex with ligand 87
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase domain in complex with ligand 90
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
|
|
Structure of unliganded, inactive ror2 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrkr2, ror2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(274 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the inactive trka kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtc, ntrk1, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the inactive egfr tyrosine kinase domain with erlotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Structural basis for eliciting a cytotoxic effect in her2- overexpressing cancer cells via binding to the extracellular domain of her2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic. Organism_taxid: 32630.
|
|
|
Chain:
C
(169 residues)
CATH domain:
|
|
|
|
|
|
Structural basis for eliciting a cytotoxic effect in her2- overexpressing cancer cells via binding to the extracellular domain of her2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic. Organism_taxid: 32630.
|
|
|
Chains:
C, A
(166 residues)
CATH domain:
|
|
|
|
|
|
Structural basis for eliciting a cytotoxic effect in her2- overexpressing cancer cells via binding to the extracellular domain of her2
|
|
|
Source: Synthetic. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: spodoptera frugiperda.
|
|
|
Chains:
C, D
(71 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of kit kinase domain with a small molecule inhibitor, plx647
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(326 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fms kinase domain with a small molecular inhibitor, plx647-ome
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the ig-c2 type 1 domain from mouse fibroblast growth factor receptor 2 (fgfr2) [nysgrc-005912]
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: bek, ect1, fgfr2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(81 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the monomeric (v948r) form of the gefitinib/erlotinib resistant egfr kinase domain l858r+t790m
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of monomeric (v948r) primary oncogenic mutant l858r egfr kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of l858r + t790m egfr kinase domain in complex with mig6 peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: errfi1, mig6. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(290 residues)
CATH domains:
|
|
|
|
|
|
Structure of the monomeric (v948r)gefitinib/erlotinib resistant double mutant (l858r+t790m) egfr kinase domain co-crystallized with gefitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the wild-type egfr kinase domain in complex with dacomitinib (soaked)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(304 residues)
CATH domains:
|
|
|
|
|
|
Structure of t790m egfr kinase domain co-crystallized with dacomitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(295 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of insulin receptor kinase domain in complex with an inhibitor irfin-1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(301 residues)
CATH domains:
|
|
|
|
|
|
Structure of dually phosphorylated c-met receptor kinase in complex with an mk-8033 analog
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met
|
|
|
Chain:
A
(302 residues)
CATH domains:
|
|
|
|
|
|
Low resolution crystal structure of the fgfr2d2d3/fgf1/sr128545 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bek, fgfr2, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fgf1, fgfa. Expression_system_taxid: 562
|
|
|
Chain:
A
(198 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k659n mutation responsible for an unclassified craniosynostosis syndrome in space group c2.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bek, fgfr2, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(279 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic gain-of-function k659m mutation identified in cervical cancer.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bek, fgfr2, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(302 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic gain-of-function k659e mutation identified in endometrial cancer.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bek, fgfr2, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(282 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 85.19% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the gain-of-function k659q mutation.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bek, fgfr2, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(304 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor 2 (fgfr2) kinase domain harboring the gain-of-function k659t mutation.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bek, fgfr2, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(280 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of human anaplastic lymphoma kinase in complex with 7-azaindole based inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(251 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with compound 2a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with compound 4b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with compound 3g
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with compound 4c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Structural basis for angiopoietin-1 mediated signaling initiation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hek 293. Gene: angpt1, kiaa0003. Expression_system_cell_line: hek 293
|
|
|
Chain:
A
(514 residues)
|
|
|
|
|
|
Crystal structure of fgf receptor 3 (fgfr3) kinase domain harboring the k650e mutation, a gain-of-function mutation responsible for thanatophoric dysplasia type ii and spermatocytic seminoma
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr3, jtk4. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of onartuzumab fab in complex with met and hgf-beta
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: met. Mus musculus, homo sapiens. Organism_taxid: 10090, 9606.
|
|
|
Chain:
B
(499 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of kit d4d5 fragment in complex with anti-kit antibody fab19
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: kit, scfr. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
C
(195 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of kit d4d5 fragment in complex with anti-kit antibodies fab79d
|
|
|
Source: Mus musculus. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: unidentified baculovirus.
|
|
|
Chain:
C
(193 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
C-met in complex with osi ligand
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: insecta. Expression_system_taxid: 50557.
|
|
|
Chains:
A, B, C, D
(273 residues)
CATH domains:
|
|
|
|
|
|
Nanobody/vhh domain 7d12 in complex with domain iii of the extracellular region of egfr, ph 6.0
|
|
|
Source: Lama glama. Llama. Organism_taxid: 9844. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1.
|
|
|
Chain:
A
(205 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Nanobody/vhh domain 7d12 in complex with domain iii of the extracellular region of egfr, ph 3.5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Lama glama. Llama. Organism_taxid: 9844.
|
|
|
Chains:
A, C, E, G, I, K
(197 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Nanobody/vhh domain ega1 in complex with the extracellular region of egfr
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Lama glama. Llama. Organism_taxid: 9844.
|
|
|
Chain:
A
(570 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Nanobody/vhh domain 9g8 in complex with the extracellular region of egfr
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Lama glama. Llama. Organism_taxid: 9844.
|
|
|
Chain:
A
(534 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the human epha3 receptor ligand binding domain complexed with ephrin-a5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3, epha3_human, etk, etk1, hek, tyro4. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: efna5, efna5_human, eplg7, lerk7. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(175 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of anti-her3 fab rg7116 in complex with the extracellular domains of human her3 (erbb3)
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3.
|
|
|
Chain:
C
(601 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Egfr-k in complex with n-[3-[[5-chloro-4-(1h-indol-3-yl)pyrimidin-2- yl]amino]-4-methoxy-phenyl] prop-2-enamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(306 residues)
CATH domains:
|
|
|
|
|
|
Structure of the extracellular domain of human csf-1 receptor in complex with the fab fragment of rg7155
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek-293. Mus musculus. Mouse.
|
|
|
Chain:
E
(469 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr l858r/t790m in complex with pd168393
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(291 residues)
CATH domains:
|
|
|
|
|
|
Egfr l858r in complex with pd168393
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(305 residues)
CATH domains:
|
|
|
|
|
|
Egfr d770_n771insnpg in complex with pd168393
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D, E
(307 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bri1 sud1 (gly643glu) bound to brassinolide
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Strain: col 0. Gene: at4g39400, bri1, f23k16.30. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(743 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Isolated serk1 co-receptor ectodomain at high resolution
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Strain: col 0. Gene: at1g71830, f14o23.21, f14o23_24, serk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(186 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Plant steroid receptor ectodomain bound to brassinolide and serk1 co- receptor ectodomain
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Strain: col 0. Gene: at4g39400, bri1, f23k16.30. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: at1g71830, f14o23.21, f14o23_24, serk1.
|
|
|
Chains:
A, B, C, D
(740 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase mer in complex with inhibitor unc1917
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mer, mertk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(243 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of epha4 ectodomain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha4, hek8, sek, tyro1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_organ: ovary.
|
|
|
Chain:
A
(513 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Epha4 ectodomain complex with ephrin a5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha4, hek8, sek, tyro1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_organ: ovary. Gene: efna5, eplg7, lerk7.
|
|
|
Chains:
A, C, E, G
(516 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structural insight into bl-induced activation of the bri1-bak1 complex
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: bri1, at4g39400, f23k16.30. Expression_system_cell: high five. Gene: bak1, elg, serk3, at4g33430, f17m5.190.
|
|
|
Chains:
A, B, D, C
(733 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase mer in complex with inhibitor unc1896
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mer, mertk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(248 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase mer in complex with inhibitor unc1817
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mer, mertk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(256 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of anaplastic lymphoma kinase complexed with ldk378
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of flg22 in complex with the fls2 and bak1 ectodomains
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: fls2, at5g46330, mpl12.13, mpl12.8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: high five. Gene: bak1, elg, serk3, at4g33430, f17m5.190. Synthetic: yes.
|
|
|
Chain:
B
(175 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of cmet in complex with novel inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cmet, met. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(281 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(279 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(265 residues)
CATH domains:
|
|
|
|
|
|
Zymogen hgf-beta/met with zymogen activator peptide zap.14
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: met. Synthetic: yes. Synthetic.
|
|
|
Chain:
B
(499 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Zymogen hgf-beta/met with zymogen activator peptide zap2.3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: met. Synthetic: yes. Synthetic.
|
|
|
Chain:
B
(500 residues)
CATH domains:
|
|
|
|
|
|
Insulin in complex with site 1 of the human insulin receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ins. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Mus musculus. Mouse. Organism_taxid: 10090.
|
|
|
Chains:
E, F
(288 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of bri1 in complex with bki1
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: at4g39400, bri1, f23k16.30. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence occurs naturally in arabidopsis thaliana.
|
|
|
Chains:
A, B
(303 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of ephrin type-a receptor 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: de3.
|
|
|
Chain:
A
(259 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase domain in complex with quinoxaline derivatives
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 25Q
is 40.54% similar to
enzyme product ADP
|
|
|
|
|
|
|
Her3 extracellular domain in complex with fab fragment of mor09825
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(592 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Human epha3 kinase domain in complex with quinoxaline derivatives
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3, etk, etk1, hek, tyro4. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase domain in complex with quinoxaline derivatives
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3, etk, etk1, hek, tyro4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(267 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with trkc
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ntrk3, trkc. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s. Gene: crypalpha1.
|
|
|
Chains:
A, B
(257 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with trkc
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ntrk3, trkc. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s. Gene: crypalpha1.
|
|
|
Chains:
B, A, C
(262 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of ephrin type-a receptor 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Structural basis of kit activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand- dependent or oncogenic receptor tyrosine kinase activation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
C, A, B
(165 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
The structure of trka kinase bound to the inhibitor n-(3-cyclopropyl- 1-phenyl-1h-pyrazol-5-yl)-2-{4-[3-methoxy-4-(4-methyl-1h-imidazol-1- yl)phenyl]-1h-1,2,3-triazol-1-yl}acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
|
|
The structure of trka kinase bound to the inhibitor 1-cyclopropyl-1- [3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(280 residues)
CATH domains:
|
|
|
|
|
|
The structure of trka kinase bound to the inhibitor 4-naphthalen-1-yl- 1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1h-pyrrolo[3,2-c]pyridine- 2-carboxylic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(283 residues)
CATH domains:
|
|
|
|
|
|
The structure of trka kinase bound to the inhibitor n~4~-(4-morpholin- 4-ylphenyl)-n~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6- diamine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of semet derivative bri1 in complex with bki1
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress,thale-cress. Organism_taxid: 3702. Gene: at4g39400, bri1, f23k16.30. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in arabidopsis thaliana.
|
|
|
Chains:
A, B
(298 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgf receptor (fgfr) 4 kinase harboring the v550l gate-keeper mutation in complex with fiin-2, an irreversible tyrosine kinase inhibitor capable of overcoming fgfr kinase gate-keeper mutations
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgf receptor (fgfr) 4 kinase domain in complex with fiin-2, an irreversible tyrosine kinase inhibitor capable of overcoming fgfr kinase gate-keeper mutations
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgf receptor (fgfr) 4 kinase domain harboring the v550l gate-keeper mutation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(282 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgf receptor (fgfr) 4 tyrosine kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(283 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of fgf receptor 4 in complex with ponatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mst1r, ptk8, ron. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Gene: d3f15s2, dnf15s2, hgfl, msi1, mst1.
|
|
|
Chains:
B, A
(629 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Identification and optimization of pyridazinones as potent and selectivE C-met kinase inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Identification and optimization of pyridazinones as potent and selectivE C-met kinase inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Crystal structures of egfr in complex with mig6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
A
(310 residues)
CATH domains:
|
|
|
|
|
|
Crystal structures of egfr in complex with mig6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, erbb1(egfr), her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
A
(309 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr 696-1022 l858r in complex with fiin-3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(299 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgf receptor (fgfr) 4 kinase harboring the v550l gate-keeper mutation in complex with fiin-3, an irreversible tyrosine kinase inhibitor capable of overcoming fgfr kinase gate-keeper mutations
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fms kinase domain with a small molecular inhibitor, plx3397
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(308 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fms kinase domain with a small molecular inhibitor, gleevec
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
An engineered axl 'decoy receptor' effectively silences the gas6-axl signaling axis
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gas6, axllg. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek. Gene: axl, ufo. Expressed in: escherichia coli.
|
|
|
Chains:
C, D
(191 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of an egfr/her3 kinase domain heterodimer
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: egfr, erbb, erbb1, her1. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(269 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of an egfr/her3 kinase domain heterodimer containing the cancer-associated her3-q790r mutation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: egfr. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(269 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of an egfr/her3 kinase domain heterodimer containing the cancer-associated her3-e909g mutation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: egfr. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(269 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Egfr kinase (t790m/l858r) with inhibitor compound 6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(299 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase (t790m/l858r) with inhibitor compound 5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(296 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase (t790m/l858r) with inhibitor compound 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase (t790m/l858r) with inhibitor compound 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(295 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase (t790m/l858r) with inhibitor compound 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(298 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of flt3 with a small molecule inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flt3, cd135, flk2, stk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of v561m fgfr1 gatekeeper mutation (c488a, c584s, v561m), apo
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bfgfr, cek, fgfbr, fgfr1, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(305 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgfr1 (c488a, c584s) in complex with azd4547 (n- {3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5- dimethylpiperazin-1-yl]benzamide)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bfgfr, cek, fgfbr, fgfr1, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(307 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of v561m fgfr1 gatekeeper mutation (c488a, c584s, v561m) in complex with n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h- pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide (azd4547)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bfgfr, cek, fgfbr, fgfr1, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(308 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgfr1 (c488a, c584c) in complex with 6-(7-((1- aminocyclopropyl) methoxy)-6-methoxyquinolin-4-yloxy)-n-methyl-1- naphthamide (e3810)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bfgfr, cek, fgfbr, fgfr1, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(282 residues)
CATH domains:
|
|
|
|
|
|
Native-sad phasing for human egfr kinase domain.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(307 residues)
CATH domains:
|
|
|
|
|
|
Structure of ephrin type-a receptor 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(269 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human alk with a covalent modification
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sp9
|
|
|
Chain:
A
(291 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase domain in complex with birb796
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3, etk, etk1, hek, tyro4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(276 residues)
CATH domains:
|
|
|
|
|
|
Human epha3 kinase domain in complex with compound 164
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3, etk, etk1, hek, tyro4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Structural analysis of the human fibroblast growth factor receptor 4 kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(292 residues)
CATH domains:
|
|
|
|
|
|
Structural analysis of the human fibroblast growth factor receptor 4 kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf9.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Structural analysis of the human fibroblast growth factor receptor 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Structural analysis of the human fibroblast growth factor receptor 4 kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of kit in complex with ponatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
The complex structure of extracellular domain of egfr with repebody (rac1).
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Listeria monocytogenes, synthetic construct, eptatretus burgeri. Organism_taxid: 1639, 32630, 7764. Expressed in: escherichia coli.
|
|
|
Chain:
A
(612 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
The complex structure of extracellular domain of egfr and gc1118a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho.
|
|
|
Chain:
A
(596 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Fibroblast growth factor receptor 1 kinase in complex with jk-p5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chains:
A, B
(299 residues)
CATH domains:
|
|
|
|
|
|
Fibroblast growth factor receptor 1 kinase in complex with jk-p3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chains:
A, B
(301 residues)
CATH domains:
|
|
|
|
|
|
Fgfr1 apo structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: c41, lambda 37.
|
|
|
Chains:
A, B
(296 residues)
CATH domains:
|
|
|
|
|
|
Ret recognition of gdnf-gfralpha1 ligand by a composite binding site promotes membrane-proximal self-association
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho lec8. Rattus norvegicus. Norway rat. Organism_taxid: 10116.
|
|
|
Chains:
A, B
(448 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Structure of human ros1 kinase domain in complex with pf-06463922
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Fgfr4 in complex with ponatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(286 residues)
CATH domains:
|
|
|
|
|
|
Fgfr1 in complex with ponatinib (co-crystallisation).
