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PDB code
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Protein
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C-src (sh2 domain) complexed with ace-malonyl tyr-glu-(n,n-dipentyl amine)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Gene: src. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chains:
A, B
(105 residues)
CATH domain:
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C-src (sh2 domain) complexed with ace-difluoro phosphotyr-glu-(n,n- dipentyl amine)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Gene: src. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chains:
A, B
(105 residues)
CATH domain:
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C-src (sh2 domain) complexed with ace-formyl phosphotyr-glu-(n,n- dipentyl amine)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Gene: src. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chains:
A, B
(106 residues)
CATH domain:
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Nmr study of the sh3 domain from fyn proto-oncogene tyrosine kinase complexed with the synthetic peptide p2l corresponding to residues 91-104 of the p85 subunit of pi3-kinase, family of 25 structures
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Chain:
B
(58 residues)
CATH domain:
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C-src (sh2 domain with c188a mutation) complexed with ace-formyl phosphotyr-glu-(n,n-dipentyl amine)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Chains:
A, B
(106 residues)
CATH domain:
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C-src (sh2 domain) complexed with ace-phosphotyr-glu-(n,n-dipentyl amine)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Chains:
A, B
(105 residues)
CATH domain:
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C-src (sh2 domain) complexed with ace-phosphotyr-glu-(n-me(-(ch2)3- cyclopentyl))
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Chains:
A, B
(105 residues)
CATH domain:
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C-src (sh2 domain) complexed with ace-phosphotyr-glu-(3- butylpiperidine)
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Chains:
A, B
(104 residues)
CATH domain:
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Bis mg-atp-k-oxalate complex of pyruvate kinase
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Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle
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Chains:
A, B, C, D, E, F, G, H
(519 residues)
CATH domains:
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Bound ligands:
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Het Group ATP
corresponds to
enzyme reactant ATP
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Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
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Pyruvate kinase complex with bis mg-atp-na-oxalate
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Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle
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Chains:
A, B, C, D, E, F, G, H
(519 residues)
CATH domains:
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Bound ligands:
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Het Group ATP
corresponds to
enzyme reactant ATP
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Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
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Crystal structure of the tandem sh2 domain of the syk kinase bound to a dually tyrosine-phosphorylated itam
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
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Chains:
A, C, E, G, I, K
(254 residues)
CATH domains:
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Three-dimensional solution structure of the src homology 2 domain of c-abl
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Source: Homo sapiens. Human. Organism_taxid: 9606
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Chain:
A
(109 residues)
CATH domain:
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Crystal structure of the complex of the abl tyrosine kinase sh3 domain with 3bp-1 synthetic peptide
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Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
A, B
(58 residues)
CATH domain:
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Crystal structure of the unliganded abl tyrosine kinase sh3 domain
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Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(56 residues)
CATH domain:
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Src family kinase hck-amp-pnp complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Gene: human hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Chains:
A, B
(438 residues)
CATH domains:
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Bound ligand:
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Het Group ANP
is 81.25% similar to
enzyme product ADP
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Nmr structure of the fyn sh2 domain complexed with a phosphotyrosyl peptide, minimized average structure
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: lyss. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Hamster polyomavirus. Organism_taxid: 10626
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Chain:
F
(106 residues)
CATH domain:
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Nmr structure of the fyn sh2 domain complexed with a phosphotyrosyl peptide, 22 structures
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: lyss. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Hamster polyomavirus. Organism_taxid: 10626
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Chain:
F
(106 residues)
CATH domain:
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Pyruvate kinase from rabbit muscle with mg, k, and l-phospholactate
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Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle
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Chains:
A, B, C, D, E, F, G, H
(519 residues)
CATH domains:
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Bound ligand:
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Het Group PEQ
corresponds to
enzyme product phosphoenolpyruvate
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Fkbp-rapamycin binding domain (frb) of the fkbp-rapamycin associated protein
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jurkat tcell cdna library. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chains:
A, B
(92 residues)
CATH domain:
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V-1 nef protein in complex with wild type fyn sh3 domain
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Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Variant: lai isolate. Cell_line: bl21. Gene: HIV-1 nef. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human.
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Chain:
C
(57 residues)
CATH domain:
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Intramolecular itk-proline complex, nmr, minimized average structure
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Source: Mus musculus. House mouse. Organism_taxid: 10090. Organ: thymus. Cell: t-cell. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chain:
A
(77 residues)
CATH domain:
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The solution nmr structure of abl sh3 and its relationship to sh2 in the sh(32) construct, 20 structures
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: expressed as gst fusions and cleaved
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Chain:
A
(57 residues)
CATH domain:
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Sh3 domain from bruton's tyrosine kinase, nmr, 42 structures
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Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(67 residues)
CATH domain:
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Sh3 domain from bruton's tyrosine kinase, nmr, minimized average structure
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Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(67 residues)
CATH domain:
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Nmr study of the sh3 domain from fyn proto-oncogene tyrosine kinase kinase complexed with the synthetic peptide p2l corresponding to residues 91-104 of the p85 subunit of pi3-kinase, minimized average (probmap) structure
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chain:
B
(58 residues)
CATH domain:
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Ph domain from bruton's tyrosine kinase in complex with inositol 1,3, 4,5-tetrakisphosphate
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Cell: b-lymphocyte. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chains:
A, B
(163 residues)
CATH domain:
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Crystal structure of the abl-sh3 domain complexed with a designed high-affinity peptide ligand: implications for sh3-ligand interactions
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
A, C, E, G
(58 residues)
CATH domain:
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P56lck sh2 domain inhibitor complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
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Chain:
A
(105 residues)
CATH domain:
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Free p56lck sh2 domain
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Chains:
A, B
(104 residues)
CATH domain:
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Self-associated apo src sh2 domain
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Source: Rous sarcoma virus. Organism_taxid: 11886. Strain: schmidt-ruppin strain a. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(110 residues)
CATH domain:
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Cocrystal structure of d-amino acid substituted phosphopeptide complex
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Source: Rous sarcoma virus. Organism_taxid: 11886. Strain: schmidt-ruppin strain a. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(102 residues)
CATH domain:
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Nmr ensemble of blk sh2 domain, 20 structures
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Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: p55 blk kinase (residues 107 -. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chain:
A
(114 residues)
CATH domain:
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Nmr ensemble of blk sh2 domain using chemical shift refinement, 20 structures
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Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: p55 blk kinase (residues 107 -. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chain:
A
(114 residues)
CATH domain:
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Ph domain and btk motif from bruton's tyrosine kinase mutant r28c
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Cell: b-lymphocyte. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chains:
A, B
(160 residues)
CATH domain:
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Src family kinase hck sh3 domain
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21 (de3). Gene: human hck. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chains:
A, B, C, D, E, F
(57 residues)
CATH domain:
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Ph domain and btk motif from bruton's tyrosine kinase mutant e41k in complex with ins(1,3,4,5)p4
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Cell: b-lymphocyte. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chains:
A, B
(166 residues)
CATH domain:
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Kinase domain of human c-terminal src kinase (csk) in complex with inhibitor staurosporine
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Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: lung. Cell: granulocyte. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: the cdna for the catalytic domain of csk was isolated by polymerase chain reaction from granulocyte cdna obtained from
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Chain:
A
(246 residues)
CATH domains:
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Cdc42/ack gtpase-binding domain complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 9606
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Chain:
B
(44 residues)
CATH domain:
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Bound ligand:
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Het Group GNP
is 78.79% similar to
enzyme product ADP
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The crystal structure of human csksh3: structural diversity near the rt-src and n-src loop
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Source: Homo sapiens. Human. Organism_taxid: 9606
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Chains:
A, B, C, D
(58 residues)
CATH domain:
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Syk tyrosine kinasE C-terminal sh2 domain complexed with a phosphopeptidefrom the gamma chain of the high affinity immunoglobin g receptor, nmr
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: recombinant construct added to protein domain
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Chain:
A
(112 residues)
CATH domain:
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Syk tyrosine kinasE C-terminal sh2 domain complexed with a phosphopeptidefrom the gamma chain of the high affinity immunoglobin g receptor, nmr
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: recombinant construct added to protein domain
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Chain:
A
(112 residues)
CATH domain:
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Human p56lck tyrosine kinase complexed with phosphopeptide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
L
(98 residues)
CATH domain:
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Human p56lck tyrosine kinase complexed with phosphopeptide
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 32630. Other_details: synthesized using step-wise na-fmoc strategy
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Chains:
A, C
(98 residues)
CATH domain:
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HIV-1 nef protein in complex with r96i mutant fyn sh3 domain
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: HIV-1 nef. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Human immunodeficiency virus 1. Organism_taxid: 11676. Strain: nl4-3.
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Chains:
A, C
(57 residues)
CATH domain:
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Src sh2 thref1trp mutant complexed with the phosphopeptide s(ptr)vnvqn
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Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized
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Chain:
A
(104 residues)
CATH domain:
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Src sh2 thref1trp mutant
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Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(104 residues)
CATH domain:
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Recombinant rabbit muscle pyruvate kinase
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Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
A, B, C, D, E, F, G, H
(519 residues)
CATH domains:
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Bound ligand:
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Het Group PYR
corresponds to
enzyme reactant pyruvate
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S402p mutant of rabbit muscle pyruvate kinase
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Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chains:
A, B, C, D, E, F, G, H
(519 residues)
CATH domains:
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Bound ligand:
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Het Group PYR
corresponds to
enzyme reactant pyruvate
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Wstf-phd
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
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Chain:
A
(51 residues)
CATH domain:
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The structure of the immunophilin-immunosuppressant fkbp12-rapamycin complex interacting with human frap
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: human hippocampal cdna library. Expressed in: escherichia coli. Expression_system_taxid: 562. Palo alto, ca).
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Chain:
B
(95 residues)
CATH domain:
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Structure-based design of a novel, osteoclast-selective, nonpeptide src sh2 inhibitor with in vivo anti-resorptive activity
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
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Chains:
A, B
(104 residues)
CATH domain:
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Crystal structure of human tyrosine-protein kinasE C-src
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Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
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Chain:
A
(438 residues)
CATH domains:
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Crystal structure of abl kinase domain in complex with a small molecule inhibitor
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Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Chains:
A, B
(275 residues)
CATH domains:
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Phosphotransferase
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Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21 de3. Gene: fyn tyrosine kinase. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Chain:
A
(62 residues)
CATH domain:
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Crystal structure of fyn sh3-sh2
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chains:
A, B
(161 residues)
CATH domains:
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Nmr structure of the sh3 domain from the tec protein tyrosine kinase
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Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: gst-fusion
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Chain:
A
(67 residues)
CATH domain:
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Sh3 domain of human lck tyrosine kinase
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Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: intracellular. Expressed in: escherichia coli. Expression_system_taxid: 511693.
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Chain:
A
(63 residues)
CATH domain:
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Nmr structure of the human src sh2 domain complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nucleotide sequence a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chain:
B
(107 residues)
CATH domain:
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Bound ligand:
|
Het Group PTR
is 76.19% similar to
enzyme product [protein]-L-tyrosine phosphate
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Nmr structure of the human src sh2 domain complex
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Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nucleotide sequence a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Chain:
B
(107 residues)
CATH domain:
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Bound ligand:
|
Het Group PTR
is 76.19% similar to
enzyme product [protein]-L-tyrosine phosphate
|
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Crystal structure of thE C-abl kinase domain in complex with sti-571.
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|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(274 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of lck sh2 complexed with nonpeptide phosphotyrosine mimetic
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(104 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of a complex of the src sh2 domain with conformationally constrained peptide inhibitor
|
|
|
Source: Rous sarcoma virus. Organism_taxid: 11886. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized.
|
|
|
Chains:
A, B
(102 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the sh3 domain from c-terminal src kinase complexed with a peptide from the tyrosine phosphatase pep
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
|
|
|
Chain:
A
(60 residues)
CATH domain:
|
|
|
|
|
|
Ternary complex of an crk sh2 domain, crk-derived phophopeptide, and abl sh3 domain by nmr spectroscopy
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Mus musculus. House mouse. Organism_taxid: 10090.
|
|
|
Chain:
C
(60 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure analysis of the sh2 domain of the csk homologous kinase chk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: matk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(97 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the focal adhesion targeting domain of focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fak. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(142 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the focal adhesion targeting domain of focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fak. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C
(135 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bruton's tyrosine kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(258 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the fat domain of focal adhesion kinase
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(126 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure analysis of full-length carboxyl-terminal src kinase at 2.5 a resolution
|
|
|
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D, E, F
(439 residues)
CATH domains:
|
|
|
|
|
|
Structure of the triple (lys(beta)d3ala, asp(beta)c8ala, aspcd2ala) mutant of the src sh2 domain bound to the pqpyeeipi peptide
|
|
|
Source: Rous sarcoma virus. Organism_taxid: 11886. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized.
|
|
|
Chain:
A
(96 residues)
CATH domain:
|
|
|
|
|
|
Sh3 domain of lymphocyte specific kinase (lck)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
Structure of human c-src tyrosine kinase (thr338gly mutant) in complex with n6-benzyl adp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(450 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group NBS
is 79.41% similar to
enzyme product ADP
|
|
|
|
|
|
|
Solution structure of fat domain of focal adhesion kinase
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(139 residues)
CATH domains:
|
|
|
|
|
|
Sh2 (src homology-2) domain of human p56-lck tyrosine kinase complexed with the 11 residue phosphotyrosyl peptide epqpyeeipiyl
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(104 residues)
CATH domain:
|
|
|
|
|
|
Sh3-sh2 domain fragment of human p56-lck tyrosine kinase complexed with the 10 residue synthetic phosphotyrosyl peptide tegqpyqpqpa
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: tail. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(164 residues)
CATH domains:
|
|
|
|
|
|
Human p56-lck tyrosine kinase sh2 domain in complex with the phosphotyrosyl peptide ac-ptyr-glu-glu-ile (pyeei peptide)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(105 residues)
CATH domain:
|
|
|
|
|
|
Human p56-lck tyrosine kinase sh2 domain in complex with the phosphotyrosyl peptide ac-ptyr-glu-glu-gly (pyeeg peptide)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(104 residues)
CATH domain:
|
|
|
|
|
|
Nmr structures of itk sh2 domain, pro287cis isoform, ensemble of 20 low energy structures
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(110 residues)
CATH domain:
|
|
|
|
|
|
Nmr structure of the itk sh2 domain, pro287cis, energy minimized average structure
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(110 residues)
CATH domain:
|
|
|
|
|
|
Nmr structure of the itk sh2 domain, pro287trans, 20 low energy structures
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(110 residues)
CATH domain:
|
|
|
|
|
|
Nmr structure of the itk sh2 domain, pro287trans, energy minimized average structure
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(110 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sap/fynsh3/slam ternary complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans. This sequence was chemically synthesized.. Expression_system_taxid: 562
|
|
|
Chain:
C
(61 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of thE C-abl kinase domain in complex with pd173955
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the apo sh2 domains of zap-70
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(259 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of focal adhesion kinase (fak)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi 5.
|
|
|
Chain:
A
(252 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Structure of signal transduction protein, nmr, minimized average structure
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: chicken. Expressed in: gst-fusion.
|
|
|
Chain:
C
(56 residues)
CATH domain:
|
|
|
|
|
|
Structure of signal transduction protein, nmr, minimized average structure
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: chicken. Expressed in: gst-fusion.
|
|
|
Chain:
C
(56 residues)
CATH domain:
|
|
|
|
|
|
The structure of the immunophilin-immunosuppressant fkbp12-rapamycin complex interacting with human frap
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: human hippocampal cdna library. Expressed in: escherichia coli. Expression_system_taxid: 562. Palo alto, ca). Palo alto, ca)
|
|
|
Chain:
B
(94 residues)
CATH domain:
|
|
|
|
|
|
Nmr study of the sh3 domain from fyn proto-oncogene tyrosine kinase, minimized average (probmap) structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(58 residues)
CATH domain:
|
|
|
|
|
|
Nmr study of the sh3 domain from fyn proto-oncogene tyrosine kinase, family of 20 structures
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(58 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of src sh2 domain bound to doubly phosphorylated peptide pqpyepyipi
|
|
|
Source: Rous sarcoma virus (strain schmidt-ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Gene: v-src. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes
|
|
|
Chains:
A, B
(101 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of src sh2 domain bound to doubly phosphorylated peptide pqpyipyvpa
|
|
|
Source: Rous sarcoma virus (strain schmidt-ruppin). Organism_taxid: 11889. Strain: schmidt-ruppin. Gene: v-src. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes
|
|
|
Chains:
A, B
(101 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru78300.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru81843.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru82129.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru85052
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru84687.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru90395.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru82209.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru85053.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru85493.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru82197.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru83876.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with phosphate.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(105 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru78262.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(105 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru78299.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru79073.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(105 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with dpi59.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru79072.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with pas219.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with iso24.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with pasbn.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with fragment2.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(105 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with malonicacid.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(105 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with oxalic acid.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with phenylphosphate.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru78791.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(105 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru79256.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 in complex with ru78783.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(105 residues)
CATH domain:
|
|
|
|
|
|
Structural basis for the auto-inhibition of c-abl tyrosine kinase
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: abl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(287 residues)
CATH domains:
|
|
|
|
|
|
Structural basis for the auto-inhibition of c-abl tyrosine kinase
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: abl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(449 residues)
CATH domains:
|
|
|
|
|
|
Structural basis for the auto-inhibition of c-abl tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(451 residues)
CATH domains:
|
|
|
|
|
|
Paxillin ld4 motif bound to the focal adhesion targeting (fat) domain of the focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2 or fak1 or fak. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: sequence derived from human paxillin
|
|
|
Chains:
A, B, C
(134 residues)
CATH domains:
|
|
|
|
|
|
Paxillin ld4 motif bound to the focal adhesion targeting (fat) domain of the focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2 or fak1 or fak. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: sequence derived from human paxillin
|
|
|
Chains:
A, B, C
(134 residues)
CATH domains:
|
|
|
|
|
|
Paxillin ld2 motif bound to the focal adhesion targeting (fat) domain of the focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2 or fak1 or fak. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: sequence derived from human paxillin
|
|
|
Chains:
A, B, C
(134 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the src sh2 domain complexed with peptide (sdpyanfk)
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: the peptide was chemically synthesized.
|
|
|
Chains:
A, B
(102 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group PTR
is 76.19% similar to
enzyme product [protein]-L-tyrosine phosphate
|
|
|
|
|
|
|
The refined three-dimensional structure of cat muscle (m1) pyruvate kinase, at a resolution of 2.6 angstroms
|
|
|
Source: Felis catus. Domestic cat. Organism_taxid: 9685. Tissue: muscle
|
|
|
Chain:
A
(519 residues)
CATH domains:
|
|
|
|
|
|
Structure of rabbit muscle pyruvate kinase complexed with mn2+, k+, and pyruvate
|
|
|
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986
|
|
|
Chain:
A
(514 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group PYR
corresponds to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Two binding orientations for peptides to src sh3 domain: development of a general model for sh3-ligand interactions
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: synthetic oligo. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
C
(56 residues)
CATH domain:
|
|
|
|
|
|
Two binding orientations for peptides to src sh3 domain: development of a general model for sh3-ligand interactions
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: synthetic oligo. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
C
(56 residues)
CATH domain:
|
|
|
|
|
|
Protein kinasE C delta cys2 domain
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(50 residues)
CATH domain:
|
|
|
|
|
|
Protein kinasE C delta cys2 domain complexed with phorbol-13-acetate
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(50 residues)
CATH domain:
|
|
|
|
|
|
Nmr solution structure of the avian fat-domain of focal adhesion kinase
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: fak1 or fak. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(146 residues)
CATH domains:
|
|
|
|
|
|
Solution structure of t-cell surface glycoprotein cd4 and proto- oncogene tyrosine-protein kinase lck fragments
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cd4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: lck.
|
|
|
Chain:
B
(29 residues)
|
|
|
|
|
|
Solution structure of t-cell surface glycoprotein cd8 alpha chain and proto-oncogene tyrosine-protein kinase lck fragments
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cd8a or mal. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: lck.
|
|
|
Chain:
B
(29 residues)
|
|
|
|
|
|
Crystal structure of hck in complex with a src family-selective tyrosine kinase inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck.
|
|
|
Chain:
A
(450 residues)
CATH domains:
|
|
|
|
|
|
Nmr study of the sh3 domain from bruton's tyrosine kinase, 20 structures
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(58 residues)
CATH domain:
|
|
|
|
|
|
Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective and src family selective kinase inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: lymphocyte. Cellular_location: cytoplasm. Gene: lck. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell: lymphocyte.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 92.86% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective and src family selective kinase inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: lymphocyte. Cellular_location: cytoplasm. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell: lymphocyte.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
Structural analysis of the lymphocyte-specific kinase lck in complex with non-selective and src family selective kinase inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: lymphocyte. Cellular_location: cytoplasm. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the lymphocyte-specific kinase lck in complex with staurosporine.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: lymphocyte. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
|
|
Structure of the double-stranded RNA-binding domain of the protein kinase pkr reveals the molecular basis of its dsrna-mediated activation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(179 residues)
CATH domains:
|
|
|
|
|
|
Solution structure of the fat domain of focal adhesion kinase
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: fak. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(134 residues)
CATH domain:
|
|
|
|
|
|
C-src sh3 domain complexed with ligand app12
|
|
|
Source: Avian sarcoma virus. Organism_taxid: 11876. Gene: chicken. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: gst-fusion.
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
C-src sh3 domain complexed with ligand vsl12
|
|
|
Source: Avian sarcoma virus. Organism_taxid: 11876. Gene: chicken. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: gst-fusion.
