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Ligand clusters for UniProt code Q04631

Ligand clusters for Q04631: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha from Rattus norvegicus

5 ligand clusters


Cluster 1. 46 ligand types 92 ligands		Cluster 2. 1 ligand type 2 ligands		Cluster 3. 1 ligand type 1 ligand		Cluster 4. 1 ligand type 1 ligand		Cluster 5. 1 ligand type 3 ligands

Representative protein: 1d8dA

Structures

PDB		Schematic diagram

1d8dA
3e32A
3e30A
1kzpA
4gtmA
		more ...

Cluster 1 contains 46 ligand types (of which only 20 are listed. Click for all)

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Ligand

Description

1. Ligand: DMS × 3

dimethyl sulfoxide

Dimethyl sulfoxide

PDB codes: 4gtp(A), 4gtr(A).

2. Ligand: FPP × 26

Farnesyl diphosphate

PDB codes: 1ft2(A), 1fti(A), 1hz7(A), 1jcr(A), 1kzo(A), 1kzr(A), 1o5m(A), 1sa5(A), 2bed(A), 2fti(A), 2r2l(A), 2zir(A), 2zis(A), 3dpy(A), 3e30(A), 3e32(A), 3e33(A), 3e34(A), 3fti(A), 3ksq(A), 3pz4(A), 4gtm(A), 4gto(A), 4gtp(A), 4gtq(A), 4gtr(A).

3. Ligand: HFP × 6

Alpha-Hydroxyfarnesylphosphonic acid

PDB codes: 1n94(A), 1n95(A), 1n9a(A), 1ni1(A), 1nl4(A), 1qbq(A).

4. Ligand: MGM × 6

2-[Methyl-(5-Geranyl-4-Methyl-Pent-3-Enyl)-Amino]- Ethyl-Diphosphate

PDB codes: 1n4q(A), 1tnb(A), 1tno(A), 1tnu(A), 1tny(A), 1tnz(A).

5. Ligand: FII × 5

[(3,7,11-Trimethyl-Dodeca-2,6,10-Trienyloxycarbamoyl)- Methyl]-Phosphonic acid

PDB codes: 1d8d(A), 1d8e(A), 1jcs(A), 1tn7(A), 1tn8(A).

6. Ligand: GRG × 3

Geranylgeranyl diphosphate

PDB codes: 1n4p(A), 1n4s(A), 1o1r(A).

7. Ligand: THR-LYS-CYS-VAL-ILE-MET × 3

PDB codes: 1d8e(A), 1kzo(A), 1tno(A).

8. Ligand: GBO × 2

(2e,6e)-3,7-Dimethyl-8-({5-[(3as,4s,6ar)-2- Oxohexahydro-1h-Thieno[3,4-D]imidazol-4-
Yl]pentanoyl}amino)octa-2,6-Dien-1-Yl trihydrogen diphosphate

PDB codes: 3eu5(A), 3euv(A).

9. Ligand: 1NH × 1

(2e,6e)-8-[(3-Benzoylbenzyl)oxy]-3,7-Dimethylocta-2,6- Dienyl trihydrogen diphosphate

PDB code: 1o1s(A).

10. Ligand: 2C5 × 1

2-Chloro-5-(3-Chloro-Phenyl)-6-[(4-Cyano-Phenyl)-(3- Methyl-3h-Imidazol-4-Yl)- Methoxymethyl]-
Nicotinonitrile

PDB code: 1ni1(A).

11. Ligand: 2NH × 1

N-Acetyl-S-[(2e,6e)-3,7,11-Trimethyldodeca-2,6,10- Trienyl]-L-Cysteinyl-D-Valyl-L-Isoleucyl-L-
Methionine

PDB code: 1o1t(A).

12. Ligand: 336 × 1

4-{2-[4-(3,10-Dibromo-8-Chloro-6,11-Dihydro-5h-Benzo[5, 6]cyclohepta[1,2-B]pyridin-11-Yl)piperidin-
1-Yl]-2- Oxoethyl}piperidine-1-Carboxamide

PDB code: 1o5m(A).

13. Ligand: 736 × 1

(11s)-8-Chloro-11-[1-(Methylsulfonyl)piperidin-4-Yl]-6- Piperazin-1-Yl-11h-
Benzo[5,6]cyclohepta[1,2-B]pyridine

PDB code: 2bed(A).

14. Ligand: 778 × 1

4-[(5-{[4-(3-Chlorophenyl)-3-Oxopiperazin-1- Yl]methyl}-1h-Imidazol-1-Yl)methyl]benzonitrile

PDB code: 1s64(A).

15. Ligand: 7TP × 1

5-{(3r)-3-(4-Hydroxybenzyl)-4-[(4-Methoxyphenyl) sulfonyl]-1-[(1-Methyl-1h-Imidazol-5-Yl)methyl]-
2,3,4, 5-Tetrahydro-1h-1,4-Benzodiazepin-7-Yl}furan-2- Carbaldehyde

PDB code: 4gtp(A).

16. Ligand: 7TQ × 1

4-({(3r)-7-Cyano-4-[(4-Methoxyphenyl)sulfonyl]-1-[(1- Methyl-1h-Imidazol-5-Yl)methyl]-2,3,4,5-
Tetrahydro-1h- 1,4-Benzodiazepin-3-Yl}methyl)phenyl benzylcarbamate

PDB code: 4gtq(A).