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(273 residues)
CATH domains:
|
|
|
|
|
|
Fgfr1 in complex with ponatinib.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(293 residues)
CATH domains:
|
|
|
|
|
|
Fgfr1 in complex with azd4547.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(287 residues)
CATH domains:
|
|
|
|
|
|
Structure of the epha4 lbd in complex with peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha4, hek8, sek, tyro1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B, C, D
(177 residues)
CATH domain:
|
|
|
|
|
|
Structure of the epha4 lbd in complex with peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha4, hek8, sek, tyro1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B, C, D
(177 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m in complex with ql-x138
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(307 residues)
CATH domains:
|
|
|
|
|
|
1.85 angstrom structure of egfr kinase domain with gefitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
1.9 angstrom structure of egfr kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Structure of the human csf-1:csf-1r complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek-293s. Gene: csf1. Expressed in: escherichia coli.
|
|
|
Chains:
A, C
(274 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the human csf-1:csf-1r complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t. Gene: csf1. Expressed in: escherichia coli.
|
|
|
Chain:
A
(445 residues)
|
|
|
|
|
|
Structure of fgfr1 in complex with azd4547 (n-{3-[2-(3,5- dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5- dimethylpiperazin-1-yl]benzamide) at 1.65 angstrom
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(282 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the fgfr2 d2 domain in complex with fab 2b.1.3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
|
|
|
Chains:
F, C
(98 residues)
CATH domain:
|
|
|
|
|
|
Selection of fragments for kinase inhibitor design: decoration is key
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tek, tie2, vmcm, vmcm1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(234 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgfr4 with an irreversible inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the activated insulin receptor tyrosine kinase dimer
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(310 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of c-met in complex with (r)-5-(8-fluoro-3-(1- fluoro-1-(3-methoxyquinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3- a]pyridin-6-yl)-3-methylisoxazole
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Insulin-like growth factor i in complex with site 1 of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1, ibp1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
|
|
|
Chains:
E, F
(309 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the endoglycosidase-h treated l1-cr domains of the human insulin receptor in complex with residues 697-719 of the human insulin receptor (a-isoform)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec 8 mutant cho cell. Synthetic: yes. Rattus norvegicus.
|
|
|
Chains:
E, F
(287 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the flt3 kinase domain bound to the inhibitor quizartinib (ac220)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flt3, cd135, flk2, stk1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chains:
A, B
(270 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met in complex with (s)-5-(8-fluoro-3-(1-(3-(2- methoxyethoxy)quinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6- yl)-3-methylisoxazole
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
(R)-2-phenylpyrrolidine substitute imidazopyridazines: a new class of potent and selective pan-trk inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk3, trkc. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(271 residues)
CATH domains:
|
|
|
|
|
|
(R)-2-phenylpyrrolidine substitute imidazopyridazines: a new class of potent and selective pan-trk inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
(R)-2-phenylpyrrolidine substitute imidazopyridazines: a new class of potent and selective pan-trk inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(280 residues)
CATH domains:
|
|
|
|
|
|
Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of ldk378
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(294 residues)
CATH domains:
|
|
|
|
|
|
The plant peptide hormone receptor complex in arabidopsis
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: pskr1, pskr, at2g02220, f5o4.1. Expressed in: insect cell expression vector ptie1. Expression_system_taxid: 266783. Gene: serk1. Expressed in: insect ba phytoplasma. Expression_system_taxid: 1286942.
|
|
|
Chain:
C
(186 residues)
CATH domain:
|
|
|
|
|
|
Azd9291 complex with wild type egfr
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(283 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with mitogen- inducible gene 6 protein
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: errfi1, mig6. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(282 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fgfr1 kinase domain in complex with 7n
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(290 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m/v948r, crystal form ii
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(297 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the human insulin receptor ectodomain, irdeltabeta construct, in complex with four fab molecules
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: mus musculus. Expression_system_taxid: 10090. Gene: igh-1a. Gene: igkc, igk-c. Homo sapiens. Organism_taxid: 9606.
|
|
|
Chain:
E
(800 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Fgfr1 in complex with dovitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(290 residues)
CATH domains:
|
|
|
|
|
|
Fgfr1 ligand complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(294 residues)
CATH domains:
|
|
|
|
|
|
Structure of c1156y mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo- 10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Structure of c1156y,l1198f mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Structure of l1198f mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo- 10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(296 residues)
CATH domains:
|
|
|
|
|
|
Structure of l1198f mutant human anaplastic lymphoma kinase in complex with crizotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(295 residues)
|
|
|
|
|
|
Structure of c1156y,l1198f mutant human anaplastic lymphoma kinase in complex with crizotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(294 residues)
|
|
|
|
|
|
Structure of c1156y mutant human anaplastic lymphoma kinase in complex with crizotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
|
|
|
|
|
|
Crystal structure of vegfr-1 domain 2 in presence of cu
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta-gami plyss.
|
|
|
Chains:
E, I, X
(95 residues)
CATH domain:
|
|
|
|
|
|
Native fgfr1 with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: c41 lambda 37.
|
|
|
Chains:
A, B
(295 residues)
CATH domains:
|
|
|
|
|
|
Fgfr1 mutant with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: c41 lambda 37.
|
|
|
Chains:
A, B
(294 residues)
CATH domains:
|
|
|
|
|
|
The discovery of 2-substituted phenol quinazolines as potent and selective ret kinase inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group DTQ
is 40.00% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structural basis of neurohormone perception by the receptor tyrosine kinase torso
|
|
|
Source: Bombyx mori. Domestic silkworm. Organism_taxid: 7091. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(233 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Human fgfr1 kinase in complex with ch5183284
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(282 residues)
CATH domains:
|
|
|
|
|
|
Fragment-based discovery of potent and selective ddr1/2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Fragment-based discovery of potent and selective ddr1/2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Fragment-based discovery of potent and selective ddr1/2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(276 residues)
CATH domains:
|
|
|
|
|
|
Fragment-based discovery of potent and selective ddr1/2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 17
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(302 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 23
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 24
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 27
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 29
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera. Expression_system_taxid: 7106
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 30
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 33
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 41a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(299 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 41b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain with compound 41a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(306 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the egfr kinase domain mutant i682q
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chains:
A, B
(300 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the egfr kinase domain mutant v924r
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chains:
A, B
(300 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of serbb3-fab3379 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(561 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr l858r mutant in complex with an optimal peptide substrate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Escherichia coli h489. Organism_taxid: 656404.
|
|
|
Chain:
A
(311 residues)
CATH domains:
|
|
|
|
|
|
Egfr l858r mutant in complex with a shc peptide substrate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Escherichia coli h489. Organism_taxid: 656404.
|
|
|
Chain:
A
(310 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain in complex with mutant selective allosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(300 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with altiratinib analog dp- 4157
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(297 residues)
CATH domains:
|
|
|
|
|
|
The crystal structure of insr tyrosine kinase in complex with the inhibitor bi 885578
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(284 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase (t790m/l858r) apo
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(295 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase (t790m/l858r) with inhibitor compound 15: ~{n}-(7- chloranyl-1~{h}-indazol-3-yl)-7,7-dimethyl-2-(1~{h}-pyrazol-4-yl)- 5~{h}-furo[3,4-d]pyrimidin-4-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(298 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase (t790m/l858r) with inhibitor compound 27: ~{n}-(1~{h}- indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5~{h}-furo[3,4- d]pyrimidin-4-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(299 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the activated fgf receptor 2 (fgfr2) kinase domain in complex with the csh2 domain of phospholipasE C gamma (plcgamma)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562. Rattus norvegicus. Rat. Organism_taxid: 10116.
|
|
|
Chain:
A
(302 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the autoinhibited epha2 jms-kd
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with pyridone compound 2: 4-[2-(4- chlorophenyl)ethylamino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2- oxidanylidene-1~{h}-pyridine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(298 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with pyridone compound 19: 4-[(2- azanylpyrimidin-4-yl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]- 2-oxidanylidene-1~{h}-pyridine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with pyridone compound 13: 4-[(2- methoxyphenyl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2- oxidanylidene-1~{h}-pyridine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain with pyridone compound 13: 4-[(2-methoxyphenyl) amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}- pyridine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of cmet in complex with novel inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Human vascular endothelial growth factor receptor 2 (kdr) kinase domain in complex with aal993
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(274 residues)
CATH domains:
|
|
|
|
|
|
Fibroblast growth factor receptor 1 in complex with jnj-4275693
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(291 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met in complex with naphthyridinone inhibitor 5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met in complex with amg 337
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Structure of ddr1 receptor tyrosine kinase in complex with d2099 inhibitor at 2.25 angstroms resolution.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
|
|
Structure of ddr1 receptor tyrosine kinase in complex with d2164 inhibitor at 2.65 angstroms resolution.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(280 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain in complex with a covalent aminobenzimidazole inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain t790m mutant in complex with a covalent aminobenzimidazole inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain in complex with a covalent aminobenzimidazole
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Disease linked mutation in fgfr
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: codon plus lambda 37.
|
|
|
Chains:
A, B, C, D, E
(296 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hyper-phosphorylated ret kinase domain with (proximal) juxtamembrane segment
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hyper-phosphorylated ret kinase domain with (proximal) juxtamembrane segment
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(280 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the alk kinase domain in complex with entrectinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(298 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the alk kinase domain in complex with cmpd 17
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Igfr-1r complex with a pyrimidine inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(302 residues)
CATH domains:
|
|
|
|
|
|
Igfr-1r complex with a pyrimidine inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Igfr-1r complex with a pyrimidine inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(308 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m in complex with xtf-262
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(305 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-988 t790m in complex with lxx-6-34
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pdgfra in complex with wq-c-159
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(286 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m in complex with lxx-6-26
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, D, E, F, G, H, C
(300 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m in complex with jts-1-39
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(317 residues)
|
|
|
|
|
|
Crystal structure of trka kinase with ligand
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with azabenzimidazole compound 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(298 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with 3-carboxamide azaindole compound 13
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(302 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with 3-azetidinyl azaindazole compound 21
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Egfr (l858r, t790m, v948r) in complex with n-{3-[(2-{[4-(4- methylpiperazin-1-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl) oxy]phenyl}prop-2-enamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(302 residues)
CATH domains:
|
|
|
|
|
|
Egfr (l858r, t790m, v948r) in complex with 1-{(3r,4r)-3-[5-chloro-2- (1-methyl-1h-pyrazol-4-ylamino)-7h-pyrrolo[2,3-d]pyrimidin-4- yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (pf-06459988)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(280 residues)
CATH domains:
|
|
|
|
|
|
Egfr (l858r, t790m, v948r) in complex with n-[3-({2-[(1-methyl-1h- pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]prop- 2-enamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Egfr (l858r, t790m, v948r) in complex with 1-[(3r,4r)-3-[({2-[(1- methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy) methyl]-4-(trifluoromethyl)pyrrolidin-1-yl]prop-2-en-1-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(280 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of insulin receptor kinase domain in complex with cis-(r)-7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-((tetrahydro-2h- pyran-2-yl)methoxy)phenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(306 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with a pyrazolopyrimidine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(314 residues)
CATH domains:
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with a imidazopyridinyl- aminopyrimidine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(302 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met mutant y1230h in complex with compound 14
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(284 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of cmet wt with compound 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
X, Y
(245 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of cmet in complex with cmpd.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(240 residues)
CATH domains:
Unassigned
|
|
|
|
|
|
Crystal structure of c-met l1195v in complex with sar125844
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(225 residues)
CATH domains:
Unassigned
|
|
|
|
|
|
Crystal structure of c-met-m1250t in complex with sar125844.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(247 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-met kinase domain in complex with lxm108
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(290 residues)
CATH domains:
Unassigned
|
|
|
|
|
|
Structure of nvp-aew541 in complex with igf-1r kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chains:
A, B, C, D, E, F, G, H
(296 residues)
CATH domains:
|
|
|
|
|
|
Trka with (6~{r})-3-methylsulfanyl-6-phenyl-1-(1~{h}-pyrazol-3-yl)-6, 7-dihydro-5~{h}-thieno[3,4-c]pyridin-4-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with ags
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(279 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group AGS
is 93.75% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with anp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(267 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with bosutinib (ski-606)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(284 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with dasatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with danusertib (pha739358)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with alisertib (mln8237)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chains:
A, B, C
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with mln8054
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(261 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 66
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with pd173955
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with foretinib (xl880)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(269 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with golvatinib (e7050)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Anaplastic lymphoma kinase (alk) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of anaplastic lymphoma kinase (alk) in complex with 5a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf21.
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the anaplastic lymphoma kinase (alk) in complex with 5d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of anaplastic lyphoma kinase (alk) in complex with 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(303 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the arabidopsis receptor kinase haesa lrr ectdomain (apo form).
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Organ: flower. Tissue: abscission zone. Gene: rlk5, hae, at4g28490, f21o9.180. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(596 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the arabidopsis receptor kinase haesa lrr ectdomain in complex with the peptide hormone ida.
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Organ: flower. Tissue: abscission zone. Gene: rlk5, hae, at4g28490, f21o9.180. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Synthetic: yes.
|
|
|
Chain:
A
(595 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
The crystal structure of the arabidopsis receptor kinase haesa lrr ectdomain in complex with a n-terminal extended ida peptide hormone ligand.
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Organ: flower. Tissue: abscission zone. Gene: rlk5, hae, at4g28490, f21o9.180. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Synthetic: yes.
|
|
|
Chain:
A
(595 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the arabidopsis receptor kinase haesa lrr ectdomain in complex with the peptide hormone idl1.
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Organ: flowers. Tissue: abscission zone. Gene: rlk5, hae, at4g28490, f21o9.180. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: bti38.
|
|
|
Chain:
A
(588 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the arabidopsis receptor kinase haesa in complex with the peptide hormone ida and the co-receptor serk1
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Organ: flower. Tissue: abcsission. Gene: rlk5, hae, at4g28490, f21o9.180. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: bti38.
|
|
|
Chains:
A, C
(596 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Human insulin receptor domains l1-cr in complex with peptide s519c16 and 83-7 fv
|
|
|
Source: Synthetic: yes. Endothia gyrosa. Organism_taxid: 40263. Mus musculus. Organism_taxid: 10090. Expressed in: brevibacillus. Expression_system_taxid: 55080. Homo sapiens. Human.
|
|
|
Chain:
E
(271 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr-t790m in complex with pyrazolopyrimidine inhibitor 1b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Egfr-t790m in complex with pyrazolopyrimidine inhibitor 1a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(291 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of egfr tyrosine kinase domain with novel inhibitor of active state of her2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(299 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of trka in complex with pf-00593174
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21s.
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of trka in complex with pf-05206283
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21s.
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of trka in complex with pf-05247452
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21s.
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of trka in complex with pf-06273340
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21s.
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
The crystal structure of fgfr4 kinase domain in complex with ly2874455
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the epha4 lbd in complex with apyd3 peptide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha4, hek8, sek, tyro1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B, C, D
(179 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase mer in complex with inhibitor unc2434
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
Unassigned
|
|
|
|
|
|
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase mer in complex with inhibitor unc2541
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(258 residues)
CATH domains:
Unassigned
|
|
|
|
|
|
Crystal structure of extracellular domain of her2 in complex with fcab stab19
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ighg1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293-6e. Expression_system_organ: kidney. Gene: erbb2, her2, mln19, neu, ngl.
|
|
|
Chain:
C
(563 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of human pdgfra
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(345 residues)
CATH domains:
|
|
|
|
|
|
Trka jm-kinase with 1-(9{h}-fluoren-9-yl)-3-(2-methyl-4-phenyl- pyrimidin-5-yl)urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Trka jm-kinase with {n}-(2-pyridylmethyl)-2-[2-(2-thienyl)indol-1- yl]acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Trka jm-kinase with 2-fluoro-{n}-[2-(4-fluorophenyl)-6-methyl-3- pyridyl]-4-(trifluoromethyl)benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(304 residues)
CATH domains:
|
|
|
|
|
|
Trka jm-kinase with 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2- (trifluoromethyl)phenyl]methyl]urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
|
|
Trka jm-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(1- naphthyl)urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
CATH domains:
|
|
|
|
|
|
Trka jm-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2- (trifluoromethyl)phenyl]methyl]urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(297 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 6UK
is 40.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Trka jm-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(2- pyridyl)urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(291 residues)
CATH domains:
|
|
|
|
|
|
Insulin receptor ectodomain construct comprising domains l1,cr,l2, fniii-1 and alphact peptide in complex with bovine insulin and fab 83-14 (revised structure)
|
|
|
Source: Bos taurus. Bovine. Organism_taxid: 9913. Mus musculus. Organism_taxid: 10090. Homo sapiens. Human. Organism_taxid: 9606. Gene: insr.
|
|
|
Chains:
E, F
(593 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
The structure of trka kinase domain bound to the inhibitor entrectinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Crystal structure of extracellular domain of her2 in complex with fcab h10-03-6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho lec1. Expression_system_organ: ovary. Gene: ighg1.
|
|
|
Chain:
C
(561 residues)
|
|
|
|
|
|
Structure of human anaplastic lymphoma kinase in complex with 2-[(1r)- 1-{[2-amino-5-(1,3-dimethyl-1h-pyrazol-4-yl)pyridin-3-yl]oxy}ethyl]- 4-fluoro-n,n-dimethylbenzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf9.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Ephb3 kinase domain covalently bound to an irreversible inhibitor (compound 3)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb3, etk2, hek2, tyro6. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(267 residues)
CATH domains:
|
|
|
|
|
|
Ephb3 kinase domain covalently bound to an irreversible inhibitor (compound 6)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb3, etk2, hek2, tyro6. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the bri1 kinase domain (865-1160) in complex with adp from arabidopsis thaliana
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: bri1, at4g39400, f23k16.30. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: ril.
|
|
|
Chain:
A
(284 residues)
|
|
|
|
Bound ligand:
|
Het Group ADP
is 74.07% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the bri1 kinase domain (865-1160) in complex with amppnp and mn from arabidopsis thaliana
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: bri1, at4g39400, f23k16.30. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
|
|
|
Chain:
A
(285 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the apo-bri1 kinase domain (865-1160)
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: bri1, at4g39400, f23k16.30. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: ril.
|
|
|
Chain:
A
(284 residues)
|
|
|
|
|
|
Crystal structure of the bri1 kinase domain (865-1160) in complex with atp from arabidopsis thaliana
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: bri1, at4g39400, f23k16.30. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
|
|
|
Chain:
A
(286 residues)
|
|
|
|
Bound ligand:
|
Het Group ATP
corresponds to
enzyme reactant ATP
|
|
|
|
|
|
|
Crystal structure of the bri1 kinase domain (865-1196) in complex with adp from arabidopsis thaliana
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: bri1, at4g39400, f23k16.30. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: ril.
