UniProt functional annotation for P41145



	UniProt functional annotation for P41145

UniProt code: P41145.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.

Subunit: Interacts with SLC9A3R1. Interacts with GABARAPL1. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:16431922, ECO:0000269|PubMed:22437504}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.

Tissue specificity: Detected in brain and placenta. {ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.

Similarity: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269\|PubMed:12004055, ECO:0000269\|PubMed:22437504, ECO:0000269\|PubMed:7624359, ECO:0000269\|PubMed:8060324}.


Subunit:		Interacts with SLC9A3R1. Interacts with GABARAPL1. {ECO:0000269\|PubMed:12004055, ECO:0000269\|PubMed:16431922, ECO:0000269\|PubMed:22437504}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:12004055, ECO:0000269\|PubMed:22437504, ECO:0000269\|PubMed:7624359, ECO:0000269\|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269\|PubMed:12004055, ECO:0000269\|PubMed:22437504, ECO:0000269\|PubMed:7624359, ECO:0000269\|PubMed:8060324}.
Tissue specificity:		Detected in brain and placenta. {ECO:0000269\|PubMed:7624359, ECO:0000269\|PubMed:8060324}.
Similarity:		Belongs to the G-protein coupled receptor 1 family. {ECO:0000255\|PROSITE-ProRule:PRU00521}.