PDBsum entry 6bd9

Transferase

PDB id: 6bd9

Contents

Protein chains

542 a.a.

Ligands

FAD ×2

TPP ×2

PYR ×4

OXY ×8

PO4

Metals

__K ×2

_MG ×2

Waters ×635

PDB id:

6bd9

Name:

Transferase

Title:

Saccharomyces cerevisiae acetohydroxyacid synthase

Structure:

Acetolactate synthase catalytic subunit, mitochondrial. Chain: a, b. Synonym: acetohydroxy-acid synthase catalytic subunit,als. Engineered: yes

Source:

Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ilv2, smr1, ymr108w, ym9718.07. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.98Å R-factor: 0.159 R-free: 0.181

Authors:

L.W.Guddat,T.Lonhienne

Key ref:

L.W.Guddat and t.lonhienne High resolution crystal structures of the acetohydrox synthase-Pyruvate complex provide new insights into i catalytic mechanism. To be published, .

Date:

22-Oct-17 Release date: 08-Nov-17

Supersedes:

5inu

Protein chains

P07342  (ILVB_YEAST) -  Acetolactate synthase catalytic subunit, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: 687 a.a.

Struc: 542 a.a.

Enzyme reactions

• Enzyme class: E.C.2.2.1.6 - acetolactate synthase.
• Pathway: Isoleucine and Valine Biosynthesis
• Reaction: 2 pyruvate + H⁺ = (2S)-2-acetolactate + CO2

2 × pyruvate + H(+) (Bound ligand (Het Group name = PYR) corresponds exactly) = (2S)-2-acetolactate + CO2

• Cofactor: Thiamine diphosphate

Thiamine diphosphate (Bound ligand (Het Group name = TPP) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site