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
Solution structure and backbone dynamics of the nonreceptor tyrosine kinase ptk6/brk sh2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(100 residues)
CATH domain:
|
|
|
|
|
|
Two binding orientations for peptides to src sh3 domain: development of a general model for sh3-ligand interactions
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: synthetic oligo. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
C
(56 residues)
CATH domain:
|
|
|
|
|
|
Two binding orientations for peptides to src sh3 domain: development of a general model for sh3-ligand interactions
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: synthetic oligo. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
C
(56 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the phosphotyrosine recognition domain sh2 of v- src complexed with tyrosine-phosphorylated peptides
|
|
|
Source: Rous sarcoma virus. Organism_taxid: 11886. Organism_taxid: 11886
|
|
|
Chain:
A
(103 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the phosphotyrosine recognition domain sh2 of v- src complexed with tyrosine-phosphorylated peptides
|
|
|
Source: Rous sarcoma virus. Organism_taxid: 11886. Organism_taxid: 11886
|
|
|
Chain:
A
(103 residues)
CATH domain:
|
|
|
|
|
|
Peptide inhibitors of src sh3-sh2-phosphoprotein interactions
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(101 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the sh3 domain in human fyn; comparison of the three-dimensional structures of sh3 domains in tyrosine kinases and spectrin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B
(59 residues)
CATH domain:
|
|
|
|
|
|
Cocrystal structure of urea-substituted phosphopeptide complex
|
|
|
Source: Rous sarcoma virus. Organism_taxid: 11886. Strain: schmidt-ruppin strain a. Cell_line: jm 83. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: jm83.
|
|
|
Chain:
A
(102 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the phosphorylated interleukin-2 tyrosine kinase catalytic domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, lyk, emt. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(245 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the unphosphorylated interleukin-2 tyrosine kinase catalytic domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, lyk, emt. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(245 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of apo interleukin-2 tyrosine kinase catalytic domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, lyk, emt. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(245 residues)
CATH domains:
|
|
|
|
|
|
Binding of a high affinity phosphotyrosyl peptide to the src sh2 domain: crystal structures of the complexed and peptide-free forms
|
|
|
Source: Rous sarcoma virus. Organism_taxid: 11886
|
|
|
Chains:
A, B, C, D
(103 residues)
CATH domain:
|
|
|
|
|
|
Binding of a high affinity phosphotyrosyl peptide to the src sh2 domain: crystal structures of the complexed and peptide-free forms
|
|
|
Source: Rous sarcoma virus. Organism_taxid: 11886. Hamster polyomavirus. Organism_taxid: 10626
|
|
|
Chains:
A, B, C
(103 residues)
CATH domain:
|
|
|
|
|
|
1h and 15n assignments and secondary structure of the src sh3 domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
1h and 15n assignments and secondary structure of the src sh3 domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
Human pyruvate kinase m2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(519 residues)
CATH domains:
|
|
|
|
Bound ligands:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of the unphosphorylated kinase domain of the tyrosine kinase ack1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-9.
|
|
|
Chains:
A, B
(255 residues)
CATH domains:
|
|
|
|
|
|
Structure of the ack1 kinase domain bound to debromohymenialdisine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(258 residues)
CATH domains:
|
|
|
|
|
|
Crystal structures of the phosphorylated and unphosphorylated kinase domains of the cdc42-associated tyrosine kinase ack1 bound to amp-pcp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-9.
|
|
|
Chains:
A, B
(263 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the zap-70 kinase domain in complex with staurosporine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: zap70, srk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(282 residues)
CATH domains:
|
|
|
|
|
|
Sh3 domain of human lyn tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(60 residues)
CATH domain:
|
|
|
|
|
|
Sh3 domain of human lyn tyrosine kinase in complex with a herpesviral ligand
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: intracellular. Expressed in: escherichia coli. Expression_system_taxid: 511693. Saimiriine herpesvirus 2. Human saimiriine herpesvirus 2. Organism_taxid: 10381.
|
|
|
Chain:
A
(60 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the human fes sh2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(114 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of lck sh2-sh3 with sh2 binding site of p130cas
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: the peptide was chemically synthesized. Identical to naturally accured sequence in p130cas
|
|
|
Chains:
A, B, C, D, E, F
(163 residues)
CATH domains:
|
|
|
|
|
|
Solution structure of the second dsrm domain in interferon-induced, double-stranded RNA-activated protein kinase
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: prkr, eif2ak2, pkr, tik. Other_details: cell free protein synthesis
|
|
|
Chain:
A
(88 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the first dsrm domain in interferon-induced, double-stranded RNA-activated protein kinase
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: prkr, eif2ak2, pkr, tik. Other_details: cell free protein synthesis
|
|
|
Chain:
A
(97 residues)
CATH domain:
|
|
|
|
|
|
Solution structures of the sh3 domain of human megakaryocyte- associated tyrosine-protein kinase.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: matk. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(81 residues)
CATH domain:
|
|
|
|
|
|
Structure of human wee1a kinase: kinase domain complexed with inhibitor pd0407824
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(259 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of apo syk tyrosine kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the syk tyrosine kinase domain with gleevec
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the syk tyrosine kinase domain with staurosporin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Structure of unphosphorylated c-src in complex with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(452 residues)
CATH domains:
|
|
|
|
|
|
C-term tail segment of human tyrosine kinase (258-533)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(276 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of src kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(234 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of src kinase domain in complex with cgp77675
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(256 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of src kinase domain in complex with purvalanol a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
|
|
|
|
|
|
The c2 domain of pkc is a new phospho-tyrosine binding domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized
|
|
|
Chain:
A
(126 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the jak3 kinase domain in complex with a staurosporine analogue
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Inferential structure determination of the fyn sh3 domain using noesy data from a 15n,h2 enriched protein
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(59 residues)
CATH domain:
|
|
|
|
|
|
Structure of human muscle pyruvate kinase (pkm2)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pkm. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(507 residues)
CATH domains:
|
|
|
|
|
|
Solution structure of the f-actin binding domain of bcr-abl/c-abl
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(109 residues)
CATH domain:
|
|
|
|
|
|
Pkr kinase domain- eif2alpha- amp-pnp complex.
|
|
|
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: sui2, tif211. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
B, C
(264 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Pkr kinase domain-eif2alpha complex
|
|
|
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: sui2, tif211. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chain:
B
(270 residues)
CATH domains:
|
|
|
|
|
|
Sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: abl sh3-sh2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(163 residues)
CATH domains:
|
|
|
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|
Focal adhesion kinase 1
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: fak1, fak. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(331 residues)
CATH domains:
|
|
|
|
|
|
Ferm domain of focal adhesion kinase
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: fak1, fak. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(343 residues)
CATH domains:
|
|
|
|
|
|
The structural basis of janus kinase 2 inhibition by a potent and specific pan-janus kinase inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Src kinase in complex with inhibitor ap23451
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-9.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Src kinase in complex with inhibitor ap23464
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-9.
|
|
|
Chain:
A
(254 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the human serine-threonine kinase 16 in complex with staurosporine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: rosetta ii.
|
|
|
Chains:
A, B
(291 residues)
CATH domains:
|
|
|
|
|
|
Src family kinase hck with bound inhibitor a-420983
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: lymphocyte. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(434 residues)
CATH domains:
|
|
|
|
|
|
Src family kinase hck with bound inhibitor a-770041
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: lymphocyte. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(434 residues)
CATH domains:
|
|
|
|
|
|
Src family kinase hck with bound inhibitor a-641359
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: lymphocyte. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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|
|
Chains:
A, B
(428 residues)
CATH domains:
|
|
|
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|
Solution structure of the sh3 domain of fyn-related kinase
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: frk. Other_details: cell free protein synthesis
|
|
|
Chain:
A
(77 residues)
CATH domain:
|
|
|
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|
Fully automated solution structure determination of the fes sh2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cell free synthesis. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(114 residues)
CATH domain:
|
|
|
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|
|
Solution structure of the sh2 domain of murine fyn-related kinase
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: frk. Expressed in: cell free synthesis. Other_details: cell free protein synthesis
|
|
|
Chain:
A
(121 residues)
CATH domain:
|
|
|
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|
Solution structure of the sh2 domain of human tyrosine-protein kinase txk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: txk. Expressed in: cell free synthesis. Other_details: cell free protein synthesis
|
|
|
Chain:
A
(125 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of fyn kinase domain complexed with staurosporine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
X
(263 residues)
CATH domains:
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Crystal structure of thE C-abl kinase domain in complex with inno-406
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(270 residues)
CATH domains:
|
|
|
|
|
|
Solution structure of the btk motif of tyrosine-protein kinase itk from human
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(64 residues)
CATH domain:
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|
Solution structure of the human abl2 sh2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl2. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(119 residues)
CATH domain:
|
|
|
|
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|
Solution structure of the human bmx sh2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmx. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(110 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of focal adhesion kinase domain complexed with 7h- pyrrolo [2,3-d] pyrimidine derivative
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(262 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 7PY
is 41.03% similar to
enzyme product ADP
|
|
|
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|
|
|
The nmr minimized average structure of the itk sh2 domain bound to a phosphopeptide
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: itk, emt, tlk, tsk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: the sequence of the peptide is naturally found in mus musculus (mouse).
|
|
|
Chain:
A
(109 residues)
CATH domain:
|
|
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|
The nmr ensemble structure of the itk sh2 domain bound to a phosphopeptide
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: itk, emt, tlk, tsk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence occurs naturally in mus musculus (mouse)
|
|
|
Chain:
A
(109 residues)
CATH domain:
|
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|
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|
Structure of the kinase domain of an imatinib-resistant abl mutant in complex with the aurora kinase inhibitor vx-680
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
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|
The structure of the immunophilin-immunosuppressant fkbp12-(c16)- ethoxy rapamycin complex interacting with huma
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: human hippocampal cdna library (clontech, palo alto, ca). Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: human hippocampal cdna library. Expressed in: escherichia coli bl21(de3).
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|
|
Chain:
B
(94 residues)
CATH domain:
|
|
|
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|
|
Structural basis for the requirement of two phosphotyrosines in signaling mediated by syk tyrosine kinase
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|
|
Source: Synthetic: yes. Other_details: peptide synthesis. Bos taurus. Cattle. Organism_taxid: 9913. Gene: plcg1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: bl21(de3).
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|
|
Chain:
B
(14 residues)
|
|
|
|
|
|
Organization of the sh3-sh2 unit in active and inactive forms of the c-abl tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: c-abl. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(466 residues)
CATH domains:
|
|
|
|
|
|
A src-like inactive conformation in the abl tyrosine kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: solid phase peptide synthesis
|
|
|
Chains:
A, B, C, D
(271 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 112
is 83.33% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
A src-like inactive conformation in the abl tyrosine kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: solid phase peptide synthesis
|
|
|
Chains:
A, B
(275 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group AGS
is 93.75% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
A src-like inactive conformation in the abl tyrosine kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(272 residues)
CATH domains:
|
|
|
|
|
|
A src-like inactive conformation in the abl tyrosine kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: solid phase peptide synthesis
|
|
|
Chains:
A, B
(271 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
The location of the allosteric amino acid binding site of muscle pyruvate kinase.
|
|
|
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Other_details: muscle isozyme
|
|
|
Chains:
A, B, C, D, E, F, G, H
(519 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group PYR
corresponds to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Nmr solution structure of the frb domain of mtor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: frap1, frap, frap2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(100 residues)
CATH domain:
|
|
|
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|
|
Solution structures of the sh2 domain of bruton's tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(118 residues)
CATH domain:
|
|
|
|
|
|
X-ray crystal structure of dasatinib (bms-354825) bound to activated abl kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(278 residues)
CATH domains:
|
|
|
|
|
|
Src kinase in complex with a quinazoline inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9 cells.
|
|
|
Chain:
A
(445 residues)
CATH domains:
|
|
|
|
|
|
Src family kinase hck-quercetin complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Gene: human hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(438 residues)
CATH domains:
|
|
|
|
|
|
Yes sh3 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: yes1, yes. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(59 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of inactive conformation abl kinase catalytic domain complexed with type ii inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chains:
A, B
(274 residues)
CATH domains:
|
|
|
|
|
|
Hck kinase in complex with lck targetted inhibitor pg-1009247
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(269 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of src kinase domain in complex with covalent inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(251 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of src kinase domain in complex with covalent inhibitor pd168393
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(245 residues)
CATH domains:
|
|
|
|
|
|
Human abl kinase domain in complex with imatinib (sti571, glivec)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(263 residues)
CATH domains:
|
|
|
|
|
|
Abl kinase domain in complex with nvp-aeg082
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(265 residues)
CATH domains:
|
|
|
|
|
|
Abl kinase domain unligated and in complex with tetrahydrostaurosporine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C
(262 residues)
CATH domains:
|
|
|
|
|
|
Abl kinase domain in complex with pd180970
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(268 residues)
CATH domains:
|
|
|
|
|
|
Abl kinase domain in complex with nvp-afg210
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: abl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Sh3 domain of human lck
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(62 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of focal adhesion kinase domain with 2 molecules in the asymmetric unit complexed with adp and atp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ATP
corresponds to
enzyme reactant ATP
|
|
|
|
|
|
|
Wee1 kinase complex with inhibitor pd311839
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(256 residues)
CATH domains:
|
|
|
|
|
|
Wee1 kinase complexed with inhibitor pd330961
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(252 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a fragment of focal adhesion kinase containing the ferm and kinase domains.
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chain:
A
(611 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a fragment of focal adhesion kinase containing the ferm and kinase domains.
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B
(598 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a the active conformation of the kinase domain of focal adhesion kinase with a phosphorylated activation loop.
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chain:
A
(276 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure a two-chain complex between the ferm and kinase domains of focal adhesion kinase.
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B
(329 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chain:
A
(258 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chain:
A
(260 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chain:
A
(256 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chain:
A
(258 residues)
CATH domains:
|
|
|
|
|
|
Nmr structure of the apo v-src sh2 domain
|
|
|
Source: Rous sarcoma virus. Organism_taxid: 11886. Strain: schmidt-ruppin e. Gene: v-src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the binary complex between the sh3 and sh2 domain of interleukin-2 tyrosine kinase
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: itk, emt, tlk, tsk. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(63 residues)
CATH domain:
|
|
|
|
|
|
Ensemble structures of the binary complex between the sh3 and sh2 domain of interleukin-2 tyrosine kinase.
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: itk, emt, tlk, tsk. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(63 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of sh3 domain of ptk6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(72 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of c-terminal domain of tyrosine-protein kinase abl2 from homo sapiens, northeast structural genomics consortium (nesg) target hr5537a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl2, abll, arg. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(135 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of sh2 domain of proto-oncogene tyrosine-protein kinase fer from homo sapiens, northeast structural genomics consortium (nesg) target hr3461d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fer, tyk3. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(116 residues)
CATH domain:
|
|
|
|
|
|
Folding intermediate of the fyn sh3 a39v/n53p/v55l from nmr relaxation dispersion experiments
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
Nmr solution structure of fat domain of fak complexed with ld2 and ld4 motifs of paxillin
|
|
|
Source: Gallus gallus, unidentified. Chicken. Organism_taxid: 9031, 32644. Gene: ptk2, fak, fak1, pxn. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(176 residues)
CATH domain:
|
|
|
|
|
|
Fat-ld2 double labeled construct with free ld4 peptide
|
|
|
Source: Gallus gallus, unidentified. Organism_taxid: 9031, 32644. Gene: ptk2, fak, fak1, pxn. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_organelle: 469008.
|
|
|
Chain:
A
(161 residues)
CATH domain:
|
|
|
|
|
|
Fat domain of focal adhesion kinase tethered to ld4 motif of paxillin via ggs linker
|
|
|
Source: Gallus gallus, unidentified. Chicken. Organism_taxid: 9031, 32644. Gene: ptk2, fak, fak1, pxn. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(154 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the vav1 sh2 domain complexed with a syk-derived doubly phosphorylated peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: vav, vav1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Mus musculus. Mouse.
|
|
|
Chain:
B
(13 residues)
|
|
|
|
|
|
Structural and mechanistic insights into the interaction between pat pyk2 and paxillin ld motif
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(135 residues)
CATH domain:
|
|
|
|
|
|
Itk-sh3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(66 residues)
CATH domain:
|
|
|
|
|
|
Native structure of the fyn sh3 a39v/n53p/v55l
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(59 residues)
CATH domain:
|
|
|
|
|
|
Solution nmr structure of ph domain of tyrosine-protein kinase tec from homo sapiens, northeast structural genomics consortium (nesg) target hr3504c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: psctk4, tec. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(164 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the vav1 sh2 domain complexed with a syk-derived singly phosphorylated peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: vav1, vav. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Mus musculus. Mouse.
|
|
|
Chain:
B
(13 residues)
|
|
|
|
|
|
Human fyn sh2 free state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: de3.
|
|
|
Chain:
A
(100 residues)
CATH domain:
|
|
|
|
|
|
Structure of fyn protein sh2 bound
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(100 residues)
CATH domain:
|
|
|
|
|
|
Fyn sh2 domain in complex with the natural inhibitory phosphotyrosine peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: the sh2 domain from human p59fyn is represented by residues 149-248.. Synthetic: yes.
|
|
|
Chain:
A
(100 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of rip2 card
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(106 residues)
CATH domain:
|
|
|
|
|
|
P75ntr dd:rip2 card
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ngfr, tnfrsf16. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092.
|
|
|
Chain:
B
(105 residues)
|
|
|
|
|
|
The solution structure of the rapamycin-binding domain of mtor (frb)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(101 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the n114a mutant of abl-sh3 domain complexed with a designed high-affinity peptide ligand: implications for sh3-ligand interactions
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pbat4. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct.
|
|
|
Chains:
A, B
(58 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of furanopyrimidine 8 bound to lck
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: insect cell.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of furanopyrimidine 1 bound to lck
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: insect cell.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
X-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to lck
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: insect cell.
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of aminoquinazoline 1 bound to lck
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: insect cell.
|
|
|
Chains:
A, B
(244 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of aminoquinazoline 36 bound to lck
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: insect cell.
|
|
|
Chains:
A, B
(246 residues)
CATH domains:
|
|
|
|
|
|
Nmr structure analysis of the hematopoetic cell kinase sh3 domain complexed with an artificial high affinity ligand (pd1)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes
|
|
|
Chain:
A
(86 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of chicken c-src kinase domain in complex with the cancer drug imatinib.
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(265 residues)
CATH domains:
|
|
|
|
|
|
Nmr structure analysis of the hematopoetic cell kinase sh3 domain complexed with an artificial high affinity ligand (pd1)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes. Other_details: the peptide was identified as high affinity ligand of hck-sh3 from screening a phage displayed peptide libary, acetylated
|
|
|
Chain:
A
(86 residues)
CATH domain:
|
|
|
|
|
|
Tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in homo sapiens (humans)
|
|
|
Chain:
A
(254 residues)
CATH domains:
|
|
|
|
|
|
Autoinhibited intact human zap-70
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: zap70, srk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: baculovirus-infected insect cells sf9.
|
|
|
Chain:
A
(545 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Lck bound to imatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Chicken src tyrosine kinase
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031
|
|
|
Chain:
A
(426 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of drug resistant src kinase domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(255 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of src kinase domain with covalent inhibitor rl3
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(245 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of abl kinase bound with ppy-a
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of drug resistant src kinase domain with irreversible inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(251 residues)
CATH domains:
|
|
|
|
|
|
Nmr structure note: murine itk sh3 domain
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: itk, emt, tlk, tsk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(64 residues)
CATH domain:
|
|
|
|
|
|
Itk sh3 average minimized
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: itk, emt, tlk, tsk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(64 residues)
CATH domain:
|
|
|
|
|
|
Nmr structure of fkbp12-mtor frb domain-rapamycin complex structure determined based on pcs
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mtor, frap, frap1, frap2, raft1, rapt1.
|
|
|
Chain:
B
(94 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the sh2 domain of csk in complex with a phosphopeptide from cbp
|
|
|
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: csk. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: pag1, cbp, pag.
|
|
|
Chain:
A
(99 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of human tyrosine-protein kinasE C-src, in complex with amp-pnp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(450 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the t315i abl mutant in complex with the inhibitor pha-739358
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: autographa. Expression_system_taxid: 254361. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the chimerical mutant capabk55m protein
|
|
|
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: capa1, capb2. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chains:
A, B
(252 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Structure determination of aurora kinase in complex with inhibitor
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Inhibitors of jak2 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chains:
A, B
(278 residues)
CATH domains:
|
|
|
|
|
|
Human abl2 in complex with aurora kinase inhibitor vx-680
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B, C
(264 residues)
CATH domains:
|
|
|
|
|
|
Solution structure of the btk motif of human cytoplasmic tyrosine- protein kinase bmx
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmx. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(50 residues)
|
|
|
|
|
|
Solution structure of the sh3_1 domain of yamaguchi sarcoma viral (v- yes) oncogene homolog 1
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: yes1. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(109 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the sh3 domain of human tyrosine-protein kinase itk/tsk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk. Expressed in: cell-free protein synthesis.
|
|
|
Chain:
A
(85 residues)
CATH domain:
|
|
|
|
|
|
Solution structure of the first phorbol esters/diacylglycerol binding domain of human protein kinasE C, delta
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: prkcd. Other_details: cell-free protein synthesis
|
|
|
Chain:
A
(83 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of ph domain of bruton's tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(158 residues)
CATH domain:
|
|
|
|
|
|
Human wee1 kinase complexed with inhibitor pf0335770
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(261 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the t315i mutant of abl kinase bound with ppy-a
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of imidazo pyrazin 1 bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human lck, activated form (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Lyn tyrosine kinase domain, apo form
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(257 residues)
CATH domains:
|
|
|
|
|
|
Lyn tyrosine kinase domain-amp-pnp complex
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(257 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Lyn tyrosine kinase domain-pp2 complex
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(256 residues)
CATH domains:
|
|
|
|
|
|
Lyn tyrosine kinase domain-dasatinib complex
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(261 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Lyn kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
X
(259 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyrazin derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of triazolo pyrimidine derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of triazolo pyrimidine derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of imidazo pyrimidine derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group KSS
is 40.00% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of pyrrolo pyrazine derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group KSR
is 41.18% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of methoxy benzofuran derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of triazolone derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyrimidine amide 11 bound to lck
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Expression_system_collection: insect cell
|
|
|
Chain:
A
(261 residues)
CATH domains:
|
|
|
|
|
|
Cd4 endocytosis motif bound to the focal adhesion targeting (fat) domain of the focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes
|
|
|
Chains:
A, B, C
(134 residues)
CATH domains:
|
|
|
|
|
|
Wee1 kinase complex with inhibitor pd352396
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(258 residues)
CATH domains:
|
|
|
|
|
|
Wee1 kinase complex with inhibitor pd331618
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(250 residues)
CATH domains:
|
|
|
|
|
|
Pyruvate kinase m2 is a phosphotyrosine binding protein
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B, C, D
(518 residues)
CATH domains:
|
|
|
|
Bound ligands:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Pyruvate kinase m2 is a phosphotyrosine binding protein
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B, C, D
(512 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Crystal structure of human feline sarcoma viral oncogene homologue (v- fes)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fes, fps. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(373 residues)
CATH domains:
|
|
|
|
|
|
X-ray co-crystal structure aminobenzimidazole triazine 1 bound to lck
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: baculovirus. Expression_system_cell_line: insect cell
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
X-ray co-crystal structure of 2-amino-6-phenylpyrimido[5',4':5, 6]pyrimido[1,2-a]benzimidazol-5(6h)-one 25 bound to lck
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Expression_system_cell_line: insect cell
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Co-crystal structure of lck and aminopyrimidine amide 10b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: baculovirus. Expression_system_cell_line: insect cell
|
|
|
Chain:
A
(255 residues)
CATH domains:
|
|
|
|
|
|
Co-crystal structure of lck and aminopyrimidine reverse amide 23
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: baculovirus. Expression_system_cell_line: insect cell
|
|
|
Chain:
A
(256 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure analysis of focal adhesion kinase with a methanesulfonamide diaminopyrimidine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(259 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human feline sarcoma viral oncogene homologue (v- fes) in complex with staurosporine and a consensus peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fes, fps. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
|
|
|
Chain:
A
(356 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of kinase domain of protein tyrosine kinase 2 beta (ptk2b)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(269 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of phosphorylated human feline sarcoma viral oncogene homologue (v-fes) in complex with staurosporine and a consensus peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fes, fps. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
|
|
|
Chain:
A
(353 residues)
CATH domains:
|
|
|
|
|
|
Wee1 kinase complex with inhibitor pd074291
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: wee1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(258 residues)
CATH domains:
|
|
|
|
|
|
N53i v55l mutant of fyn sh3 domain
|
|
|
Source: Gallus gallus. Chicken. Expressed in: escherichia coli.
|
|
|
Chain:
A
(58 residues)
CATH domain:
|
|
|
|
|
|
Wee1 kinase complex with inhibitor pd259_809
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: wee1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(257 residues)
CATH domains:
|
|
|
|
|
|
Human abl kinase in complex with nilotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(264 residues)
CATH domains:
|
|
|
|
|
|
Structural basis for the recognition of c-src by its inactivator csk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csk. Expressed in: escherichia coli. Expression_system_taxid: 562. Gallus gallus. Chicken. Organism_taxid: 9031.
|
|
|
Chains:
A, B
(249 residues)
CATH domains:
|
|
|
|
|
|
Structural basis for the recognition of c-src by its inactivator csk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csk. Expressed in: escherichia coli. Expression_system_taxid: 562. Gallus gallus. Chicken. Organism_taxid: 9031.
|
|
|
Chains:
A, B, C, D
(257 residues)
|
|
|
|
|
|
Crystal structure of mutant abl kinase domain in complex with small molecule fragment
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl1, abl. Expressed in: escherichia coli
|
|
|
Chains:
A, B
(266 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of mutant abl kinase domain in complex with small molecule fragment
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl1, abl. Expressed in: escherichia coli
|
|
|
Chains:
A, B
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of mutant abl kinase domain in complex with small molecule fragment
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl1, abl. Expressed in: escherichia coli
|
|
|
Chains:
A, B
(266 residues)
CATH domains:
|
|
|
|
|
|
C-src kinase domain thr338ile mutant in complex with atpgs
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(279 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group AGS
is 93.75% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Chicken c-src kinase domain in complex with atpgs
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(267 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group AMP
is 85.19% similar to
enzyme product ADP
|
|
|
|
|
|
|
Fragment based discovery of jak-2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Fragment based discovery of jak-2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
A
(292 residues)
CATH domains:
|
|
|
|
|
|
Fragment based discovery of jak-2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of sh2 domain of human csk (carboxyl-terminal src kinase), oxidized form.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21(de3). Gene: csk. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(101 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh2 domain of human csk (carboxyl-terminal src kinase), c122s mutant.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21(de3). Gene: csk. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(102 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the n114t mutant of abl-sh3 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pbat4. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the n114q mutant of abl-sh3 domain complexed with a designed high-affinity peptide ligand: implications for sh3-ligand interactions
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pbat4. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct.
|
|
|
Chains:
A, B
(58 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the n114q mutant of abl-sh3 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pbat4. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(63 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the n114a mutant of abl-sh3 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pbat4. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(63 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the n114a mutant of abl-sh3 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pbat4. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of c-src in complex with pyrazolopyrimidine 3
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli.
|
|
|
Chain:
A
(254 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of c-src in complex with pyrazolopyrimidine 5
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli.
|
|
|
Chains:
A, B
(263 residues)
CATH domains:
|
|
|
|
|
|
Discovery and sar of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (syk)
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: insect cells.
|
|
|
Chain:
A
(255 residues)
CATH domains:
|
|
|
|
|
|
Targeted polypharmacology: crystal structure of thE C-src kinase domain in complex with pp121, a multitargeted kinase inhibitor
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(257 residues)
CATH domains:
|
|
|
|
|
|
Targeted polypharmacology: crystal structure of thE C-src kinase domain in complex with pp494, a multitargeted kinase inhibitor
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(238 residues)
CATH domains:
|
|
|
|
|
|
Targeted polypharmacology: crystal structure of thE C-src kinase domain in complex with pp102, a multitargeted kinase inhibitor
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(236 residues)
CATH domains:
|
|
|
|
|
|
Targeted polypharmacology: crystal structure of thE C-src kinase domain in complex with s1, a multitargeted kinase inhibitor
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(247 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ack1 with compound t95
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1. Expressed in: insect cells
|
|
|
Chains:
B, A
(270 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ack1 with compound t74
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1. Expressed in: insect cells
|
|
|
Chains:
A, B
(270 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyk2 complexed with pf-2318841
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(261 residues)
CATH domains:
|
|
|
|
|
|
Crystal structures of jak1 and jak2 inhibitor complexes
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, hcg_22179. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(282 residues)
CATH domains:
|
|
|
|
|
|
Crystal structures of jak1 and jak2 inhibitor complexes
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, hcg_22179. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with inhibitor rl38 (type iii)
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with inhibitor rl37 (type iii)
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with inhibitor rl45 (type ii)
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Drug resistant csrc kinase domain in complex with inhibitor rl45 (type ii)
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
C-src kinase domain in complex with small molecule inhibitor
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(264 residues)
CATH domains:
|
|
|
|
|
|
Atomic structures of the rapamycin analogs in complex with both human fkbp12 and frb domain of frap
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human hippocampal cdna library source 8 (clontech, palo alto, ca). Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 9606
|
|
|
Chain:
B
(94 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of thE C-src-sh3 domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: c-src, src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(57 residues)
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with ym193306
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(269 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with a 2- substituted 7-azaindole
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(262 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with r406
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Crystal structures of jak1 and jak2 inhibitor complexes
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2, jak2 (amino acids 843 - 1132). Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyk2-apo, proline-rich tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(262 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyk2 complexed with atpgs
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(259 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group AGS
is 93.75% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Crystal structure of pyk2 complexed with pf-431396
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(261 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyk2 complexed with birb796
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(254 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyk2 complexed with pf-4618433
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(259 residues)
CATH domains:
|
|
|
|
|
|
S437y mutant of human muscle pyruvate kinase, isoform m2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(455 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with dasatinib
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(256 residues)
CATH domains:
|
|
|
|
|
|
Equally potent inhibition of c-src and abl by compounds that recognize inactive kinase conformations
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(264 residues)
CATH domains:
|
|
|
|
|
|
Src thr338ile inhibited in the dfg-asp-out conformation
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(266 residues)
CATH domains:
|
|
|
|
|
|
The 1.6 a crystal structure of human bruton's tyrosine kinase bound to a pyrrolopyrimidine-containing compound
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
Structural basis for the chemical rescue of src kinase activity
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(272 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the focal adhesion targeting (fat) domain of pyk2 in complex with paxillin ld4 motif-derived peptides
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans
|
|
|
Chains:
A, B
(140 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the focal adhesion targeting (fat) domain of pyk2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(127 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the focal adhesion targeting (fat) domain of pyk2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(133 residues)
CATH domain:
|
|
|
|
|
|
Activator-bound structure of human pyruvate kinase m2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(514 residues)
CATH domains:
|
|
|
|
Bound ligands:
|
Het Group TLA
is 60.00% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Activator-bound structure of human pyruvate kinase m2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(519 residues)
CATH domains:
|
|
|
|
Bound ligands:
|
Het Group TLA
is 60.00% similar to
enzyme reactant pyruvate
|
|
|
Het Group ADP
is 66.67% similar to
enzyme product ADP
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
The crystal structure of human abl2 in complex with gleevec
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high5 insect cell.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the human fyn sh3 r96w mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(59 residues)
CATH domain:
|
|
|
|
|
|
Human fyn sh3 domain r96i mutant, crystal form i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(63 residues)
CATH domain:
|
|
|
|
|
|
Human fyn sh3 domain r96i mutant, crystal form ii
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(59 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of pyk2 in complex with sulfoximine-substituted trifluoromethylpyrimidine analog
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Activator-bound structure of human pyruvate kinase m2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(490 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Nmr ensemble of the uncomplexed human hck sh2 domain, 20 structures
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: residues e119-k224 of human hc. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(107 residues)
CATH domain:
|
|
|
|
|
|
The crystal structure of human abl2 in complex with 5-amino-3-{[4- (aminosulfonyl)phenyl]amino}-n-(2,6-difluorophenyl)-1h-1,2,4- triazole-1-carbothioamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high 5 insect cells.
