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PDBsum entry 6s1f
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Signaling protein
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PDB id
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6s1f
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PDB id:
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| Name: |
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Signaling protein
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Title:
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Structure of the kinase domain of human ripk2 in complex with the inhibitor cslp3
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Structure:
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Receptor-interacting serine/threonine-protein kinase 2. Chain: a, b, c, d. Synonym: card-containing interleukin-1 beta-converting enzyme- associated kinase,card-containing il-1 beta ice-kinase,rip-like- interacting clarp kinase,receptor-interacting protein 2,rip-2, tyrosine-protein kinase ripk2. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Resolution:
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3.11Å
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R-factor:
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0.256
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R-free:
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0.300
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Authors:
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D.M.Pinkas,J.C.Bufton,K.Kupinska,N.A.Burgess-Brown,F.Von Delft, C.H.Arrowsmith,A.M.Edwards,C.Bountra,A.N.Bullock
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Key ref:
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C.Suebsuwong
et al.
Design of 3,5-Diaryl-2-Aminopyridines as receptor-Interacting protein kinase 2 (ripk2) and nucleotide-Binding oligomerization domain (nod) cell signaling inhibitors.
To be published,
.
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Date:
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18-Jun-19
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Release date:
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16-Oct-19
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PROCHECK
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Headers
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References
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O43353
(RIPK2_HUMAN) -
Receptor-interacting serine/threonine-protein kinase 2 from Homo sapiens
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Seq:
Struc:
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540 a.a.
291 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class 2:
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E.C.2.7.10.2
- non-specific protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Enzyme class 3:
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E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