|
|
|
Chain:
A
(286 residues)
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
107_a07 fab in complex with fragment of the met receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec3.2.8.1. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
A, P
(222 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
N-terminal motif dimerization of egfr transmembrane domain in bicellar environment
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(44 residues)
|
|
|
|
|
|
Kinase domain of human ephb1 bound to a quinazoline-based inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb1, elk, epht2, hek6, net. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: gold
|
|
|
Chains:
A, B
(273 residues)
|
|
|
|
|
|
Kinase domain of human ephb1, g703c mutant, covalently bound to a quinazoline-based inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb1, elk, epht2, hek6, net. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold
|
|
|
Chains:
A, B
(278 residues)
|
|
|
|
|
|
Structure of human trkb receptor ligand binding domain in complex with the fab frgment of antibody ab20
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho. Expression_system_organ: ovary. Expression_system_tissue: epithelium. Organ: ovary.
|
|
|
Chain:
X
(102 residues)
|
|
|
|
|
|
Crystal structure of a her2-nb complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Camelus dromedarius. Camel.
|
|
|
Chain:
A
(556 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Homodimerization of tie2 fibronectin-like domains 1-3 in space group c2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tek, tie2, vmcm, vmcm1. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790
|
|
|
Chains:
A, B
(292 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Homodimerization of tie2 fibronectin-like domains 2 and 3 in space group p21
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tek, tie2, vmcm, vmcm1. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790
|
|
|
Chains:
A, B
(190 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of tie1 fibronectin-like domain 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tie1, tie. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790
|
|
|
Chains:
A, B
(93 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 1g
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 1j
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 1k
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(284 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 2b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 1l
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 2c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 1m
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 2d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(284 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 2a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(284 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 2f
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 2e
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(285 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 2g
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 4a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(285 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 2h
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(286 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 2i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 3a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 3b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 3d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 3e
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(295 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 4b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Fibroblast growth factor receptor 4 kinase domain (449-753) in complex with irreversible ligand cga159527
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B
(267 residues)
|
|
|
|
|
|
Fibroblast growth factor receptor 4 kinase domain (449-753) in complex with irreversible ligand cga159527
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B
(271 residues)
|
|
|
|
|
|
Nmr structure of an epha2-sam fragment
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(27 residues)
|
|
|
|
|
|
Human fgf in complex with a covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(289 residues)
|
|
|
|
Bound ligand:
|
Het Group 9K5
is 50.00% similar to
enzyme product ADP
|
|
|
|
|
|
|
Human fgf in complex with a covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(290 residues)
|
|
|
|
Bound ligand:
|
Het Group 9K8
is 47.50% similar to
enzyme product ADP
|
|
|
|
|
|
|
Her2 in complex with fab mf3958
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Expression_system_cell_line: hek293
|
|
|
Chain:
C
(530 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Her3 in complex with fab mf3178
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Human. Gene: erbb3, her3. Expression_system_cell_line: hek293
|
|
|
Chain:
C
(347 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Her3 in complex with fab mf3178
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Expression_system_cell_line: hek293
|
|
|
Chain:
C
(582 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Nmr spatial structure of her2 tm domain dimer in dpc micelles.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(44 residues)
|
|
|
|
|
|
Crystal structure of vegfr-2 domains 4-5 in complex with darpin d4b
|
|
|
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: homo sapiens.
|
|
|
Chains:
C, D
(223 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Ddr1, 3-[2-(6-aminopyridin-3-yl)ethynyl]-n-[3-(trifluoromethyl) phenyl]benzamide, 1.800a, p212121, rfree=23.1%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Ddr1, n-[2-[3-(2-aminopyrimidin-5-yl)oxyphenyl]ethyl]-3- (trifluoromethoxy)benzamide, 1.760a, p212121, rfree=23.5%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Ddr1, 2-[3-(2-pyridin-3-ylethynyl)phenyl]-n-[3-(trifluoromethyl) phenyl]acetamide, 1.601a, p212121, rfree=22.6%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Ddr1, 2-[3-(2-pyridin-3-ylethynyl)phenyl]-n-[3-(trifluoromethyl) phenyl]acetamide, 1.902a, second p212121 form, rfree=25.4%, second form
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(302 residues)
|
|
|
|
|
|
Ddr1, n-[2-[3-(2-aminopyrimidin-5-yl)oxyphenyl]ethyl]-3- (trifluoromethoxy)benzamide, 2.190a, p1211, rfree=27.7%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(290 residues)
|
|
|
|
|
|
Ddr1, 3-chloro-n-[4-chloro-3-(1h-pyrrolo[2,3-b]pyridin-5-ylcarbamoyl) phenyl]-4-(2-hydroxyethylamino)benzamide, 1.802a, p212121, rfree=22.2%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Ddr1, n-[[2-(2-pyridin-3-yloxyethyl)cyclohexyl]methyl]-3- (trifluoromethoxy)benzamide, 1.970a, p212121, rfree=25.6%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(284 residues)
|
|
|
|
|
|
Ddr1, 4-chloro-n-[(3s,4r)-4-phenylpyrrolidin-3-yl]-3-(1h-pyrrolo[2,3- b]pyridin-5-yloxymethyl)benzamide, 1.530a, p212121, rfree=21.4%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(284 residues)
|
|
|
|
|
|
Ddr1, 3-chloro-n-[(1r,2s)-2-phenylcyclopropyl]-5-(1h-pyrrolo[2,3- b]pyridin-5-yloxymethyl)benzamide, 1.600a, p212121, rfree=23.2%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(286 residues)
|
|
|
|
|
|
Crystal structure of panitumumab in complex with epidermal growth factor receptor domain 3.
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Human. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
M, N
(191 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant s468r.
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Human. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
M, N
(194 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of thE C-met kinase domain in complex with a pyrazolone inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of vegf-a in complex with vegfr-1 domains d1-6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: vegfa, vegf. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Gene: flt1, flt, frt, vegfr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
X, Y
(596 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure-based optimization of 1h-imidazole-2-carboxamides as axl kinase inhibitors utilizing a mer mutant surrogate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(238 residues)
|
|
|
|
|
|
Structure-based optimization of 1h-imidazole-2-carboxamides as axl kinase inhibitors utilizing a mer mutant surrogate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(240 residues)
|
|
|
|
|
|
Structure of the axl kinase domain in complex with a macrocyclic inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: axl, ufo. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(270 residues)
|
|
|
|
|
|
Crystal structure of the mer kinase domain in complex with a macrocyclic inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(272 residues)
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with a sulfonyl fluoride probe xo44
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Structure of the ectodomain of the human type 1 insulin-like growth factor receptor in complex with igf-i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec8. Gene: igf1, ibp1. Expressed in: escherichia coli.
|
|
|
Chain:
A
(801 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the ectodomain of the human type 1 insulin-like growth factor receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec8. Mus musculus. Organism_taxid: 10090.
|
|
|
Chain:
A
(801 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Met tyrosine kinase inhibition enhances the antitumor efficacy of an hgf antibody
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(288 residues)
|
|
|
|
|
|
Met tyrosine kinase inhibition enhances the antitumor efficacy of an hgf antibody
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Crystal structure of the egfr kinase domain (l858r, t790m, v948r) in complex with a covalent inhibitor n-[(3r,4r)-4-fluoro-1-{6-[(1- methyl-1h-pyrazol-4-yl)amino]-9-(propan-2-yl)-9h-purin-2- yl}pyrrolidin-3-yl]propanamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790
|
|
|
Chain:
A
(280 residues)
|
|
|
|
|
|
Crystal structure of the egfr kinase domain (l858r, t790m, v948r) in complex with a covalent inhibitor n-[(3r,4r)-4-fluoro-1-{6-[(3- methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-(propan-2-yl)-9h-purin-2- yl}pyrrolidin-3-yl]propanamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790
|
|
|
Chain:
A
(280 residues)
|
|
|
|
|
|
Crystal structure of the egfr kinase domain (l858r, t790m, v948r) in complex with 4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9- (propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790
|
|
|
Chain:
A
(283 residues)
|
|
|
|
|
|
Crystal structure of the egfr kinase domain in complex with 4-(4-{[2- {[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6- yl]amino}phenyl)-1-methylpiperazin-1-ium
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790
|
|
|
Chain:
A
(307 residues)
|
|
|
|
|
|
Crystal structure of the egfr kinase domain (l858r, t790m, v948r) in complex with a covalent inhibitor n-[(3r,4r)-4-fluoro-1-{6-[(3- methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2- yl}pyrrolidin-3-yl]propanamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790
|
|
|
Chain:
A
(280 residues)
|
|
|
|
|
|
Crystal structure of fgf receptor 2 tyrosine kinase domain harboring the d650v activating mutation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
B, A
(271 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of fgf receptor 2 harboring a e565a/d650v double gain-of-function mutation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
B, A
(282 residues)
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of fgf receptor 2 harboring a n549h/e565a double gain-of-function mutation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(282 residues)
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the tyrosine kinase domain of fgf receptor 2 harboring an e565a/k659m double gain-of-function mutation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(301 residues)
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Fgfr1 kinase domain complex with fragment 2,2-dimethyl-2,3- dihydrobenzofuran-7-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(266 residues)
|
|
|
|
|
|
Fgfr1 kinase domain complex with sn37333 in reversible binding mode
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(278 residues)
|
|
|
|
|
|
Crystal structure of the membrane proximal three fibronectin type iii (fniii) domains of tie2 (tie2[fniiia-c])
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tek, tie2, vmcm, vmcm1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(291 residues)
|
|
|
|
|
|
Crystal structure of egfr kinase domain (l858r, t790m, v948r) in complex with the covalent inhibitor co-1686
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of fgfr1-y563c (fgfr4 surrogate) covalently bound to h3b-6527
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(302 residues)
|
|
|
|
|
|
High-affinity axl decoy receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gas6, axllg. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: axl, ufo. Expressed in: escherichia coli bl21(de3).
|
|
|
Chains:
C, D
(102 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of a 1:1:1 fgf23-fgfr1c-aklotho ternary complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: fgf23, hypf, unq3027/pro9828. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
C
(213 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of a monomeric human fgf9 in complex with the ectodomain of human fgfr1c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expression_system_taxid: 562
|
|
|
Chain:
B
(208 residues)
|
|
|
|
|
|
Crystal structure of the epidermal growth factor receptor extracellular region in complex with epiregulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ereg. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
|
|
|
Chains:
A, B, C, D
(500 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: epgn, unq3072/pro9904. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
|
|
|
Chains:
A, D
(501 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of c. Elegans let-23 kinase domain complexed with amp-pnp
|
|
|
Source: Caenorhabditis elegans. Organism_taxid: 6239. Gene: let-23, kin-7, zk1067.1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(302 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of trk-a complexed with a selective inhibitor ch7057288
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(302 residues)
|
|
|
|
|
|
Crystal structure of the flt3 kinase domain bound to the inhibitor ff- 10101
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flt3, cd135, flk2, stk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(305 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 l858r in complex with sklb(3)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(302 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 l858r in complex with sklb(5)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(302 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 l858r in complex with sklb(6)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(310 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m/v948r in complex with sklb(3)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(297 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m/v948r in complex with sklb(5)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(304 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m/v948r in complex with sklb(6)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(301 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m in complex with wz4003
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(314 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m in complex with co-1686
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(307 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 l858r in complex with co-1686
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Crystal structure of ly2874455 in complex of fgfr4 gatekeeper mutation (v550l)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(269 residues)
|
|
|
|
|
|
Crystal structure of ly2874455 in complex of fgfr4 gatekeeper mutation (v550m)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m in complex with go6976
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(288 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m/c797s in complex with go6976
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(302 residues)
|
|
|
|
|
|
Crystal structure of the complex of 059-152-fv and egfr-ecd
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expressed in: cell-free synthesis. Other_details: cell-free synthesis based on e.Coli extract. Other_details: cell-free synthesis based on e.Coli extract
|
|
|
Chain:
A
(611 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr kinase domain mutant (t790m/l858r) with covalent ligand ns-062
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Crystal structure of egfr t790m mutant in complex with naquotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of c-met in complex with novel inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m in complex with ibrutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(302 residues)
|
|
|
|
|
|
Crystal structure of fgfr1 kinase domain in complex with a novel inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(285 residues)
|
|
|
|
|
|
Crystal structure of epha2/ship2 complex
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: inppl1, ship2, epha2, eck, myk2, sek2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(126 residues)
|
|
|
|
|
|
Crystal structure of epha6/odin complex
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: anks1a, anks1, kiaa0229, odin, epha6, ehk-2, ehk2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(169 residues)
|
|
|
|
|
|
Crystal structure of epha5/samd5 complex
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: epha5, bsk, ehk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: samd5, e130306m17rik, mcg_52174. Expression_system_taxid: 562
|
|
|
Chain:
A
(69 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m/c797s in complex with d3003
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(294 residues)
|
|
|
|
|
|
Fgfr-1 in complex with ligand lenvatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(284 residues)
|
|
|
|
|
|
Crystal structure of egfr 675-1022 t790m/c797s/v948r in complex with eai045
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Crystal structure of pdgfra kinase domain mutant t674i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(336 residues)
|
|
|
|
|
|
The cocrystal structure of fgfr2 bound with compound 14 harboring 5h- pyrrolo[2,3-b]pyrazine scaffold
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768
|
|
|
Chains:
A, B, C, D
(285 residues)
|
|
|
|
|
|
Structure of cetuximab fab mutant in complex with egfr extracellular domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_taxid: 9606
|
|
|
Chain:
A
(609 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
39s fab bound to her2 ecd
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: hek293. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: mammalian expression vector pbgsa. Expression_system_taxid: 285261. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chain:
A
(567 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the fab fragment of necitumumab (fab11f8) in complex with domain iii from a cetuximab resistant variant of egfr (segfrd3-s468r)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: mus musculus. Expression_system_taxid: 10090.
|
|
|
Chains:
A, B, E, I
(191 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of epha2 with peptide 135e2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli o103:h2 str. 12009. Expression_system_taxid: 585395. Unidentified. Organism_taxid: 32644. Expressed in: escherichia coli k-12.
|
|
|
Chains:
A, B, C, D
(174 residues)
|
|
|
|
|
|
Structure of trastuzumab fab mutant in complex with her2 extracellular domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_taxid: 9606
|
|
|
Chain:
C
(589 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Ddr1 bound to vx-680
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expression_system_atcc_number: crl-1711
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Ddr1 bound to dasatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expression_system_atcc_number: crl-1711
|
|
|
Chain:
A
(278 residues)
|
|
|
|
|
|
Fgfr1 kinase complex with inhibitor sn37115
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(276 residues)
|
|
|
|
|
|
Fgfr1 kinase complex with inhibitor sn36985
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(276 residues)
|
|
|
|
|
|
Fgfr1 kinase complex with inhibitor sn37118
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(265 residues)
|
|
|
|
|
|
Fgfr1 kinase complex with inhibitor sn37116
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(276 residues)
|
|
|
|
|
|
Fgfr1 kinase domain complexed with fiin-1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(280 residues)
|
|
|
|
|
|
Structure of human anaplastic lymphoma kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Insulin receptor ectodomain in complex with one insulin molecule
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: mus musculus. Expression_system_taxid: 10090. Synthetic: yes. Ovis aries. Sheep.
|
|
|
Chains:
B, A, P
(659 residues)
|
|
|
|
|
|
Insulin receptor ectodomain in complex with two insulin molecules
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: mus musculus. Expression_system_taxid: 10090. Synthetic: yes. Ovis aries. Sheep.
|
|
|
Chains:
A, B, M, P
(562 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Insulin receptor ectodomain in complex with two insulin molecules - c1 symmetry
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: mus musculus. Expression_system_taxid: 10090. Synthetic: yes. Ovis aries. Sheep.
|
|
|
Chains:
A, B, M, P
(682 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of tyrosine-protein kinase receptor in complex with 2,4-dichloro-n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)benzamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: insect cell expression vector ptie1. Expression_system_taxid: 266783.
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of tyrosine-protein kinase receptor in complex with 5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3h)-one inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: insect cell expression vector ptie1. Expression_system_taxid: 266783.