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Ap24534, a pan-bcr-abl inhibitor for chronic myeloid leukemia, potently inhibits the t315i mutant and overcomes mutation-based resistance
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl1, abl. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(280 residues)
CATH domains:
|
|
|
|
|
|
2-aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of jak2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
A
(284 residues)
CATH domains:
|
|
|
|
|
|
2-aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of jak2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of mtor docked into em map of dimeric atm kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: frap, frap1, frap2, mtor, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f
|
|
|
Chain:
A
(960 residues)
|
|
|
|
Bound ligands:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Janus kinase 2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
A
(284 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of monobody ha4/abl1 sh2 domain complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: synthetic.
|
|
|
Chains:
A, B
(100 residues)
CATH domain:
|
|
|
|
|
|
Structures of human bruton's tyrosine kinase in active and inactive conformations suggests a mechanism of activation for tec family kinases.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(243 residues)
CATH domains:
|
|
|
|
|
|
Structure of abl kinase in complex with imatinib and gnf-2
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl, abl1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
A novel chemotype of kinase inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9 insect cells.
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Structural analysis of dfg-in and dfg-out dual src-abl inhibitors sharing a common vinyl purine template
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl, abl1, c-abl. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(281 residues)
CATH domains:
|
|
|
|
|
|
Structural analysis of dfg-in and dfg-out dual src-abl inhibitors sharing a common vinyl purine template
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl, abl1, c-abl. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(284 residues)
CATH domains:
|
|
|
|
|
|
Structure of human lck kinase with a small molecule inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of jak2 complexed with a potent quinoxaline atp site inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9de.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
The complex crystal structure of lck with a probe molecule w259
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: baculoviridae. Expression_system_taxid: 10442. Expression_system_cell_line: e. Coli.
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
The kinase domain of human lymphocyte kinase (lck), activated form (auto-phosphorylated on tyr394)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Drug resistant csrc kinase domain in complex with covalent inhibitor pd168393
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src, v-src sarcoma viral oncogene. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(248 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of jak2 complexed with a potent 2,8-diaryl- quinoxaline inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9de.
|
|
|
Chains:
A, B
(280 residues)
CATH domains:
|
|
|
|
|
|
Structural and thermodynamic characterization of the tyk2 and jak3 kinase domains in complex with cp-690550 and cmp-6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(279 residues)
CATH domains:
|
|
|
|
|
|
Structural and thermodynamic characterization of the tyk2 and jak3 kinase domains in complex with cp-690550 and cmp-6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Structural and thermodynamic characterization of the tyk2 and jak3 kinase domains in complex with cp-690550 and cmp-6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Structural and thermodynamic characterization of the tyk2 and jak3 kinase domains in complex with cp-690550 and cmp-6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(286 residues)
CATH domains:
|
|
|
|
|
|
Activator-bound structure of human pyruvate kinase m2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, oip3, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(518 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
X-ray crystal structure of itk complexed with sunitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(239 residues)
CATH domains:
|
|
|
|
|
|
X-ray crystal structure of itk complexed with inhibitor ro5191614
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(228 residues)
CATH domains:
|
|
|
|
|
|
X-ray crystal structure of itk complexed with inhibitor bms-509744
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(259 residues)
CATH domains:
|
|
|
|
|
|
Lck complexed with a pyrazolopyrimidine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(257 residues)
CATH domains:
|
|
|
|
|
|
Abl kinase in complex with imatinib and a fragment (frag1) in the myristate pocket
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl1, abl. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(265 residues)
CATH domains:
|
|
|
|
|
|
Abl kinase in complex with imatinib and fragment (frag2) in the myristate site
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(264 residues)
CATH domains:
|
|
|
|
|
|
The structure of muscle pyruvate kinase in complex with proline, pyruvate, and mn2+
|
|
|
Source: Oryctolagus cuniculus. European rabbit,japanese white rabbit,domestic rabbit,rabbits. Organism_taxid: 9986. Tissue: muscle
|
|
|
Chains:
A, B, C, D, E, F, G, H
(519 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group PYR
corresponds to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Crystal structure of the src-family kinase hck sh3-sh2-linker regulatory region
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(163 residues)
CATH domains:
|
|
|
|
|
|
Non-phosphorylated tyk2 jh1 domain with quinoline-thiadiazole- thiophene inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Non-phosphorylated tyk2 kinase with cmp6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bruton's tyrosine kinase in complex with inhibitor cgi1746
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bruton's tyrosine kinase mutant v555r in complex with dasatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(244 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the l317i mutant of the chicken c-src tyrosine kinase domain complexed with imatinib
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the l317i mutant of the chicken c-src tyrosine kinase domain
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of abl kinase domain bound with a dfg-out inhibitor ap24534
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl1, abl. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of abl t315i mutant kinase domain bound with a dfg- out inhibitor ap24589
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl1, abl. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(284 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the human btk kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(252 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 2-isopropyl-7- (4-methyl-piperazin-1-yl)-4-(5-methyl-2h-pyrazol-3-ylamino)-2h- phthalazin-1-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with r406
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(262 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with (5-amino-1-o- tolyl-1h-pyrazol-4-yl)-[3-(1-methanesulfonyl-piperidin-4-yl)-phenyl]- methanone
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(245 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 3-(2,6-dichloro- phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4- dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(241 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 2-[4-(2- diethylamino-ethoxy)-phenylamino]-6-(4-fluoro-phenoxy)-8-methyl-8h- pyrido[2,3-d]pyrimidin-7-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(248 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 2-methyl-5-[(e)- (3-phenyl-acryloyl)amino]-n-(2-phenyl-3h-imidazo[4,5-b]pyridin-6-yl)- benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(240 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of jak3 complexed with a potent atp site inhibitor showing high selectivity within the janus kinase family
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(286 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with pyrrolo[2,3- d]thiazole
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(256 residues)
CATH domains:
|
|
|
|
|
|
Discovery and characterization of a cell-permeable, small-moleculE C- abl kinase activator that binds to the myristoyl binding site
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(265 residues)
CATH domains:
|
|
|
|
|
|
Structure of janus kinase 2 with a pyrrolotriazine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(293 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of mouse perk kinase domain
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: eif2ak3. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chain:
B
(272 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of itk kinase bound to an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(244 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of itk inhibitor complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(246 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the l317i mutant of thE C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(249 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the l317i mutant of thE C-src tyrosine kinase domain complexed with dasatinib
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(259 residues)
CATH domains:
|
|
|
|
|
|
The crystal structure of human abl1 kinase domain in complex with dcc- 2036
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(275 residues)
CATH domains:
|
|
|
|
|
|
The crystal structure of human abl1 kinase domain t315i mutant in complex with dcc-2036
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(258 residues)
CATH domains:
|
|
|
|
|
|
The crystal structure of human abl1 kinase domain in complex with dp- 987
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(270 residues)
CATH domains:
|
|
|
|
|
|
HIV-1 nef protein in complex with engineered hck sh3 domain
|
|
|
Source: HIV-1 m:b_arv2/sf2. HIV-1. Organism_taxid: 11685. Strain: sf2. Gene: HIV-1 nef, nef. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human.
|
|
|
Chains:
B, D
(60 residues)
CATH domain:
|
|
|
|
|
|
HIV-1 nef protein in complex with engineered hck-sh3 domain
|
|
|
Source: HIV-1 m:b_arv2/sf2. HIV-1. Organism_taxid: 11685. Strain: sf2. Gene: HIV-1 nef, nef. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human.
|
|
|
Chains:
B, D
(60 residues)
CATH domain:
|
|
|
|
|
|
HIV-1 nef protein in complex with engineered hck-sh3 domain
|
|
|
Source: HIV-1 m:b_arv2/sf2. HIV-1. Organism_taxid: 11685. Strain: sf2. Gene: HIV-1 nef, nef. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human.
|
|
|
Chains:
B, D
(59 residues)
CATH domain:
|
|
|
|
|
|
Crystals structure of jak2 with a 1-amino-5h-pyrido[4,3-b]indol-4- carboxamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the itk sh2 domain.
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: emt, il-2 inducible t cell kinase, itk, tlk, tsk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(114 residues)
CATH domain:
|
|
|
|
|
|
The focal adhesion targeting (fat) domain of the focal adhesion kinase showing n-terminal interactions in cis
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fak, fak1, ptk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C
(141 residues)
CATH domains:
|
|
|
|
|
|
Human m2 pyruvate kinase in complex with fructose 1-6 bisphosphate and oxalate.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: oip3, pk2, pk3, pkm, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(515 residues)
CATH domains:
|
|
|
|
Bound ligands:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Human m1 pyruvate kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: oip3, pk2, pk3, pkm, pkm1, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
C, A, B, D, E, F, G, H
(517 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group PYR
corresponds to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Human m2 pyruvate kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: oip3, pk2, pk3, pkm, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(518 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group PO4
is 50.00% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase (syk) in complex with a diaminopyrimidine carboxamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of t338c c-src covalently bound to vinylsulfonamide- pyrazolopyrimidine 9
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bmx non-receptor tyrosine kinase complex with dasatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bmx, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bmx non-receptor tyrosine kinase complexed with pp2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bmx, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of monobody 7c12/abl1 sh2 domain complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(98 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of btk mutant (f435t,k596r) complexed with imidazo[1,5-a]quinoxaline
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk.
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Co-crystal structure of jak2 with thienopyridine 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Co-crystal structure of jak2 with thienopyridine 19
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of syk kinase domain with 1-(5-(6,7- dimethoxyquinolin-4-yloxy)pyridin-2-yl)-3-((1r,2s)-2- phenylcyclopropyl)urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk.
|
|
|
Chain:
A
(253 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of syk kinase domain with 1-benzyl-n-(5-(6,7- dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1,2-dihydropyridine-3- carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk.
|
|
|
Chain:
A
(257 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of syk kinase domain with n-(4-methyl-3-(8-methyl-7- oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3- (trifluoromethyl)benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk.
|
|
|
Chain:
A
(256 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with rl103
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src, v-src sarcoma viral oncogene. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with rl104
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src, v-src sarcoma viral oncogene. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with rl130
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src, v-src sarcoma viral oncogene. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Activator-bound structure of human pyruvate kinase m2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, oip3, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(519 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Structural basis for the interaction of pyk2 pat domain with paxillin ld motifs
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic peptide
|
|
|
Chains:
A, B, C, D
(130 residues)
CATH domain:
|
|
|
|
|
|
Src in complex with DNA-templated macrocyclic inhibitor mc4b
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 08M
is 48.28% similar to
enzyme product ADP
|
|
|
|
|
|
|
Src in complex with DNA-templated macrocyclic inhibitor mc1
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
|
|
|
Chains:
A, B
(256 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 08M
is 48.28% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the human fyn sh3 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the human fyn sh3 domain in complex with a peptide from the hepatitis c virus ns5a-protein
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Hepatitis c virus. Hcv.
|
|
|
Chains:
A, B, C, D
(63 residues)
CATH domain:
|
|
|
|
|
|
Structural and spectroscopic analysis of the kinase inhibitor bosutinib binding to the abl tyrosine kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(270 residues)
CATH domains:
|
|
|
|
|
|
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase cdelta
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: prkcd, pkcd. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(65 residues)
CATH domain:
|
|
|
|
|
|
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase cdelta
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: prkcd, pkcd. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(65 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of a sh3 and sh2 domains of fyn protein (proto- concogene tyrosine-protein kinase fyn) from mus musculus at 1.98 a resolution
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: bc092217, fyn. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(160 residues)
CATH domains:
|
|
|
|
|
|
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase cdelta
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: prkcd, pkcd. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(65 residues)
CATH domain:
|
|
|
|
|
|
Structural basis of jak2 inhibition by the type ii inhibtor nvp-bbt594
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9de.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinasE C delta
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: prkcd, pkcd. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(65 residues)
CATH domain:
|
|
|
|
|
|
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinasE C delta
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: prkcd, pkcd. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(65 residues)
CATH domain:
|
|
|
|
|
|
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinasE C delta
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: prkcd, pkcd. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(65 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of apo-pkr kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak2, pkr, prkr. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(255 residues)
CATH domains:
|
|
|
|
|
|
Lysozyme contamination facilitates crystallization of a hetero- trimericcortactin:arg:lysozyme complex
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: lyz. Mus musculus. Mouse. Organism_taxid: 10090. Gene: cttn, ems1. Expressed in: escherichia coli.
|
|
|
Chain:
C
(13 residues)
|
|
|
|
|
|
C-src kinase domain in complex with bki rm-1-89
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
|
|
|
|
|
|
C-src kinase domain in complex with bumpless bki analog uw1243
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a sh2 domain of a megakaryocyte-associated tyrosine kinase (matk) from homo sapiens at 1.50 a resolution
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ctk, hyl, matk, nm_139355. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(97 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of monobody sh13/abl1 sh2 domain complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(114 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of interleukin-2 inducible t-cell kinase itk catalytic domain with thienopyrazolylindole inhibitor 090
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(241 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of interleukin-2 inducible t-cell kinase itk catalytic domain with thienopyrazolylindole inhibitor 542
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(240 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of interleukin-2 inducible t-cell kinase itk catalytic domain with thienopyrazolylindole inhibitor 477
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(238 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of interleukin-2 inducible t-cell kinase itk catalytic domain with thienopyrazolylindole inhibitor 469
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(243 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase syk catalytic domain with pyrazolylbenzimidazole inhibitor 416
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase syk catalytic domain with thienopyrazolylindole inhibitor 027
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl- cyclopentane
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(429 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]- 3-benzylurea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(430 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor n-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl) phenyl]benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(429 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]- 3-phenylurea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(425 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h- pyrrolo[2,3-d]pyrimidin-4-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(431 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)- 7h-pyrrolo[2,3-d]pyrimidin-4-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(435 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3- d]pyrimidin-4-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(430 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3- d]pyrimidin-4-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(430 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4- d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(435 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h- pyrazolo[3,4-d]pyrimidin-4-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(433 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of jak3 kinase domain in complex with an indazole substituted pyrrolopyrazine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(279 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of basic patch mutant fak ferm domain fak31- 405 k216a, k218a, r221a, k222a
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(326 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of jak3 kinase domain in complex with a pyrrolopyrazine-2-phenyl ether inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(276 residues)
CATH domains:
|
|
|
|
|
|
Inhibitors of jak2 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chains:
A, B
(275 residues)
CATH domains:
|
|
|
|
|
|
Human tyk2 pseudokinase domain bound to a kinase inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(261 residues)
CATH domains:
|
|
|
|
|
|
Discovery of a small molecule type ii inhibitor of wild-type and gatekeeper mutants of bcr-abl, pdgfralpha, kit, and src kinases
|
|
|
Source: Gallus gallus. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(258 residues)
CATH domains:
|
|
|
|
|
|
Triazolopyridine-based inhibitor of janus kinase 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(291 residues)
CATH domains:
|
|
|
|
|
|
Human pkm2 with l-serine and fbp bound.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(518 residues)
CATH domains:
|
|
|
|
Bound ligands:
|
Het Group SER
is 62.50% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Aminoalkylpyrimidine inhibitor complexes with jak2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(288 residues)
CATH domains:
|
|
|
|
|
|
Aminoalkylpyrimidine inhibitor complexes with jak2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(288 residues)
CATH domains:
|
|
|
|
|
|
The crystal structure of mouse pk38
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(313 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex with pyrrolopyrazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(311 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex with a benzodipyrazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(309 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex with amp-pnp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(312 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chain:
A
(260 residues)
CATH domains:
|
|
|
|
|
|
Structure of lck in complex with a compound discovered by virtual fragment linking
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(257 residues)
CATH domains:
|
|
|
|
|
|
Inhibitors of jak2 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: star.
|
|
|
Chains:
A, B
(274 residues)
CATH domains:
|
|
|
|
|
|
Inhibitors of jak2 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: star.
|
|
|
Chains:
A, B
(275 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chain:
A
(259 residues)
CATH domains:
|
|
|
|
|
|
Structure of the kinase domain of human ripk2 in complex with ponatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(279 residues)
CATH domain:
|
|
|
|
|
|
The crystal structure of mpk38 in complex with otssp167, an orally- administrative melk selective inhibitor
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: melk, kiaa0175, pk38. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(313 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of avian fak ferm domain fak31-405 at 3.2a
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(330 residues)
CATH domains:
|
|
|
|
|
|
Pyrrole-3-carboxamides as potent and selective jak2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(291 residues)
CATH domains:
|
|
|
|
|
|
Pyrrole-3-carboxamides as potent and selective jak2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(293 residues)
CATH domains:
|
|
|
|
|
|
Pyrrole-3-carboxamides as potent and selective jak2 inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(282 residues)
CATH domains:
|
|
|
|
|
|
Structure of melk in complex with inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: image clone
|
|
|
Chains:
A, B, C, D
(313 residues)
CATH domain:
|
|
|
|
|
|
Structure of melk in complex with inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: image clone
|
|
|
Chains:
A, B, C, D
(316 residues)
CATH domain:
|
|
|
|
|
|
Structure of melk in complex with inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: image clone
|
|
|
Chains:
A, B, C, D
(313 residues)
CATH domain:
|
|
|
|
|
|
Structure of melk in complex with inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: image clone
|
|
|
Chains:
A, B, C, D
(314 residues)
CATH domain:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B
(251 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B
(255 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B
(256 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B
(255 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chain:
A
(260 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B
(255 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B
(255 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: trichoplusia. Expression_system_taxid: 7110. Expression_system_cell_line: high five.
|
|
|
Chains:
A, B
(255 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of HIV-1 nef fyn-sh3 r96w variant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn, fyn tyrosine kinase. Expressed in: escherichia coli. Expression_system_taxid: 562. Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11686.
|
|
|
Chains:
A, C
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of a sh3-sh2 domains of a lymphocyte-specific protein tyrosine kinase (lck) from homo sapiens at 2.36 a resolution
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bc013200, lck. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(163 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(269 residues)
CATH domains:
|
|
|
|
|
|
C-src kinase domain in complex with rm-1-176
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Co-crystal structure of the ppiase domain of fkbp51, rapamycin and the frb fragment of mtor at low ph
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aig6, fkbp5, fkbp51. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: frap, frap1, frap2, mtor, raft1, rapt1.
|
|
|
Chains:
B, E
(95 residues)
CATH domain:
|
|
|
|
|
|
Co-crystal structure of the ppiase domain of fkbp51, rapamycin and the frb fragment of mtor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aig6, fkbp5, fkbp51. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: frap, frap1, frap2, mtor, raft1, rapt1.
|
|
|
Chain:
B
(96 residues)
CATH domain:
|
|
|
|
|
|
O-crystal structure of the ppiase domain of fkbp52, rapamycin and the frb fragment of mtor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp4, fkbp52. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: frap, frap1, frap2, mtor, raft1, rapt1.
