Ligand clusters for UniProt code P07342

Ligand clusters for P07342: Acetolactate synthase catalytic subunit, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

		5 ligand clusters Cluster 1. 19 ligand types 49 ligands Cluster 2. 19 ligand types 39 ligands Cluster 3. 2 ligand types 6 ligands Cluster 4. 1 ligand type 1 ligand Cluster 5. 2 ligand types 12 ligands
Representative protein: 1n0hA

Structures

PDB		Schematic diagram
1n0hA
1t9aA
1t9cA
5femA
1t9bA
		more ...

Cluster 1 contains 19 ligand types

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Ligand		Description
		1. Ligand: TPP × 1 Thiamine diphosphate PDB code: 1jsc(A).
		2. Ligand: FAD × 13 flavin adenine dinucleotide Flavin-Adenine dinucleotide PDB codes: 1jsc(A), 1n0h(A), 1t9a(A), 1t9b(A), 1t9c(A), 1t9d(A), 5fem(A), 5ims(A), 5inu(A), 5inv(A), 5wkc(A), 6bd3(A), 6bd9(A).
_Mg		3. Metal: _MG × 13 PDB codes: 1jsc(A), 1n0h(A), 1t9a(A), 1t9b(A), 1t9c(A), 1t9d(A), 5fem(A), 5ims(A), 5inu(A), 5inv(A), 5wkc(A), 6bd3(A), 6bd9(A).
		4. Ligand: P23 × 1 Propyl trihydrogen diphosphate PDB code: 1t9a(A).
		5. Ligand: P25 × 1 Pentyl trihydrogen diphosphate PDB code: 1t9d(A).
		6. Ligand: P22 × 2 Ethyl dihydrogen diphosphate PDB codes: 1t9b(A), 1t9c(A).
		7. Ligand: YF4 × 1 5-{[Ethyl(methyl)amino]methyl}-2-Methyl-5,6- Dihydropyrimidin-4-Amine PDB code: 1t9a(A).
		8. Ligand: YF3 × 1 2-{[(4-Amino-2-Methylpyrimidin-5-Yl) methyl]amino}propane-1-Thiol PDB code: 1t9b(A).
		9. Ligand: AYD × 1 4-{[(4'-Amino-2'-Methylpyrimidin-5'-Yl) methyl]amino}pent-3-Enyl diphosphate PDB code: 1n0h(A).
		10. Ligand: 1CS × 1 1-(2-Chlorophenylsulfonyl)-3-(4-Methoxy-6-Methyl-L,3,5- Triazin-2-Yl)urea PDB code: 1t9b(A).
		11. Ligand: 1MM × 1 Methyl 2-[({[(4-Methoxy-6-Methyl-1,3,5-Triazin-2-Yl) amino]carbonyl}amino)sulfonyl]benzoate PDB code: 1t9d(A).
		12. Ligand: 1SM × 1 Methyl 2-[({[(4,6-Dimethylpyrimidin-2-Yl) amino]carbonyl}amino)sulfonyl]benzoate PDB code: 1t9c(A).
		13. Ligand: 1TB × 1 Methyl 2-[4-Methoxy-6-Methyl-1,3,5-Trazin-2-Yl(methyl) carbamoylsulfamoyl]benzoate PDB code: 1t9a(A).
		14. Ligand: CIE × 1 2-[[[[(4-Chloro-6-Methoxy-2-Pyrimidinyl) amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester PDB code: 1n0h(A).
		15. Ligand: TPP × 6 Thiamine diphosphate PDB codes: 5fem(A), 5ims(A), 5inu(A), 5inv(A), 6bd3(A), 6bd9(A).
		16. Ligand: 60G × 1 Methyl 2-[(4,6-Dimethoxypyrimidin-2-Yl) carbamoylsulfamoylmethyl]benzoate PDB code: 5fem(A).
		17. Ligand: AUJ × 1 2-[3-[(4-Azanyl-2-Methyl-Pyrimidin-5-Yl)methyl]-2- [(1~{s})-1-(Dioxidanyl)-1-Oxidanyl-Ethyl]-4- Methyl-1, 3-Thiazol-5-Yl]ethyl phosphono hydrogen phosphate PDB code: 5wkc(A).
		18. Ligand: PXD × 1 2-(2,2-Difluoroethoxy)-N-(5,8-Dimethoxy[1,2, 4]triazolo[1,5-C]pyrimidin-2-Yl)-6- (Trifluoromethyl) benzenesulfonamide PDB code: 5wkc(A).
		19. Ligand: PYD × 1 2,5-Dimethyl-Pyrimidin-4-Ylamine PDB code: 1t9d(A).