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Crystal structure of tyrosine-protein kinase receptor in complex with 5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3h)-one and 5-{[2,4- dichloro-5-(pyridin-2-yl)benzene-1-carbonyl]amino}-n-(2-hydroxy-2- methylpropyl)-1-phenyl-1h-pyrazole-3-carboxamide inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: insect cell expression vector ptie1. Expression_system_taxid: 266783.
|
|
|
Chain:
A
(296 residues)
|
|
|
|
|
|
Crystal structure of tyrosine-protein kinase receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Discovery of a highly potent and broadly effective egfr and her2 exon 20 insertion mutant inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(304 residues)
|
|
|
|
|
|
Crystal structure of trk-a in complex with the pan-trk kinase inhibitor, compound 10b.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Crystal structure of trk-a in complex with the pan-trk kinase inhibitor, compound 13b.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(276 residues)
|
|
|
|
|
|
Crystal structure of trk-a in complex with the pan-trk kinase inhibitor, compound 19.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Crystal structure of trk-a in complex with the pan-trk kinase inhibitor, compound 3.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(284 residues)
|
|
|
|
|
|
Egfr with an allosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D, E, F
(306 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Halk in complex with compound 7 n-((1s)-1-(5-fluoropyridin-2-yl) ethyl)-1-(5-methyl-1h-pyrazol-3-yl)-3-(oxetan-3-ylsulfonyl)-1h- pyrrolo[2,3-b]pyridin-6-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Halk in complex with compound 9 (6-(((1s)-1-(5-fluoropyridin-2-yl) ethyl)amino)-1-(3-methyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-3- yl)(morpholin-4-yl)methanone
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(277 residues)
|
|
|
|
|
|
Halk in complex with compound 1 (s)-n-(1-(2,4-difluorophenyl)ethyl)-3- (3-methyl-1h-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Nmr structure of epha2-sam stapled peptides (s13st)
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(27 residues)
|
|
|
|
|
|
Nmr structure of epha2-sam stapled peptides (s13stshort)
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(15 residues)
|
|
|
|
|
|
Oncogenic point mutation of ret receptor tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(296 residues)
|
|
|
|
Bound ligand:
|
Het Group ADN
is 70.37% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of human ddr2 kinase in complex with 2-[4,5- difluoro-2-oxo-1'-(1h-pyrazolo[3,4-b]pyridine-5-carbonyl) spiro[indole-3,4'-piperidine]-1-yl]-n-(2,2,2-trifluoroethyl)acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr2, ntrkr3, tkt, tyro10. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D, E, F, G, H, I, J, K, L
(271 residues)
|
|
|
|
|
|
Ddr1, 2-[8-(1h-indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8- triazaspiro[4.5]decan-3-yl]-n-methylacetamide, 1.440a, p1211, rfree=24.1%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Ddr1, 2-[4-bromo-2-oxo-1'-(1h-pyrazolo[4,3-b]pyridine-5-carbonyl) spiro[indole-3,4'-piperidine]-1-yl]-n-(2,2,2-trifluoroethyl) acetamide, 1.291a, p212121, rfree=17.4%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Crystal structure of the bir3 - serk1 complex from arabidopsis thaliana.
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Tissue: seedling. Gene: serk1, at1g71830, f14o23.21, f14o23_24. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: 38. Gene: at1g27190, t7n9.25.
|
|
|
Chain:
A
(188 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the bri1 gly644-asp (bri1-6) mutant from arabidopsis thaliana.
|
|
|
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Organ: seedling. Gene: bri1, at4g39400, f23k16.30. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: tnao-37.
|
|
|
Chain:
A
(744 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Ddr1, 2-[8-(1h-indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8- triazaspiro[4.5]decan-3-yl]-n-methylacetamide, 1.730a, p212121, rfree=24.5%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Ddr1, 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1h-indazole-5- carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 1.670a, p1211, rfree=22.8%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(294 residues)
|
|
|
|
|
|
Ddr1, 2-[1'-(1h-indazole-5-carbonyl)-4-methyl-2-oxospiro[indole-3,4'- piperidine]-1-yl]-n-(2,2,2-trifluoroethyl)acetamide, 1.990a, p6522, rfree=27.7%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(307 residues)
|
|
|
|
|
|
Ddr1, 1-(1h-indazole-5-carbonyl)-5'-methoxy-1'-[2-oxo-2-[(2s)-2- (trifluoromethyl)pyrrolidin-1-yl]ethyl]spiro[piperidine-4,3'- pyrrolo[3,2-b]pyridine]-2'-one, 1.790a, p212121, rfree=23.8%
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with nvp-bhg712
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with an isomer of nvp-bhg712
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(277 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with a pyrazolo[3,4-d]pyrimidine fragment of nvp-bhg712
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C
(277 residues)
|
|
|
|
Bound ligand:
|
Het Group DXK
is 41.94% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of ephrin b4 (ephb4) receptor protein kinase with nvp-bhg712
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb4, htk, myk1, tyro11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Crystal structure of ephrin b4 (ephb4) receptor protein kinase with an isomer of nvp-bhg712
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb4, htk, myk1, tyro11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(262 residues)
|
|
|
|
|
|
Crystal structure of ephrin b4 (ephb4) receptor protein kinase with a pyrazolo[3,4-d]pyrimidine fragment of nvp-bhg712
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb4, htk, myk1, tyro11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(274 residues)
|
|
|
|
Bound ligand:
|
Het Group DXK
is 41.94% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of ephrin b4 (ephb4) receptor protein kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb4, htk, myk1, tyro11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(262 residues)
|
|
|
|
|
|
Crystal structure of ephrin b4 (ephb4) receptor protein kinase with dasatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb4, htk, myk1, tyro11. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Met receptor in complex with inlb internalin domain and darpin a3a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho lec3.2.8.1. Listeria monocytogenes serovar 1/2a (strain atcc baa-679 / egd-e).
|
|
|
Chains:
A, D
(675 residues)
|
|
|
|
|
|
Neurturin-gfra2-ret extracellular complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nrtn. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gfra2, gdnfrb, retl2, trnr2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
|
|
|
Chains:
F, E
(450 residues)
|
|
|
|
|
|
Crystal structure of human c-kit kinase domain in complex with azd3229-analogue (compound 18)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(298 residues)
|
|
|
|
|
|
Crystal structure of human c-kit kinase domain in complex with azd3229-analogue (compound 23)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star
|
|
|
Chains:
A, B
(305 residues)
|
|
|
|
|
|
Crystal structure of human c-kit kinase domain in complex with azd3229-analogue (compound 35)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star
|
|
|
Chains:
A, B
(298 residues)
|
|
|
|
|
|
Crystal structure of human c-kit kinase domain in complex with a small molecule inhibitor, azd3229
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star
|
|
|
Chains:
A, B
(297 residues)
|
|
|
|
|
|
Crystal structure of human kdr (vegfr2) kinase domain in complex with azd3229-analogue (compound 18)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(308 residues)
|
|
|
|
|
|
Crystal structure of human kdr (vegfr2) kinase domain in complex with azd3229-analogue (compound 23)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(298 residues)
|
|
|
|
|
|
Crystal structure of human kdr (vegfr2) kinase domain in complex with azd3229-analogue (compound 35)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(305 residues)
|
|
|
|
|
|
Structure of the kinase domain of human ddr1 in complex with a potent and selective inhibitor of ddr1 and ddr2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(300 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative at050
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative at055
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative at058
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative at061
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative at069
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative atmm006
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative atnk002
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(277 residues)
|
|
|
|
|
|
Structure of c-kit with allosteric inhibitor 3g8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(303 residues)
|
|
|
|
|
|
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part
|
|
|
Source: Homo sapiens, saccharomyces cerevisiae (strain atcc 204508 / s288c). Human, baker's yeast. Organism_taxid: 9606, 559292. Strain: atcc 204508 / s288c. Gene: insr, gcn4, aas3, arg9, yel009c. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec8.
|
|
|
Chains:
E, F
(202 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Homo sapiens, saccharomyces cerevisiae (strain atcc 204508 / s288c). Human, baker's yeast. Organism_taxid: 9606, 559292. Strain: atcc 204508 / s288c.
|
|
|
Chains:
E, F
(584 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Structure of the kinase domain of human ddr1 in complex with a 2- amino-2,3-dihydro-1h-indene-5-carboxamide-based inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(297 residues)
|
|
|
|
|
|
Crystal structure of sema domain of the met receptor in complex with fab
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293f cells. Expression_system_cell_line: expi293f cells
|
|
|
Chains:
A, B
(442 residues)
|
|
|
|
|
|
Crystal structure of partially phosphorylated ret v804m tyrosine kinase domain complexed with pdd00018412
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f.
|
|
|
Chains:
A, B
(281 residues)
|
|
|
|
|
|
Crystal structure of phosphorylated ret v804m tyrosine kinase domain complexed with pdd00018366
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293k.
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Crystal structure of csf-1r kinase domain with a small molecular inhibitor, jte-952
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(301 residues)
|
|
|
|
|
|
Crystal structure of the flt3 kinase bound to a small molecule inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flt3, cd135, flk2, stk1. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(310 residues)
|
|
|
|
|
|
Crystal structure of epha3 in complex with 18-crown-6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha3, etk, etk1, hek, tyro4. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Crystal structure of trka kinase with ligand
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(272 residues)
|
|
|
|
|
|
Crystal structure of fgfr1 kinase domain in complex with compound 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(290 residues)
|
|
|
|
|
|
Crystal structure of unactivated c-kit in complex with compound
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(301 residues)
|
|
|
|
|
|
Crystal structure of activated c-kit in complex with compound
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(298 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain in complex with a covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain in complex with compound 5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(288 residues)
|
|
|
|
|
|
Crystal structure of trk-a in complex with the pan-trk kinase inhibitor, compound 10e
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Fgfr4 d2 - fab complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic construct. Organism_taxid: 32630. Expressed in: homo sapiens.
|
|
|
Chains:
A, D
(101 residues)
|
|
|
|
|
|
Hua21-scfv in complex with the extracellular domain(ecd) of her2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
|
|
|
Chain:
A
(618 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of the full-length human igf-1r in complex with insulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t. Gene: ins. Expression_system_cell_line: hek293t
|
|
|
Chains:
A, B
(823 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of pdgfra t674i in complex with crenolanib by co- crystallization
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(296 residues)
|
|
|
|
|
|
Crystal structure of pdgfra t674i in complex with crenolanib by soaking
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(338 residues)
|
|
|
|
|
|
Crystal structure of pdgfra in complex with sunitinib by soaking
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(338 residues)
|
|
|
|
|
|
Crystal structure of pdgfra in complex with imatinib by co- crystallization
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain with irreversible inhibitor 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(298 residues)
|
|
|
|
|
|
Crystal structure of fgf401 in complex of fgfr4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Crystal structure of flt3 in complex with gilteritinib
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(301 residues)
|
|
|
|
|
|
The structure of co-crystals of 8r-b-egfr t790m/c797s complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(288 residues)
|
|
|
|
|
|
The structure of co-crystals of 8r-b-egfr wt complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(283 residues)
|
|
|
|
|
|
Egfr t790m/c797s in complex with compound 6i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 l858r in complex with azd9291
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(319 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m in complex with azd9291 prepared by co-crystallization
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m in complex with azd9291 prepared by soaking
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(315 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 wt in complex with azd9291 prepared by cocrystallization
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(284 residues)
|
|
|
|
|
|
Crystal structure of egfr kinase domain in complex with compound 78
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high five
|
|
|
Chain:
A
(311 residues)
|
|
|
|
|
|
Crystal structure of erbb3 n418q mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
|
|
|
Chains:
A, B
(550 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of human c-kit kinase domain in complex with compound 15a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expression_system_atcc_number: crl-1711.
|
|
|
Chain:
A
(309 residues)
|
|
|
|
|
|
Crystal structure of trkc in complex with 3-(imidazo[1,2-a]pyrazin-3- ylethynyl)-2-methyl-n-(3-((4- methylpiperazin-1-yl)methyl)-5- (trifluoromethyl)phenyl)benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk3, trkc. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Crystal structure of trkc in complex with 3-((6-(4-aminophenyl) imidazo[1,2-a]pyrazin-3-yl)ethynyl)- n-(3-isopropyl-5-((4- methylpiperazin-1-yl)methyl)phenyl)-2- methylbenzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk3, trkc. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Crystal structure of her2 domain iv and rb-h2
|
|
|
Source: Cyclostomata. Organism_taxid: 1476529. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: spodoptera frugiperda.
|
|
|
Chain:
B
(72 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr(l858r/t790m/c797s) in complex with ch7233163
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
|
|
|
|
|
|
Crystal structure of egfr(l858r/t790m/c797s) in complex with osimertinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(310 residues)
|
|
|
|
|
|
Crystal structure of fgfr2 in complex with 1,3,5-triazine derivative
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Crystal structure of fgfr2 in complex with 1,3,5-triazine derivative
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Crystal structure of fgfr3 in complex with pyrimidine derivative
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr3, jtk4. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(288 residues)
|
|
|
|
|
|
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase mer in complex with inhibitor unc3437
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(250 residues)
|
|
|
|
|
|
Crystal structure of kit1 in complex with dp2976 via co- crystallization
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(306 residues)
|
|
|
|
|
|
Crystal structure of tie2 in complex with decipera compound dp1919
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tek, tie2, vmcm, vmcm1. Expressed in: trichoptera. Expression_system_taxid: 30263.
|
|
|
Chains:
A, B
(292 residues)
|
|
|
|
|
|
Crystal structure of anaplastic lymphoma kinase (alk) bound by brigatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Tas-120 in reversible binding mode with fgfr1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(277 residues)
|
|
|
|
|
|
Tas-120 covalent complex with fgfr1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(282 residues)
|
|
|
|
|
|
Crystal structure of fms kinase domain with a small molecular inhibitor, plx5622
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Structure of g810a mutant of ret protein tyrosine kinase domain.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(295 residues)
|
|
|
|
|
|
Structure of ret protein tyrosine kinase domain in complex with nintedanib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chains:
A, C
(287 residues)
|
|
|
|
|
|
Structure of wt ret protein tyrosine kinase domain at 1.92a resolution.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(294 residues)
|
|
|
|
|
|
Epha2 lbd in complex with ysa-gsgsk-bio peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B
(179 residues)
|
|
|
|
|
|
Epha2 lbd in complex with ba-wla-yam peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B
(178 residues)
|
|
|
|
|
|
Epha2 lbd in complex with ba-wla-yrpkbio peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B
(181 residues)
|
|
|
|
|
|
Epha2 lbd in complex with ba-wla-yrpk bio peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B
(177 residues)
|
|
|
|
|
|
Epha2 lbd in complex with ba-wla-yskbio peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B
(175 residues)
|
|
|
|
|
|
Trk-a in complex with ligand 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(288 residues)
|
|
|
|
|
|
Trk-a in complex with ligand 9
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(293 residues)
|
|
|
|
|
|
Trk-a in complex with ligand 6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(303 residues)
|
|
|
|
|
|
Fgfr4 complex with n-(3,5-dichloro-2-((5-((2,6-dichloro-3,5- dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)phenyl)acrylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Fgfr4 complex with n-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy) pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Fgfr4 complex with n-(3-chloro-2-((5-((2,6-dichloro-3,5- dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-5-fluorophenyl)acrylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Fgfr4 complex with n-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy) pyrimidin-2-yl)amino)-3-fluorophenyl)acrylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Fgfr4 complex with blu-554, n-((3s,4s)-3-((6-(2,6-dichloro-3,5- dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2h-pyran-4-yl) acrylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Fgfr1 complex with n-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy) pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(280 residues)
|
|
|
|
|
|
Cryo-em structure of her2 extracellular domain-trastuzumab fab- pertuzumab fab complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: igkc. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
|
|
|
Chain:
A
(619 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Her3 pseudokinase domain bound to bosutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(276 residues)
|
|
|
|
|
|
Potent and selective antitumor antibody targeting a membrane-proximal epitope of ror2
|
|
|
Source: Oryctolagus cuniculus. Organism_taxid: 9986. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: ror2, ntrkr2. Expression_system_taxid: 562
|
|
|
Chain:
K
(81 residues)
|
|
|
|
|
|
Potent and selective antitumor antibody targeting a membrane-proximal epitope of ror2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ror2, ntrkr2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(85 residues)
|
|
|
|
|
|
Potent and selective antitumor antibody targeting a membrane-proximal epitope of ror2
|
|
|
Source: Oryctolagus cuniculus. Organism_taxid: 9986. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: ror2, ntrkr2. Expression_system_taxid: 562
|
|
|
Chain:
K
(81 residues)
|
|
|
|
|
|
Crystal structure of egfr with mutant-selective dihydrodibenzodiazepinone allosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, B, C
(295 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr in complex with eai045
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(288 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgfr1-y563c (fgfr4 surrogate) covalently bound to compound 22.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C
(287 residues)
|
|
|
|
|
|
Crystal structure of fgfr1-y563c (fgfr4 surrogate) covalently bound to compound 11.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Egfr in complex with a dihydrodibenzodiazepinone allosteric inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(309 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Trk-a in complex with ligand 1b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Trk-a in complex with ligand 1a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(297 residues)
|
|
|
|
|
|
Trk-a in complex with ligand 2a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Trk-a in complex with ligand 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Trk-a in complex with ligand
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Trk-a in complex with ligand 1a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(288 residues)
|
|
|
|
|
|
Trk-a in complex with ligand 1a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Trk-a in complex with ligand
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C
(268 residues)
|
|
|
|
|
|
Crystal structure of an asymmetric dimer of fgf receptor 3 kinases trapped in a-loop tyrosine transphosphorylation reaction
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr3, jtk4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(291 residues)
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of full-length insulin receptor bound to 4 insulin. 3d refinement was focused on the extracellular region.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: ins. Expression_system_taxid: 9606
|
|
|
Chains:
A, C
(823 residues)
|
|
|
|
|
|
Cryo-em structure of full-length insulin receptor bound to 4 insulin. 3d refinement was focused on the top part of the receptor complex.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: ins. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(601 residues)
|
|
|
|
|
|
Cryo-em structure of full-length igf1r-igf1 complex. Only the extracellular region of the complex is resolved.