|
|
|
Chain:
B
(96 residues)
CATH domain:
|
|
|
|
|
|
F-bar domain of human fes tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fes, fps. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(376 residues)
CATH domains:
|
|
|
|
|
|
Structure of mouse tyk-2 complexed to a 3-aminoindazole inhibitor
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Structure of mouse tyk-2 complexed to a 3-aminoindazole inhibitor
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(282 residues)
CATH domains:
|
|
|
|
|
|
Jak1 kinase (jh1 domain) in complex with compound 30
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, E, D
(279 residues)
CATH domains:
|
|
|
|
|
|
Jak2 kinase (jh1 domain) in complex with compound 30
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, D, E
(298 residues)
CATH domains:
|
|
|
|
|
|
Jak1 kinase (jh1 domain) in complex with compound 49
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(293 residues)
CATH domains:
|
|
|
|
|
|
Jak1 kinase (jh1 domain) in complex with compound 26
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(294 residues)
CATH domains:
|
|
|
|
|
|
Jak2 kinase (jh1 domain) triple mutant in complex with compound 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(288 residues)
CATH domains:
|
|
|
|
|
|
Jak2 kinase (jh1 domain) triple mutant in complex with compound 12
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(298 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human feline sarcoma viral oncogene homologue (v- fes)in complex with tae684
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fes, fps. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(361 residues)
CATH domains:
|
|
|
|
|
|
Structure of focal adhesion kinase catalytic domain in complex with novel allosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(262 residues)
CATH domains:
|
|
|
|
|
|
Structure of focal adhesion kinase catalytic domain in complex with novel allosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(259 residues)
CATH domains:
|
|
|
|
|
|
The jak1 kinase domain in complex with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(292 residues)
CATH domains:
|
|
|
|
|
|
Jak1 kinase (jh1 domain) in complex with compound 20
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(291 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 0Q2
is 46.88% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of arg sh2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl2, abll, arg. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(101 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the human fyn sh3 domain in complex with the synthetic peptide vsl12
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(58 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of ferm domain of proline-rich tyrosine kinase 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fak2, nm4103, ptk2b, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(348 residues)
CATH domains:
|
|
|
|
|
|
Co-crystal structure of ack1 with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1
|
|
|
Chains:
B, A
(274 residues)
CATH domains:
|
|
|
|
|
|
Discovery and optimization of c-2 methyl imidazo-pyrrolopyridines as potent and orally bioavailable jak1 inhibitors with selectivity over jak2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2, jak2 kinase domain. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(290 residues)
CATH domains:
|
|
|
|
|
|
Discovery and optimization of c-2 methyl imidazo-pyrrolopyridines as potent and orally bioavailable jak1 inhibitors with selectivity over jak2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2 kinase domain. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Syk in complex with ligand lasw836
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(262 residues)
CATH domains:
|
|
|
|
|
|
Triple mutant src sh2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(108 residues)
CATH domain:
|
|
|
|
|
|
Triple mutant src sh2 domain bound to phosphate ion
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(108 residues)
CATH domain:
|
|
|
|
|
|
Triple mutant src sh2 domain bound to phosphotyrosine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(108 residues)
CATH domain:
|
|
|
|
|
|
Atomic structures of the rapamycin analogs in complex with both human fkbp12 and frb domain of frap
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21 (de3) (novagen). Gene: human hippocampal cdna library source 8 (clontech, palo alto, ca). Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 9606
|
|
|
Chain:
B
(94 residues)
CATH domain:
|
|
|
|
|
|
Kinase domain of csrc in complex with a hinge region-binding fragment
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src, v-src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(251 residues)
CATH domains:
|
|
|
|
|
|
Jak1 kinase (jh1 domain) in complex with compound 72
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(287 residues)
CATH domains:
|
|
|
|
|
|
Structural and biophysical characterization of the syk activation switch
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structural and biophysical characterization of the syk activation switch
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five
|
|
|
Chain:
A
(555 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structural and biophysical characterization of the syk activation switch
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five
|
|
|
Chain:
A
(538 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the jak2 pseudokinase domain (apo form)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the jak2 pseudokinase domain (mg-atp-bound form)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ATP
corresponds to
enzyme reactant ATP
|
|
|
|
|
|
|
Crystal structure of the jak2 pseudokinase domain mutant v617f (mg- atp-bound form)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ATP
corresponds to
enzyme reactant ATP
|
|
|
|
|
|
|
Structure of m2 pyruvate kinase in complex with phenylalanine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: oip3, pk2, pk3, pkm, pkm2, pyruvate kinase m2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, D, C, B
(501 residues)
CATH domains:
|
|
|
|
Bound ligands:
|
Het Group ATP
corresponds to
enzyme reactant ATP
|
|
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Structure of m2 pyruvate kinase in complex with phenylalanine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: oip3, pk2, pk3, pkm, pkm2, pyruvate kinase m2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(498 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group PO4
is 50.00% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with 3-(8-{4- [ethyl-(2-hydroxy-ethyl)-amino]-phenylamino}-imidazo[1,2-a]pyrazin-5- yl)-phenol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(267 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with n-{(s)-1- [7-(3,4-dimethoxy-phenylamino)-thiazolo[5,4-d]pyrimidin-5-yl]- pyrrolidin-3-yl}-terephthalamic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(267 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with [6-((s)-2- methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2- b]pyridazin-8-yl)-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with 6-((1r,2s)- 2-amino-cyclohexylamino)-4-(6-ethyl-pyridin-2-ylamino)-pyridazine-3- carboxylic acid amide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Pkm2 in complex with an activator
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm2, oip3, pk2, pk3, pkm. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(518 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Crystal structure of gsk6414 bound to perk (r587-r1092, delete a660- t867) at 2.28 a resolution
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(248 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of gsk6924 bound to perk (r587-r1092, delete a660- t867) at 2.70 a resolution
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(248 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with r9021
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Jak2 kinase (jh1 domain) with 2,6-dichloro-n-(2-oxo-2,5- dihydropyridin-4-yl)benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(291 residues)
CATH domains:
|
|
|
|
|
|
Tyk2 kinase (jh1 domain) with 2,6-dichloro-n-(2-oxo-2,5- dihydropyridin-4-yl)benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
Tyk2 (jh1) in complex with 2,6-dichloro-n-{2-[(cyclopropylcarbonyl) amino]pyridin-4-yl}benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Tyk2 (jh1) in complex with 2,6-dichloro-4-cyano-n-{2- [(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Tyk2 (jh1) in complex with 2,6-dichloro-n-[2-({[(1r,2r)-2- fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2 gene. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Tyk2 (jh1) in complex with 2,6-dichloro-4-cyano-n-[2-({[(1r,2r)-2- fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(288 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of inhibitory protein socs3 in complex with jak2 kinase domain and fragment of gp130 intracellular domain
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: jak2, mcg_9104. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Mouse, mouse. Gene: socs3, cis3, cish3.
|
|
|
Chains:
A, B, C, D
(284 residues)
CATH domains:
|
|
|
|
|
|
Jak2 kinase (jh1 domain) in complex with 2,6-dichloro-n-{2- [(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with n-{3-[(5-cyano- 2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-ylamino)- methyl]-pyridin-2-yl}- n-methyl-methanesulfonamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(271 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with (2-fluoro- phenyl)-(1h-pyrazolo[3,4-d]pyrimidin-4-yl)-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(252 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 4GU
is 41.94% similar to
enzyme product ADP
|
|
|
|
|
|
|
Tyk2 (jh1) in complex with adenosine di-phosphate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: tni.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of pyk2 with the pyrazole 13a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pyk2 with the indole 10c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(256 residues)
CATH domains:
|
|
|
|
|
|
Human hck sh3 domain, nmr, 25 structures
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: residues g72-e143 of human hck. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(61 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of itk in complex with compound 52
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of itk in complext with compound 40
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of itk in complex with compound 53
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Jak2 kinase (jh1 domain) in complex with compound 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Jak3 kinase domain in complex with 2-cyclopropyl-5h-pyrrolo[2,3- b]pyrazine-7-carboxylic acid ((s)-1,2,2-trimethyl-propyl)-amide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(276 residues)
CATH domains:
|
|
|
|
|
|
Jak3 kinase domain in complex with 2-cyclopropyl-5h-pyrrolo[2,3- b]pyrazine-7-carboxylic acid ((s)-2-hydroxy-1,2-dimethyl-propyl)- amide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Jak3 kinase domain in complex with 2-cyclopropyl-5h-pyrrolo[2,3- b]pyrazine-7-carboxylic acid ((r)-2-hydroxy-1,2-dimethyl-propyl
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Jak3 kinase domain in complex with 2-cyclopropyl-5h-pyrrolo[2,3- b]pyrazine-7-carboxylic acid ((r)-1-methyl-2-oxo-2-piperidin-1-yl- ethyl)-amide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the t98d c-src-sh3 domain mutant in complex with the high affinity peptide app12
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: high affinity peptide designed from phage display experiments
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the t98E C-src-sh3 domain mutant in complex with the high affinity peptide app12
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: high affinity peptide designed from phage display experiments
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the t98E C-src-sh3 domain mutant in complex with the high affinity peptide vsl12
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: high affinity peptide designed from phage display experiments
|
|
|
Chain:
A
(61 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of sh3:rgt complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the rgt peptide was synthesized in the solid phase
|
|
|
Chains:
A, B
(60 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of ack1 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(261 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ack1 kinase domain with c-terminal sh3 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(319 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with 2-(3,4,5- trimethoxy-phenyl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with 2-(6- chloro-1-methyl-1h-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7- carboxylic acid isopropylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(267 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase complexed with 2-(5,6,7,8- tetrahydro-imidazo[1,5-a]pyridin-1-yl)-5h-pyrrolo[2,3-b]pyrazine-7- carboxylic acid tert-butylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
|
|
Structure of focal adhesion kinase catalytic domain in complex with hinge binding pyrazolobenzothiazine compound.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(254 residues)
CATH domains:
|
|
|
|
|
|
Structure of focal adhesion kinase catalytic domain in complex with an allosteric binding pyrazolobenzothiazine compound.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(255 residues)
CATH domains:
|
|
|
|
|
|
The jak1 kinase domain in complex with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(281 residues)
CATH domains:
|
|
|
|
|
|
Jak3 kinase domain in complex with 2-phenoxy-5h-pyrrolo[2,3- b]pyrazine-7-carboxylic acid ((s)-1-cyclopropyl-ethyl)-amide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Ack1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4- phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ack1, tnk2
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Jak2 kinase (jh1 domain) in complex with the inhibitor trans-4-[(8as)- 2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(8ah)- yl]cyclohexanecarbonitrile
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(292 residues)
CATH domains:
|
|
|
|
|
|
Jak1 kinase (jh1 domain) in complex with the inhibitor trans-4-{2- [(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)- yl}cyclohexanecarbonitrile
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(293 residues)
CATH domains:
|
|
|
|
|
|
Jak1 kinase (jh1 domain) in complex with the inhibitor (trans-4-{2- [(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)- yl}cyclohexyl)acetonitrile
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(293 residues)
CATH domains:
|
|
|
|
|
|
Jak1 kinase (jh1 domain) in complex with compound 34
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(292 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of maternal embryonic leucine zipper kinase (melk)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(334 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the abl-sh3 domain h59q-n96t mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(58 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the abl-sh3 domain h59q-n96t mutant complexed with the designed high-affinity peptide ligand p17
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
|
|
|
Chain:
A
(58 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the n114a mutant of the abl-sh3 domain complexed with the high affinity peptide p0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence has been optimized to increase the affinity
|
|
|
Chains:
A, C, E
(56 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the n114a mutant of the abl-sh3 domain complexed with the high affinity peptide p17
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence has been optimized to increase the affinity
|
|
|
Chains:
A, C, E
(56 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the abl-sh3 domain complexed with the high affinity peptide p0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
|
|
|
Chains:
A, C, E
(62 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the abl-sh3 domain complexed with the designed high-affinity peptide ligand p7 at ph7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pbat4. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
|
|
|
Chains:
A, C, E
(58 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the abl-sh3 domain complexed with the designed high-affinity peptide ligand p7 at ph 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pbat4. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: this sequence has been optimized to increase the
|
|
|
Chains:
A, B, C, D, E, F
(59 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the abl-sh3 domain complexed with the designed high-affinity peptide ligand p17
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: pbat4. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
|
|
|
Chains:
A, C, E
(56 residues)
CATH domain:
|
|
|
|
|
|
Jak2 kinase (jh1 domain) in complex with tg101209
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(286 residues)
CATH domains:
|
|
|
|
|
|
Jak2 kinase (jh1 domain) in complex with compound 9
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(300 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the abl-sh3 domain at ph3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the abl-sh3 domain at ph5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(58 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the n114a abl-sh3 domain mutant at ph4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl, abl1, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(59 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the chimerical protein capa1b1 in complex with adp-mg
|
|
|
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: capa1, capb1. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(228 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the chimerical protein capa2b2
|
|
|
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: capa2, capb2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(226 residues)
CATH domain:
|
|
|
|
|
|
2-((1h-benzo[d]imidazol-1-yl)methyl)-4h-pyrido[1,2-a]pyrimidin-4-ones as novel pkm2 activators
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(519 residues)
CATH domains:
|
|
|
|
Bound ligands:
|
Het Group 1OX
is 41.18% similar to
enzyme product ADP
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Structure of mtordeltan-mlst8 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: frap, frap1, frap2, mtor, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f. Gene: gbl, lst8, mlst8.
|
|
|
Chains:
B, A
(1058 residues)
|
|
|
|
|
|
Structure of mtordeltan-mlst8-atpgammas-mg complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: frap, frap1, frap2, mtor, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: gbl, lst8, mlst8.
|
|
|
Chains:
B, A
(1058 residues)
|
|
|
|
Bound ligands:
|
Het Group AGS
is 93.75% similar to
enzyme reactant ATP
|
|
|
Het Group AGS
is 93.75% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Mtor kinase structure, mechanism and regulation.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: frap, frap1, frap2, mtor, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: gbl, lst8, mlst8.
|
|
|
Chains:
B, A
(1058 residues)
|
|
|
|
Bound ligands:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Structure of mtordeltan-mlst8-torin2 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: frap, frap1, frap2, mtor, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: gbl, lst8, mlst8.
|
|
|
Chains:
B, A
(1058 residues)
|
|
|
|
|
|
Mtordeltan-mlst8-pp242 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: frap, frap1, frap2, mtor, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: gbl, lst8, mlst8.
|
|
|
Chains:
B, A
(1058 residues)
|
|
|
|
|
|
Structure of mtordeltan-mlst8-pi-103 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: mlst8.
|
|
|
Chains:
B, A
(1058 residues)
|
|
|
|
|
|
Crystal structure of the chicken c-src-sh3 domain intertwined dimer
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of chicken c-src-sh3 domain: monomeric form
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(60 residues)
CATH domain:
|
|
|
|
|
|
The structure of 1na in complex with src t338g
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(448 residues)
CATH domains:
|
|
|
|
|
|
Structural basis for activation of zap-70 by phosphorylation of the sh2-kinase linker
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: zap70, srk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(551 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
The jak1 kinase domain in complex with compound 37
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Jak1 kinase (jh1 domain) in complex with compound 6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(284 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group 1Q4
is 45.16% similar to
enzyme product ADP
|
|
|
|
|
|
|
Fragment-based discovery of focal adhesion kinase inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fak, fak1, ptk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(251 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with 1-[4-(6-amino- purin-9-yl)-phenyl]-3-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with 3-methyl-1,4- dihydro-pyrazolo[4,5-c]pyrazole
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(255 residues)
CATH domains:
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with 1-(5-tert- butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-(4-pyridin-3- yl-phenyl)-urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(252 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain mutant of human itk in complex with a covalently-binding inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(240 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the apo jak1 pseudokinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b
|
|
|
Chains:
A, B
(277 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the v658f apo jak1 pseudokinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b
|
|
|
Chains:
A, B
(274 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain mutant of human itk in complex with an aminobenzothiazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(250 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a chimeric c-src-sh3 domain
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(59 residues)
CATH domain:
|
|
|
|
|
|
Structure of 3mb-pp1 bound to analog-sensitive src kinase
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(241 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of 1nm-pp1 bound to analog-sensitive src kinase
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(243 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck in complex with the fluorescent compound skf86002
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(422 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of hck in complex with 7-[trans-4-(4- methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3- d]pyrimidin-4-amine (resulting from displacement of skf86002)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(423 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of itk in complex with compound 1 [4- (carbamoylamino)-1-(naphthalen-1-yl)-1h-pyrazole-3-carboxamide]
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of itk in complex with compound 5 {4- (carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1h-pyrazole-3- carboxamide}
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of itk in complex with compound 7 [4- (carbamoylamino)-1-(7-ethoxynaphthalen-1-yl)-1h-pyrazole-3- carboxamide]
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of itk in complex with compound 8 [4- (carbamoylamino)-1-(7-propoxynaphthalen-1-yl)-1h-pyrazole-3- carboxamide]
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of itk in complex with compound 9 [4- (carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1h-pyrazole-3- carboxamide]
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of itk in complex with compound 9 [4- (carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1h-pyrazole-3- carboxamide] and adp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of gsk6157 bound to perk (r587-r1092, delete a660- t867) at 2.34a resolution
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(247 residues)
CATH domains:
|
|
|
|
|
|
Star 12 bound to analog-sensitive src kinase
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(267 residues)
CATH domains:
|
|
|
|
|
|
Itk kinase domain in complex with benzothiazole inhibitor compound 12a (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(pyridin-3-yl)-1,3- benzothiazol-2-yl]cyclopropanecarboxamide (12a)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: emt, itk, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(240 residues)
CATH domain:
|
|
|
|
|
|
Itk kinase domain in complex with benzothiazole inhibitor 12b (1s,2s)- 2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3- benzothiazol-2-yl]cyclopropanecarboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: emt, itk, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(243 residues)
CATH domains:
|
|
|
|
|
|
Human src kinase bound to kinase inhibitor bosutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(266 residues)
CATH domains:
|
|
|
|
|
|
Human src a403t mutant bound to kinase inhibitor bosutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(266 residues)
CATH domains:
|
|
|
|
|
|
Src m314l t338m double mutant bound to kinase inhibitor bosutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(266 residues)
CATH domains:
|
|
|
|
|
|
Src m314l t338m double mutant bound to kinase inhibitor bosutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(266 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with bms-809959 aka 4-tert-butyl-n-[2-me thyl-3-(6-{[4- (morpholine-4-carbonyl)phenyl]amino}-9h- purin-2-yl)phenyl]benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(262 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ferm domain of human focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
D, A, B, C
(329 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with a substituted pyrazolopyrimidine
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src, v-src sarcoma viral oncogene. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
|
Chains:
A, B
(265 residues)
CATH domains:
|
|
|
|
|
|
The pseudokinase/kinase protein from jak-family member tyk2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(539 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the intertwined dimer of thE C-src tyrosine kinase sh3 domain mutant q128r
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the intertwined dimer of thE C-src tyrosine kinase sh3 domain mutant n113s
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the intertwined dimer of thE C-src tyrosine kinase sh3 domain mutant q128e
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of thE C-src tyrosine kinase sh3 domain mutant q128e
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(61 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the intertwined dimer of thE C-src tyrosine kinase sh3 domain mutant q128k
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the intertwined dimer of thE C-src tyrosine kinase sh3 domain mutant s94a
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
HIV-1 nef protein in complex with single domain antibody sdab19 and an engineered hck sh3 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: escherichia coli. Expression_system_taxid: 469008. HIV-1 m:b_arv2/sf2. HIV-1. Organism_taxid: 11685.
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 4-tert-butyl-n- (3-{8-[4-(4-methyl-piperazine-1-carbonyl)-phenylamino]-imidazo[1,2- a]pyrazin-6-yl}-phenyl)-benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 4- methanesulfonyl-n-(3-{8-[4-(morpholine-4-carbonyl)-phenylamino]- imidazo[1,2-a]pyrazin-6-yl}-phenyl)-benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the kinase domain of bruton's tyrosine kinase with gdc0834
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 1-[5-[3-(7-tert- butyl-4-oxo-quinazolin-3-yl)-2-methyl-phenyl]-1-methyl-2-oxo-3- pyridyl]-3-methyl-urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 6-cyclopropyl-2- [3-[5-[[5-(4-ethylpiperazin-1-yl)-2-pyridyl]amino]-1-methyl-6-oxo-3- pyridyl]-2-(hydroxymethyl)phenyl]-8-fluoro-isoquinolin-1-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Triazolopyridine compounds as selective jak1 inhibitors: from hit identification to glpg0634
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(283 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the human tyk2 ferm and sh2 domains with an ifnar1 intracellular peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ifnar, ifnar1.
|
|
|
Chain:
A
(475 residues)
|
|
|
|
|
|
Itk kinase domain with compound 1 (n-[1-(3-cyanobenzyl)-1h-pyrazol-4- yl]-2h-indazole-3-carboxamide)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(246 residues)
CATH domains:
|
|
|
|
|
|
Itk kinase domain with compound 11 (n-[1-(3-cyanobenzyl)-1h-pyrazol-4- yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(239 residues)
CATH domain:
|
|
|
|
|
|
Itk kinase domain with compound 28 (n-{1-[(1s)-3-(dimethylamino)-1- phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3- carboxamide)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(239 residues)
CATH domain:
|
|
|
|
|
|
Itk kinase domain with compound 27 (n-{1-[(1r)-3-(dimethylamino)-1- phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3- carboxamide)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(233 residues)
CATH domain:
|
|
|
|
|
|
Itk kinase domain with compound gne-9822
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(240 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase (syk) in complex with gs- 9973
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase (syk) in complex with an imidazopyrazine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Syk catalytic domain in complex with a potent pyridopyrimidinone inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(262 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of tyk2 in complex with compound 15, 6-((2,5- dimethoxyphenyl)thio)-3-(1-methyl-1h-pyrazol-4-yl)-[1,2,4]triazolo[4, 3-b]pyridazine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of human focal adhesion kinase (fak) bound to compound1 (3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1h)- one)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(252 residues)
CATH domains:
|
|
|
|
|
|
Itk kinase domain in complex with inhibitor compound
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(244 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of pkm2-y105e mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(406 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group PRO
is 44.44% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Crystal structure of pkm2-k305q mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(505 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group GOL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Crystal structure of pkm2-r399e mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(499 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ACT
is 66.67% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Crystal structure of pkm2-k422r mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(503 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group GOL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Crystal structure of jak3 complexed to n-[3-(6-phenylamino-pyrazin-2- yl)-3h-benzoimidazol-5-yl]-acrylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, C
(270 residues)
CATH domains:
|
|
|
|
|
|
Jak3 kinase domain in complex with 1-[(3s)-1-isobutylsulfonyl-3- piperidyl]-3-(5h-pyrrolo[2,3-b]pyrazin-2-yl)urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain in complex with a peptide from the hepatitis c virus ns5a-protein
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Hepatitis c virus. Organism_taxid: 11103.
|
|
|
Chain:
A
(60 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure analysis of pyk2 and paxillin ld motifs
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Gallus gallus. Bantam,chickens.
|
|
|
Chain:
A
(132 residues)
CATH domain:
|
|
|
|
|
|
Itk kinase domain in complex with compound 1 n-{1-[(1,1-dioxo-1-thian- 2-yl)(phenyl)methyl]-1h- pyrazol-4-yl}-5,5-difluoro-5a-methyl-1h,4h, 4ah,5h,5ah,6h-cyclopropa[f]indazole-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: itk, emt, lyk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(249 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 6- (dimethylamino)-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(morpholine-4- carbonyl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-3,4- dihydroisoquinolin-1-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 6- (dimethylamino)-8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5- (morpholine-4-carbonyl)-2-pyridyl]amino]-6-oxo-3- pyridyl]phenyl]isoquinolin-1-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 2-[8-fluoro-2- [2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)-2- pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-1-oxo-3,4-dihydroisoquinolin- 6-yl]-2-methyl-propanenitrile
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of jak3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pkm2-k422r mutant bound with fbp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(411 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of tyrosine-protein kinase syk with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(269 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the intertwined form of the src tyrosine kinase sh3 domain t96g/q128r mutant
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the src tyrosine kinase sh3 domain s94a/q128r mutant in complex with the high affinity synthetic peptide app12
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 32630. Other_details: synthetic high affinity peptide
|
|
|
Chain:
A
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of thE C-src-sh3 domain e93v/q128r mutant in complex with the high affinity peptide app12
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 32630. Other_details: designed high affinity peptide
|
|
|
Chains:
A, C
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the src tyrosine kinase sh3 domain t96g/q128r mutant
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(61 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of thE C-src-sh3 domain in complex with the high affinity peptide app12
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 32630. Other_details: synthetic high affinity peptide
|
|
|
Chain:
A
(58 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of thE C-src-sh3 domain in complex with the high affinity peptide vsl12
|
|
|
Source: Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 32630. Other_details: synthetic high affinity peptide
|
|
|
Chain:
A
(61 residues)
CATH domain:
|
|
|
|
|
|
Bruton's tyrosine kinase (btk) with pyridazinone compound 23
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Syk catalytic domain complexed with a potent triazine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
Syk catalytic domain complexed with a potent triazine inhibitor2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(269 residues)
CATH domains:
|
|
|
|
|
|
Syk catalytic domain complexed with a potent pyrimidine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
The crystal structure of human abl1 t315i gatekeeper mutant kinase domain in complex with axitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(266 residues)
CATH domains:
|
|
|
|
|
|
Structure of unliganded lyn sh2 domain
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: lyn. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(110 residues)
CATH domain:
|
|
|
|
|
|
Swapped dimer of the human fyn-sh2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B, C
(102 residues)
CATH domain:
|
|
|
|
|
|
Human fyn-sh2 domain in complex with a synthetic high-affinity phospho-peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Hamster polyomavirus. Hapyv.
|
|
|
Chain:
A
(105 residues)
CATH domain:
|
|
|
|
|
|
C-src in complex with ruxolitinib
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli #1/h766. Expression_system_taxid: 1354003
|
|
|
Chains:
A, B
(267 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of HIV-1 nef-sf2 core domain in complex with the src family kinase hck sh3-sh2 tandem regulatory domains
|
|
|
Source: Human immunodeficiency virus type 1. HIV-1. Organism_taxid: 11685. Strain: isolate arv2/sf2. Gene: nef. Expressed in: escherichia coli. Expression_system_taxid: 469008. Homo sapiens. Human.
|
|
|
Chains:
B, D
(163 residues)
|
|
|
|
|
|
Structure of melk in complex with inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: image clone
|
|
|
Chains:
A, B, C, D
(313 residues)
CATH domain:
|
|
|
|
|
|
Structure of melk in complex with inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: image clone
|
|
|
Chain:
A
(314 residues)
CATH domain:
|
|
|
|
|
|
Structure of melk in complex with inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: image clone
|
|
|
Chain:
A
(313 residues)
CATH domain:
|
|
|
|
|
|
Structure of melk in complex with inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: image clone
|
|
|
Chain:
A
(316 residues)
CATH domain:
|
|
|
|
|
|
Structure of melk in complex with inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: image clone
|
|
|
Chain:
A
(316 residues)
CATH domain:
|
|
|
|
|
|
Jak3 in complex with a covalent egfr inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(269 residues)
CATH domains:
|
|
|
|
|
|
The crystal structure of human abl1 wild type kinase domain in complex with axitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
B, A
(276 residues)
CATH domains:
|
|
|
|
|
|
Human pyruvate kinase m2 mutant c424a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(518 residues)
CATH domains:
|
|
|
|
Bound ligands:
|
Het Group OXD
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Syk catalytic domain in complex with a potent triazolopyridine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with bms-066 aka 2-methoxy-n-({6-[3-methyl-7-(methylamino)- 3,5,8,10-tetraazatricyclo[7.3.0.0, 6]dodeca-1(9),2(6),4,7,11-pentaen- 11-yl]pyridin-2-yl}methy l)acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chains:
A, B
(258 residues)
CATH domains:
|
|
|
|
|
|
Co-crystal structure of perk bound to n-{5-[(6,7-dimethoxyquinolin-4- yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3- dihydro-1h-pyrazole-4-carboxamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(256 residues)
|
|
|
|
|
|
Co-crystal structure of perk with 2-amino-n-[4-methoxy-3- (trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6- yl]benzamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(257 residues)
|
|
|
|
|
|
Co-crystal structure of perk bound to 4-{2-amino-3-[5-fluoro-2- (methylamino)quinazolin-6-yl]-4-methylbenzoyl}-1-methyl-2,5-diphenyl- 1,2-dihydro-3h-pyrazol-3-one inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(260 residues)
|
|
|
|
|
|
Co-crystal structure of perk bound to 4-{2-amino-4-methyl-3-[2- (methylamino)-1,3-benzothiazol-6-yl]benzoyl}-1-methyl-2,5-diphenyl-1, 2-dihydro-3h-pyrazol-3-one inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(260 residues)
|
|
|
|
|
|
Co-crystal structure of perk bound to 4-[2-amino-4-methyl-3-(2- methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenyl-1,2-dihydro-3h- pyrazol-3-one inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(259 residues)
|
|
|
|
|
|
Co-crystal structure of perk bound to 1-[5-(4-amino-2,7-dimethyl-7h- pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1h-indol-1-yl]-2-[3-fluoro- 5-(trifluoromethyl)phenyl]ethanone inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(246 residues)
|
|
|
|
|
|
Pyk2-fat complexed with leupaxin ld motif ld1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chains:
A, D
(136 residues)
CATH domain:
|
|
|
|
|
|
Pyk2-fat domain in complex with leupaxin ld4 motif
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
A
(137 residues)
CATH domain:
|
|
|
|
|
|
Fusion of pyk2-fat domain with leupaxin ld1 motif, complexed with leupaxin ld4 peptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chains:
A, D
(148 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of an sh2-kinase domain construct of c-abl tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
B, A
(359 residues)
|
|
|
|
|
|
Crystal structure of ligand-free syk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(259 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of an inhibitor-bound syk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(262 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of an inhibitor-bound syk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of an inhibitor-bound syk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of an inhibitor-bound syk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of an inhibitor-bound syk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, C
(258 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of an inhibitor-bound syk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(259 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of an auto-inhibited form of bruton's tryrosine kinase
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: btk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(421 residues)
|
|
|
|
|
|
Crystal structure of abl2/arg kinase in complex with dasatinib
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chains:
A, B
(264 residues)
CATH domains:
|
|
|
|
|
|
Zap-70-tsh2:compound-a complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: zap70, srk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(258 residues)
CATH domains:
|
|
|
|
|
|
Zap-70-tsh2:compound-b adduct
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: zap70, srk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
A
(254 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the intertwined form of the src tyrosine kinase sh3 domain e97t-q128r mutant
|
|
|
Source: Avian sarcoma virus pr2257/16. Organism_taxid: 385048. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the ph-th-kinase construct of bruton's tyrosine kinase (btk)
|
|
|
Source: Bos taurus. Bovine. Organism_taxid: 9913. Gene: btk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(429 residues)
|
|
|
|
|
|
Crystal structure of the ph-th module of bruton's tyrosine kinase bound to inositol hexakisphosphate
|
|
|
Source: Bos taurus. Bovine. Organism_taxid: 9913. Gene: btk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
B, C, A, D
(149 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the kinase domain of bruton's tyrosine kinase with mutations in the activation loop
|
|
|
Source: Bos taurus. Bovine. Organism_taxid: 9913. Gene: btk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(266 residues)
CATH domains:
|
|
|
|
|
|
Type ii dasatinib analog crystallized with c-src kinase
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(255 residues)
CATH domains:
|
|
|
|
|
|
C-helix-out dasatinib analog crystallized with c-src kinase
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
|
|
C-helix-out binding of dasatinib analog to c-abl kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(259 residues)
CATH domains:
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with a t-butyl cyanoacrylamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chains:
A, B
(268 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of pkm2 mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(518 residues)
CATH domains:
|
|
|
|
Bound ligands:
|
Het Group PYR
corresponds to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
The kinase domain of human spleen tyrosine (syk) in complex with gtc000222
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(267 residues)
CATH domains:
|
|
|
|
|
|
The kinase domain of human spleen tyrosine (syk) in complex with gtc000223
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(263 residues)
CATH domains:
|
|
|
|
|
|
Syk kinase domain in complex with inhibitor gtc000224
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(266 residues)
CATH domains:
|
|
|
|
|
|
Syk kinase domain in complex with inhibitor gtc000225
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
The kinase domain of human spleen tyrosine (syk) in complex with gtc000226
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(257 residues)
CATH domains:
|
|
|
|
|
|
The kinase domain of human spleen tyrosine (syk) in complex with gtc000233
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(270 residues)
CATH domains:
|
|
|
|
|
|
The kinase domain of human spleen tyrosine (syk) in complex with gtc000249
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(267 residues)
CATH domains:
|
|
|
|
|
|
The kinase domain of human spleen tyrosine (syk) in complex with gtc000250
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Discovery of vx-509 (decernotinib): a potent and selective janus kinase (jak) 3 inhibitor for the treatment of autoimmune disease
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(286 residues)
CATH domains:
|
|
|
|
|
|
Discovery of vx-509 (decernotinib): a potent and selective janus kinase (jak) 3 inhibitor for the treatment of autoimmune diseases
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(285 residues)
CATH domains:
|
|
|
|
|
|
Discovery of vx-509 (decernotinib): a potent and selective janus kinase (jak) 3 inhibitor for the treatment of autoimmune diseases
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Discovery of vx-509 (decernotinib): a potent and selective janus kinase (jak) 3 inhibitor for the treatment of autoimmune disease
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(286 residues)
CATH domains:
|
|
|
|
|
|
Crystal structures reveal transient perk luminal domain tetramerization in er stress signaling
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(200 residues)
|
|
|
|
|
|
Crystal structures reveal transient perk luminal domain tetramerization in er stress signaling
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: eif2ak3, pek, perk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(163 residues)
|
|
|
|
|
|
Crystal structure of the jak3 kinase domain covalently bound to n-(3- (((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino) pyrimidin-4-yl)amino)methyl)phenyl)acrylamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B, C, D
(273 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the ferm-sh2 domains of jak2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B, C, D, E, F, G, H
(441 residues)
|
|
|
|
|
|
Fragment-based discovery of a small molecule reversible inhibitor of bruton's tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
A
(271 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of janus kinase 2 in complex with a 9h-carbazole-1- carboxamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bruton's tyrosine kinase bound to a cinnoline fragment
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
A
(270 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bruton's tyrosine kinase in complex with a substituted cinnoline
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
A
(270 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the fyn-sh3 domain in complex with the high affinity peptide app12
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B, C, D
(58 residues)
CATH domain:
|
|
|
|
|
|
Vx-680/mk-0457 binds to human abl1 also in inactive dfg conformations.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chains:
A, B
(269 residues)
CATH domains:
|
|
|
|
|
|
Novel pyrrole carboxamide inhibitors of jak2 as potential treatment of myeloproliferative disorders
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(289 residues)
CATH domains:
|
|
|
|
|
|
Rip2 kinase catalytic domain (1 - 310)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(277 residues)
CATH domain:
|
|
|
|
|
|
Rip2 kinase catalytic domain (1 - 310) complex with amp-pcp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(279 residues)
CATH domain:
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Rip2 kinase catalytic domain (1 - 310) complex with sb-203580
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(274 residues)
CATH domain:
|
|
|
|
|
|
Rip2 kinase catalytic domain (1 - 310) complex with benzimidazole
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(284 residues)
CATH domain:
|
|
|
|
|
|
Rip2 kinase catalytic domain (1 - 310) complex with biaryl urea
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(278 residues)
CATH domain:
|
|
|
|
|
|
Rip2 kinase catalytic domain (1 - 310) complex with biphenylsulfonamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(255 residues)
CATH domain:
|
|
|
|
|
|
Src in complex with DNA-templated macrocyclic inhibitor mc25b
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B
(275 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with bms-824171 aka 6-[(3r)-3-(4-tert-bu tylbenzamido) piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) phenyl]amino}pyridine- 3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590.
|
|
|
Chains:
A, B
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with bms-824171 aka 6-[(3r)-3-(4-tert-bu tylbenzamido) piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) phenyl]amino}pyridine- 3-carboxamide
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of kinase
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(258 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group AGS
is 93.75% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Crystal structure of syk in complex with compound 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group PTR
is 76.19% similar to
enzyme product [protein]-L-tyrosine phosphate
|
|
|
|
|
|
|
Crystal structure of syk in complex with compound 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group TYR
is 70.59% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of janus kinase 2 in complex with n,n-dicyclopropyl- 10-ethyl-7-[(3-methoxypropyl)amino] -3-methyl-3,5,8,10- tetraazatricyclo[7.3.0.0,6] dodeca-1(9),2(6),4,7,11-pentaene-11- carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(285 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of janus kinase 2 in complex with n,n-dicyclopropyl- 7-[(dimethyl-1,3-thiazol-2-yl)amino]-10-ethyl-3-methyl-3,5,8,10- tetraazatricyclo[7.3.0.02,6] dodeca-1(9),2(6),4,7,11-pentaene-11- carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(289 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of janus kinase 2 in complex with n,n-dicyclopropyl- 10-[(2s)-2,3-dihydroxypropyl]-3-methyl-7-(methylamino)-3,5,8,10- tetraazatricyclo [7.3.0.02,6]dodeca-1(9),2(6),4,7,11-pentaene-11- carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(287 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of janus kinase 2 in complex with n,n-dicyclopropyl- 10-ethyl-7-[(3-methoxypropyl)amino] -3-methyl-3,5,8,10- tetraazatricyclo[7.3.0.0,6] dodeca-1(9),2(6),4,7,11-pentaene-11- carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(287 residues)
CATH domains:
|
|
|
|
|
|
Syk catalytic domain complexed with a potent orally bioavailable thiazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(277 residues)
CATH domains:
|
|
|
|
|
|
Syk catalytic domain complexed with naphthyridine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(269 residues)
CATH domains:
|
|
|
|
|
|
Syk catalytic domain complexed with a potent and orally bioavailable benzisothiazole inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(276 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with rl236
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(248 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with rl235
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(254 residues)
CATH domains:
|
|
|
|
|
|
Kinase domain of csrc in complex with rl40
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(260 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ptk6 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(269 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of ptk6 kinase domain with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(264 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of monobody gg3/abl1 sh2 domain complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fn1, fn. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: abl1, abl, jtk7.
|
|
|
Chain:
B
(98 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of monobody as25/abl1 sh2 domain complex, crystal a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(100 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of monobody as25/abl1 sh2 domain complex, crystal b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(100 residues)
CATH domain:
|
|
|
|
|
|
Human jak1 kinase in complex with compound 30 at 2.30 angstroms resolution
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(281 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of a chimeric c-src-sh3 domain with the sequence of the rt-loop from the abl-sh3 domain at ph 5.0
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C
(57 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of a chimeric c-src-sh3 domain with the sequence of the rt-loop from the abl-sh3 domain at ph 6.5
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(60 residues)
CATH domain:
|
|
|
|
|
|
Structure of tyk2 with inhibitor 16: 3-azanyl-5-[(2~{s})-3- methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]- 1~{h}-pyrazolo[4,3-c]pyridin-4-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(281 residues)
CATH domains:
|
|
|
|
|
|
Structure of tyk2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1- methylpyrazol-3-yl)-1~{h}-pyrazolo[4,3-c]pyridin-4-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of fat domain of focal adhesion kinase (fak) bound to the transcription factor mef2c
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
E, F, G
(128 residues)
CATH domain:
|
|
|
|
|
|
Btk kinase domain with inhibitor 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chains:
C, D
(256 residues)
CATH domains:
|
|
|
|
|
|
Btk-inhibitor co-structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(255 residues)
CATH domains:
|
|
|
|
|
|
Architecture of human mtor complex 1 - 5.9 angstrom reconstruction
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Spodoptera frugiperda. Fall armyworm. Organism_taxid: 7108.
|
|
|
Chains:
B, F
(1050 residues)
|
|
|
|
|
|
Crystal structure of an inhibitor-bound syk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(265 residues)
CATH domains:
|
|
|
|
|
|
Co-crystal structure of the fk506 binding domain of human fkbp25, rapamycin and the frb domain of human mtor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp3, fkbp25. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: mtor, frap, frap1, frap2, raft1, rapt1.
|
|
|
Chain:
B
(93 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor (s)-ethyl2-(((1r,4s)-4-(4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3- d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(447 residues)
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor (s)-2-(((1r,4s)-4-(4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3- d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanoic acid
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(447 residues)
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor (s)-2-(((1r,4s)-4-(4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3- d]pyrimidin-7-yl)cyclohexyl)amino)-4-methylpentanamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(447 residues)
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor (s)-2-(((1r,4s)-4-(4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3- d]pyrimidin-7-yl)cyclohexyl)amino)-n,4-dimethylpentanamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(447 residues)
|
|
|
|
|
|
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor (s)-2-(((1r,4s)-4-(4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3- d]pyrimidin-7-yl)cyclohexyl)amino)-n,n,4-trimethylpentanamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(447 residues)
|
|
|
|
|
|
Crystal structure of ptk6 kinase domain complexed with dasatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B, C, D
(266 residues)
CATH domains:
|
|
|
|
|
|
Cryo-em structure of mtorc1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Gene: rptor, kiaa1303, raptor. Gene: mlst8, gbl, lst8.
|
|
|
Chains:
A, a
(2101 residues)
|
|
|
|
|
|
Human hck sh3 domain, nmr, minimized average structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: residues g72-e143 of human hck. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(61 residues)
CATH domain:
|
|
|
|
|
|
Jak2 kinase (jh1 domain) mutant p1057a in complex with tg101209
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(289 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of abl1 in complex with chmfl-074
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(270 residues)
CATH domains:
|
|
|
|
|
|
Jak1 complex with 4-[(4-aminocyclohexyl)amino]-3-(1h-benzimidazol-2- yl)-1h-pyridin-2-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(293 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of the intertwined form of the src tyrosine kinase sh3 domain t114s-q128r mutant
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(56 residues)
CATH domain:
|
|
|
|
|
|
Crystal structure of the e596a v617f mutant jak2 pseudokinase domain bound to mg-atp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(275 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ATP
corresponds to
enzyme reactant ATP
|
|
|
|
|
|
|
Structure, thermodynamics, and the role of conformational dynamics in the interactions between the n-terminal sh3 domain of crkii and proline-rich motifs in cabl
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: crk, crko. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Endothia gyrosa. Organism_taxid: 40263
|
|
|
Chains:
M, N
(12 residues)
|
|
|
|
|
|
Melk in complex with nvs-melk1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(306 residues)
|
|
|
|
|
|
Melk in complex with nvs-melk8a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(308 residues)
|
|
|
|
|
|
Melk in complex with nvs-melk8f
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(303 residues)
|
|
|
|
|
|
Melk in complex with nvs-melk12b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(305 residues)
|
|
|
|
|
|
Structure of human jak1 ferm/sh2 in complex with ifn lambda receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ifnlr1, il28ra, licr2.
|
|
|
Chain:
A
(420 residues)
|
|
|
|
|
|
Structure of human jak1 ferm/sh2 in complex with ifnlr1/il10ra chimera
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ifnlr1, il28ra, licr2, il10ra, il10r.
|
|
|
Chain:
A
(436 residues)
|
|
|
|
|
|
Src kinase in complex with a sulfonamide inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(258 residues)
CATH domains:
|
|
|
|
|
|
The identification and pharmacological characterization of 6-(tert- butylsulfonyl)-n-(5-fluoro-1h-indazol-3-yl)quinolin-4-amine (gsk583), a highly potent and selective inhibitor of rip2 kinase, compound 3 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(283 residues)
CATH domain:
|
|
|
|
|
|
The identification and pharmacological characterization of 6-(tert- butylsulfonyl)-n-(5-fluoro-1h-indazol-3-yl)quinolin-4-amine (gsk583), a highly potent and selective inhibitor of rip2 kinase, gsk583 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(277 residues)
CATH domain:
|
|
|
|
|
|
Discovery of n-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl) amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4- (tert-butyl)benzamide (chmfl-btk-01) as a highly selective irreversible btk kinase inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(263 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with 4-[2-fluoro-3-(4-oxo -3,4-dihydroquinazolin-3-yl) phenyl]-7-(2-hydroxypropan-2-y l)-9h-carbazole-1-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(258 residues)
CATH domains:
|
|
|
|
|
|
Melk in complex with nvs-melk5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(311 residues)
|
|
|
|
|
|
Crystal structure of c-src in complex with a covalent lysine probe
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: de3.
|
|
|
Chains:
A, B
(258 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of jak1 in complex with adp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(278 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of jak1 in complex with pf-4950736
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Bruton's tyrosine kinase (btk) with pyridazinone compound 9
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(265 residues)
CATH domains:
|
|
|
|
|
|
Structure of interferon lambda 1 receptor with human kinase jak1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: rosetta 2 (de3). Gene: ifnlr1, il28ra, licr2.
|
|
|
Chain:
A
(460 residues)
|
|
|
|
|
|
Fragment-based discovery of 6-arylindazole jak inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Human spleen tyrosine kinase kinase domain in complex with azanaphthyridine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(268 residues)
CATH domains:
|
|
|
|
|
|
Human spleen tyrosine kinase kinase domain in complex with azanaphthyridine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(265 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of jak3 in complex with compound 4 (fm381)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
|
|
Crystal structure of jak3 in complex with compound 5 (fm409)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(290 residues)
CATH domains:
|
|
|
|
Bound ligand:
|
Het Group PHU
is 50.00% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of melk in complex with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(315 residues)
|
|
|
|
|
|
Crystal structure of melk in complex with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(315 residues)
|
|
|
|
|
|
Crystal structure of melk in complex with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(314 residues)
|
|
|
|
|
|
Crystal structure of melk in complex with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(316 residues)
|
|
|
|
|
|
Crystal structure of melk in complex with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(312 residues)
|
|
|
|
|
|
Abl1 kinase (t334i_d382n) in complex with asciminib and nilotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(429 residues)
|
|
|
|
|
|
Yes1-sh2 in complex with monobody mb(yes_1)
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: yes1, yes. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chain:
A
(109 residues)
|
|
|
|
|
|
Monobody mb(lck_3) bound to lck-sh2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse. Organism_taxid: 10090
|
|
|
Chain:
A
(108 residues)
|
|
|
|
|
|
Monobody mb(lck_1) bound to lck-sh2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Synthetic construct. Organism_taxid: 32630. Expression_system_taxid: 866768
|
|
|
Chain:
A
(88 residues)
|
|
|
|
|
|
Structure of rip2k(l294f) with bound amppcp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(274 residues)
|
|
|
|
Bound ligand:
|
Het Group ACP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Structure of rip2k(d146n) with bound staurosporine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(274 residues)
|
|
|
|
|
|
Structure of inactive kinase rip2k(k47r)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_taxid: 7108
|
|
|
Chains:
D, B, A, C
(279 residues)
|
|
|
|
|
|
Abl1 sh3 ptyr89/134
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(57 residues)
|
|
|
|
|
|
Abl2 sh3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl2, abll, arg. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(57 residues)
|
|
|
|
|
|
Abl2 sh3 ptyr116/161
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl2, abll, arg. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(61 residues)
|
|
|
|
|
|
Crystal structure of sivmac239 nef bound to an engineered hck sh3 domain
|
|
|
Source: Simian immunodeficiency virus. Siv. Organism_taxid: 11723. Gene: nef. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chains:
C, D
(54 residues)
|
|
|
|
|
|
High resolution crystal structure of thE C-src-sh3 domain mutant e93v in complex with the high affinity synthetic peptide app12: monoclinic crystal
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, C
(57 residues)
|
|
|
|
|
|
Crystal structure of the abl-sh3 domain at ph 7.5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(59 residues)
|
|
|
|
|
|
Crystal structure of thE C-src-sh3 domain q128e mutant in complex with the high affinity peptide app12
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
Crystal structure of thE C-src-sh3 domain q128r mutant in complex with the high affinity peptide app12
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
Crystal structure of thE C-src-sh3 domain e97t mutant in complex with the high affinity peptide app12
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, C
(56 residues)
|
|
|
|
|
|
Btk in complex with gdc-0834
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Structure of btk with rn486
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Btk1 cocrystallized with rn983
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Btk1 soaked with ibrutinib-rev
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Btk1 cocrystallized with ibrutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(263 residues)
|
|
|
|
|
|
Crystal structure of btk with cnx 774
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Btk1 in complex with cc 292
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(252 residues)
|
|
|
|
|
|
Btk1 binds covalently to hy-15771 ono-4059
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
The crystal structure of a chaperone
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak3, pek, perk. Expressed in: bacteria. Expression_system_taxid: 469008. Expression_system_variant: codon plus
|
|
|
Chains:
A, B, C, D
(203 residues)
|
|
|
|
|
|
C-src v281c kinase domain in complex with rao-iv-151
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(258 residues)
|
|
|
|
|
|
C-src v281c bound to n-[3-({6-[(1e)-2-cyano-3-(methylamino)-3-oxoprop- 1-en-1-yl]-7-(2-methoxyethyl)-7h-pyrrolo[2,3-d]pyrimidin-5- yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(258 residues)
|
|
|
|
|
|
C-src kinase domain in complex with rao-iv-151
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(264 residues)
|
|
|
|
|
|
Crystal structure of bruton agammabulinemia tyrosine kinase complexed with bms-986142 aka (2s)-6-fluoro-5-[3-(8-fluoro-1-methyl-2,4-dioxo- 1,2,3,4-tetrahydroquinazolin-3-yl)-2-methylphenyl]-2-(2- hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: baculovirus. Expression_system_taxid: 10469.
