Domain

Glycosyl hydrolase 101, beta-sandwich domain (IPR035364)

Short name: Glyco_hyd_101_beta

Domain relationships

None.

Description

Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolise the resultant carbohydrates. Endo-alpha-N-acetylgalactosaminidase (EC:3.2.1.97) belongs to the GH101 family of glycoside hydrolases, and specifically cleaves Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins [PMID: 19788271].

This entry represents a beta sandwich domain in GH101 family proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam