PDBsum entry 7na7

Membrane protein

PDB id: 7na7

Contents

Protein chains

217 a.a.

336 a.a.

54 a.a.

232 a.a.

291 a.a.

12 a.a.

Ligands

CLR ×2

PDB id:

7na7

Name:

Membrane protein

Title:

Structures of human ghrelin receptor-gi complexes with ghrelin and a synthetic agonist

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: insect expression vector pbluebacmsgca1his. Expression_system_taxid: 1944738. Gene: gnb1. Gene: gng2. Mus musculus.

Authors:

H.Liu,D.Sun,J.Sun,C.Zhang

Key ref:

H.Liu et al. (2021). Structural basis of human ghrelin receptor signaling ghrelin and the synthetic agonist ibutamoren. Nat commun, 12, 6410.

Date:

20-Jun-21 Release date: 15-Dec-21

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.*

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

Q92847  (GHSR_HUMAN) -  Growth hormone secretagogue receptor type 1 from Homo sapiens

Seq: 366 a.a.

Struc: 291 a.a.*

Protein chain

Q9UBU3  (GHRL_HUMAN) -  Appetite-regulating hormone from Homo sapiens

Seq: 117 a.a.

Struc: 12 a.a.*

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, G, R, L: E.C.?