Cluster 2 contains 19 ligand types

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Ligand		Description
		1. Ligand: TPP × 2 Thiamine diphosphate PDB codes: 1jsc(A), 1n0h(A).
		2. Ligand: FAD × 13 flavin adenine dinucleotide Flavin-Adenine dinucleotide PDB codes: 1jsc(A), 1n0h(A), 1t9a(A), 1t9b(A), 1t9c(A), 1t9d(A), 5fem(A), 5ims(A), 5inu(A), 5inv(A), 5wkc(A), 6bd3(A), 6bd9(A).
		3. Ligand: PYR × 4 pyruvic acid Pyruvic acid PDB codes: 5inu(A), 6bd9(A),
		4. Ligand: NSP × 1 5-(Aminomethyl)-2-Methylpyrimidin-4-Amine PDB code: 1t9b(A).
		5. Ligand: YF3 × 1 2-{[(4-Amino-2-Methylpyrimidin-5-Yl) methyl]amino}propane-1-Thiol PDB code: 1t9a(A).
		6. Ligand: 2HP × 1 Dihydrogenphosphate ion PDB code: 1jsc(A).
		7. Ligand: 1CS × 1 1-(2-Chlorophenylsulfonyl)-3-(4-Methoxy-6-Methyl-L,3,5- Triazin-2-Yl)urea PDB code: 1t9b(A).
		8. Ligand: 1MM × 1 Methyl 2-[({[(4-Methoxy-6-Methyl-1,3,5-Triazin-2-Yl) amino]carbonyl}amino)sulfonyl]benzoate PDB code: 1t9d(A).
		9. Ligand: 1SM × 1 Methyl 2-[({[(4,6-Dimethylpyrimidin-2-Yl) amino]carbonyl}amino)sulfonyl]benzoate PDB code: 1t9c(A).
		10. Ligand: 1TB × 1 Methyl 2-[4-Methoxy-6-Methyl-1,3,5-Trazin-2-Yl(methyl) carbamoylsulfamoyl]benzoate PDB code: 1t9a(A).
		11. Ligand: CIE × 1 2-[[[[(4-Chloro-6-Methoxy-2-Pyrimidinyl) amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester PDB code: 1n0h(A).
		12. Ligand: TPP × 4 Thiamine diphosphate PDB codes: 5fem(A), 5ims(A), 5inu(A), 6bd9(A).
		13. Ligand: HTL × 2 2-Acetyl-Thiamine diphosphate PDB codes: 5inv(A), 6bd3(A).
		14. Ligand: 60G × 1 Methyl 2-[(4,6-Dimethoxypyrimidin-2-Yl) carbamoylsulfamoylmethyl]benzoate PDB code: 5fem(A).
		15. Ligand: ACT × 1 Acetate ion PDB code: 5ims(A).
		16. Ligand: F50 × 1 Ethaneperoxoic acid PDB code: 5wkc(A).
		17. Ligand: PXD × 1 2-(2,2-Difluoroethoxy)-N-(5,8-Dimethoxy[1,2, 4]triazolo[1,5-C]pyrimidin-2-Yl)-6- (Trifluoromethyl) benzenesulfonamide PDB code: 5wkc(A).
		18. Ligand: PYD × 1 2,5-Dimethyl-Pyrimidin-4-Ylamine PDB code: 1t9d(A).
		19. Ligand: TP9 × 1 (3z)-4-{[(4-Amino-2-Methylpyrimidin-5-Yl)methyl]amino}- 3-Mercaptopent-3-En-1- Yl trihydrogen diphosphate PDB code: 5wkc(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: 2HP × 1 Dihydrogenphosphate ion PDB code: 1jsc(A).
		2. Ligand: PO4 × 5 Phosphate ion PDB codes: 5ims(A), 5inu(A), 5inv(A), 6bd3(A), 6bd9(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: DTT × 1 2,3-Dihydroxy-1,4-Dithiobutane PDB code: 1n0h(A).

Cluster 5 contains 2 ligand types

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Ligand		Description
__K		1. Metal: __K × 11 PDB codes: 1jsc(A), 1n0h(A), 1t9a(A), 1t9b(A), 1t9c(A), 1t9d(A), 5ims(A), 5inu(A), 5inv(A), 6bd3(A), 6bd9(A).
_Mg		2. Metal: _MG × 1 PDB code: 5fem(A).