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Crystal structure of syk catalytic domain in complex with a furo[3,2- d]pyrimidine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(266 residues)
CATH domains:
|
|
|
|
|
|
C-src v281c kinase domain in complex with rao-iv-156
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(261 residues)
|
|
|
|
|
|
Crystal structure of syk kinase domain with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Other_details: gateway (invitrogen) adapted pcdna6 attb hisc vector
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with 6-[(3,5-dimethylphe nyl)amino]-8- (methylamino) imidazo[1,2-b]pyridazine-3-carbo xamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(248 residues)
CATH domains:
|
|
|
|
|
|
Selectivity switch between fak and pyk2: macrocyclization of fak inhibitors improves pyk2 potency
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(250 residues)
CATH domains:
|
|
|
|
|
|
Selectivity switch between fak and pyk2: macrocyclization of fak inhibitors improves pyk2 potency
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(245 residues)
|
|
|
|
|
|
Jak3 with covalent inhibitor pf-06651600
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(278 residues)
CATH domains:
|
|
|
|
|
|
Design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for the treatment of inflammatory diseases of the lungs and skin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: sf9
|
|
|
Chains:
A, B
(284 residues)
|
|
|
|
|
|
Design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(276 residues)
|
|
|
|
|
|
Design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(277 residues)
|
|
|
|
|
|
Design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Discovery of tak-659, an orally available investigational inhibitor of spleen tyrosine kinase (syk)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590.
|
|
|
Chain:
A
(272 residues)
CATH domains:
|
|
|
|
|
|
Discovery of tak-659, an orally available investigational inhibitor of spleen tyrosine kinase (syk)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(274 residues)
CATH domains:
|
|
|
|
|
|
Jak3 with covalent inhibitor 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Jak3 with covalent inhibitor 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Jak3 with covalent inhibitor 6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(280 residues)
|
|
|
|
Bound ligand:
|
Het Group 7KX
is 48.00% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Structure of maternal embryonic leucine zipper kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(321 residues)
|
|
|
|
|
|
Structure of maternal embryonic leucine zipper kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(319 residues)
|
|
|
|
|
|
Structure of maternal embryonic leucine zipper kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(318 residues)
|
|
|
|
|
|
Structure of maternal embryonic leucine zipper kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(313 residues)
|
|
|
|
|
|
Structure of maternal embryonic leucine zipper kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(313 residues)
|
|
|
|
|
|
Structure of maternal embryonic leucine zipper kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(306 residues)
|
|
|
|
|
|
Discovery of a potent btk inhibitor with a novel binding mode using parallel selections with a DNA-encoded chemical library
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with jnj-7706621
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jnj-7706621
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with at9283
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with bi-d1870
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
Bound ligand:
|
Het Group 7DZ
is 41.67% similar to
enzyme product ADP
|
|
|
|
|
|
|
Jak2 jh2 in complex with prt062607
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with ikk-2 inhibitor vi
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with nvp-bsk805
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with glpg0634
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with a diaminopyrimidine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Complex structure of the bovine perk luminal domain and its substrate peptide
|
|
|
Source: Bos taurus. Bovine. Organism_taxid: 9913. Gene: eif2ak3. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B, C, D
(193 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with mk1775
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(259 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with bosutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(260 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with bosutinib-isomer
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with pd- 166285
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with pha- 848125
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(259 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with pf- 03814735
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(258 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with rac-iv- 016, a mk1775 analougue
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with rac-iv- 050, a mk1775 analougue
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(260 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with rac-iv- 098, a mk1775 analogue
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with rac-iv- 099, a mk1775 analogue
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(260 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with rac-iv- 097, a mk1775 analogue
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with rac-iv- 101, a mk1775 analogue
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(259 residues)
|
|
|
|
|
|
Crystal structure of human wee2 kinase domain in complex with mk1775
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee2, wee1b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(260 residues)
|
|
|
|
|
|
Crystal structure of sugen kinase 223
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: sgk223. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(348 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase (btk) with gdc-0853
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera. Expression_system_taxid: 7106
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase (btk) with compound g-744
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Crystal structure of jak3 kinase domain in complex with a pyrrolopyridazine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Identification of potent and selective ripk2 inhibitors for the treatment of inflammatory diseases
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chains:
A, B
(251 residues)
|
|
|
|
|
|
Identification of potent and selective ripk2 inhibitors for the treatment of inflammatory diseases.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chains:
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
(275 residues)
|
|
|
|
|
|
Crystal structure of jak3 kinase domain with a 4,6-diaminonicotinamide inhibitor (compound number 7)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B, C, D
(271 residues)
|
|
|
|
|
|
Identification of an imidazopyridine scaffold to generate potent and selective tyk2 inhibitors that demonstrate activity in an in vivo psoriasis model
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(286 residues)
|
|
|
|
|
|
Structure of the frb domain of mtor bound to a substrate recruitment peptide of s6k1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: rps6kb1, stk14a.
|
|
|
Chains:
A, B, C, D, E
(92 residues)
|
|
|
|
|
|
Crystal structure of mtor(deltan)-mlst8-pras40(alpha-helix & beta- strand) complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: mlst8, gbl, lst8. Gene: akt1s1, pras40.
|
|
|
Chains:
B, A
(1058 residues)
|
|
|
|
|
|
Crystal structure of mtor(deltan)-mlst8-pras40(beta-strand) complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: mlst8, gbl, lst8. Gene: akt1s1, pras40.
|
|
|
Chains:
B, A
(1058 residues)
|
|
|
|
|
|
Identification of an imidazopyridine scaffold to generate potent and selective tyk2 inhibitors that demonstrate activity in an in vivo psoriasis model
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(295 residues)
|
|
|
|
|
|
The jak3 kinase domain in complex with a covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Jak2 pseudokinase in complex with nu6140
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Jak2 pseudokinase in complex with bi-d1870
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
B
(274 residues)
|
|
|
|
|
|
Jak2 pseudokinase in complex with azd7762
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Jak2 pseudokinase in complex with at9283
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Jak2 pseudokinase in complex with jnj7706621
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Jak1 complexed with compound 28
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chains:
A, B
(294 residues)
|
|
|
|
|
|
Crystal structure of pkm2 r399e mutant complexed with fbp and serine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(518 residues)
|
|
|
|
Bound ligands:
|
Het Group PYR
corresponds to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Pkm2 in complex with compound 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(512 residues)
|
|
|
|
Bound ligand:
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Pkm2 in complex with compound 5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B, C, D
(518 residues)
|
|
|
|
Bound ligand:
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
C-src in complex with atp-chf
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333.
|
|
|
Chains:
A, B
(267 residues)
|
|
|
|
Bound ligand:
|
Het Group 8BU
is 59.46% similar to
enzyme product ADP
|
|
|
|
|
|
|
C-src in complex with atp-chcl
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333.
|
|
|
Chains:
A, B
(265 residues)
|
|
|
|
Bound ligand:
|
Het Group 8C6
is 66.67% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of lyn kinase domain in complex with n-(1h-indazol- 6-yl)-8-(piperidin-4-yloxy)-6-propylquinazolin-2-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lyn, jtk8. Expressed in: insect cell expression vector ptie1. Expression_system_taxid: 266783
|
|
|
Chain:
A
(253 residues)
|
|
|
|
|
|
The structure of human btk kinase domain in complex with a covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(230 residues)
|
|
|
|
|
|
Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
|
|
|
|
|
|
Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(266 residues)
|
|
|
|
|
|
Structure of rip2 card domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D, E, F, G, H, I, J, K, L
(87 residues)
|
|
|
|
|
|
Complex of the human fyn sh3 and monobody binder
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 562. Sulfolobus solfataricus. Organism_taxid: 2287. Expression_system_taxid: 562
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
4.9 angstrom cryo-em structure of human mtor complex 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f. Gene: mlst8, gbl, lst8. Gene: rictor, kiaa1999.
|
|
|
Chains:
A, B
(2178 residues)
|
|
|
|
|
|
Crystal structure of hck kinase complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4- phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(271 residues)
|
|
|
|
|
|
Crystal structure of ack1 with compound 10d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(240 residues)
|
|
|
|
|
|
Crystal structure of bruton's tyrosine kinase in complex with inhibitor 2e
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chains:
A, B, C, D, E, F
(261 residues)
|
|
|
|
|
|
Crystal structure of jak1 in complex with peficitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(285 residues)
|
|
|
|
|
|
Crystal structure of jak2 in complex with peficitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(283 residues)
|
|
|
|
|
|
Crystal structure of jak3 in complex with peficitinib
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B, C, D
(277 residues)
|
|
|
|
|
|
Crystal structure of tyk2 in complex with peficitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(269 residues)
|
|
|
|
|
|
Abl 1b regulatory module 'inhibiting state'
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693
|
|
|
Chain:
A
(255 residues)
|
|
|
|
|
|
Abl1b regulatory module 'activating' conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693
|
|
|
Chain:
A
(255 residues)
|
|
|
|
|
|
Src kinase bound to covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(255 residues)
|
|
|
|
|
|
Crystal structure of bruton's tyrosine kinase in complex with inhibitor cgi2625
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Crystal structure of bruton's tyrosine kinase in complex with inhibitor cgi2815
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Pyruvate kinase m2 mutant - s437y
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(522 residues)
|
|
|
|
Bound ligand:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Crystal structure of jak1 in complex with compound 25
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Crystal structure of jak2 in complex with compound 25
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Crystal structure of pseduokinase peak1 (sugen kinase 269)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: peak1, kiaa2002. Expressed in: escherichia coli. Expression_system_taxid: 469008.
|
|
|
Chain:
A
(371 residues)
|
|
|
|
|
|
Btk complex with compound 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Btk complex with compound 10
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Btk complex with compound 11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
|
|
|
|
|
|
Btk complex with compound 12
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Predicting the conformational variability of abl tyrosine kinase using molecular dynamics simulations and markov state models
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(270 residues)
|
|
|
|
|
|
Btk complex with compound 13
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with xmu-mp-1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with 63552444
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with nu6102
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Complex structure of fak fat domain and dcc p3 motif
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ptk2, fadk, fak, fak1, kiaa4203. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Rattus norvegicus. Rat.
|
|
|
Chains:
A, C
(125 residues)
|
|
|
|
|
|
Human csrc sh3 domain in complex with choline kinase fragment 60-69
|
|
|
Source: Homo sapiens. Human, human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(74 residues)
|
|
|
|
|
|
Crystal structure of inhibitory protein socs1 in complex with jak1 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gallus gallus. Chicken. Organism_taxid: 9031.
|
|
|
Chain:
A
(274 residues)
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of the fak ferm domain
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ptk2, fak, fak1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(357 residues)
|
|
|
|
|
|
Structure of the ptk6 kinase domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk6, brk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(262 residues)
|
|
|
|
|
|
Structure of the ptk6 kinase domain bound to a type i inhibitor (3- fluoro-4-{[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8- yl]amino}phenyl)(morpholin-4-yl)methanone
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk6, brk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(262 residues)
|
|
|
|
|
|
Structure of the ptk6 kinase domain bound to a type ii inhibitor 2- {[(3r,4s)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4- yl]oxy}-5-(1-methyl-1h-imidazol-4-yl)pyridine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk6, brk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(257 residues)
|
|
|
|
|
|
Jak2 pseudokinase v617f in complex with at9283
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(273 residues)
|
|
|
|
|
|
Crystal structure of unphosphorylated human pkr kinase domain in complex with adp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak2, pkr, prkr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
B, A, C
(254 residues)
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of unphosphorylated human pkr
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak2, pkr, prkr. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(248 residues)
|
|
|
|
|
|
Jak3 with cyanamide cp10
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Jak3 with cyanamide cp23
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
Jak3 with cyanamide cp34
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(276 residues)
|
|
|
|
|
|
Tyk2 with compound 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Tyk2 with compound 23
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Jak1 with compound 23
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(281 residues)
|
|
|
|
|
|
Waap in complex with acyl carrier protein
|
|
|
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Gene: rfap, waap, pa5009. Expressed in: escherichia coli. Expression_system_taxid: 562. Escherichia coli. Organism_taxid: 562. Gene: acpp. Expression_system_taxid: 562
|
|
|
Chain:
A
(241 residues)
|
|
|
|
|
|
Crystal structure of btk in complex with fragment ligand
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of btk in complex with covalent fragment ligand
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of btk in complex with fragment ligand
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(256 residues)
|
|
|
|
|
|
Crystal structure of btk in complex with covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of btk in complex with covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(252 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with jnj-7706621 (crystal form 2)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Jak3 with cyanamide cp12
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Structure of human jak2 ferm/sh2 in complex with leptin receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: lepr, db, obr. Expression_system_cell_line: sf9
|
|
|
Chains:
A, B
(457 residues)
|
|
|
|
|
|
Structure of human jak2 ferm/sh2 in complex with erythropoietin receptor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: epor. Expression_system_taxid: 7111
|
|
|
Chains:
A, B, C, D
(473 residues)
|
|
|
|
|
|
Crystal structure of arq 531 in complex with the kinase domain of btk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Dgy-06-116, a novel and selective covalent inhibitor of src kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D, E, F, G, H
(266 residues)
|
|
|
|
|
|
Fragment of a tyrosine-protein kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(77 residues)
|
|
|
|
|
|
Human jak1 kinase domain in complex with compound 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(289 residues)
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with n-[2-methyl-3- [4-methyl-6-[4-(4-methylpiperazine-1-carbonyl)anilino]-5-oxo-pyrazin- 2-yl]phenyl]-4-(1-piperidyl)benzamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
|
|
|
|
|
|
Crystal structure of the kinase domain of human ripk2 in complex with the activation loop targeting inhibitor cs-r35
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Autoinhibited src kinase bound to adp
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: src. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(449 residues)
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Structure of the kinase domain of human ripk2 in complex with the inhibitor cslp18
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(282 residues)
|
|
|
|
|
|
Crystal structure of jak2-v617f pseudokinase domain in complex with compound 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
|
|
|
Chains:
A, B
(272 residues)
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with irreversible inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ptk2, fak, fak1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(258 residues)
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with irreversible inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ptk2, fak, fak1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chains:
A, B
(254 residues)
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with irreversible inhibitor
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ptk2, fak, fak1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(258 residues)
|
|
|
|
|
|
Structure of rip2 card domain fused to crystallisable mbp tag
|
|
|
Source: Methanosarcina mazei, homo sapiens. Methanosarcina frisia, human. Organism_taxid: 2209, 9606. Strain: k12. Gene: male, du74_04045, ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(457 residues)
|
|
|
|
|
|
Crystal structure of m2 pyk in complex with alanine.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D, E, F, G, H, I, J, K, L
(519 residues)
|
|
|
|
Bound ligands:
|
Het Group ALA
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group PO4
is 50.00% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of m2 pyk in complex with phenyalanine.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(509 residues)
|
|
|
|
Bound ligand:
|
Het Group PO4
is 50.00% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of m2 pyk in complex with tryptophan.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(509 residues)
|
|
|
|
Bound ligand:
|
Het Group PO4
is 50.00% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of m2 pyk in complex with serine.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D, E, F, G, H
(510 residues)
|
|
|
|
Bound ligand:
|
Het Group SER
is 62.50% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Human jak1 kinase domain in complex with inhibitor
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B
(286 residues)
|
|
|
|
|
|
Structure of rip2 card filament
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
F, A, B, C, D, E, G, H, I, J
(86 residues)
|
|
|
|
|
|
Crystal structure of jak3 in complex with compound 10 (fm475)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(292 residues)
|
|
|
|
|
|
Crystal structure of jak3 in complex with compound 11 (fm481)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Crystal structure of jak3 in complex with compound 20 (fm484)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Crystal structure of maternal embryonic leucine zipper kinase (melk) in complex with dorsomorphin (compound c)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(315 residues)
|
|
|
|
|
|
Solution structure of rat rip2 caspase recruitment domain
|
|
|
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: ripk2, rcg_54865. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: plyss.
|
|
|
Chain:
A
(125 residues)
|
|
|
|
|
|
Abl1 in complex with compound 7 and imatinib (sti-571)
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: abl1, abl. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chains:
A, B
(287 residues)
|
|
|
|
|
|
Abl1 in complex with compound6 and imatinib (sti-571)
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: abl1, abl. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_variant: sf9
|
|
|
Chains:
A, B
(285 residues)
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase (syk) in complex with a 2- (pyridinyloxymethyl)pyridine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase (syk) in complex with a 2- (phenoxymethyl)pyridine inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Rip2 kinase catalytic domain complex with n(4,5dimethyl1hpyrazol3yl) 7methoxy6(2methylpropane2sulfonyl)quinolin4amine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(280 residues)
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 6- (dimethylamino)-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(morpholine-4- carbonyl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-3,4- dihydroisoquinolin-1-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
|
|
|
|
|
|
Crystal structure of btk kinase domain complexed with 12-(6-tert- butyl-8-fluoro-1-oxo-phthalazin-2-yl)-9-hydroxy-6-methyl-4-[[5- (morpholine-4-carbonyl)-2-pyridyl]amino]-6-azatricyclo[9.4.0.02, 7]pentadeca-1(15),2(7),3,11,13-pentaen-5-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(263 residues)
|
|
|
|
|
|
Crystal structure of human btk sh2 domain bound to rf10 repebody
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic construct. Organism_taxid: 32630. Expressed in: escherichia coli.
|
|
|
Chain:
A
(104 residues)
|
|
|
|
|
|
Kinase domain of csrc in complex with compound 9
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693
|
|
|
Chains:
A, B
(267 residues)
|
|
|
|
Bound ligand:
|
Het Group GUW
is 50.00% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Kinase domain of csrc in complex with compound 29b
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693
|
|
|
Chains:
A, B
(246 residues)
|
|
|
|
|
|
Human jak1 in complex with lasw1393
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B
(294 residues)
|
|
|
|
|
|
Human jak3 in complex with lasw959 protein in complex with ligand
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B, C, D
(266 residues)
|
|
|
|
|
|
Crystal structure of ptk2 in complex with bi-4464.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Bone marrow tyrosine kinase in chromosome x in complex with a newly designed covalent inhibitor js24
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Variant: 2. Cell: hematopoietic, endothelial, metastatic carcinoma. Gene: bmx. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590.
|
|
|
Chains:
A, B
(266 residues)
|
|
|
|
|
|
His-tagged fyn sh3 domain r96i mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
|
|
|
Chain:
A
(67 residues)
|
|
|
|
|
|
Fyn sh3 domain r96w mutant, crystallized with 18-crown-6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
|
|
|
Chain:
Z
(63 residues)
|
|
|
|
|
|
Co-crystal structure of btk kinase domain with zanubrutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Crystal structure of human pyruvate kinase m2 isoform
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(522 residues)
|
|
|
|
Bound ligand:
|
Het Group SER
is 62.50% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Crystal structure of human tyrosine-protein kinase fes/fps in complex with compound 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fes, fps. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(372 residues)
|
|
|
|
|
|
Crystal structure of human fer sh2 domain bound to a phosphopeptide (depyenvd)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fer, tyk3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, C, E, G, I, K
(101 residues)
|
|
|
|
|
|
C-src in complex with ibrutinib
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333
|
|
|
Chains:
A, B, C, D
(258 residues)
|
|
|
|
|
|
3d domain-swapped dimer of the maltose-binding protein fused to a fragment of the focal adhesion kinase
|
|
|
Source: Escherichia coli (strain k12), homo sapiens. Human. Organism_taxid: 83333, 9606. Gene: male, b4034, jw3994, ptk2, fak, fak1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, X, Y
(366 residues)
|
|
|
|
|
|
3d domain-swapped dimer of the maltose-binding protein fused to a fragment of the protein-tyrosine kinase 2-beta
|
|
|
Source: Escherichia coli (strain k12), homo sapiens. Human. Organism_taxid: 83333, 9606. Gene: male, b4034, jw3994, ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D, E, F
(369 residues)
|
|
|
|
|
|
Crystal structure of fkbp-frb t2098l mutant in complex with rapamycin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mtor. Expression_system_taxid: 562
|
|
|
Chains:
B, F
(93 residues)
|
|
|
|
|
|
Crystal structure of mbp fused split fkbp-frb t2098l mutant in complex with rapamycin
|
|
|
Source: Escherichia coli k-12, homo sapiens. Human. Organism_taxid: 83333, 9606. Strain: k-12. Gene: male, b4034, jw3994, fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Organism_taxid: 9606.
|
|
|
Chains:
G, H, I
(93 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with diaminopyrimidine jak040
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Crystal structure of mouse btk kinase domain in complex with compound 9a
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(252 residues)
|
|
|
|
|
|
Structure of the human jak1 kinase domain with compound 15
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(280 residues)
|
|
|
|
Bound ligand:
|
Het Group KEJ
is 41.94% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Structure of the human jak1 kinase domain with compound 21
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(277 residues)
|
|
|
|
|
|
Structure of the human jak1 kinase domain with compound 20
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Structure of the human jak1 kinase domain with compound 39
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(278 residues)
|
|
|
|
Bound ligand:
|
Het Group KEV
is 40.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Structure of the human jak1 kinase domain with compound 38
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(280 residues)
|
|
|
|
|
|
Structure of the human jak1 kinase domain with compound 56
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(275 residues)
|
|
|
|
|
|
Structure of the human jak1 kinase domain with compound 54
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(280 residues)
|
|
|
|
Bound ligand:
|
Het Group KF4
is 40.62% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Discovery of affinity-based probes for btk occupancy assay
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Btk in complex with inhibitor 8-(2,3-dihydro-1h-inden-5-yl)-2-({4- [(2s)-3-(dimethylamino)-2-hydroxypropoxy]phenyl}amino)-5,8- dihydropteridine-6,7-dione
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Btk in complex with inhibitor n-(3-{[(2,6-dimethylphenyl) methyl]amino}-7-methoxyindeno[1,2-c]pyrazol-6-yl)methanesulfonamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(243 residues)
|
|
|
|
|
|
Crystal structure of the human lyn sh3 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lyn, jtk8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(63 residues)
|
|
|
|
|
|
C-abl kinase domain with the activator(cmpd6), 2-cyano-n-(4-(3,4- dichlorophenyl)thiazol-2-yl)acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(264 residues)
|
|
|
|
|
|
C-abl kinase domain with the activator(cmpd29), n-(1-(3,4- dichlorophenyl)-4,5-dihydro-1h-pyrazol-3-yl)acetamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790
|
|
|
Chains:
A, B
(264 residues)
|
|
|
|
|
|
C-abl kinase domain with the activator(cmpd51), n-(1-(3,4- dichlorophenyl)-4-(2-hydroxyethyl)-4,5-dihydro-1h-pyrazol-3-yl) isonicotinamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790
|
|
|
Chains:
A, B
(264 residues)
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with compound-6c aka 6-((1-(4-cyanopheny l)-2-oxo-1,2- dihydro-3-pyridinyl)amino)-n-cyclopropyl-8-(m ethylamino)imidazo[1,2- b]pyridazine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(251 residues)
|
|
|
|
|
|
Crystal structure of human pkm2 in complex with l-cysteine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(476 residues)
|
|
|
|
Bound ligands:
|
Het Group CYS
is 62.50% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Pyruvate kinase m2 mutant - s437y in complex with l-cysteine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(522 residues)
|
|
|
|
Bound ligand:
|
Het Group CYS
is 62.50% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Pyruvate kinase m2 mutant - s437y in complex with l-serine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chains:
A, B
(522 residues)
|
|
|
|
Bound ligand:
|
Het Group SER
is 62.50% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Crystal structure of jak3 kinase domain in complex with a pyrrolopyridazine carboxamide inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(277 residues)
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with compound_5 aka 4-[(2-carbamoylphen yl)amino]-6-[(5- fluoropyridin-2-yl)amino]-n-methylpyridine -3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(250 residues)
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with compound_5 aka 4-[(2-carbamoylphen yl)amino]-6-[(5- fluoropyridin-2-yl)amino]-n-methylpyridine -3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(247 residues)
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with compound_40 aka 6-cyclopropaneamido-4-[(2- methanesulfonylphenyl)amino]-n-methylpyridine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(249 residues)
|
|
|
|
|
|
Brutons tyrosine kinase in complex with compound 50.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, D
(263 residues)
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with compound-11 aka 6-cyclopropaneamido-4-{[2-methoxy-3- (1-methyl-1h-1,2,4-tri azol-3-yl)phenyl]amino}-n-(?h?) methylpyridazine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(259 residues)
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with compound_29 aka 6-[(5-fluoro-4-meth ylpyridin-2-yl) amino]-4-({2-methoxy-3-[(pyridin-2-ylmethyl )carbamoyl]phenyl}amino)- n-methylpyridine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(256 residues)
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with compound_12 aka 4-[(2-methanesulfonylphenyl)amino]-n- (h3)methyl-6-[(pyridin-2- yl)amino]pyridazine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(260 residues)
|
|
|
|
|
|
Btk in complex with inhibitor
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(260 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak146
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak170
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak179
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak168
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak190
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Structure of human bruton's tyrosine kinase in complex with evobrutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of tyk2 with novel pyrrolidinone inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Tyrosine-protein kinase lck bound to compound 11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Hydrocarbon-stapled paxillin peptide bound to the focal adhesion targeting (fat) domain of the focal adhesion kinase (fak)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
A
(126 residues)
|
|
|
|
|
|
Rip2 kinase catalytic domain complex with 2(4[(1,3benzothiazol5yl) amino]6(2methylpropane2sulfonyl)quinazolin7yl)oxy)ethyl phosphate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(281 residues)
|
|
|
|
|
|
Rip2 kinase catalytic domain complex with 2({4[(1,3benzothiazol5yl) amino]6(2methylpropane2sulfonyl)quinazolin7yl}oxy)ethan1ol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(277 residues)
|
|
|
|
|
|
Structure based optimization of jak1-atp binding pocket inhibitors in the aminopyrazole class
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera aff. Frugiperda 1 bold-2017. Expression_system_taxid: 2449148
|
|
|
Chains:
A, B
(286 residues)
|
|
|
|
|
|
Structure based optimization of jak1-atp binding pocket inhibitors in the aminopyrazole class
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera aff. Frugiperda 1 bold-2017. Expression_system_taxid: 2449148
|
|
|
Chains:
A, B
(286 residues)
|
|
|
|
|
|
Structure based optimization of jak1-atp binding pocket inhibitors in the aminopyrazole class
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera aff. Frugiperda 1 bold-2017. Expression_system_taxid: 2449148
|
|
|
Chains:
A, B
(286 residues)
|
|
|
|
|
|
Structure based optimization of jak1-atp binding pocket inhibitors in the aminopyrazole class
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera aff. Frugiperda 1 bold-2017. Expression_system_taxid: 2449148
|
|
|
Chains:
A, B
(286 residues)
|
|
|
|
|
|
Structure based optimization of jak1-atp binding pocket inhibitors in the aminopyrazole class
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera aff. Frugiperda 1 bold-2017. Expression_system_taxid: 2449148
|
|
|
Chains:
A, B
(286 residues)
|
|
|
|
|
|
Structure of the kinase domain of human ripk2 in complex with the inhibitor cslp3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(291 residues)
|
|
|
|
|
|
Btk in complex with an inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(262 residues)
|
|
|
|
|
|
Cryo-em structure of mtorc1 bound to pras40-fused active raga/c gtpases
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: mlst8, gbl, lst8. Gene: rraga. Expressed in: escherichia coli.
|
|
|
Chains:
A, B
(2178 residues)
|
|
|
|
Bound ligands:
|
Het Group GTP
is 96.88% similar to
enzyme reactant ATP
|
|
|
Het Group GTP
is 96.88% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Cryo-em structure of mtorc1 bound to active raga/c gtpases
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: mlst8, gbl, lst8. Gene: rraga. Expressed in: escherichia coli.
|
|
|
Chains:
A, B
(2178 residues)
|
|
|
|
Bound ligands:
|
Het Group GTP
is 96.88% similar to
enzyme reactant ATP
|
|
|
Het Group GTP
is 96.88% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Human jak1 kinase domain in complex with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(297 residues)
|
|
|
|
|
|
Human jak1 kinase domain in complex with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
|
|
Syk in complex with compound 30
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Rip2 kinase catalytic domain complex with 5-amino-1-phenylpyrazole-4- carboxamide.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(274 residues)
|
|
|
|
|
|
Rip2 kinase catalytic domain complex with 5amino1tertbutyl3(3methoxyphenyl)1h pyrazole4carboxamide.
