› 8a1a

X-ray diffraction
2.05Å resolution

Structure of a leucinostatin derivative determined by host lattice display : L1F11V1 construct

Released:
DOI: 10.2210/pdb8a1a/pdb
PDB entry 8a1a coloured by chain, front view.
PDB entry 8a1a coloured by chain, side view.
PDB entry 8a1a coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Structure of a hydrophobic leucinostatin derivative determined by host lattice display.
Kiss C, Gall FM, Dreier B, Adams M, Riedl R, Plückthun A, Mittl PRE
Acta Crystallogr D Struct Biol 78 1439-1450 (2022)
PMID: 36458615

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169217 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
L1F11v1 Chain: A
Molecule details ›
Chain: A
Length: 1347 amino acids
Theoretical weight: 147.04 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
6-(2-methoxyethoxy)-11,15-dimethyl-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.17 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

4 bound ligands:
Ligand MN 4 x MN
Ligand MPD 4 x MPD
Ligand MES 1 x MES
Ligand CL 4 x CL
2 modified residues:
Ligand HPE 1 x HPE
Ligand AIB 3 x AIB

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P65
Unit cell:
a: 191.866Å b: 191.866Å c: 122.409Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.162 0.161 0.185
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 mention without citation

The cytochrome P450 genes of channel catfish: their involvement in disease defense responses as revealed by meta-analysis of RNA-Seq data sets.
Zhang et al. (2014)