Ligand clusters for UniProt code P36897

Ligand clusters for P36897: TGF-beta receptor type-1 from Homo sapiens

		Top 6 (of 11) ligand clusters Cluster 1. 28 ligand types 30 ligands Cluster 2. 3 ligand types 4 ligands Cluster 3. 2 ligand types 13 ligands Cluster 4. 2 ligand types 8 ligands Cluster 5. 2 ligand types 2 ligands Cluster 6. 1 ligand type 2 ligands
Representative protein: 1iasA

Structures

PDB		Schematic diagram
1iasA
3kcfA
3faaA
2x7oA
3hmmA
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Cluster 1 contains 28 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5e8t(A).
		2. Ligand: TRS × 1 tromethamine 2-Amino-2-Hydroxymethyl-Propane-1,3-Diol PDB code: 4x2g(A).
		3. Ligand: 580 × 1 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6- Dihydro-4h-Pyrrolo[1,2-B]pyrazole PDB code: 1rw8(A).
		4. Ligand: 460 × 1 2-[5-(6-Methylpyridin-2-Yl)-2,3-Dihydro-1h-Pyrazol-4- Yl]-1,5-Naphthyridine PDB code: 1vjy(A).
		5. Ligand: PY1 × 1 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)quinoline PDB code: 1py5(A).
		6. Ligand: 5L4 × 2 3-Amino-6-[4-(2-Hydroxyethyl)phenyl]-N-[4-(Morpholin-4- Yl)pyridin-3-Yl]pyrazine-2-Carboxamide PDB codes: 5e8z(A), 5e90(A).
		7. Ligand: STU × 2 Staurosporine PDB codes: 5e8w(A), 5e8x(A).
		8. Ligand: 085 × 1 4-[5-(1,3-Benzodioxol-5-Yl)-4-(Pyridin-2-Yl)-1h- Imidazol-2-Yl]benzamide PDB code: 3tzm(A).
		9. Ligand: 3WA × 1 4-Aminopyrido[2,3-D]pyrimidin-5(8h)-One PDB code: 4x0m(A).
		10. Ligand: 3WJ × 1 4-Amino-8-(4-Aminophenyl)pyrido[2,3-D]pyrimidin-5(8h)- One PDB code: 4x2f(A).
		11. Ligand: 3WK × 1 4-[(4-Aminophenyl)amino]pyrido[2,3-D]pyrimidin-5(6h)- One PDB code: 4x2g(A).
		12. Ligand: 3WN × 1 4-[(3-Aminophenyl)amino]pyrido[2,3-D]pyrimidin-5(8h)- One PDB code: 4x2j(A).
		13. Ligand: 3WO × 1 4-[(3-Aminophenyl)amino]pyrido[2,3-D]pyrimidin-5(6h)- One PDB code: 4x2k(A).
		14. Ligand: 55F × 1 N-[4-(5-Fluoro-6-Methylpyridin-2-Yl)-5-Quinoxalin-6-Yl- 1h-Imidazol-2-Yl]acetamide PDB code: 3faa(A).
		15. Ligand: 855 × 1 2-(6-Methylpyridin-2-Yl)-N-Pyridin-4-Ylquinazolin-4- Amine PDB code: 3hmm(A).
		16. Ligand: 8LY × 1 N-[2-(5-Chloro-2-Fluorophenyl)pyridin-4-Yl]-2- [(Piperidin-4-Yl)methyl]-2h-Pyrazolo[4,3-B]pyridin- 7- Amine PDB code: 5usq(A).
		17. Ligand: D0A × 1 N-(3-Fluoropyridin-4-Yl)-2-[6-(Trifluoromethyl)pyridin- 2-Yl]-7h-Pyrrolo[2,3-D]pyrimidin-4-Amine PDB code: 6b8y(A).
		18. Ligand: J2M × 1 N-{4-[3-(6-Fluoropyridin-3-Yl)-4-Oxo-4,5,6,7- Tetrahydro-1h-Pyrrolo[3,2-C]pyridin-2-Yl]pyridin-2- Yl}acetamide PDB code: 5qik(A).
		19. Ligand: J2V × 1 N-{4-[3-(6-Methoxypyridin-3-Yl)-1h-Pyrrolo[3,2- B]pyridin-2-Yl]pyridin-2-Yl}acetamide PDB code: 5qil(A).
		20. Ligand: J2Y × 1 N-{4-[3-(5-Methoxypyridin-2-Yl)-1h-Pyrrolo[3,2- B]pyridin-2-Yl]pyridin-2-Yl}acetamide PDB code: 5qim(A).
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Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5qtz(A).
		2. Ligand: PO4 × 2 Phosphate ion PDB codes: 3faa(A), 3kcf(A).
		3. Ligand: SO4 × 1 Sulfate ion PDB code: 1ias(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: SO4 × 9 Sulfate ion PDB codes: 1b6c(B), 1ias(A), 1py5(A), 4x0m(A), 4x2f(A), 4x2g(A), 4x2j(A), 4x2k(A), 4x2n(A).
		2. Ligand: PO4 × 4 Phosphate ion PDB codes: 3faa(A), 3kcf(A),

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 6 glycerin Glycerol PDB codes: 5e8t(A), 5e8u(A), 5qik(A), 5qim(A), 5qtz(A), 5qu0(A).
		2. Ligand: EDO × 2 1,2-Ethanediol PDB codes: 2wou(A), 5fri(A).

Cluster 5 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5e8w(A).
		2. Ligand: EDO × 1 1,2-Ethanediol PDB code: 5fri(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 5e8t(A), 5e8u(A).