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: igf1r. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Homo sapiens. Human.
|
|
|
Chains:
A, D
(793 residues)
|
|
|
|
|
|
Cryo-em structure of extracellular dimeric complex of ret/gfral/gdf15
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gdf15, mic1, pdf, plab, ptgfb. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gfral, c6orf144, unq9356/pro34128. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
E, F
(571 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of ret/gfra1/gdnf extracellular complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gdnf. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gfra1, gdnfra, retl1, trnr1. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
E, F
(553 residues)
|
|
|
|
|
|
Cryo-em structure of ret/gfra2/nrtn extracellular complex. The 3d refinement was applied with c2 symmetry.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nrtn. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gfra2, gdnfrb, retl2, trnr2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
E, F
(572 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Cryo-em structure of ret/gfra2/nrtn extracellular complex in the tetrameric form
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nrtn. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gfra2, gdnfrb, retl2, trnr2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
E, F, Y, Z
(572 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of ret/gfra3/artn extracellular complex. The 3d refinement was applied with c2 symmetry.
|
|
|
Source: Saccharomyces cerevisiae, homo sapiens. Baker's yeast, human. Organism_taxid: 4932, 9606. Gene: smt3, artn, evn. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
E, F
(570 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative atdl09
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative atdl11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(277 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative atdl13
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative atdl14
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative atdl18
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with the nvp-bhg712 derivative atha01
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Crystal structure of the lrr ectodomain of the receptor kinase sobir1 from arabidopsis thaliana.
|
|
|
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: sobir1, evr, at2g31880, f20m17.8. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_variant: tnao38.
|
|
|
Chains:
A, B
(184 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Bicycle toxin conjugate bound to epha2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(175 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/c797s in complex with covalent pyrrolopyrimidine 19g
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(310 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/c797s in complex with covalent pyrrolopyrimidine 19h
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(313 residues)
|
|
|
|
|
|
Egfr-kinase in complex with compound 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Egfr-kinase in complex with compound 5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
|
|
|
|
|
|
Egfr-kinase in complex with compound 6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of wild-type cmet bound by foretinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Crystal structure of d1228v cmet bound by foretinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(286 residues)
|
|
|
|
|
|
Crystal structure of d1228v cmet bound by bms-777607
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of wild-type cmet bound by savolitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Human insulin receptor ectodomain bound by 4 insulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Gene: ins. Expressed in: saccharomyces cerevisiae.
|
|
|
Chains:
A, B, C, D
(719 residues)
|
|
|
|
|
|
Crystal structure of the csf1r kinase domain with a dihydropurinone inhibitor (compound 4)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
|
|
|
Chain:
A
(304 residues)
|
|
|
|
|
|
Crystal structure of egfr t790m/v948r in complex with covalent pyrrolopyrimidine 14d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(267 residues)
|
|
|
|
|
|
Crystal structure of egfr t790m/v948r in complex with covalent pyrrolopyrimidine 18b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(269 residues)
|
|
|
|
|
|
Crystal structure of egfr t790m/v948r in complex with covalent pyrrolopyrimidine 18d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(266 residues)
|
|
|
|
|
|
Crystal structure of egfr t790m/v948r in complex with covalent pyrrolopyrimidine 18c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(266 residues)
|
|
|
|
|
|
Crystal structure of egfr t790m/v948r in complex with covalent pyrrolopyrimidine 19
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(264 residues)
|
|
|
|
|
|
Crystal structure of egfr t790m/v948r in complex with covalent pyrrolopyrimidine 21a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(267 residues)
|
|
|
|
|
|
Crystal structure of egfr t790m/v948r in complex with covalent pyrrolopyrimidine 21b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(268 residues)
|
|
|
|
|
|
The ryk pseudokinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ryk, jtk5a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(294 residues)
|
|
|
|
|
|
Met tyrosine kinase inhibition enhances the antitumor efficacy of an hgf antibody
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590.
|
|
|
Chain:
A
(296 residues)
|
|
|
|
|
|
Crystal structure of hephb1 bound with chlortetracycline
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb1, elk, epht2, hek6, net. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(257 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with ln2084
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, B, C
(308 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with ln2725
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(314 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with ln2899
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, B, C
(314 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with ln2057
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, B, C, E, F, G, H
(314 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with ln2380
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, B, C, E, F, G, H
(314 residues)
|
|
|
|
|
|
Crystal structure of monophosphorylated fgf receptor 2 isoform iiib with ptr657
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(286 residues)
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain in complex with covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Human insulin in complex with the human insulin microreceptor in turn in complex with fv 83-7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ins. Expressed in: saccharomyces pastorianus cbs 1513. Expression_system_taxid: 1073566. Mus musculus. Mouse. Organism_taxid: 10090.
|
|
|
Chains:
E, F, K, L, Q, R, W, X
(293 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Con-ins g1 in complex with the human insulin microreceptor in turn in complex with fv 83-7
|
|
|
Source: Synthetic: yes. Conus geographus. Geography cone. Organism_taxid: 6491. Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: cricetulus griseus.
|
|
|
Chains:
E, F, K, L
(287 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Wild type egfr in complex with ln2380
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(295 residues)
|
|
|
|
|
|
Crystal structure of phosphorylated ret tyrosine kinase domain complexed with a pyrazolo[1,5-a]pyrimidine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(283 residues)
|
|
|
|
|
|
Wild type egfr in complex with ln2057
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(286 residues)
|
|
|
|
|
|
Wild type egfr in complex with ln2899
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(308 residues)
|
|
|
|
|
|
Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii.
|
|
|
Source: Homo sapiens, saccharomyces cerevisiae (strain atcc 204508 / s288c). Human, baker's yeast. Organism_taxid: 9606, 559292. Strain: atcc 204508 / s288c. Gene: igf1r, gcn4, aas3, arg9, yel009c. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho-k1.
|
|
|
Chains:
A, B
(439 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Leg region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii.
|
|
|
Source: Homo sapiens, saccharomyces cerevisiae (strain atcc 204508 / s288c). Human, baker's yeast. Organism_taxid: 9606, 559292. Strain: atcc 204508 / s288c. Gene: igf1r, gcn4, aas3, arg9, yel009c. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho-k1.
|
|
|
Chains:
A, B
(136 residues)
|
|
|
|
|
|
Head region of the closed conformation of the human type 1 insulin- like growth factor receptor ectodomain in complex with human insulin- like growth factor ii.
|
|
|
Source: Homo sapiens, saccharomyces cerevisiae (strain atcc 204508 / s288c). Human, baker's yeast. Organism_taxid: 9606, 559292. Strain: atcc 204508 / s288c. Gene: igf1r, gcn4, aas3, arg9, yel009c. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho-k1.
|
|
|
Chains:
A, B
(439 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Leg region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii
|
|
|
Source: Homo sapiens, saccharomyces cerevisiae (strain atcc 204508 / s288c). Human, baker's yeast. Organism_taxid: 9606, 559292. Strain: atcc 204508 / s288c. Gene: igf1r, gcn4, aas3, arg9, yel009c. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho-k1.
|
|
|
Chains:
A, B
(240 residues)
|
|
|
|
|
|
Crystal structure of egfr(t790m/v948r) in complex with ln3753
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
D, A, B, C
(314 residues)
|
|
|
|
|
|
A crystal structure of egfr(t790m/v948r) in complex with ln3754
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
D, A, B, C
(297 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of anti-met fab arm of amivantamab in complex with human met
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Expression_system_organ: kidney. Human. Gene: met. Expressed in: trichoplusia ni.
|
|
|
Chain:
M
(518 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Csf1r signaling is a regulator of pathogenesis in progressive ms
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with ln3844
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
D, A, B, C
(292 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with azd9291 and ddc4002
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(293 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the kinase domain of human c-kit in complex with a type-ii inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(306 residues)
|
|
|
|
|
|
Crystal structure of the kinase domain of human c-kit in complex with a type-ii inhibitor bearing an acrylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: bl21 star (de3).
|
|
|
Chains:
A, B
(294 residues)
|
|
|
|
|
|
Crystal structure of the kinase domain of human c-kit with a cyclic imidate inhibitor covalently bound to cys788
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: bl21 star (de3).
|
|
|
Chains:
A, B
(297 residues)
|
|
|
|
|
|
Crystal structure of the kdr (vegfr2) kinase domain in complex with a type-ii inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(305 residues)
|
|
|
|
|
|
Crystal structure of the kdr (vegfr2) kinase domain in complex with a type-ii inhibitor bearing an acrylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(298 residues)
|
|
|
|
|
|
Ddr1 kinase autoinhibited by its juxtamembrane region
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C
(305 residues)
|
|
|
|
|
|
Human fgfr4 kinase domain (447-753) in complex with roblitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B
(277 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/v948r in complex with osimertinib and eai045
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(271 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/v948r in complex with mavelertinib and eai001
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(269 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/v948r in complex with spebrutinib and eai001
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(266 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/v948r in complex with ldc8201
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/v948r in complex with poziotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(270 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/v948r in complex with tak-788
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(266 residues)
|
|
|
|
|
|
Crystal structure of mertk kinase domain in complex with ldc1267
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of mertk kinase domain in complex with merestinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Crystal structure of mertk in complex with a type 1.5 aminopyridine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Apo crystal structure of the mertk kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of mertk kinase domain in complex with gilteritinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Crystal structure of mertk kinase domain in complex with unc2025
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Studies towards a reversible egfr c797s triple mutant inhibitor series
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(315 residues)
|
|
|
|
|
|
Studies towards a reversible egfr c797s triple mutant inhibitor series
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(312 residues)
|
|
|
|
|
|
Zebrafish ret cadherin like domains 1 to 4.
|
|
|
Source: Danio rerio. Zebrafish. Organism_taxid: 7955. Gene: ret, ret1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chains:
A, B
(476 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Ret/gdnf/gfra1 extracellular complex cryo-em structure
|
|
|
Source: Danio rerio. Zebrafish. Organism_taxid: 7955. Gene: ret, ret1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gfra1a, gfralpha1a. Gene: gdnf.
|
|
|
Chains:
A, D
(596 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Mertk kinase domain in complex with nps-1034
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chains:
A, B
(276 residues)
|
|
|
|
|
|
Mertk kinase domain in complex with quinazoline-based inhbitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Mertk kinase domain in complex with a bisaminopyrimidine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Mertk kinase domain in complex with purine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(269 residues)
|
|
|
|
Bound ligand:
|
Het Group S4Q
is 43.24% similar to
enzyme product ADP
|
|
|
|
|
|
|
Mertk kinase domain in complex with a type 2 inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Mertk kinase domain with type 1.5 inhibitor from a DNA-encoded library
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Mertk kinase domain with type 1 inhibitor from a DNA-encoded library
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(269 residues)
|
|
|
|
|
|
Mertk kinase domain with type 3 inhibitor from a DNA-encoded library
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chains:
A, B
(264 residues)
|
|
|
|
|
|
Structure of ddr2 kinase domain in complex with ibz3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr2, ntrkr3, tkt, tyro10, ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
Structure of ddr2 ds domain in complex with vhh
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr2, ntrkr3, tkt, tyro10. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(160 residues)
|
|
|
|
|
|
Crystal structure of c-met bound by compound 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(283 residues)
|
|
|
|
|
|
Crystal structure of c-met bound by compound 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Crystal structure of c-met bound by compound 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Crystal structure of c-met bound by compound 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(259 residues)
|
|
|
|
|
|
Crystal structure of c-met bound by compound 5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(277 residues)
|
|
|
|
|
|
Crystal structure of c-met bound by compound 6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Crystal structure of c-met bound by compound 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Crystal structure of c-met bound by compound 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Crystal structure of c-met bound by compound 9
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(277 residues)
|
|
|
|
|
|
Crystal structure of c-met bound by compound s1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Human herpesvirus-8 gh/gl in complex with epha2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: schneider's drosophila line 2. Expression_system_atcc_number: crl-1963. Human herpesvirus 8.
|
|
|
Chain:
E
(158 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr-wt in complex with tak-788
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(312 residues)
|
|
|
|
|
|
The ddr1 kinase domain bound to sr302
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(273 residues)
|
|
|
|
|
|
Structure of ddr1 receptor tyrosine kinase in complex with inhibitor sr159
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(302 residues)
|
|
|
|
|
|
Darpin_d5/her3 domain 4 complex, monoclinic crystals
|
|
|
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: spodoptera frugiperda.
|
|
|
Chains:
B, D
(131 residues)
|
|
|
|
|
|
Darpin_d5/her3 domain 4 complex, orthorhombic crystals
|
|
|
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: spodoptera frugiperda.
|
|
|
Chains:
B, D
(131 residues)
|
|
|
|
|
|
A x-ray cocrystal structure of xmu-mp-5 bound to the alk kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(304 residues)
|
|
|
|
|
|
Cryo-em structure for the ectodomain of the full-length human insulin receptor in complex with 1 insulin.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t. Gene: ins. Expressed in: saccharomyces cerevisiae.
|
|
|
Chains:
A, C
(647 residues)
|
|
|
|
|
|
Cryo-em structure for the insulin binding region in the ectodomain of the full-length human insulin receptor in complex with 1 insulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t. Gene: ins. Expressed in: saccharomyces cerevisiae.
|
|
|
Chains:
A, C
(551 residues)
|
|
|
|
|
|
Cryo-em structure for the ectodomain of the full-length human insulin receptor in complex with 2 insulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: ins. Expressed in: saccharomyces cerevisiae.
|
|
|
Chains:
A, C
(674 residues)
|
|
|
|
|
|
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase mer in complex with azd-7762
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, C
(253 residues)
|
|
|
|
|
|
Crystal structure of arabidopsis thaliana sobir1 kinase domain d489a mutant in complex with amp-pnp and magnesium
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: sobir1, evr, at2g31880, f20m17.8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(299 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of arabidopsis thaliana sobir1 kinase domain(residues 388-401 deleted) in complex with amp-pnp and magnesium
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: sobir1, evr, at2g31880, f20m17.8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(295 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of epstein-barr virus (ebv) ghgl and in complex with the ligand binding domian (lbd) of epha2
|
|
|
Source: Epstein-barr virus (strain b95-8). Hhv-4. Organism_taxid: 10377. Strain: b95-8. Gene: gh, bxlf2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Human herpesvirus 4 strain b95-8. Gene: gl, bkrf2.
|
|
|
Chains:
I, J, K, L
(165 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of kaposi sarcoma associated herpesvirus (kshv ) ghgl in complex with the ligand binding domian (lbd) of epha2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Human herpesvirus 8. Hhv-8. Organism_taxid: 37296.
|
|
|
Chains:
A, D
(170 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of anti-erbb3 fab isu104 in complex with human erbb3 extracellular domain 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
|
|
|
Chains:
A, D
(193 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of fgfr3 in complex with pyrimidine derivative
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr3, jtk4. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Fgfr4 complex with a covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Crystal structure of human proto-oncogene tyrosine-protein kinase receptor ret in complex with selpercatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(286 residues)
|
|
|
|
|
|
Crystal structure of human proto-oncogene tyrosine-protein kinase receptor ret in complex with pralsetinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(285 residues)
|
|
|
|
|
|
Crystal structure of human proto-oncogene tyrosine-protein kinase receptor ret in complex with 4-amino-7-(1-methylcyclopropyl)-n-(5- methyl-1h-pyrazol-3-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(287 residues)
|
|
|
|
|
|
Fragment-based lead discovery of indazole-based compounds as axl kinase inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(261 residues)
|
|
|
|
|
|
Crystal structure of tie2-agonistic antibody in complex with human tie2 fn2-3
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Human. Gene: tek, tie2, vmcm, vmcm1. Expression_system_taxid: 469008
|
|
|
Chains:
E, F
(196 residues)
|
|
|
|
|
|
Crystal structure of epha7 mutant g656r
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha7, ehk3, hek11. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(277 residues)
|
|
|
|
|
|
Crystal structure of epha7 mutant d751h
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha7, ehk3, hek11. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(278 residues)
|
|
|
|
|
|
Crystal structure of epha7 mutant g656e
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha7, ehk3, hek11. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(283 residues)
|
|
|
|
|
|
Crystal structure of egfr 696-1022 t790m/c797s in complex with ls_2_40
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain with prn1371
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333
|
|
|
Chain:
A
(298 residues)
|
|
|
|
|
|
Crystal structure of human ddr1 in complex with ch5541127
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(293 residues)
|
|
|
|
|
|
Structure of ret protein tyrosine kinase in complex with pralsetinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera aff. Frugiperda 1 bold-2017. Expression_system_taxid: 2449148. Expression_system_cell_line: sf21.
|
|
|
Chains:
A, B
(287 residues)
|
|
|
|
|
|
Structure of ret protein tyrosine kinase in complex with selpercatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790. Expression_system_cell_line: sf21.
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Her2 in complex with jbj-08-178-01
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
B, A, C, D, E, F, G, H
(276 residues)
|
|
|
|
|
|
Egfr kinase (t790m/v948r) in complex with pf-06747775
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, C, B
(289 residues)
|
|
|
|
|
|
Egfr kinase (t790m/v948r) in complex with pf-06747775 and jbj-04-125- 02
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, C, F, E, B
(294 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr kinase (t790m/v948r) in complex with az5104
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, C, B
(292 residues)
|
|
|
|
|
|
Egfr kinase (t790m/v948r) in complex with osimertinib and eai045
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, C, B
(291 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr kinase (t790m/v948r) in complex with osimertinib and jbj-04-125- 02
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, C, F, B, E
(294 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr kinase (t790m/v948r) in complex with allosteric inhibitor jbj-09- 063
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, B, C
(298 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr kinase (t790m/v948r) in complex with osimertinib and jbj-09-063
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, C, B
(287 residues)
|
|
|
|
|
|
Halk in complex with ((1s,2s)-1-(2,4-difluorophenyl)-2-(2-(3-methyl- 1h-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy)cyclopropyl)methanamine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Halk in complex with 1-[(1r,2r)-1-(2,4-difluorophenyl)-2-[2-(5-methyl- 1h-pyrazol-3-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl]methanamine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf9.