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(279 residues)
|
|
|
|
|
|
Btk in complex with lou064, a potent and highly selective covalent inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D, E
(266 residues)
|
|
|
|
|
|
Fragment-based discovery of pyrazolopyridones as jak1 inhibitors with excellent subtype selectivity
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Fragment-based discovery of pyrazolopyridones as jak1 inhibitors with excellent subtype selectivity
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(283 residues)
|
|
|
|
|
|
Fragment-based discovery of pyrazolopyridones as jak1 inhibitors with excellent subtype selectivity
|
|
|
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chains:
A, B
(288 residues)
|
|
|
|
Bound ligand:
|
Het Group NTQ
is 40.00% similar to
enzyme reactant [protein]-L-tyrosine
|
|
|
|
|
|
|
Crystal structure of 1-methylindoline-2,3-dione covalently bound to the ph domain of bruton's tyrosine kinase mutant r28c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(164 residues)
|
|
|
|
Bound ligand:
|
Het Group 72V
is 44.44% similar to
enzyme product ADP
|
|
|
|
|
|
|
The ph domain of bruton's tyrosine kinase mutant r28c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(164 residues)
|
|
|
|
|
|
Pkm2 in complex with compound 5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(514 residues)
|
|
|
|
Bound ligand:
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Pkm2 in complex with l-threonine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(410 residues)
|
|
|
|
Bound ligands:
|
Het Group THR
is 55.56% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Pkm2 in complex with compound 6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(416 residues)
|
|
|
|
Bound ligand:
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Pkm2 in complex with compound 10
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(510 residues)
|
|
|
|
Bound ligand:
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Ph domain of bruton's tyrosine kinase bound to compound 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(157 residues)
|
|
|
|
|
|
Crystal structure of 5-bromoindoline-2,3-dione covalently bound to the ph domain of bruton's tyrosine kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(160 residues)
|
|
|
|
|
|
Fak structure from single particle analysis of 2d crystals
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ptk2, fak, fak1. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(600 residues)
|
|
|
|
|
|
Fak structure with amp-pnp from single particle analysis of 2d crystals
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: ptk2, fak, fak1. Expressed in: homo sapiens. Expression_system_taxid: 9606
|
|
|
Chains:
A, B
(621 residues)
|
|
|
|
Bound ligand:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of vpso (vc0937) kinase domain
|
|
|
Source: Vibrio cholerae. Organism_taxid: 666. Gene: vpso. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(208 residues)
|
|
|
|
|
|
Rip2 kinase catalytic domain complex with (5s,6s,8r)-2- (benzo[d]thiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8- methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
|
|
|
Chains:
A, B
(279 residues)
|
|
|
|
|
|
Crystal structure of human pkm2 in complex with l-asparagine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(513 residues)
|
|
|
|
Bound ligands:
|
Het Group GOL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of human pkm2 in complex with l-aspartate
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
C, A, B, D
(517 residues)
|
|
|
|
Bound ligands:
|
Het Group GOL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of human pkm2 in complex with l-valine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
C, A, B, D
(511 residues)
|
|
|
|
Bound ligands:
|
Het Group GOL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Jak2 jh1 in complex with ruxolitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293f.
|
|
|
Chains:
D, B, C, A
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with baricitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, A
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with bl2-084
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, A
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with bl2-096
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, A
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with fedratinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, A
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with ma9-086
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, A
(291 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with pn2-118
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, A
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with pn2-123
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, A
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with pn3-115
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, A
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with pn4-014
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, A
(290 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with pn4-073
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
D, B, C, A
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with sg3-179
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
D, B, C, A
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with sy5-103
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
B, A
(289 residues)
|
|
|
|
|
|
Crystal structure of tyk2 kinase with compound 13
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Crystal structure of tyk2 kinase with compound 14
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
Crystal structure of tyk2 kinase with compound 19
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
Crystal structure of tyk2 kinase with compound 10
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Crystal structure of syk in complex with gs-9876
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chains:
A, B
(258 residues)
|
|
|
|
|
|
Crystal structure analysis of human ack1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(267 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with bl2-057
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
A, B
(289 residues)
|
|
|
|
|
|
Jak2 jh1 in complex with bl2-110
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: homo sapiens. Expression_system_taxid: 9606.
|
|
|
Chains:
D, B, C, A
(289 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with compound 5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(258 residues)
|
|
|
|
|
|
Structure of maternal embryonic leucine zipper kinase bound to ldsm276
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: melk, kiaa0175. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(309 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with compound 6
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with compound 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Ternary complex structure - btk ciap compound 17
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790. Gene: birc2, api1, mihb, rnf48. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(261 residues)
|
|
|
|
|
|
Ternary complex structure - btk ciap compound 15
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790. Gene: birc2, api1, mihb, rnf48. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C
(254 residues)
|
|
|
|
|
|
Crystal structure of jak1 kinase with compound 10
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(280 residues)
|
|
|
|
|
|
C-src bound to atp-competitive inhibitor i14
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(255 residues)
|
|
|
|
|
|
Pyruvate kinase m2 mutant-k433q
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(510 residues)
|
|
|
|
Bound ligand:
|
Het Group GOL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Pyruvate kinase m2 mutant-s37e
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(511 residues)
|
|
|
|
Bound ligands:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group PO4
is 50.00% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Pyruvate kinase m2 mutant-s37d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
B, A, C, D
(510 residues)
|
|
|
|
Bound ligand:
|
Het Group GOL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Pyruvate kinase m2 mutant-s37e k433e
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
C, A
(500 residues)
|
|
|
|
Bound ligand:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Human jak2 jh1 domain in complex with ruxolitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell: sf9.
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Human jak2 jh1 domain in complex with baricitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(279 residues)
|
|
|
|
|
|
Human jak2 jh1 domain in complex with protac-intermediate linker handle 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(276 residues)
|
|
|
|
|
|
Human jak2 jh1 domain in complex with protac-intermediate linker handle 4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Co-structure of btk kinase domain with l-005085737 inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(254 residues)
|
|
|
|
|
|
Co-structure of btk kinase domain with l-005191930 inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chains:
A, B
(265 residues)
|
|
|
|
|
|
Co-structure of btk kinase domain with l-005298385 inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Crystal structure of jak2 with compound 11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chains:
A, B
(274 residues)
|
|
|
|
|
|
Crystal structure of tyk2 with compound 11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chains:
A, C
(283 residues)
|
|
|
|
|
|
Crystal structure of tyk2 with compound 22
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Btk fluorocyclopropyl amide inhibitor, compound 25
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak067
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Abl 1b isoform active state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Abl isoform 1b inactive1 state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Abl 1b isoform inactive2 state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Crystal structure of c-src sh3 domain without atcun motif: monomer 2
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(59 residues)
|
|
|
|
|
|
Crystal structure of c-src sh3 domain without atcun motif: monomer 1
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(59 residues)
|
|
|
|
|
|
Crystal structure of the intertwined dimer of thE C-src sh3 domain without atcun motif
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain h122r-q128k mutant in complex with cu(ii) at ph 7.5 co-crystallized with methyl beta- cyclodextrin
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(56 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain h122r-q128e mutant in complex with cu(ii) at ph 6.5 co-crystallized with methyl beta- cyclodextrin
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(54 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain h122r-q128e mutant in complex with ni(ii) at ph 7.5 co-crystallized with methyl beta- cyclodextrin
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(55 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain h122r-q128k mutant in complex with ni(ii) at ph 7.5 co-crystallized with methyl beta- cyclodextrin
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with 6-[4-(3- methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]- 3,4-dihydro-1h-quinolin-2-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(259 residues)
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with n-methyl-n-(3- {[2-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-ylamino)-5-trifluoromethyl- pyrimidin-4-ylamino]-methyl}-pyridin-2-yl)-methanesulfonamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B, C, D
(269 residues)
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with n-methyl-n-(2- {[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl- pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B, C, D
(260 residues)
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with n-methyl-n-(3- {[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-pyrimidin-4-ylamino]- methyl}-pyridin-2-yl)-methanesulfonamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(256 residues)
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with 5-{4-[(pyridin- 3-ylmethyl)-amino]-5-trifluoromethyl-pyrimidin-2-ylamino}-1,3- dihydro-indol-2-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B, C, D
(260 residues)
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with 4-{[4-{[(1r, 2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin- 2-yl]amino}-n-methylbenzenesulfonamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B, C, D
(265 residues)
|
|
|
|
|
|
Focal adhesion kinase catalytic domain in complex with n-methyl-n-{3- [(2-phenylamino-5-trifluoromethyl-pyrimidin-4-ylamino)-methyl]- pyridin-2-yl}-methanesulfonamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B, C, D
(261 residues)
|
|
|
|
|
|
Crystal structure of 5-chloroindoline-2,3-dione covalently bound to the ph domain of bruton's tyrosine kinase mutant r28c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(156 residues)
|
|
|
|
|
|
Crystal structure of 5-(trifluoromethoxy)indoline-2,3-dione covalently bound to the ph domain of bruton's tyrosine kinase mutant r28c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(164 residues)
|
|
|
|
|
|
Crystal structure of 1,5-dimethylindoline-2,3-dione covalently bound to the ph domain of bruton's tyrosine kinase mutant r28c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(164 residues)
|
|
|
|
|
|
Syk kinase domain in complex with azabenzimidazole inhibitor 2b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Syk kinase domain in complex with azabenzimidazole inhibitor 2b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Syk kinase domain in complex with diamine inhibitor 5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Syk kinase domain in complex with azabenzimidazole inhibitor 7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Syk kinase domain in complex with azabenzimidazole inhibitor 3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(269 residues)
|
|
|
|
|
|
Syk in complex with 57262_sykb-az13344324-2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Syk kinase domain in complex with azabenzimidazole inhibitor 18
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Syk kinase domain in complex with diamine inhibitor 16
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Cryo-em structure of human mtor complex 2, overall refinement
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mlst8, gbl, lst8. Gene: rictor, kiaa1999. Gene: mapkap1, mip1, sin1.
|
|
|
Chains:
A, B
(2184 residues)
|
|
|
|
Bound ligand:
|
Het Group AGS
is 93.75% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Cryo-em structure of human mtor complex 2, focused on one half
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mlst8, gbl, lst8. Gene: rictor, kiaa1999. Gene: mapkap1, mip1, sin1.
|
|
|
Chain:
B
(1592 residues)
|
|
|
|
Bound ligand:
|
Het Group AGS
is 93.75% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain in space group c21 at ph 7.5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(58 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain in space group p1 at ph 7.5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(58 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain mutant e129q in space group c21 at ph 4.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(57 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain a95s-d99t mutant in c21 space group
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(58 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain a95s-d99t mutant in space group p21
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(59 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e121l-r123h mutant at ph 4.5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(60 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e121l-r123h mutant at ph 5.0 with peg
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(59 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e121l-r123h mutant at ph 3.0 with peg
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(58 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e121l-r123h mutant at ph 6.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(61 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e121l-r123h mutant at ph 5.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(60 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e121l-r123h mutant at ph 4.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(59 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t at ph 4.5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(60 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e129q at ph 4.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(60 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e121l-r123h mutant in complex with vsl12 at ph 3.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(61 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e121l-r123h mutant in complex with vsl12 at ph 5.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(60 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e121l-r123h mutant in complex with vsl12 at ph 4.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(60 residues)
|
|
|
|
|
|
Crystal structure of the fyn sh3 domain l112v-s114n-s115t-e121l-r123h mutant in complex with vsl12 at ph 6.0
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chain:
A
(59 residues)
|
|
|
|
|
|
Intertwined dimer of thE C-src sh3 domain mutant q128e
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain mutant s94a-t98d-v111l- n113s-t114s at ph 4.5
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(59 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain mutant s94a-t98d-v111l- n113s-t114s at ph 7.0
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(58 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain mutant s94a-t98d-v111l- n113s-t114s at ph 3.0
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(59 residues)
|
|
|
|
|
|
Intertwined dimer of thE C-src sh3 domain mutant v111l-n113s-t114s
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(55 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain mutant v111l-n113s-t114s at ph 7.0
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(60 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain mutant v111l-n113s-t114s in 7 m urea
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(60 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain mutant v111l-n113s-t114s in 3 m urea
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(60 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain mutant v111l-n113s-t114s- q128e at ph 6.0
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(59 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain mutant v111l-n113s-t114s- q128e at ph 7.0
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(58 residues)
|
|
|
|
|
|
Intertwined dimer of thE C-src sh3 domain mutant v111l-n113s-t114s- q128e at ph 6.0
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
Intertwined dimer of thE C-src sh3 domain mutant e106d
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain mutant l100i at ph 3.0
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(61 residues)
|
|
|
|
|
|
Intertwined dimer of thE C-src sh3 domain mutant t125s
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(57 residues)
|
|
|
|
|
|
Intertwined dimer of thE C-src sh3 domain mutant t126s
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
Kinase domain of csrc in complex with a pyrazolopyrimidine
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693
|
|
|
Chains:
A, B
(265 residues)
|
|
|
|
|
|
Crystal structure of jak3 in complex with fm601 (compound 10a)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(290 residues)
|
|
|
|
|
|
Crystal structure of jak3 in complex with fm587 (compound 9a)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(279 residues)
|
|
|
|
|
|
Human tyk2 pseudokinase domain (575-869) in complex with 5-(4-fluoro- phenyl)-2-ureido-thiophene-3-carboxylic acid amide.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
|
|
|
Chains:
A, B
(261 residues)
|
|
|
|
|
|
Crystal structure of jak3 in complex with delgocitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Strategic design of catalytic lysine-targeting reversible covalent bcr-abl inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(263 residues)
|
|
|
|
|
|
C-src in complex with fiin-2
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(261 residues)
|
|
|
|
|
|
C-src in complex with tas-120
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
B, A
(247 residues)
|
|
|
|
|
|
Strategic design of catalytic lysine-targeting reversible covalent bcr-abl inhibitors
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(265 residues)
|
|
|
|
|
|
Cryo-em structure of inactive mglu2-7 heterodimer
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Expression_system_taxid: 1092587
|
|
|
Chain:
B
(792 residues)
|
|
|
|
|
|
Jak2-jh2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(275 residues)
|
|
|
|
|
|
Fgr sh3 domain crystal structure
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgr, src2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(71 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak064
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak020
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with compound-12 aka:6-[(cyclopropanecarbonyl)amino]-4-{[2- methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3- carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(257 residues)
|
|
|
|
|
|
Crystal structure of tyrosine kinase 2 jh2 (pseudo kinase domain) complexed with compound-12 aka:6-[(cyclopropanecarbonyl)amino]-4-({3- [6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n- methylpyridazine-3-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(256 residues)
|
|
|
|
|
|
Structure of ack1 kinase in complex with a selective inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chains:
A, B
(268 residues)
|
|
|
|
|
|
Btk1 soaked with compound 5, y551 is sequestered
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Btk1 soaked with compound 5, y551 is sequestered
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Btk1 soaked with compound 26
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Btk1 soaked with compound 24
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Btk1 soaked with compound 25
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Btk1 soaked with compound 30
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Pyruvate kinase m2 mutant-n70d
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(515 residues)
|
|
|
|
Bound ligands:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 80.00% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of the noncovalently bonded complex of rilzabrutinib with btk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Crystal structure of the covalently bonded complex of rilzabrutinib with btk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(268 residues)
|
|
|
|
|
|
High-resolution crystal structure of human jak2 kinase domain (jh1) bound to pn5-114.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: mammalian expression vector flag-mcs-pcdna3.1. Expression_system_taxid: 2021188
|
|
|
Chain:
A
(297 residues)
|
|
|
|
|
|
High-resolution crystal structure of human jak2 kinase domain (jh1) bound to pn5-150.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: mammalian expression vector bsrgi-mcs-pcdna3.1. Expression_system_taxid: 2021187
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with compound 23
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(255 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with compound 51
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Co-crystal structure of perk with inhibitor (r)-2-amino-n-cyclopropyl-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-methylphenyl)nicotinamide
|
|
|
Source: not given
|
|
|
Chain:
A
(259 residues)
|
|
|
|
|
|
Crystal structure of human wee1 kinase domain in complex with zn-c3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Expression_system_variant: codon plus.
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with compound 45
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(260 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with compound 21
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(257 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with compound 65
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(257 residues)
|
|
|
|
|
|
Fragment-based discovery of a novel bruton's tyrosine kinase inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Fragment-based discovery of a novel bruton's tyrosine kinase inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Fragment-based discovery of a novel bruton's tyrosine kinase inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(269 residues)
|
|
|
|
|
|
Fragment-based drug design of a novel, covalent bruton's tyrosine kinase inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Expression_system_cell_line: sf9
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Crystal structure of the abl 1b kinase domain in complex with dasatinib and imatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C
(250 residues)
|
|
|
|
|
|
Crystal structure of the v-src sh3 domain q128r mutant
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(60 residues)
|
|
|
|
|
|
Crystal structure of the v-src sh3 domain n117d-v124l mutant
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(58 residues)
|
|
|
|
|
|
Crystal structure of the v-src sh3 domain w95r-i96t mutant
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(57 residues)
|
|
|
|
|
|
Src kinase bound to ecf506 trapped in inactive conformation
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Wzc-k540m-4ye c8
|
|
|
Source: Escherichia coli. Organism_taxid: 562. Gene: ge031_21350. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D, E, F, G, H
(510 residues)
|
|
|
|
|
|
Wzc-k540m-4ye c1
|
|
|
Source: Escherichia coli. Organism_taxid: 562. Gene: ge031_21350. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D, E, F, G, H
(651 residues)
|
|
|
|
|
|
Src kinase domain in complex with ponatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(259 residues)
|
|
|
|
|
|
Human deptor in a complex with mutant human mtorc1 a1459p
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1, mmtor. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293f. Gene: mlst8, gbl, lst8. Gene: deptor, depdc6.
|
|
|
Chain:
B
(2152 residues)
|
|
|
|
|
|
Cryo-em structure of deptor bound to human mtor complex 2, overall refinement
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mlst8, gbl, lst8. Gene: rictor, kiaa1999. Gene: mapkap1, mip1, sin1.
|
|
|
Chains:
B, A
(2194 residues)
|
|
|
|
|
|
Cryo-em structure of deptor bound to human mtor complex 2, focussed on one protomer
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mlst8, gbl, lst8. Gene: rictor, kiaa1999. Gene: mapkap1, mip1, sin1.
|
|
|
Chain:
A
(2194 residues)
|
|
|
|
|
|
Cryo-em structure of deptor bound to human mtor complex 2, dept-bound subset local refinement
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mlst8, gbl, lst8. Gene: rictor, kiaa1999. Gene: mapkap1, mip1, sin1.
|
|
|
Chain:
A
(2194 residues)
|
|
|
|
|
|
Cryo-em structure of deptor bound to human mtor complex 1, overall refinement
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mlst8, gbl, lst8. Gene: rptor, kiaa1303, raptor. Gene: deptor, depdc6.
|
|
|
Chains:
B, A
(2192 residues)
|
|
|
|
|
|
Cryo-em structure of deptor bound to human mtor complex 1, focussed on one protomer
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mlst8, gbl, lst8. Gene: rptor, kiaa1303, raptor. Gene: deptor, depdc6.
|
|
|
Chain:
A
(2192 residues)
|
|
|
|
|
|
Cryo-em structure of deptor bound to human mtor complex 1, dept-bound subset local refinement
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mlst8, gbl, lst8. Gene: rptor, kiaa1303, raptor. Gene: deptor, depdc6.
|
|
|
Chain:
A
(2192 residues)
|
|
|
|
|
|
Fak protac gsk215 in complex with fak and pvhl:elonginc:elonginb
|
|
|
Source: not given
|
|
|
Chain:
D
(264 residues)
|
|
|
|
|
|
Structure of the murine cortactin c-sh3 domain in complex with a pyk2 proline-rich ligand
|
|
|
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: cttn, ems1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes. Homo sapiens. Human.
|
|
|
Chain:
B
(19 residues)
|
|
|
|
|
|
Crystal structure of the abl sh3 domain v73e-a74s-s75r-g76t-d77e-g92n- y93n-n94t-h95e mutant in the space group p21221
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(58 residues)
|
|
|
|
|
|
Crystal structure of the abl sh3 domain v73e-a74s-s75r-g76t-d77e-g92n- y93n-n94t-h95e mutant in the space group p41
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(58 residues)
|
|
|
|
|
|
Crystal structure of the abl sh3 domain v73e-a74s-s75r-g76t-d77e-g92n- y93n-n94t-h95e mutant in presence of peg 200
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(58 residues)
|
|
|
|
|
|
Crystal structure of the v-src sh3 domain q128r mutant in complex with the synthetic peptide vsl12
|
|
|
Source: Rous sarcoma virus (strain schmidt-ruppin e). Rsv-sr-e. Organism_taxid: 270623. Strain: schmidt-ruppin e. Gene: v-src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Unidentified.
|
|
|
Chains:
A, C
(53 residues)
|
|
|
|
|
|
Crystal structure of the abl sh3 domain g92n-y93n-n94t-h95e mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bcr-abl1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
Crystal structure of the intertwined dimer of thE C-src sh3 domain e93v-s94a-r95s-t96g-n112g-n113y-t114n-e115h mutant
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(59 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain mutant e93v-s94a-r95s-t96g- n112g-n113y-t114n-e115h in complex with the synthetic peptide vsl12
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, C
(60 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain e93v-s94a-r95s-t96g mutant
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(56 residues)
|
|
|
|
|
|
Crystal structure of the intertwined dimer of thE C-src sh3 domain e93v-s94a-r95s-t96g mutant
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(60 residues)
|
|
|
|
|
|
Crystal structure of thE C-src sh3 domain n112g-n113y-t114n-e115h mutant
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D, E, F, G, H
(58 residues)
|
|
|
|
|
|
Crystal structure of the abl sh3 domain v73e-a74s-s75r-g76t-d77e mutant
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bcr/abl fusion. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(57 residues)
|
|
|
|
|
|
The tandem sh2 domains of syk
|
|
|
Source: Homo sapiens
|
|
|
Chains:
A, B, C
(259 residues)
|
|
|
|
|
|
Human jak3 kinase domain with 1-(4-((2-((1-methyl-1h-pyrazol-4-yl)amino)quinazolin-8-yl)amino)piperidin-1-yl)ethan-1-one'
|
|
|
Source: Homo sapiens
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Jak2 in complex with 4-{8-methoxy-2-[(1-methyl-1h-pyrazol-4-yl) amino]quinazolin-6-yl}phenol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Jak2 in complex with 4-(2-amino-8-methoxyquinazolin-6-yl)phenol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Jak2 in complex with 4-(2-amino-8-{[(2s)-1-hydroxypropan-2- yl]amino}quinazolin-6-yl)-5-ethyl-2-fluorophenol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(289 residues)
|
|
|
|
|
|
Jak2 in complex with 4-(2-{[5-(dimethylamino)pentyl]amino}-8-{[(2s)-1- hydroxypropan-2-yl]amino}quinazolin-6-yl)-5-ethyl-2-fluorophenol
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590
|
|
|
Chain:
A
(292 residues)
|
|
|
|
|
|
Btk in complex with 18a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Btk in complex with 25a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
E117k mutant pyruvate kinase from rabbit muscle
|
|
|
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Gene: pkm, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(519 residues)
|
|
|
|
Bound ligand:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
High-resolution crystal structure of human jak2 kinase domain (jh1) bound to ym2-059
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: mammalia sp. Mma-2019. Expression_system_taxid: 2598437
|
|
|
Chain:
A
(291 residues)
|
|
|
|
|
|
High-resolution crystal structure of human jak2 kinase domain (jh1) bound to type-ii inhibitor bbt594
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: mammalia sp. Mma-2019. Expression_system_taxid: 2598437. Expression_system_cell: expi293f.
