PDBsum entry 8vvf

Membrane protein

PDB id: 8vvf

Contents

Protein chains

286 a.a.

339 a.a.

55 a.a.

223 a.a.

232 a.a.

Ligands

JDC

PDB id:

8vvf

Name:

Membrane protein

Title:

Kappa opioid receptor:galphai protein in complex with inverse agonist jdtic

Structure:

Kappa-type opioid receptor. Chain: a. Synonym: k-or-1,kor-1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: c. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: oprk1, oprk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: gnai1.

Authors:

C.Gati,Z.Motiwala,A.S.Tyson,D.Styrpejko,G.W.Han,S.Khan,N.Ramos- Gonzalez,R.Shenvi,S.Majumdar

Key ref:

A.S.Tyson et al. Molecular mechanisms of inverse agonism via kappa-Opi receptor-G protein complexes. Nat chem biol, . PubMed id: 39775170

Date:

31-Jan-24 Release date: 15-Jan-25

Protein chain

P41145  (OPRK_HUMAN) -  Kappa-type opioid receptor from Homo sapiens

Seq: 380 a.a.

Struc: 286 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 223 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????