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Halk in complex with 3-(3-chlorophenyl)-5-methyl-1h-pyrazole
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf9.
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Halk in complex with 3-(3-methyl-1h-pyrazol-5-yl)pyridine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf9.
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Egfr l858r/v948r in complex with osimertinib and allosteric inhibitor jbj-09-063
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
B, A, C, D, E, F
(291 residues)
|
|
|
|
|
|
Egfr kinase (l858r/v948r) in complex with allosteric inhibitor jbj-09- 063
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(288 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Insulin receptor l1-cr plus alphact fragment in co-complex with fv 83- 7 and single-chain insulin sci-b
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Mus musculus. Organism_taxid: 10090. Expressed in: brevibacillus brevis. Expression_system_taxid: 1393. Human.
|
|
|
Chains:
E, F, K, L, Q, R, W, X
(286 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of kit kinase domain with a small molecule inhibitor, plx3397
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(327 residues)
|
|
|
|
|
|
Crystal structure of kit kinase domain with a small molecule inhibitor, plx8512 in the dfg-in state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Crystal structure of kit kinase domain with a small molecule inhibitor, plx9486 (bezuclastinib) in the dfg-in state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(291 residues)
|
|
|
|
|
|
Crystal structure of fgfr2 kinase domain gatekeeper mutant v564f in complex with covalent compound 19
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(287 residues)
|
|
|
|
|
|
Crystal structure of fgfr2 kinase domain gatekeeper mutant v564f in complex with covalent compound 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(291 residues)
|
|
|
|
|
|
Crystal structure of the epha2 intracellular kd-sam domains
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(364 residues)
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the epha2 s897e/s901e mutant intracellular kd-sam domains
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(361 residues)
|
|
|
|
|
|
Crystal structure of the epha2 s901e mutant intracellular kd-sam domains
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(376 residues)
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of hephb1 in apo form
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb1, elk, epht2, hek6, net. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(256 residues)
|
|
|
|
|
|
Crystal structure of hephb1 bound with adp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ephb1, elk, epht2, hek6, net. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(255 residues)
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Active conformation of egfr kinase in complex with bi-4020
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Inactive conformation of egfr (t790m/v948r) kinase in complex with bi- 4020
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
D, A, B, C
(294 residues)
|
|
|
|
|
|
Cryoem structure of the hcmv trimer ghglgo in complex with human platelet-derived growth factor receptor alpha and neutralizing fabs 13h11 and msl-109
|
|
|
Source: Human cytomegalovirus (strain merlin). Hhv-5. Organism_taxid: 295027. Strain: merlin. Gene: gh, ul75. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293. Gene: gl, ul115.
|
|
|
Chain:
D
(274 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the epidermal growth factor receptor extracellular region with r84k mutation in complex with epiregulin crystallized with trehalose
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ereg. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227
|
|
|
Chains:
A, B
(500 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the epidermal growth factor receptor extracellular region with r84k mutation in complex with epiregulin crystallized with spermine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ereg. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227
|
|
|
Chains:
A, B
(500 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the epidermal growth factor receptor extracellular region with a265v mutation in complex with epiregulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ereg. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227
|
|
|
Chains:
A, B, C, D
(500 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr (t79m/v948r) in complex with naquotinib and an allosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(280 residues)
|
|
|
|
|
|
Structure of egfr_d770_n771insnpg/v948r in complex with covalent inhibitor osimertinib.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: baculoviridae sp.. Expression_system_taxid: 2681587
|
|
|
Chains:
A, B, C, D
(283 residues)
|
|
|
|
|
|
Structure of the invertebrate alk grd
|
|
|
Source: Caenorhabditis elegans. Organism_taxid: 6239. Gene: scd-2, t10h9.2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(347 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the human alk grd
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(306 residues)
|
|
|
|
|
|
Structure of the human alk grd bound to aug
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk, alkal2, fam150b, unq542/pro1097. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B, C, D
(361 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr (t790m/v948r) in complex with quinazolinone allosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(292 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the mertk kinase domain in complex with inhibitor mips15692
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(263 residues)
|
|
|
|
|
|
Insulin receptor ectodomain dimer complexed with two irpa-3 partial agonists
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell_line: myeloma. Gene: ins. Expressed in: escherichia coli.
|
|
|
Chains:
N, M, B, A
(22 residues)
|
|
|
|
|
|
Insulin receptor ectodomain dimer complexed with two irpa-9 partial agonists
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell_line: myeloma. Gene: ins. Expressed in: escherichia coli.
|
|
|
Chains:
A, B, M, N
(682 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Structure of the extracellular wnt-binding module in drosophila ror2/nrk
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: nrk, ror2, cg4007. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(227 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of csf1r in complex with vimseltinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Structure of the her2/her3/nrg1b heterodimer extracellular domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: nrg1, ggf, hgl, hrga, ndf, smdf. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(585 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Structure of the her2 s310f/her3/nrg1b heterodimer extracellular domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens, escherichia coli. Organism_taxid: 9606, 83333. Strain: k12.
|
|
|
Chains:
A, B
(599 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the her2/her3/nrg1b heterodimer extracellular domain bound to trastuzumab fab
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: nrg1, ggf, hgl, hrga, ndf, smdf. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(599 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Cryo-em structure of 2:2 c-met/hgf holo-complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: met. Expression_system_taxid: 9606
|
|
|
Chains:
E, B
(688 residues)
|
|
|
|
|
|
Cryo-em structure of 1:1 c-met i/hgf i complex after focused 3d refinement of holo-complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: met. Expression_system_taxid: 9606
|
|
|
Chain:
B
(613 residues)
|
|
|
|
|
|
Cryo-em map of thE C-met ii/hgf i/hgf ii (k4 and sph) sub-complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: met. Expression_system_taxid: 9606
|
|
|
Chain:
E
(688 residues)
|
|
|
|
|
|
Cryo-em structure of thE C-met ii/hgf i complex bound with hgf ii in a rigid conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: met. Expression_system_taxid: 9606
|
|
|
Chain:
E
(688 residues)
|
|
|
|
|
|
Cryo-em structure of 2:2 c-met/nk1 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hgf, hpta. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: met. Expression_system_taxid: 9606
|
|
|
Chains:
C, D
(489 residues)
|
|
|
|
|
|
The insulin receptor ectodomain in complex with a venom hybrid insulin analog - "head" region
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
F, E
(602 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
The insulin receptor ectodomain in complex with four venom hybrid insulins - symmetric conformation
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
E, F
(823 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
The insulin receptor ectodomain in complex with three venom hybrid insulin molecules - asymmetric conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chains:
E, F
(806 residues)
|
|
|
|
|
|
Anaplastic lymphoma kinase (alk) extracellular ligand binding region 673-1025
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(353 residues)
|
|
|
|
|
|
Anaplastic lymphoma kinase (alk) extracellular fragment of ligand binding region 673-986
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(307 residues)
|
|
|
|
|
|
Anaplastic lymphoma kinase (alk) extracellular fragment of ligand binding region 648-1025 in complex with aug-alpha
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: alkal2, fam150b, unq542/pro1097.
|
|
|
Chains:
A, C
(346 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 domain 3 in complex with a de novo-designed mini-binder
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic construct. Organism_taxid: 32630. Expression_system_taxid: 562
|
|
|
Chains:
A, C
(125 residues)
|
|
|
|
|
|
Trka ecd complex with designed miniprotein ligand
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli.
|
|
|
Chains:
A, B
(348 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Alk:alkal2 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alkal2, fam150b, unq542/pro1097. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: alk. Expression_system_taxid: 9606
|
|
|
Chains:
F, E, B, A
(307 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Ltk:alkal1 complex stabilized by a nanobody
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ltk, tyk1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Lama glama. Organism_taxid: 9844. Expressed in: komagataella phaffii.
|
|
|
Chains:
C, B
(297 residues)
|
|
|
|
|
|
Tg domain of ltk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ltk, tyk1. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Crystal structure of alk in complex with fab324
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: homo sapiens. Expression_system_taxid: 9606. Mus musculus. Organism_taxid: 10090. Expression_system_taxid: 9606
|
|
|
Chains:
A, F
(292 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the tg and egf-like domains of alk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chain:
A
(348 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of ret kinase domain bound to inhibitor jb-48
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Kinase domain of mertk in complex with compound 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(260 residues)
|
|
|
|
|
|
Nmr-guided design of potent and selective epha4 agonistic ligands
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha4, hek8, sek, tyro1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(184 residues)
|
|
|
|
|
|
Plant peptide hormone receptor complex h1l3s1
|
|
|
Source: not given
|
|
|
Chains:
B, E
(185 residues)
|
|
|
|
|
|
Mertk kinase domain with type 1.5 inhibitor containing a di-methyl pyrazole group
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Mertk kinase domain with type 1.5 inhibitor containing a di-methyl, cyano pyrazole group
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Mertk kinase domain with type 1.5 inhibitor containing a tri-methyl pyrazole group
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
Nanobody egb4 bound to the full extracellular egfr-egf complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: egf. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(614 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr double mutant (t790m/l858r) in complex with compound 6.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(305 residues)
|
|
|
|
|
|
Fgfr1 kinase domain (residues 458-765) with mutations c488a, c584s incomplex with 38.
|
|
|
Source: Homo sapiens
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Fgfr1 kinase domain (residues 458-765) with mutations c488a, c584s incomplex with 34.
|
|
|
Source: Homo sapiens
|
|
|
Chains:
A, B
(282 residues)
|
|
|
|
|
|
Fgfr1 kinase domain (residues 458-765) with mutations c488a, c584s incomplex with 19.
|
|
|
Source: Homo sapiens
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Fgfr2 kinase domain (residues 461-763) in complex with 38.
|
|
|
Source: Homo sapiens
|
|
|
Chains:
A, B
(281 residues)
|
|
|
|
|
|
Her2 in complex with a covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Low resolution cryo-em structure of full-length insulin receptor bound to 3 insulin with visible ddm micelle, conf 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: ins. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
|
|
|
Chains:
A, B
(786 residues)
|
|
|
|
|
|
Low resolution cryo-em structure of full-length insulin receptor bound to 3 insulin, conf 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: ins. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
|
|
|
Chains:
A, B
(786 residues)
|
|
|
|
|
|
Low resolution cryo-em structure of the full-length insulin receptor bound to 3 insulin, conf 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: ins. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
|
|
|
Chains:
A, B
(786 residues)
|
|
|
|
|
|
Low resolution cryo-em structure of the full-length insulin receptor bound to 2 insulin, conf 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: ins. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
|
|
|
Chains:
A, B
(786 residues)
|
|
|
|
|
|
Structure of insulin-like growth factor 1 receptor's transmembrane domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(31 residues)
|
|
|
|
|
|
Structure of insulin receptor's transmembrane domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(30 residues)
|
|
|
|
|
|
Structure of insulin receptor-related receptor's transmembrane domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insrr, irr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(31 residues)
|
|
|
|
|
|
Crystal structure of flt3 t343i in complex with the canonical ligand fl
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flt3lg. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: flt3, cd135, flk2, stk1. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
E, F, G, H
(332 residues)
|
|
|
|
|
|
Tentative model of the human insulin receptor ectodomain bound by three insulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Gene: ins. Expressed in: saccharomyces cerevisiae.
|
|
|
Chains:
A, B, C, D
(719 residues)
|
|
|
|
|
|
Nm-02 in complex with her2-ecd
|
|
|
Source: not given
|
|
|
Chain:
A
(506 residues)
|
|
|
|
|
|
Structure of human anaplastic lymphoma kinase domain in complex with (4-[6-amino-5-[(1~{r})-1-[5-fluoro-2-(triazol-2-yl)phenyl]ethoxy]-3- pyridyl]isoindolin-1-one)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf9.
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Structure of human anaplastic lymphoma kinase domain in complex with ((2~{r})-2-[5-[6-amino-5-[(1~{r})-1-[5-fluoro-2-(triazol-2-yl) phenyl]ethoxy]-3-pyridyl]-4-methyl-thiazol-2-yl]propane-1,2-diol)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf9.
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Cryo-em structure of the hcmv ghglgo trimer derived from ad169 and tr strains in complex with pdgfralpha
|
|
|
Source: Human herpesvirus 5 strain ad169. Organism_taxid: 10360. Strain: ad169. Gene: gh, ul75. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: gl, ul115. Expression_system_cell_line: hek293-6e. Human betaherpesvirus 5.
|
|
|
Chain:
D
(289 residues)
|
|
|
|
|
|
Crystal structure of phosphorylated ret tyrosine kinase domain complexed with a pyrrolo[2,3-d]pyrimidine inhibitor.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ret, cdhf12, cdhr16, ptc, ret51. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(287 residues)
|
|
|
|
|
|
Head region of a complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho lec8. Gene: insr. Expression_system_cell_line: cho lek8.
|
|
|
Chains:
A, B
(575 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of the ephb2 extracellular domain
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ephb2, epth3, nuk, sek3. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(525 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Leg region of a complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: insr. Expression_system_taxid: 10029
|
|
|
Chains:
A, B
(264 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 47.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of apo egfr kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(302 residues)
|
|
|
|
|
|
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (a-v3e)
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(813 residues)
|
|
|
|
|
|
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- asymmetric conformation
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(806 residues)
|
|
|
|
|
|
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- symmetric conformation
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(820 residues)
|
|
|
|
|
|
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- asymmetric conformation
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(786 residues)
|
|
|
|
|
|
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- symmetric conformation
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(819 residues)
|
|
|
|
|
|
Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (a-v3e) and site 2 binding deficient mutant insulin (a-l13r)
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(819 residues)
|
|
|
|
|
|
Full-length insulin receptor bound with unsaturated insulin wt (2 insulin bound) symmetric conformation
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(820 residues)
|
|
|
|
|
|
Full-length insulin receptor bound with unsaturated insulin wt (1 insulin bound) asymmetric conformation
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(816 residues)
|
|
|
|
|
|
Full-length insulin receptor bound with unsaturated insulin wt (2 insulins bound) asymmetric conformation (conformation 1)
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(786 residues)
|
|
|
|
|
|
Full-length insulin receptor bound with unsaturated insulin wt (2 insulins bound) asymmetric conformation (conformation 2)
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(815 residues)
|
|
|
|
|
|
Cryo-em structure of the extracellular module of the full-length egfr bound to egf "tips-juxtaposed" conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: egf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(614 residues)
|
|
|
|
|
|
Cryo-em structure of the extracellular module of the full-length egfr bound to egf. "Tips-separated" conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: egf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(614 residues)
|
|
|
|
|
|
Cryo-em structure of the extracellular module of the full-length egfr l834r bound to egf. "Tips-juxtaposed" conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: egf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(614 residues)
|
|
|
|
|
|
Cryo-em structure of the extracellular module of the full-length egfr l834r bound to egf. "Tips-separated" conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: egf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(614 residues)
|
|
|
|
|
|
Cryo-em structure of the extracellular module of the full-length egfr bound to tgf-alpha "tips-separated" conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: tgfa. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(614 residues)
|
|
|
|
|
|
Cryo-em structure of the extracellular module of the full-length egfr bound to tgf-alpha. "Tips-juxtaposed" conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: tgfa. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(614 residues)
|
|
|
|
|
|
Crystal structure of wild type egfr in complex with tak-788
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(309 residues)
|
|
|
|
|
|
Crystal structure of egfr_d770_n771insnpg/v948r in complex with tak- 788
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chains:
A, B
(279 residues)
|
|
|
|
|
|
Crystal structure of csf1r kinase domain in complex with dp-6233
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms, fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(280 residues)
|
|
|
|
|
|
Crystal structure of the kinase domain of egfr exon-19 (del-747-749) mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 domain 3 in complex with a de novo-designed mini-binder in p21 space group
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic construct. Organism_taxid: 32630. Expression_system_taxid: 562
|
|
|
Chains:
A, C
(98 residues)
|
|
|
|
|
|
Cryo-em structure of insulin receptor-related receptor (irr) in apo- state captured at ph 7. The 3d refinement was focused on one of two halves with c1 symmetry applied
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insrr, irr. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(447 residues)
|
|
|
|
|
|
Cryo-em structure of insulin receptor-related receptor (irr) in apo- state captured at ph 7. The 3d refinement was applied with c2 symmetry
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insrr, irr. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(809 residues)
|
|
|
|
|
|
Cryo-em structure of insulin receptor-related receptor (irr) in active-state captured at ph 9. The 3d refinement was applied with c2 symmetry
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insrr, irr. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(771 residues)
|
|
|
|
|
|
Single-chain lcdv-1 viral insulin-like peptide bound to igf-1r ectodomain, leucine-zippered form
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic: yes. Lymphocystis disease virus 1. Organism_taxid: 36363
|
|
|
Chains:
E, F
(669 residues)
|
|
|
|
|
|
Head region of insulin receptor ectodomain (a-isoform) bound to the non-insulin agonist im459
|
|
|
Source: Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
|
|
|
Chains:
C, B
(562 residues)
|
|
|
|
|
|
Head region of insulin receptor ectodomain (a-isoform) bound to the non-insulin agonist im462
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ins. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Gene: insr. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
|
|
|
Chains:
E, F
(584 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with a macrocyclic inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(287 residues)
|
|
|
|
|
|
Egfr kinase in complex with a macrocyclic inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(304 residues)
|
|
|
|
|
|
Egfr in complex with a macrocyclic inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(295 residues)
|
|
|
|
|
|
Wild type egfr in complex with lazertinib (yh25448)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with lazertinib (yh25448)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
D, A, B, C
(300 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 with a dual-warhead covalent inhhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768
|
|
|
Chains:
B, A
(290 residues)
|
|
|
|
|
|
Cryo-em structure of the igf1r/insulin complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: ins. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(807 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of cmet in complex with a novel inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(285 residues)
|
|
|
|
|
|
Crystal structure of cmet in complex with a novel inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(284 residues)
|
|
|
|
|
|
The crystal structure of fgfr4 kinase domain in complex with n-(5- cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-(2,2,2- trifluoroacetyl)-3,4-dihydro-1,8-naphthyridine-1(2h)-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia alba. Expression_system_taxid: 2562891
|
|
|
Chains:
A, B
(263 residues)
|
|
|
|
|
|
Crystal structure of trka (g595r) kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of trka (g595r) kinase with repotrectinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(297 residues)
|
|
|
|
|
|
Crystal structure of trka kinase with repotrectinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(297 residues)
|
|
|
|
|
|
The crystal structure of egfr t790m/c797s with the inhibitor hc5476
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
The crystal structure of egfr t790m/c797s with the inhibitor hcd2892
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(312 residues)
|
|
|
|
|
|
Crystal structure of fgfr1 kinase domain with pemigatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(306 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain with 7v
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of fgfr4(v550l) kinase domain with 7v
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of fgfr4(v550m) kinase domain with 7v
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
The crystal structure of trka kinase in complex with 4^6,14-dimethyl- n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5- oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo- tetradecaphan-2-yne-45-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
The crystal structure of human trka kinase bound to the inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Cryo-em structure of apo-igf1r map 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293
|
|
|
Chains:
A, B
(836 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of mertk kinase domain with bms794833
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mertk, mer. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Conformation ii of apo-igf1r states
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293
|
|
|
Chains:
A, B
(828 residues)
|
|
|
|
|
|
Crystal structure of cmet kinase domain bound by compound 9i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Crystal structure of cmet kinase domain bound by compound 9y
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain with 10z
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(294 residues)
|
|
|
|
|
|
Crystal structure of fgfr4(v550l) kinase domain with 10z
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of fgfr4(v550m) kinase domain with 10z
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain with 10d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain with 10t
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Human insulin receptor bound with a43 DNA aptamer and insulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ins. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Gene: ins-igf2. Gene: insr.
