Petsalaki Group

Whole Cell Signalling

The group studies human cell signalling to understand what controls different cell responses in different conditions. Our long-term aim is to create whole-cell signalling models, to better understand cell functions and disease.


Welcome to the Petsalaki group web pages!

We are a computational lab, heavily collaborating with experimental groups, and we use data-driven strategies to understand what drives the specificity of human cell signalling responses. Examples of questions we are interested in are:

a) How does rewiring human cell signalling networks result in different cell phenotypes?

b)    Which are the regulators of this rewiring? What are the molecular mechanisms?

c)    How do differences in the genome, or transcriptome layer of cell regulation affect the cell’s signalling networks?

You can find us in the South building of EMBL-EBI on the beautiful Wellcome Genome Campus, Hinxton, UK.

Select publications

1. Wadie B*, Kleshchevnikov V*, Sandaltzopoulou E, Benz C, Petsalaki E. Use of viral motif mimicry improves the proteome-wide discovery of human linear motifs bioRxiv, 449930

2. Barker CG, Petsalaki Ei, Giudice G, Sero J, Ekpenyong EN, Bakal C, Petsalaki E Identification of phenotype-specific networks from paired gene expression-cell shape imaging data bioRxiv, 430597

3. Weidemueller P*, Kholmatov M*, Petsalaki E#, Zaugg JB#, Transcription factors: Bridge between cell signaling and gene regulation. Proteomics, 2021

4. Sharma S#*, Dincer C*, Weidemüller P, Wright G, Petsalaki E#. CEN-tools: An integrative platform to identify the contexts of essential genes. Mol.Sys.Biol, 2020

5. Invergo BM*, Petursson B*, Bradley B, Giudice G, Hijazi M, Cutillas P, Petsalaki E#, Beltrao P#, Prediction of Signed Protein Kinase Regulatory Circuits. Cell Syst., 2020

6. Müller PM*, Rademacher J*, Bagshaw RD*, Wortmann C, Barth C, van Unen J, Alp KM, Giudice G, Eccles RL, Heinrich LE, Pascual-Vargas P, Sanchez-Castro M, Brandenburg L, Mbamalu G, Tucholska M, Spatt L, Czajkowski MT, Welke RW, Zhang S, Nguyen V, Rrustemi T, Trnka P, Freitag K, Larsen B, Popp O, Mertins P, Gingras AC, Roth FP, Colwill K, Bakal C, Pertz O, Pawson T, Petsalaki E#, Rocks O#. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organezed RAC1 signalling from integrin adhesions. Nat Cell Biol., 2020