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Crystal structure of the apo sh2 domains of syk
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B, C, D, E, F
(221 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak249
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak315
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(273 residues)
|
|
|
|
|
|
Crystal structure of a superbinder fes sh2 domain (sfes1) in complex with a high affinity phosphopeptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fes, fps. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
A
(102 residues)
|
|
|
|
|
|
Crystal structure of a superbinder fes sh2 domain (sfess) in complex with a high affinity phosphopeptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fes, fps. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chains:
A, B
(99 residues)
|
|
|
|
|
|
Jak2 jh2 in complex with jak292
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Crystal structure of a superbinder src sh2 domain (ssrcf) in complex with a high affinity phosphopeptide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
|
|
|
Chains:
A, B
(105 residues)
|
|
|
|
|
|
Structure of active janus kinase (jak) dimer complexed with cytokine receptor intracellular domain
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Variant: v657f. Gene: jak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ifnlr1, il28ra. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(1045 residues)
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
The ubiquitin-associated domain of human thirty-eight negative kinase- 1 flexibly fused to the 1tel crystallization chaperone via a gsgg linker
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: etv6, tel, tel1, tnk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(147 residues)
|
|
|
|
|
|
The ubiquitin-associated domain of human thirty-eight negative kinase i
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(77 residues)
|
|
|
|
|
|
The ubiquitin-associated domain of human thirty-eight negative kinase 1, flexibly fused to the 1tel crystallization chaperone via a 2- glycine linker and crystallized at low protein concentration
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: etv6, tel, tel1, tnk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(148 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh1 with type ii inhibitor yliu-04-105-1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(276 residues)
|
|
|
|
|
|
The apo structure of human mtorc2 complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: mlst8, gbl, lst8. Gene: rictor, kiaa1999. Gene: mapkap1, mip1, sin1.
|
|
|
Chains:
A, B
(2184 residues)
|
|
|
|
|
|
The ubiquitin-associated domain of human thirty-eight negative kinase- 1 flexibly fused to the 1tel crystallization chaperone via a 2- glycine linker and crystallized at traditional protein concentration
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: etv6, tel, tel1, tnk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(144 residues)
|
|
|
|
|
|
The ubiquitin-associated domain of human thirty-eight negative kinase- 1 flexibly fused to the 1tel crystallization chaperone via a 2- glycine linker and crystallized at very low protein concentration
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: etv6, tel, tel1, tnk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(153 residues)
|
|
|
|
|
|
Designed enzyme sh3-588 (catechol o-methyltransferase catalytic domain and src homology 3 binding domain fusion)
|
|
|
Source: Homo sapiens, rattus norvegicus. Human, norway rat. Organism_taxid: 9606, 10116. Gene: fyn, comt. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chain:
A
(265 residues)
|
|
|
|
Bound ligand:
|
Het Group SAH
is 51.43% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of the mtorc1-tfeb-rag-ragulator complex with symmetry expansion
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: mlst8, gbl, lst8. Gene: rptor, kiaa1303, raptor. Gene: rraga.
|
|
|
Chain:
A
(2188 residues)
|
|
|
|
Bound ligands:
|
Het Group GTP
is 96.88% similar to
enzyme reactant ATP
|
|
|
Het Group GTP
is 96.88% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Crystal structure of human fgr tyrosine kinase in complex with a- 419259
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgr, src2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chains:
A, B
(448 residues)
|
|
|
|
|
|
Crystal structure of human fgr tyrosine kinase in complex with tl02-59
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fgr, src2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
|
|
|
Chain:
A
(386 residues)
|
|
|
|
|
|
Crystal structure of tyk2 kinase domain in complex with compound 12
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Crystal structure of tyk2 kinase domain in complex with compound 16
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(282 residues)
|
|
|
|
|
|
Crystal structure of tyk2 kinase domain in complex with compound 25
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(278 residues)
|
|
|
|
|
|
Crystal structure of tyk2 kinase domain in complex with compound 30
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(269 residues)
|
|
|
|
|
|
Crystal structure of jak3 kinase domain in complex with compound 25
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(278 residues)
|
|
|
|
|
|
Crystal structure of jak2 kinase domain in complex with compound 30
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(290 residues)
|
|
|
|
|
|
The crystal structure of human abl1 kinase domain in complex with abl1-a11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(267 residues)
|
|
|
|
|
|
The crystal structure of human abl1 kinase domain in complex with abl2-a5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(269 residues)
|
|
|
|
|
|
Crystal structure of human focal adhesion targeting (fat) domain of the focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2, fak, fak1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(145 residues)
|
|
|
|
|
|
Crystal structure of human focal adhesion targeting (fat) domain of the focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(145 residues)
|
|
|
|
|
|
Crystal structure of zn bound human focal adhesion targeting (fat) domain of the focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(132 residues)
|
|
|
|
|
|
Crystal structure of zn bound human focal adhesion targeting (fat) domain of the focal adhesion kinase
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(132 residues)
|
|
|
|
|
|
C-src in complex with ponatinib
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(261 residues)
|
|
|
|
|
|
Co-crystal structure of btk kinase domain with inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Structure of human src regulatory domains in complex with thE C- terminal prrp motifs of gpr54.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1, kiss1r, axor12, gpr54. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(173 residues)
|
|
|
|
|
|
Structure of rip2k dimer bound to the xiap bir2 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: xiap, api3, birc4, iap3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(284 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2-v617f in complex with cdk2 inhibitor iv
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2-v617f in complex with hts-a3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(274 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2-v617f in complex with jnj-7706621
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2-v617f in complex with z902-a3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
|
|
|
|
Bound ligand:
|
Het Group Q7F
is 41.67% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of jak2 jh2 in complex with z902-a3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
|
|
|
|
Bound ligand:
|
Het Group Q7F
is 41.67% similar to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of jak2 jh2-v617f in complex with z902-a1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(275 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2 in complex with bemcentinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(287 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2-v617f in complex with bemcentinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(274 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2-v617f in complex with cb76
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2-v617f in complex with reversine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Syk kinase domain in complex with macrocyclic inhibitor 20a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Human wee1 kinase in complex with inhibitor 1-[6-(1-hydroxy-1-methyl- ethyl)-pyridin-2-yl]-2-(2-methoxy-phenyl)-6-[4-(4-methyl-piperazin-1- yl)-phenylamino]-1,2-dihydro-pyrazolo[3,4-d]pyrimidin-3-one
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wee1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(260 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh1 in complex with gandotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(300 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh1 in complex with pacritinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh1 in complex with lestaurtinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(300 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh1 in complex with cerdulatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh1 in complex with ilginatinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(300 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh1 in complex with itacitinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(293 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh1 in complex with momelotinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(300 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2-k539l
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(270 residues)
|
|
|
|
Bound ligand:
|
Het Group ATP
corresponds to
enzyme reactant ATP
|
|
|
|
|
|
|
Crystal structure of jak2 jh2-i559f
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2-r683s
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(274 residues)
|
|
|
|
|
|
Structure of ciap1, btk and bccov
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790. Gene: birc2, api1, mihb, rnf48. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
B
(258 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase (btk) with compound 13
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Crystal structure of the kinase domain of rtkc8 from the choanoflagellate monosiga brevicollis
|
|
|
Source: Monosiga brevicollis. Organism_taxid: 81824. Gene: 34458. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
|
Chain:
A
(268 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with 3-{[4-(1-acetylpiperidin-4- yl)phenyl]amino}-5-[(3r)-3-(3-methyl-2-oxoimidazolidin-1-yl) piperidin-1-yl]pyrazine-2-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Co-crystal structure of perk with compound 11
|
|
|
Source: not given
|
|
|
Chain:
A
(253 residues)
|
|
|
|
|
|
Co-crystal structure of perk with compound 24
|
|
|
Source: not given
|
|
|
Chain:
A
(256 residues)
|
|
|
|
|
|
Co-crystal structure of perk with compound 26
|
|
|
Source: not given
|
|
|
Chain:
A
(256 residues)
|
|
|
|
|
|
Fkbp12-frb in complex with compound 11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mtor. Expression_system_taxid: 562
|
|
|
Chains:
B, D, F
(95 residues)
|
|
|
|
|
|
Fkbp12-frb in complex with compound 12
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mtor. Expression_system_taxid: 562
|
|
|
Chains:
B, D, F
(95 residues)
|
|
|
|
|
|
Rmc-5552 in complex with mtorc1 and fkbp12
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
|
Chain:
A
(2177 residues)
|
|
|
|
|
|
Structure of janus kinase (jak) dimer complexed with cytokine receptor intracellular domain
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: jak1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ifnlr1, il28ra. Expression_system_taxid: 7111
|
|
|
Chains:
A, B
(1049 residues)
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
Crystal structure of jak2 jh2 (pseudokinase domain) in complex with cdk2-iv
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2 (pseudokinase domain) in complex with reversine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(272 residues)
|
|
|
|
|
|
Crystal structure of jak2 jh2 (pseudokinase domain) in complex with htsa3
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(273 residues)
|
|
|
|
|
|
Nef sf2 dimerization mutant bound to hck sh3
|
|
|
Source: HIV-1 m:b_arv2/sf2. Organism_taxid: 11685. Strain: isolate arv2/sf2. Gene: nef. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chain:
B
(56 residues)
|
|
|
|
|
|
Rabbit muscle pyruvate kinase in complex with sodium and magnesium
|
|
|
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986
|
|
|
Chains:
A, B, C, D, E, F, G, H
(520 residues)
|
|
|
|
Bound ligand:
|
Het Group GOL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Rabbit muscle pyruvate kinase in complex with magnesium, potassium and pyruvate
|
|
|
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986
|
|
|
Chains:
A, B, C, D
(519 residues)
|
|
|
|
Bound ligand:
|
Het Group PYR
corresponds to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Complex of rabbit muscle pyruvate kinase with adp and the phosphonate analogue of pep mimicking the michaelis complex.
|
|
|
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986
|
|
|
Chains:
A, B, C, D, E, F, G, H
(519 residues)
|
|
|
|
Bound ligands:
|
Het Group SIN
is 55.56% similar to
enzyme reactant pyruvate
|
|
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
Het Group ALA
is 45.45% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Structure of btk kinase domain with the second-generation inhibitor acalabrutinib
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: btk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(271 residues)
|
|
|
|
|
|
Crystal structure of ack1 kinase k161q mutant in complex with the selective inhibitor (r)-9b
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expression_system_atcc_number: crl-1711. Expression_system_tissue: ovary.
|
|
|
Chain:
A
(274 residues)
|
|
|
|
|
|
Structure of btk kinase domain with the second-generation inhibitor tirabrutinib
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: btk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(265 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with an orthosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with an orthosteric inhibitor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(266 residues)
|
|
|
|
|
|
Crystal structure of btk kinase domain in complex with pirtobrutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Crystal structure of btk c481s kinase domain in complex with pirtobrutinib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: trichoplusia ni. Expression_system_taxid: 7111
|
|
|
Chain:
A
(263 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with compound 34
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(267 residues)
|
|
|
|
|
|
Sterile alpha motif of human translocation ets leukemia, non-polymer crystal form
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: etv6, tel, tel1, tnk2, ack1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B, C, D
(78 residues)
|
|
|
|
|
|
Pkm2 bound to compound 2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(519 residues)
|
|
|
|
Bound ligand:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
|
|
|
|
Jak2 crystal structure in complex with compound 13
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(281 residues)
|
|
|
|
|
|
The crystal structure of jak2 in complex with compound 31
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(282 residues)
|
|
|
|
|
|
X-ray co-crystal structure of compound 27 in with complex jak2
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jak2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(279 residues)
|
|
|
|
Bound ligand:
|
Het Group YT8
is 44.12% similar to
enzyme product ADP
|
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with 5-(piperidin-1-yl)-3-{[4- (piperidin-4-yl)phenyl]amino}pyrazine-2-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase l528w mutant in complex with 5-(piperidin-1- yl)-3-{[4-(piperidin-4-yl)phenyl]amino}pyrazine-2-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(253 residues)
|
|
|
|
|
|
Crystal structure of the full-length bruton's tyrosine kinase (ph-th domain not visible)
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: btk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(438 residues)
|
|
|
|
|
|
The crystal structure of human abl1 kinase domain in complex with abl1-b-eba
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(267 residues)
|
|
|
|
|
|
The crystal structure of human abl1 kinase domain in complex with abl1-a-eba
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(269 residues)
|
|
|
|
|
|
The complex of src with gw8510
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(247 residues)
|
|
|
|
|
|
Human pkm2 mutant - c326s
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, D, C
(508 residues)
|
|
|
|
|
|
Crystal structure of pkm2 mutant p403a
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(481 residues)
|
|
|
|
Bound ligands:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of pkm2 mutant l144p
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(513 residues)
|
|
|
|
Bound ligands:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
Crystal structure of pkm2 mutant c474s
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(512 residues)
|
|
|
|
Bound ligands:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 42.86% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
The complex of ack1 with the inhibitor 2-142
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tnk2, ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C, D
(270 residues)
|
|
|
|
|
|
Crystal structure of pkm2 mutant r516c
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(512 residues)
|
|
|
|
Bound ligands:
|
Het Group OXL
is 71.43% similar to
enzyme reactant pyruvate
|
|
|
Het Group FBP
is 60.00% similar to
enzyme product phosphoenolpyruvate
|
|
|
|
|
|
|
The crystal structure of human abl1 kinase domain in complex with abl1-b1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia. Expression_system_taxid: 561
|
|
|
Chains:
A, B
(262 residues)
|
|
|
|
|
|
The crystal structure of human abl1 kinase domain in complex with abl1-b4
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia. Expression_system_taxid: 561
|
|
|
Chains:
A, B
(267 residues)
|
|
|
|
|
|
The crystal structure of human abl1 kinase domain in complex with abl1-b5
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia. Expression_system_taxid: 561
|
|
|
Chains:
A, B
(258 residues)
|
|
|
|
|
|
The pkr and e3l complex
|
|
|
Source: Vaccinia virus wr. Organism_taxid: 10254. Strain: western reserve. Gene: vacwr059, e3l. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chain:
A
(179 residues)
|
|
|
|
|
|
Structural study of interferon-induced, double-stranded RNA-activated protein kinase (pkr) and non-structural protein 1 (ns1) complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: eif2ak2, pkr, prkr. Expressed in: escherichia coli. Expression_system_taxid: 562. Influenza a virus (strain a/memphis/102/1972 h3n2). Organism_taxid: 385640.
|
|
|
Chain:
A
(179 residues)
|
|
|
|
|
|
Cryo-em structure of mglu2-mglu3 heterodimer in presence of ly341495 (dimerization mode i)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3, mtor. Expression_system_taxid: 1092587
|
|
|
Chain:
3
(765 residues)
|
|
|
|
|
|
Cryo-em structure of mglu2-mglu3 heterodimer in presence of ly341495 (dimerization mode ii)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3, mtor. Expression_system_taxid: 1092587
|
|
|
Chain:
3
(751 residues)
|
|
|
|
|
|
Cryo-em structure of mglu2-mglu3 heterodimer in presence of ly341495 and nam563 (dimerization mode i)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3, mtor. Expression_system_taxid: 1092587
|
|
|
Chain:
3
(765 residues)
|
|
|
|
|
|
Cryo-em structure of mglu2-mglu3 heterodimer in presence of ly341495 and nam563 (dimerization mode ii)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3, mtor. Expression_system_taxid: 1092587
|
|
|
Chain:
3
(751 residues)
|
|
|
|
|
|
Cryo-em structure of mglu2-mglu3 heterodimer in presence of ly341495, nam563, and ly2389575 (dimerization mode i)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3, mtor. Expression_system_taxid: 1092587
|
|
|
Chain:
3
(765 residues)
|
|
|
|
|
|
Cryo-em structure of mglu2-mglu3 heterodimer in presence of ly341495, nam563, and ly2389575 (dimerization mode iii)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3, mtor. Expression_system_taxid: 1092587
|
|
|
Chain:
3
(743 residues)
|
|
|
|
Bound ligands:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of mglu2-mglu3 heterodimer in presence of nam563
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3, mtor. Expression_system_taxid: 1092587
|
|
|
Chain:
3
(765 residues)
|
|
|
|
Bound ligands:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of mglu2-mglu3 heterodimer in rco state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3, mtor. Expression_system_taxid: 1092587
|
|
|
Chain:
3
(756 residues)
|
|
|
|
|
|
Cryo-em structure of g protein-free mglu2-mglu3 heterodimer in acc state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3, mtor. Expression_system_taxid: 1092587
|
|
|
Chain:
3
(749 residues)
|
|
|
|
Bound ligands:
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
Het Group NAG
is 41.38% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryo-em structure of g protein-free mglu2-mglu4 heterodimer in acc state
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2, fkbp1a, fkbp1, fkbp12. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm4, gprc1d, mglur4, mtor. Expression_system_taxid: 1092587
|
|
|
Chain:
4
(756 residues)
|
|
|
|
|
|
C-src in complex with compound 9
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(242 residues)
|
|
|
|
|
|
Crystal structure of c-src in complex with covalent inhibitor dc-srci- 6668
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(451 residues)
|
|
|
|
|
|
Crystal structure of c-src in complex with covalent inhibitor lw-srci- 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(451 residues)
|
|
|
|
|
|
Crystal structure of c-src kinase domain bound by tpx-0022
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(264 residues)
|
|
|
|
|
|
Tau-s214 phosphorylation inhibits fyn kinase interaction and increases the decay time of nmdar-mediated current
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
A
(60 residues)
|
|
|
|
|
|
Co-crystal structure of fkbp12, compound 7 and the frb fragment of mtor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expression_system_taxid: 866768
|
|
|
Chain:
B
(94 residues)
|
|
|
|
|
|
Structure of the lysine methyltransferase setd2 in complex with a peptide derived from human tyrosine kinase ack1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: setd2, hif1, hypb, kiaa1732, kmt3a, set2, hspc069. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chain:
B
(12 residues)
|
|
|
|
|
|
Pkr kinase domain- eif2alpha in complex with compound
|
|
|
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: sui2, tif211, yjr007w, j1429. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chain:
B
(267 residues)
|
|
|
|
|
|
Cryoem structure of mtorc1 with a paediatric kidney cancer-associated 1455-ewed-1458 duplication in mtor, overall refinement
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: mlst8, gbl, lst8. Gene: rptor, kiaa1303, raptor. Gene: eif4ebp1.
|
|
|
Chains:
A, B
(2036 residues)
|
|
|
|
Bound ligands:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryoem structure of mtorc1 with a paediatric kidney cancer-associated 1455-ewed-1458 duplication in mtor, focused on one protomer copy.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: mlst8, gbl, lst8. Gene: rptor, kiaa1303, raptor. Gene: eif4ebp1.
|
|
|
Chain:
B
(2036 residues)
|
|
|
|
Bound ligands:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Cryoem structure of mtorc1 with a paediatric kidney cancer-associated 1455-ewed-1458 duplication in mtor, focused region of mtor and raptor on one protomer copy.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: rptor, kiaa1303, raptor. Gene: eif4ebp1. Expressed in: escherichia coli.
|
|
|
Chain:
B
(1521 residues)
|
|
|
|
Bound ligands:
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
Het Group ANP
is 81.25% similar to
enzyme product ADP
|
|
|
|
|
|
|
Intertwined dimer of the ptk6 sh3 domain
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk6, brk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(61 residues)
|
|
|
|
|
|
Crystal structure of the ph-th/kinase complex of bruton's tyrosine kinase
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: btk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(429 residues)
|
|
|
|
|
|
Crystal structure of the tyk2 pseudokinase domain in complex with compound 8
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C
(256 residues)
|
|
|
|
|
|
Crystal structure of the tyk2 pseudokinase domain in complex with compound 11
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C
(261 residues)
|
|
|
|
|
|
Crystal structure of the tyk2 pseudokinase domain in complex with tak- 279
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B, C
(264 residues)
|
|
|
|
|
|
Crystal structure of the kinase domain of bruton's tyrosine kinase bound to dasatinib
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: btk, bpk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
B, A
(255 residues)
|
|
|
|
|
|
Abl kinase in complex with ski and asciminib
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B
(420 residues)
|
|
|
|
|
|
Tyk2 jh2 bound to compound7
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(257 residues)
|
|
|
|
|
|
Tyk2 jh2 bound to compound14
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tyk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(263 residues)
|
|
|
|
|
|
1tel, non-compressed, double-helical crystal form
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: etv6, tnk2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(77 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with covalent inhibitor compound 10
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(256 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with covalent inhibitor compound 25
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(256 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with covalent inhibitor compound 27
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(256 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with n-[(2r)-1-[(3r)-3- (methylcarbamoyl)-1h,2h,3h,4h,9h-pyrido[3,4-b]indol-2-yl]-3-(3- methylphenyl)-1-oxopropan-2-yl]-1h-indazole-5-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Bruton's tyrosine kinase in complex with n-[(2r)-1-[(3r)-3- (methylcarbamoyl)-1h,2h,3h,4h,9h-pyrido[3,4-b]indol-2-yl]-3-(3- methylphenyl)-1-oxopropan-2-yl]-1h-indazole-5-carboxamide
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(270 residues)
|
|
|
|
|
|
Crystal structure of superbinder src sh2 domain with cysteine to serine mutations
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(108 residues)
|
|
|
|
|
|
Mutant src sh2 domain in complex with phosphotyrosine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(108 residues)
|
|
|
|
|
|
The complex structure of cul2-vcb-protac-wee1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cul2. Expressed in: insect cell expression vector ptie1. Expression_system_taxid: 266783. Gene: rbx1. Gene: vhl. Expressed in: escherichia coli.
|
|
|
Chain:
W
(277 residues)
|
|
|
|
|
|
The crystal structure of lyn from biortus.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lyn. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(63 residues)
|
|
|
|
|
|
Crystal structure of spleen tyrosine kinase (syk) in complex with ski- o-592 (free form of ski-o-703, cevidoplenib)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(264 residues)
|
|
|
|
|
|
The crystal structure of bmx from biortus.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmx. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(259 residues)
|
|
|
|
|
|
Ripk2 in complex with k252
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ripk2, cardiak, rick, rip2, unq277/pro314/pro34092. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(278 residues)
|
|
|
|
|
|
The crystal structure of lck from biortus.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B
(98 residues)
|
|
|
|
|
|
The crystal structure of fes from biortus.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fes. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(374 residues)
|
|
|
|
|
|
Pyruvate kinase m2 (pkm2) mutant in complex with phenylalanine
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
|
|
|
Chains:
A, B, C, D
(508 residues)
|
|
|
|
|
|
The crystal structure of syk from biortus.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: syk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(264 residues)
|
|
|
|
|
|
Crystal structure of frb-fkbp fusion protein in complex with rapamycin
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1, fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(201 residues)
|
|
|
|
|
|
The crystal structure of src from biortus.
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: src. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chain:
A
(450 residues)
|
|
|
|
Bound ligand:
|
Het Group ADP
corresponds to
enzyme product ADP
|
|
|
|
|
|
|
The crystal structure of fak2 from biortus.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(261 residues)
|
|
|
|
|
|
Structure of the pyk2 from biortus.
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ptk2b, fak2, pyk2, raftk. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chain:
A
(255 residues)
|
|
|
|
|
|
The crystal structure of btk from biortus
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: btk, agmx1, atk, bpk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
|
|
|
Chains:
A, B
(262 residues)
|
|
|
|
|
|
Structure of src in complex with beta-arrestin 1 revealing sh3 binding sites
|
|
|
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Bacteriophage sp.. Organism_taxid: 38018. Expressed in: escherichia coli.
|
|
|
Chain:
C
(55 residues)
|
|
|
|
|
|
Crystal structure of hck in complex with the src-family kinase inhibitor a-419259
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hck. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star.
|
|
|
Chain:
A
(450 residues)
|
|
|
|
|
|
The ubiquitin-associated domain of human thirty-eight negative kinase 1, fused to the 2tel crystallization chaperone via a 2-glycine linker
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: etv6, tel, tel1, tnk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
A
(234 residues)
|
|
|
|
|
|
Structure of sh3 domain of src in complex with beta-arrestin 1
|
|
|
Source: Lama glama. Organism_taxid: 9844. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src. Mus musculus.
|
|
|
Chain:
C
(55 residues)
|
|
|
|
|
|
Structure of sh3 domain of src in complex with beta-arrestin 1
|
|
|
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606.
|
|
|
Chain:
B
(55 residues)
|
|
|
|
|
|
Crystal structure of a synthetic fab (r3e9) in complex with the frb domain of mtor
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
|
|
|
Chain:
C
(93 residues)
|
|
|
|
|
|
Crystal structure of a synthetic fab (r3h8) in complex with the frb domain of mtor
|
|
|
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Human. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expression_system_taxid: 562
|
|
|
Chains:
G, I
(92 residues)
|
|
|
|
|
|
Active state of mtor on membrane
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: mlst8, gbl, lst8. Gene: rheb, rheb2. Expressed in: escherichia coli.
|
|
|
Chain:
A
(2305 residues)
|
|
|
|
Bound ligand:
|
Het Group GSP
is 90.91% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Intermediate state of mtor on membrane
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: mlst8, gbl, lst8. Gene: rheb, rheb2. Expressed in: escherichia coli.
|
|
|
Chain:
A
(2267 residues)
|
|
|
|
Bound ligand:
|
Het Group GSP
is 90.91% similar to
enzyme reactant ATP
|
|
|
|
|
|
|
Cryo-em structure of lst2 tos peptide bound to human mtor complex 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mlst8, gbl, lst8. Gene: rptor, kiaa1303, raptor. Synthetic: yes.
|
|
|
Chains:
A, B
(2192 residues)
|
|
|
|
|
|
Cryo-em structure of human lst2 bound to human mtor complex 1
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mtor, frap, frap1, frap2, raft1, rapt1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mlst8, gbl, lst8. Gene: rptor, kiaa1303, raptor. Gene: zfyve28, kiaa1643, lst2.
|
|
|
Chains:
A, B
(2192 residues)
|
|
|
|
|
|
Crystal structure of fyn sh3 domain/tau 214-220 peptide complex
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
|
|
|
Chains:
A, B
(62 residues)
|
|
|
|
|
|
K115 acetylated human muscle pyruvate kinase, isoform m2 (pkm2), in complex with fbp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(519 residues)
|
|
|
|
|
|
K115 acetylated human muscle pyruvate kinase, isoform m2 (pkm2)
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(505 residues)
|
|
|
|
|
|
K166 acetylated human muscle pyruvate kinase, isoform m2 (pkm2), in complex with fbp
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pkm, oip3, pk2, pk3, pkm2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
|
Chains:
A, B, C, D
(521 residues)
|
|
|
|
|
|
The ubiquitin-associated domain of human thirty-eight negative kinase- 1 rigidly fused to a double trigger variant of the 1tel crystallization chaperone
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: etv6, tel, tel1, tnk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chains:
A, B
(153 residues)
|
|
|
|
|
|
The ubiquitin-associated domain of human thirty-eight negative kinase 1, fused to the 3tel crystallization chaperone via a 2-glycine linker
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: etv6, tel, tel1, tnk1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
|
Chain:
B
(306 residues)
|
|
|
|
|
|
Crystal structure of c-src sh3 domain in h32 space group mediated by nickel
|
|
|
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: src, src1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: rosetta.
|
|
|
Chains:
A, B, C, D
(59 residues)
|
|
|
[IntEnz]
[ExPASy]
[KEGG]