|
|
|
Chains:
E, F
(830 residues)
|
|
|
|
|
|
Human insulin receptor bound with a62 DNA aptamer and insulin - locally refined
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Gene: ins-igf2. Gene: ins.
|
|
|
Chains:
E, F
(583 residues)
|
|
|
|
|
|
Human insulin receptor bound with a62 DNA aptamer and insulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ins. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Gene: ins-igf2. Synthetic: yes.
|
|
|
Chains:
F, E
(828 residues)
|
|
|
|
|
|
Human insulin receptor bound with a62 DNA aptamer
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Synthetic: yes. Synthetic construct.
|
|
|
Chains:
E, F
(799 residues)
|
|
|
|
|
|
Cryo-em structure of igf1r with two igf1 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: igf1. Expression_system_cell_line: hek293
|
|
|
Chains:
A, B
(799 residues)
|
|
|
|
|
|
Cryo-em structure of fgf23-fgfr1c-aklotho-hs quaternary complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-. Gene: fgf23, hypf, unq3027/pro9828. Expressed in: escherichia coli.
|
|
|
Chains:
D, E
(213 residues)
|
|
|
|
|
|
Cryo-em structure of fgf23-fgfr3c-aklotho-hs quaternary complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-. Gene: fgfr3, jtk4. Gene: fgf23, hypf, unq3027/pro9828.
|
|
|
Chains:
C, E
(211 residues)
|
|
|
|
|
|
Cryo-em structure of fgf23-fgfr4-aklotho-hs quaternary complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: kl. Gene: fgf23, hypf, unq3027/pro9828.
|
|
|
Chains:
C, E
(213 residues)
|
|
|
|
|
|
Ros1 with astrazeneca ligand 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ros1, mcf3, ros. Expressed in: spodoptera frugiperda. Expression_system_taxid: 10029
|
|
|
Chains:
A, B
(271 residues)
|
|
|
|
|
|
Ros1 with astrazeneca ligand 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ros1, mcf3, ros. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(270 residues)
|
|
|
|
|
|
Crystal structure of flt3 in complex with a monomeric flt3 ligand variant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: flt3lg. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: flt3, cd135, flk2, stk1. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, D, F, H, J, L, N, P
(423 residues)
|
|
|
|
|
|
Crystal structure of the schistosoma mansoni vkr2 kinase domain in an active-like state (adp-bound)
|
|
|
Source: Schistosoma mansoni. Organism_taxid: 6183. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C
(300 residues)
|
|
|
|
|
|
Identification of m4205 a highly selective inhibitor of ckit mutations for unresectable metastatic or recurrent gist
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
|
|
|
|
|
|
Identification of m4205 a highly selective inhibitor of ckit mutations for unresectable metastatic or recurrent gist
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(293 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/c797s in complex with brigatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(321 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/c797s in complex with wz4002
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(317 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/c797s in complex with reversible aminopyrimidine 9
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(305 residues)
|
|
|
|
|
|
Crystal structure of egfr-t790m/v948r in complex with reversible aminopyrimidine 13
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(270 residues)
|
|
|
|
|
|
Egfr kinase domain in complex with 2-(6,7-dihydro-5h-pyrrolo[1,2- c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1- piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin- 2-yl]-n-thiazol-2-yl-acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(269 residues)
|
|
|
|
|
|
Egfr kinase domain in complex with 2-(6,7-dihydro-5h-pyrrolo[1,2- c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1- piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin- 2-yl]-n-thiazol-2-yl-acetamide (form 2)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(306 residues)
|
|
|
|
|
|
Egfr kinase domain (l858r/v948r) in complex with 2-(6,7-dihydro-5h- pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1- piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin- 2-yl]-n-thiazol-2-yl-acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Egfr kinase domain (l858r/v948r) in complex with 2-[4- (difluoromethyl)-6-[2-[4-[[4-(hydroxymethyl)-1- piperidyl]methyl]phenyl]ethynyl]-7-methyl-indazol-2-yl]-2-spiro[6,7- dihydropyrrolo[1,2-c]imidazole-5,1'-cyclopropane]-1-yl-n-thiazol-2- yl-acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Crystal structure of wild-typE C-met bound by compound 7.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(244 residues)
|
|
|
|
|
|
Crystal structure of d1228v c-met bound by compound 1.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(277 residues)
|
|
|
|
|
|
Anaplastic lymphoma kinase with a novel carboline inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
C-met y1234e,y1235e mutant in complex with tepotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(285 residues)
|
|
|
|
|
|
C-met f1200i mutant in complex with tepotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
C-met y1235d mutant in complex with tepotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(263 residues)
|
|
|
|
|
|
Crystal structure of human ephrin type-a receptor 2 (epha2) kinase domain in complex with mr21
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(264 residues)
|
|
|
|
Bound ligand:
|
Het Group QRR
is 40.54% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of human ephrin type-a receptor 2 (epha2) kinase domain in complex with mral5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Crystal structure of human ephrin type-a receptor 2 (epha2) kinase domain in complex with ldn-211904
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 19
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 20
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 12
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(269 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 9
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(269 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(280 residues)
|
|
|
|
|
|
Crystal structure of ephrin a2 (epha2) receptor protein kinase with compound 14
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Structure of csf1r in complex with a pyrollopyrimidine (compound 23)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(311 residues)
|
|
|
|
|
|
Drosophila melanogaster insulin receptor ectodomain in complex with dilp5
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: inr, dinr, dir-a, inr-a, cg18402. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic: yes. Organism_taxid: 7227
|
|
|
Chains:
A, B
(837 residues)
|
|
|
|
|
|
Crystal structure of egfr lrtm with compound 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(309 residues)
|
|
|
|
|
|
Crystal structure of egfr lrtm with compound 24
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(312 residues)
|
|
|
|
|
|
Ectodomain of full-length wild-type kit-scf dimers
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: kitlg, mgf, scf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(441 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Ectodomain of full-length kit(dupa502,y503)-scf dimers
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: kitlg, mgf, scf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(438 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Ectodomain of full-length kit(t417i,delta418-419)-scf dimers
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: kitlg, mgf, scf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(438 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr kinase domain, exon20 insertion fqea mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(307 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of insulin receptor (ir) bound with s597 peptide
|
|
|
Source: Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(741 residues)
|
|
|
|
|
|
Cryo-em structure of insulin receptor (ir) bound with s597 component 2
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B
(444 residues)
|
|
|
|
|
|
Crystal structure of bis-phosphorylated insulin receptor kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(286 residues)
|
|
|
|
|
|
Fgfr2 kinase domain in complex with a pyrazolo[1,5-a]pyrimidine analog (compound 29)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(290 residues)
|
|
|
|
|
|
Crystal structure of the kinase domain of rtkc8 from the choanoflagellate monosiga brevicollis
|
|
|
Source: Monosiga brevicollis. Organism_taxid: 81824. Gene: 34458. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with znl-0056
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
B, A
(282 residues)
|
|
|
|
|
|
Cryo-em structure of two igf1 bound full-length mouse igf1r mutant (four glycine residues inserted in the alpha-ct; igf1r-p674g4): symmetric conformation
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: igf1r. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
B, A
(794 residues)
|
|
|
|
|
|
Cryo-em structure of 4 insulins bound full-length mouse ir mutant with physically decoupled alpha cts (c684s/c685s/c687s; denoted as ir-3cs) asymmetric conformation 1
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(815 residues)
|
|
|
|
|
|
Cryo-em structure of 4 insulins bound full-length mouse ir mutant with physically decoupled alpha cts (c684s/c685s/c687s, denoted as ir-3cs) asymmetric conformation 2
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(775 residues)
|
|
|
|
|
|
Cryo-em structure of 4 insulins bound full-length mouse ir mutant with physically decoupled alpha cts (c684s/c685s/c687s; denoted as ir-3cs) symmetric conformation
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(816 residues)
|
|
|
|
|
|
Egfr kinase in complex with tas6417 (cln-081)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(307 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) kinase in complex with poziotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chains:
A, B, C, D
(303 residues)
|
|
|
|
|
|
Egfr kinase in complex with mobocertinib (tak-788)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(317 residues)
|
|
|
|
|
|
Egfr kinase in complex with poziotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(293 residues)
|
|
|
|
|
|
Egfr kinase in complex with bayer #33
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(310 residues)
|
|
|
|
|
|
Structure of zanidatamab bound to her2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_taxid: 10029
|
|
|
Chain:
X
(619 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with compound 1 (ln4503)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
D, A, B, C
(295 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with compound 2 (ln5993)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
D, A, B, C
(291 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Ralimetinib (ly2228820) in complex with wild type egfr
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(280 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) kinase in complex with benzimidazole allosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(292 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr(t790m/v948r) kinase in complex with osimertinib and benzimidazole allosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(294 residues)
|
|
|
|
|
|
Human insulin receptor bound with two insulin molecules
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Gene: ins. Expressed in: saccharomyces cerevisiae.
|
|
|
Chains:
E, F
(835 residues)
|
|
|
|
|
|
Crystal structure of cmet kinase domain bound by d6808
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(285 residues)
|
|
|
|
|
|
Fgfr2 in complex with yj001
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(285 residues)
|
|
|
|
|
|
Crystal structure of egfr t790m/c797s mutant in complex with brigatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(299 residues)
|
|
|
|
|
|
The egf-bound egfr/her2 ectodomain complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-. Gene: egfr, erbb, erbb1, her1. Gene: egf.
|
|
|
Chains:
B, A
(563 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
The ereg-bound egfr/her2 ectodomain complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-. Gene: egfr, erbb, erbb1, her1. Gene: ereg.
|
|
|
Chains:
B, A
(563 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
The egf-bound egfr ectodomain homodimer
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-. Gene: egf. Expressed in: escherichia coli.
|
|
|
Chains:
A, B
(593 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of egfr_dmx in complex with covalently bound fragment 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(309 residues)
|
|
|
|
|
|
Crystal structure of egfr_wt in complex with covalently bound fragment 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Crystal structure of egfr_dmx in complex with covalently bound fragment 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(307 residues)
|
|
|
|
|
|
Crystal structure of egfr_tmx in complex with covalently bound fragment 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(304 residues)
|
|
|
|
|
|
Crystal structure of egfr_dmx in complex with compound 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(306 residues)
|
|
|
|
|
|
Crystal structure of egfr_tmx in complex with covalently bound fragment 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(307 residues)
|
|
|
|
|
|
Crystal structure of egfr_tmx in complex with covalently bound fragment 9
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
|
|
|
|
|
|
Crystal structure of egfr_tmx in complex with covalently bound fragment 10
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(305 residues)
|
|
|
|
|
|
Crystal structure of egfr_tmx in complex with covalently bound fragment 12
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(306 residues)
|
|
|
|
|
|
Crystal structure of egfr_tmx in complex with covalently bound compound 14
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
|
|
|
|
|
|
Egfr kinase domain mutant "tmlr" with compound 28f
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Crystal structure of epha8/sash1 complex
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: epha8, eek. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: sash1. Expression_system_taxid: 562
|
|
|
Chain:
8
(66 residues)
|
|
|
|
|
|
The crystal structure of trka(f589l) kinase in complex with n-(3- cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14- oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)- benzenacyclotetradecaphan-2-yne-4^5-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(298 residues)
|
|
|
|
|
|
The crystal structure of trka(g595r) kinase in complex with n-(3- cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14- oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)- benzenacyclotetradecaphan-2-yne-4^5-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(296 residues)
|
|
|
|
|
|
The crystal structure of trka kinase in complex with 4^6-methyl-n-(3- (4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-14-oxo-5-oxa- 13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)- benzenacyclotetradecaphan-2-yne-4^5-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
The crystal structure of trka kinase in complex with 4^6-methyl-n-(3- (4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-11-oxo-5-oxa- 10,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)- benzenacyclotetradecaphan-2-yne-4^5-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Fgfr1 kinase domain with sulfatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(306 residues)
|
|
|
|
|
|
Crystal structure of csf-1r kinase domain with sulfatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csf1r, fms. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(306 residues)
|
|
|
|
|
|
Cryo em map of full length plc gamma 2 and fgfr1 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plcg2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Gene: fgfr1, bfgfr, cek, fgfbr, flg, flt2, hbgfr. Expression_system_cell_line: hek293f
|
|
|
Chain:
B
(307 residues)
|
|
|
|
|
|
Crystal structure of anti-her2 antibody h2mab-119 in complex with her2 domain i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Mus musculus. Organism_taxid: 10090. Expressed in: cricetulus griseus.
|
|
|
Chain:
A
(182 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of cmet kinase domain bound by tpx-0022
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(298 residues)
|
|
|
|
|
|
The crystal structure of egfr(t797m/l858r) with small molecule inhibitor b6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(301 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain with 8r
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain with 8zc
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Crystal structure of fgfr4(v550l) kinase domain with 8z
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4, jtk2, tkf. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Crystal structure of fgfr4(v550m) kinase domain with 8z
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Crystal structure of d1228v c-met bound by compound 29
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(284 residues)
|
|
|
|
|
|
Crystal structure of d1228v c-met bound by compound 15
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(294 residues)
|
|
|
|
|
|
Crystal structure of d1228v c-met bound by compound 10
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Crystal structure of d1228v c-met bound by compound 16
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(286 residues)
|
|
|
|
|
|
Crystal structure of wild-typE C-met bound by compound 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(258 residues)
|
|
|
|
|
|
Crystal structure of d1228v c-met bound by compound 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C
(244 residues)
|
|
|
|
|
|
Trkb transmembrane domain nmr structure in dmpc/dhpc bicelles
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Variant: tk+. Gene: ntrk2, trkb. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell: cell-free expression system, lysate-based.
|
|
|
Chains:
A, B
(45 residues)
|
|
|
|
|
|
Complex between ddr1 ds-like domain and prth-101 fab
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddr1, cak, eddr1, nep, ntrk4, ptk3a, rtk6, trke. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293f. Expression_system_cell: expicho-s. Expression_system_cell_line: expicho-s.
|
|
|
Chain:
A
(175 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. Compound 16 bound to egfr
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(311 residues)
|
|
|
|
|
|
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. Compound 12 bound to egfrinsnpg
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(310 residues)
|
|
|
|
|
|
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. Compound 22 bound to egfrinsnpg [v948r]
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda granulovirus. Expression_system_taxid: 307454
|
|
|
Chain:
A
(277 residues)
|
|
|
|
|
|
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. Compound 33 bound to egfrinsnpg [v948r]
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda multiple nucleopolyhedrovirus. Expression_system_taxid: 10455
|
|
|
Chains:
A, B, D
(271 residues)
|
|
|
|
|
|
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. Compound 18 bound to egfr[v948r]
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda ascovirus 1d. Expression_system_taxid: 1076708
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Discovery and optimisation of potent, efficacious and selective inhibitors targeting egfr exon20 insertion mutations. Compound 33 bound to egfr[v948r]
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(307 residues)
|
|
|
|
Bound ligand:
|
Het Group ATP
corresponds to
enzyme reactant ATP
|
|
|
|
|
|
|
C-kit kinase domain in complex with avapritinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, C
(296 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with avapritinib derivative 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, C
(293 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with avapritinib derivative 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(280 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with avapritinib derivative 9
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(297 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with avapritinib derivative 10
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(297 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with avapritinib derivative 11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(277 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with avapritinib derivative 12
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, C
(294 residues)
|
|
|
|
|
|
C-kit t670i mutated kinase domain in complex with avapritinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, C
(292 residues)
|
|
|
|
|
|
Pdgfra t674i mutant kinase domain in complex with avapritinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(321 residues)
|
|
|
|
|
|
Pdgfra t674i mutant kinase domain in complex with avapritinib derivative 9
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Pdgfra wild-type kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(329 residues)
|
|
|
|
|
|
Apo crystal structure of pdgfra-t674i kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdgfra, pdgfr2, rhepdgfra. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(322 residues)
|
|
|
|
|
|
Atomic structure and conformational variability of the her2- trastuzumab-pertuzumab complex
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Human. Gene: erbb2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293
|
|
|
Chain:
E
(624 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of human ephrin type-a receptor 2 (epha2) kinase domain in complex with jg165
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Apo c-kit-wt kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(301 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with sunitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(302 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with nintedanib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(312 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with imatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(306 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with ponatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(305 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with staurosporine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(295 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with crenolanib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(296 residues)
|
|
|
|
|
|
C-kit kinase domain in complex with idrx-42 via soaking
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kit, scfr. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(277 residues)
|
|
|
|
|
|
Crystal structure of human gabarap fused to egfr (1076-1099)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1, gabarap, flc3b, ht004. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: t1
|
|
|
Chain:
A
(137 residues)
|
|
|
|
|
|
1:1:1 agrin/lrp4/musk complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agrn, agrin. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: lrp4, kiaa0816, lrp10, megf7. Gene: musk. Expression_system_taxid: 9606
|
|
|
Chain:
C
(97 residues)
|
|
|
|
|
|
Structure of egfr in complex with mtx-531
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(326 residues)
|
|
|
|
|
|
Discovery and clinical validation of rly-4008, the first highly selective fgfr2 inhibitor with activity across fgfr2 alterations and resistance mutations
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(277 residues)
|
|
|
|
|
|
Fgfr2 kinase domain bound to reversible inhibitor cmpd 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(284 residues)
|
|
|
|
|
|
Structure of the ck variant of fab f1 (fabc-f1) in complex with thE C- terminal fn3 domain of epha2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293. Gene: epha2, eck.
|
|
|
Chains:
I, J, K, L
(89 residues)
|
|
|
|
|
|
Cryoem structure of mfrv-vilp bound to igf1rzip
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1r. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic: yes. Mandarin fish ranavirus. Organism_taxid: 2487147
|
|
|
Chains:
A, B
(831 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr kinase in complex with pyrazolopyrimidine covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(306 residues)
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with ln5461
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
D, A, B, C
(293 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Egfr(t790m/v948r) in complex with the allosteric inhibitor frf-06-057
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
D, A, B, C
(283 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the epha2 crd bound to fabs1ce_c1, trigonal form
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293. Gene: epha2, eck.
|
|
|
Chain:
D
(131 residues)
|
|
|
|
|
|
Structure of the epha2 crd bound to fabs1ce_c1, monoclinic form
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293. Gene: epha2, eck.
|
|
|
Chains:
E, D
(124 residues)
|
|
|
|
|
|
Structure of the epha2 lbdcrd bound to fabs1c_c1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293.
|
|
|
Chains:
A, B
(294 residues)
|
|
|
|
|
|
Structure of the epha2 lbdcrd bound to fabs1c_l1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293. Gene: epha2, eck.
|
|
|
Chain:
C
(303 residues)
|
|
|
|
|
|
Fgfr2 kinase domain bound to irreversible inhibitor cmpd 10
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(276 residues)
|
|
|
|
|
|
Cryo-em structure of long form insulin receptor (ir-b) in the apo state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(817 residues)
|
|
|
|
|
|
Cryo-em structure of long form insulin receptor (ir-b) with four igf2 bound, symmetric conformation.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: igf2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(817 residues)
|
|
|
|
|
|
Cryo-em structure of long form insulin receptor (ir-b) with three igf2 bound, asymmetric conformation.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: igf2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(787 residues)
|
|
|
|
|
|
Structure of the her4/nrg1b homodimer extracellular domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi393f. Gene: nrg1, ggf, hgl, hrga, ndf, smdf. Expressed in: escherichia coli.
|
|
|
Chains:
A, B
(601 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the her4/btc homodimer extracellular domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293f. Gene: btc. Expressed in: escherichia coli bl21(de3).
|
|
|
Chains:
A, B
(601 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the her2/her4/btc heterodimer extracellular domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293f. Gene: erbb2, her2, mln19, neu, ngl. Gene: btc.
|
|
|
Chains:
A, B
(598 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the her2/her4/nrg1b heterodimer extracellular domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb4, her4. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293f. Gene: erbb2, her2, mln19, neu, ngl. Gene: nrg1, ggf, hgl, hrga, ndf, smdf.
|
|
|
Chains:
A, B
(598 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the receptor tyrosine kinase human her2 (erbb2) yvma mutant kinase domain in complex with inhibitor compound 27
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(308 residues)
|
|
|
|
|
|
The x-ray co-crystal structure of human fgfr3 and kin-3248
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr3, jtk4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chains:
A, B, C
(284 residues)
|
|
|
|
|
|
The x-ray co-crystal structure of human fgfr3 and compound 17
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr3, jtk4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chains:
A, B
(280 residues)
|
|
|
|
|
|
The x-ray co-crystal structure of human fgfr3 v555m and compound 17
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr3, jtk4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chains:
A, B, C
(279 residues)
|
|
|
|
|
|
Crystal structure of nanobody/vhh domain of 34e5 in complex with the extracellular region of the epidermal growth factor variant iii (egfrviii)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Variant: var_066493. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Lama glama.
|
|
|
Chains:
A, B
(321 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure the extracellular region of the epidermal growth factor receptor variant iii (egfrviii) at ph 5.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Variant: var_066493. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(309 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure the extracellular region of the epidermal growth factor receptor variant iii (egfrviii) at ph 7.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Variant: var_066493. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(321 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of short form insulin receptor (ir-a) with four igf2 bound, symmetric conformation.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: igf2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(816 residues)
|
|
|
|
|
|
Cryo-em structure of short form insulin receptor (ir-a) with three igf2 bound, asymmetric conformation.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: igf2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(787 residues)
|
|
|
|
|
|
Her2 s310f in complex with tl1 fab
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
|
|
|
Chain:
A
(502 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Homodimeric structure of her2 s310f extracellular region
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(502 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Tas-120 covalent structure with fgfr2 molecular brake mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(298 residues)
|
|
|
|
|
|
Tas-120 covalent structure with fgfr2 molecular brake mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(279 residues)
|
|
|
|
|
|
Tas-120 covalent structure with fgfr2 molecular brake mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr2, bek, kgfr, ksam. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(298 residues)
|
|
|
|
|
|
Crystal structure of fgfr4 kinase domain in complex with 8k
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr4. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(267 residues)
|
|
|
|
|
|
Egfr(l858r/t790/c797s) in complex with compound 5j
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(299 residues)
|
|
|
|
|
|
Crystal structure of arabidopsis thaliana mik2 ectodomain in complex with bak1 ectodomain and scoop12
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: mik2, at4g08850, t32a17.160. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: bak1, elg, serk3, at4g33430, f17m5.190. Synthetic: yes. Organism_taxid: 3702
|
|
|
Chains:
B, E
(175 residues)
|
|
|
|
|
|
Crystal structure of arabidopsis thaliana mik2 ectodomain in complex with bak1 ectodomain and fusarium oxysporum scoopl
|
|
|
Source: Arabidopsis thaliana. Mouse-ear cress. Organism_taxid: 3702. Gene: mik2, at4g08850, t32a17.160. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: bak1, elg, serk3, at4g33430, f17m5.190. Synthetic: yes. Fusarium oxysporum f. Sp. Pisi hdv247.
|
|
|
Chains:
B, E
(175 residues)
|
|
|
|
|
|
Cryo-em structure of the ir/igf-i complex, conformation 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: igf1. Expression_system_cell_line: hek293
|
|
|
Chains:
A, B
(536 residues)
|
|
|
|
|
|
Cryo-em structure of the ir/igf-i complex, conformation 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hke-293. Gene: igf1. Expressed in: escherichia coli bl21(de3).
|
|
|
Chains:
A, B
(581 residues)
|
|
|
|
|
|
Crystal structure of flt3 in complex with a pyrazinamide macrocycle derivative
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(304 residues)
|
|
|
|
|
|
Cryo-em structure of human insulin receptor bound to 3 igf-i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
B, A
(517 residues)
|
|
|
|
|
|
Cryo-em structure of human insulin receptor bound to 4 igf-i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: igf1. Expressed in: escherichia coli bl21(de3).
|
|
|
Chains:
A, B
(794 residues)
|
|
|
|
|
|
The crystal structure of epha2 from biortus.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Cryo-em structure of mik2-scoop12-bak1
|
|
|
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: bak1, elg, serk3, at4g33430, f17m5.190. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: mik2, at4g08850, t32a17.160. Synthetic: yes. Organism_taxid: 3702
|
|
|
Chain:
C
(177 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Her3 in complex with fab hu3f8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_taxid: 9606
|
|
|
Chain:
A
(96 residues)
|
|
|
|
|
|
Cryo-em structure of the complex ir with three igf-ii
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: igf2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
A, B
(797 residues)
|
|
|
|
|
|
Crystal structure of trka d5 domain in complex with two different macrocyclic peptides
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630.
|
|
|
Chain:
A
(102 residues)
|
|
|
|
|
|
Crystal structure of trka d5 domain in complex with macrocyclic peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, C
(98 residues)
|
|
|
|
|
|
Cryo-em structure of the complex ir with one insulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: ins. Expression_system_cell_line: hek293
|
|
|
Chains:
A, B
(559 residues)
|
|
|
|
|
|
Cryo-em structure of the complex ir with four insulin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: ins. Expression_system_cell_line: hek293
|
|
|
Chains:
A, B
(785 residues)
|
|
|
|
|
|
Crystal structure of epha6/caskin1 complex
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: caskin1, kiaa1306, epha6, ehk-2, ehk2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(124 residues)
|
|
|
|
|
|
The crystal structure of the ron from biortus.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mst1r, ptk8, ron. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(298 residues)
|
|
|
|
|
|
Cryo-em structure of sevenless extracellular domain (monomer)
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: sev, hd-265, cg18085. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227
|
|
|
Chain:
A
(1034 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of sevenless in complex with bride of sevenless
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: sev, hd-265, cg18085. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Gene: boss, cg8285. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chain:
A
(1000 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of sevenless extracellular domain (dimer, ph 6.6)
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: sev, hd-265, cg18085. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227
|
|
|
Chains:
A, B
(1516 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of sevenless extracellular domain (composite map of the dimer, ph 4.6)
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: sev, hd-265, cg18085. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227
|
|
|
Chains:
A, B
(1652 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the extracellular domain of protein sevenless
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: sev, hd-265, cg18085. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(1048 residues)
|
|
|
|
|
|
Co-crystal structure of the kinase domain of egfr with non-covalent osimertinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(316 residues)
|
|
|
|
|
|
Crystal structure of the kinase domain of egfr soaked with non- covalent osimertinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(311 residues)
|
|
|
|
|
|
Crystal structure of trk-a in complex with staurosporin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ntrk1, mtc, trk, trka. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Insulin receptor bound with de novo designed agonist called "rf-405".
|
|
|
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens.
|
|
|
Chains:
C, D
(753 residues)
|
|
|
|
|
|
Insulin receptor bound with de novo designed agonist called "s2-f1-s1"
|
|
|
Source: Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens.
|
|
|
Chains:
C, D
(741 residues)
|
|
|
|
|
|
Insulin receptor in complex with both insulin and de novo designed site-2 binder "s2b".
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
A, B
(820 residues)
|
|
|
|
|
|
Cryo-em structure of drosophila melanogaster insulin receptor (dmir) bound with one dilp1, asymmetric conformation
|
|
|
Source: Synthetic: yes. Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: inr, dir-a, inr-a, ir, cg18402. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chains:
A, B
(816 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of drosophila melanogaster insulin receptor (dmir) bound with two dilp1, symmetric conformation
|
|
|
Source: Synthetic: yes. Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: inr, dir-a, inr-a, ir, cg18402. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chains:
A, B
(851 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of drosophila melanogaster insulin receptor (dmir) bound with one dilp2, asymmetric conformation
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: inr, dir-a, inr-a, ir, cg18402. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Synthetic: yes. Organism_taxid: 7227
|
|
|
Chains:
A, B
(818 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of drosophila melanogaster insulin receptor (dmir) bound with three dilp5, asymmetric conformation
|
|
|
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: inr, dir-a, inr-a, ir, cg18402. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Synthetic: yes. Organism_taxid: 7227
|
|
|
Chains:
A, B
(846 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Human ror2 cysteine-rich domain (crd) and kringle domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ror2, ntrkr2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
|
|
|
Chain:
A
(223 residues)
|
|
|
|
|
|
Cryo-em structure of a 2:1 alk:alkal2 complex obtained after re- processing of empiar-10930 data
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: alkal2, fam150b, unq542/pro1097. Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(331 residues)
|
|
|
|
|
|
Highly optimized cns penetrant inhibitors of egfr exon20 insertion mutations
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(262 residues)
|
|
|
|
|
|
Her3 receptor in complex with the fab fragment of tk-hu a3 monoclonal antibody
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb3, her3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Expression_system_atcc_number: crl-1573. Expressed in: cricetulus griseus.
|
|
|
Chains:
A, B, C, D
(587 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Local refinement structure of segfr and 528 fv (from hl-type bispecific diabody ex3) complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic construct. Organism_taxid: 32630. Expressed in: brevibacillus choshinensis.
|
|
|
Chain:
A
(508 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Poly-alanine model for hl-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (closed conformation)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic construct. Organism_taxid: 32630. Expressed in: brevibacillus choshinensis.
|
|
|
Chain:
A
(508 residues)
|
|
|
|
|
|
Poly-alanine model for hl-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (middle conformation)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic construct. Organism_taxid: 32630. Expressed in: brevibacillus choshinensis.
|
|
|
Chain:
A
(508 residues)
|
|
|
|
|
|
Poly-alanine model for hl-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (open conformation)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic construct. Organism_taxid: 32630. Expressed in: brevibacillus choshinensis.
|
|
|
Chain:
A
(508 residues)
|
|
|
|
|
|
Local refinement structure of segfr and 528 fv (from lh-type bispecific diabody ex3) complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic construct. Organism_taxid: 32630. Expressed in: brevibacillus choshinensis.
|
|
|
Chain:
A
(539 residues)
|
|
|
|
Bound ligand:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Poly-alanine model for lh-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (closed conformation)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic construct. Organism_taxid: 32630. Expressed in: brevibacillus choshinensis.
|
|
|
Chain:
A
(539 residues)
|
|
|
|
|
|
Poly-alanine model for lh-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (middle conformation)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic construct. Organism_taxid: 32630. Expressed in: brevibacillus choshinensis.
|
|
|
Chain:
A
(539 residues)
|
|
|
|
|
|
Poly-alanine model for lh-type bispecific diabody ex3 composed of 528 and okt3 fvs in ternary complex with segfr and cd3gamma-epsilon (open conformation)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic construct. Organism_taxid: 32630. Expressed in: brevibacillus choshinensis.
|
|
|
Chain:
A
(539 residues)
|
|
|
|
|
|
Human insulin receptor bound with a62-dimer, pseudo-arrowhead conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(799 residues)
|
|
|
|
|
|
Human insulin receptor bound with a62-dimer, arrowhead conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: insr. Expressed in: homo sapiens. Expression_system_taxid: 9606. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chains:
E, F
(799 residues)
|
|
|
|
|
|
Structure of the her2 (s310f) - pertuzumab (t30s/d31a) complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: erbb2, her2, mln19, neu, ngl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_taxid: 9606
|
|
|
Chain:
A
(553 residues)
|
|
|
|
|
|
Az5104 (metabolite of azd9291) in complex with wt egfr
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Her2/erbb2 extracellular domain (ecd) in compact conformation in complex with trastuzumab (tzb) antibody
|
|
|
Source: Homo sapiens, aequorea victoria. Human. Organism_taxid: 9606, 6100. Gene: erbb2, her2, mln19, neu, ngl, gfp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(504 residues)
|
|
|
|
|
|
Her2/erbb2 extracellular domain (ecd) in extended conformation in complex with trastuzumab (tzb) antibody
|
|
|
Source: Homo sapiens, aequorea victoria. Human. Organism_taxid: 9606, 6100. Gene: erbb2, her2, mln19, neu, ngl, gfp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(508 residues)
|
|
|
|
|
|
Her2/erbb2 extracellular domain (ecd) from a near full-length construct solubilized in amphipols.
|
|
|
Source: Homo sapiens, aequorea victoria. Human. Organism_taxid: 9606, 6100. Gene: erbb2, her2, mln19, neu, ngl, gfp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(508 residues)
|
|
|
|
|
|
Crystal structure of the brl3 ectodomain from arabidopsis thaliana in complex with brassinolide.
|
|
|
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Strain: col-0. Gene: brl3, at3g13380, mrp15.1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(721 residues)
|
|
|
[IntEnz]
[ExPASy]
[KEGG]
